scholarly journals Neurology and Covid-19: Present and Future

2020 ◽  
Vol 5 (10) ◽  
pp. 436-442
Author(s):  
Hernández Ramos, F J, PhD, MD ◽  
Hernández Chamorro, F J, ◽  
Palomino García, A ◽  
Jiménez Hernández, MD
Keyword(s):  
Public Health ◽  
Health Services ◽  
Respiratory Virus ◽  
Neurological Symptoms ◽  
Strong Impact ◽  
Neurological Manifestations ◽  
Economic Level

We´re witnessing a pandemic due to COVID-19, which has generated a strong impact in Public Health, Health Services and a economic level, still to be determinated. It´s a recently discovered respiratory virus that has the capacity to produce neurological symptoms, either indirectly o directly. Much has been written about neurological symptoms, mainly by no-neurologist, and the frecuency and type of neurological manifestations must be precisely defined in both, acute and medium-long term phases. After carrying out and extensive bibliographic review, the objective of this paper is to analyze what has been described so far and how it can be improved to know exactly the type and frecuency of neurological manifestations related to COVID-19.

scholarly journals Atypical Manifestation of Polyneuropathy in Covid-19

2021 ◽  
Author(s):  
Nayara de Lima Froio ◽  
Ana Luisa Rosas Sarmento ◽  
Sonia Maria Cesar de Azevedo Silva ◽  
Lilia Azzi Collet da Rocha Camargo
Keyword(s):  
Case Report ◽  
Physical Therapy ◽  
Sore Throat ◽  
Neurological Symptoms ◽  
Lower Limbs ◽  
Neurological Manifestations ◽  
Sensory Motor ◽  
Hands And Feet ◽  
Atypical Manifestation

Context: Neurological manifestations of Sars-CoV-2 are progressively emerging. Cases of Guillain-Barré syndrome and its variants, with onset about 5-10 days after influenza symptoms, have been described. This paper reports a case of polyneuropathy with onset 90 days after a sore throat episode and persistence of IgM positivity in serology for Sars- Cov-2. We aim to raise awareness of this possibility. Case Report: A 56-year-old male, hypertensive, presented with sore throat on April 21, 2020. Serology for Covid-19 was performed with positive IgM. There was complete improvement of the symptom. At the end of July, he started a symmetrical paresthesia in the feet with ascension to the knees and, on August 20, paresthesia in the hands too. So, he went to IAMSPE (SP) and tactile and painful hypoesthesia in hands and feet, hypopalesthesia in lower limbs, a fall in the lower limbs upon Mingazzini’s maneuver, global hyporeflexia and talon gait were found. Just the following tests were changed: second Covid-19 serology IgM and IgG positives; ENMG: sensory motor polyneuropathy, primarily axonal, with signs of chronicity and without signs of acute denervation in the current. Started gabapentin and physical therapy. Patient still has paresthesia in hands and feet, but with partial improvement. Conclusion: This case alerts to neurological symptoms of Covid-19 in the medium and long term.

scholarly journals Argentine Registry of neurological manifestations due to coronavirus-19 (COVID-19)

2021 ◽  
Author(s):  
Mariana Bendersky ◽  
Lucas Alessandro ◽  
Franco Appiani ◽  
Brenda Borrego Guerrero ◽  
Patricia Cairola ◽  
...  
Keyword(s):  
Demographic Variables ◽  
Neurological Symptoms ◽  
Neurological Manifestations ◽  
Cns Involvement ