scholarly journals Prescription Benzodiazepine Use During Pregnancy and Risk of Attention-Deficit/Hyperactivity Disorder in Offspring

2020 ◽  
Vol 5 (5) ◽  
Author(s):  
Deepa Singal
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Negative Control Group ◽  
In Utero ◽  
Negative Control ◽  
Sensitivity Analyses ◽  
Control Group ◽  
In Utero Exposure ◽  
Hyperactivity Disorder ◽  
Residual Confounding

IntroductionBenzodiazepine (BZD) prescribing rates during pregnancy have risen over the last two decades. There is little research into the potential relationship between in utero exposure to BZD and offspring risk of attention deficit/hyperactivity disorder (ADHD), although there is some evidence of negative neurodevelopmental outcomes. Objectives and ApproachWe used comprehensive linked administrative data to investigate the association between maternal use of prescription BZDs during pregnancy and ADHD in offspring. We included mother-newborn dyads in Manitoba born from 1996-2012, with follow-up through 2017. BZD exposure was defined as 2+ prescriptions between conception and delivery. We matched exposed children to unexposed children to account for differences in characteristics between women who used BZDs during pregnancy versus non-users. Several sensitivity analyses addressed the potential for residual confounding, including a negative control group and a group made entirely of recent users of BZDs. Cox Proportional Hazard Regression Models were used to estimate the risk of ADHD among offspring. ResultsAmong 495 children with at least two BZD exposures throughout pregnancy, 25.4% (n=452) had a diagnosis of ADHD compared with 18.0% (n=68) of children not exposed (adjusted HR 1.91, 95% CI 1.35-2.69). However, the association was unchanged in the negative control group analyses (aHR 1.76, 1.09-2.86), and not significant in the recent users of BZD (aHR 0.91, 0.63-1.30). Mother’s history of ADHD and teen births were also associated with ADHD in offspring. ConclusionsIn a large population-level analysis, in utero exposure to prescription BZDs during pregnancy appeared to increase risk of ADHD. However, sensitivity analyses suggest this relationship was likely due to residual confounding. The power to link data for the whole population and across generations enabled powerful sensitivity analyses that alter the initial inference.

In Utero Exposure to Ischemic-Hypoxic Conditions and Attention-Deficit/Hyperactivity Disorder

PEDIATRICS ◽  
2012 ◽  
Vol 131 (1) ◽  
pp. e53-e61 ◽  
Author(s):  
D. Getahun ◽  
G. G. Rhoads ◽  
K. Demissie ◽  
S.-E. Lu ◽  
V. P. Quinn ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
In Utero ◽  
In Utero Exposure ◽  
Hyperactivity Disorder ◽  
Hypoxic Conditions

scholarly journals In utero exposure to antidepressant drugs and risk of attention deficit hyperactivity disorder: a nationwide Danish cohort study

BMJ Open ◽  
2013 ◽  
Vol 3 (9) ◽  
pp. e003507 ◽  
Author(s):  
Kristina Laugesen ◽  
Morten Smærup Olsen ◽  
Ane Birgitte Telén Andersen ◽  
Trine Frøslev ◽  
Henrik Toft Sørensen
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Attention Deficit ◽  
Antidepressant Drugs ◽  
In Utero ◽  
In Utero Exposure ◽  
Hyperactivity Disorder ◽  
Danish Cohort

Mainstream and Remedial School Attention Deficit Hyperactivity Disorder Boys: More Alike than Different

2005 ◽  
Vol 35 (1) ◽  
pp. 73-88
Author(s):  
J. B. Savitz ◽  
P. Jansen
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Control Group ◽  
Adhd Group ◽  
Hyperactivity Disorder ◽  
Significant Difference ◽  
Executive Deficits ◽  
Mainstream School ◽  
The Difference ◽  
Neuropsychological Tasks

The literature on the neuropsychology of Attention Deficit Hyperactivity Disorder (ADHD) is plagued by inconsistent findings, which are usually attributed to a variety of extraneous variables. One of the most inadequately explored of these variables is the difference between ADHD children attending remedial and mainstream schools. This study aimed to investigate whether the performance of remedial and mainstream school ADHD boys differs on relevant neuropsychological tasks. The sample consisted of three groups of 8- to 12-year-old boys. Two of these groups consisted of children with ADHD: one from remedial schools and one from mainstream schools. The third group was made up of participants without ADHD, who attended mainstream schools. The performance of the remedial school learners on the Stroop, Lurian and cancellation tasks was investigated and compared to a mainstream school ADHD sample. The performance of the ADHD group as a whole was compared with that of a control group. No significant difference in performance was found between the two ADHD groups, except for the length of time taken to read words in the control condition of the Stroop. The control group out-performed the ADHD samples on the Stroop, Lurian and cancellation tasks. The findings suggest that mainstream and remedial ADHD boys do not differ in the severity of their executive deficits, but that boys with ADHD attending remedial schools may be more likely to have another learning disorder than their counterparts at mainstream schools.

Long-term risk of epilepsy, cerebral palsy and attention-deficit/hyperactivity disorder in children affected by a threatened abortion in utero

2021 ◽  
Author(s):  
Elena Dudukina ◽  
Erzsébet Horváth-Puhó ◽  
Henrik Toft Sørensen ◽  
Vera Ehrenstein
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cerebral Palsy ◽  
Attention Deficit ◽  
Cox Regression ◽  
In Utero ◽  
Autism Spectrum ◽  
Sibling Pairs ◽  
Hyperactivity Disorder ◽  
Hazard Ratios ◽  
Threatened Abortion

Abstract Background The birth of a child affected by a threatened abortion (TAB) in utero is associated with autism spectrum disorder; association with other neurological disorders is unknown. Methods This nationwide registry-based cohort study included singletons live-born in Denmark (1979–2010), followed through 2016. The outcomes were epilepsy, cerebral palsy (CP) and attention-deficit/hyperactivity disorder (ADHD). We used Cox regression to compute hazard ratios (HRs), adjusted for birth year, birth order, parental age, morbidity, medication use and maternal socio-economic factors. To remove time-invariant family-shared confounding, we applied sibling analyses. Results The study population included 1 864 221 singletons live-born in 1979–2010. Among the TAB-affected children (N = 59 134) vs TAB-unaffected children, at the end of follow-up, the cumulative incidence was 2.2% vs 1.6% for epilepsy, 0.4% vs 0.2% for CP and 5.5% vs 4.2% for ADHD (for children born in 1995–2010). The adjusted HRs were 1.25 [95% confidence interval (CI) 1.16–1.34] for epilepsy, 1.42 (95% CI 1.20–1.68) for CP and 1.21 (95% CI 1.14–1.29) for ADHD. In the sibling design, the adjusted HRs were unity for epilepsy (full siblings: 0.96, 95% CI 0.82–1.12; maternal: 1.04, 95% CI 0.90–1.20; paternal: 1.08, 95% CI 0.93–1.25) and ADHD (full: 1.08, 95% CI 0.92–1.27; maternal: 1.04, 95% CI 0.90–1.20; paternal: 1.08, 95% CI 0.93–1.25). For CP, HRs shifted away from unity among sibling pairs (full: 2.92, 95% CI 1.33–6.39; maternal: 2.03, 95% CI 1.15–3.57; paternal: 3.28, 95% CI 1.36–7.91). Conclusions The birth of a child affected by TAB in utero was associated with a greater risk of CP, but not epilepsy or ADHD.

A Comparison between Barkley Behavioral Therapy, Minuchin Structural Family Therapy and Neuro-feedback on Anxiety among children suffering from Attention Deficit – Hyperactivity Disorder

2020 ◽  
Vol 59 (10) ◽  
pp. 47-60
Author(s):  
Baqer Mirza Hasanvand ◽  
◽  
Kiyan Gholam Javadi Tarziloo ◽  
Mahbube Mostafa Khiri ◽  
◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Family Therapy ◽  
Attention Deficit ◽  
Attention Deficit Disorder ◽  
Behavioral Therapy ◽  
Statistical Tests ◽  
Control Group ◽  
Structural Family Therapy ◽  
Structural Family ◽  
Hyperactivity Disorder

Background & objective: Due to the consequences of attention deficit - hyperactivity disorder, various therapy approach have been formed. This research aimed to investigate a comparative study between Barkley behavioral therapy, Minuchin structural family therapy and neuro-feedback on anxiety among children suffering from attention deficit – hyperactivity disorder. Methods: This study was a quasi - experimental pretest-posttest with a control group. The study population consisted of all primary school student in Karaj in 2018. By using cluster sampling method, 400 students selected and screening conducted for hyperactivity and anxiety. The sample consisted of 40 (10 for each group) students and their mothers were selected by as an available and randomly recruits to each of groups. Instruments for gathering data were semi-structured diagnostic interview (K-SADS), short diagnostic scale for hyperactivity and attention deficit disorder (Caners, 1999) and multidimensional child anxiety scale (March et al., 1997). Then, the participants in the experimental groups (Three groups) participated in Barkley behavioral therapy (9 sessions of 90 min), Minuchin structural family therapy (8 sessions of 90 min) and neuro-feedback (25 sessions of 30 min), while the control group did not receive any intervention. Then, the data were analyzed using SPSS.v21 software and statistical tests such as MANCOVA and ANCOVA. Data analysig was performed with SPSS.v16 and significant levels of all tests set on 0.05. Results: The results indicate that Barkley behavioral therapy, Minuchin structural family therapy and neuro-feedback have significant impact on anxiety among children suffering from attention deficit – hyperactivity disorder, generally (P < 0.01). Furthermore, post-hoc test revealed that the efficacy of therapies on anxiety of experiment groups is different (P < 0.01). Three months follow-up results represent resistance of therapies (P > 0.01). Conclusion: So, using of these therapies for reduction of anxiety among children suffering from attention deficit – hyperactivity disorder. Key words: Barkley behavioral therapy, Minuchin structural family therapy, neuro-feedback, anxiety, attention deficit – hyperactivity disorder

Efficacy of cognitive-behavioral therapy and deep relaxation for children with attention-deficit hyperactivity disorder

2019 ◽  
pp. 19-26
Author(s):  
Nawel Abdesslem ◽  
Sabeur Hamrouni ◽  
Roy Jesse Shephard ◽  
Mohamed Souhaiel Chelly
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cognitive Behavioral Therapy ◽  
Attention Deficit ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Control Group ◽  
Hyperactivity Disorder ◽  
Before And After ◽  
Physically Based ◽  
One Year

Objective: This study made a preliminary exploration of the efficacy of physically-based cognitive-behavioral therapy and deep relaxation for children with attention-deficit hyperactivity disorder (ADHD). Methods: ADHD behavior and cognitive functions were assessed by test D2 and Conner’s scale before and after a one-year physically-based training program. The reliability of test scores was assessed by repeat testing of a control group (CG) of 10 students who did not have ADHD. Children (10 per group) with ADHD were assigned to physically-based cognitive-behavioral therapy and deep relaxation (E1) or physically-based cognitive-behavioral alone (E2). Results: After 52 weeks of treatment, an intra-group comparison showed that E1 and E2 had improved their scores on the test D2, whereas CG showed no significant change. In addition, most participants with ADHD showed a remarkable improvement in their attentional behavior, with group E1 responding better to treatment than group E2. Conclusions: Physically-based cognitive behavioral therapy appears to improve function and social competence in children with ADHD, and should be recommended as an alternative or supplement to pharmaceutical treatment.

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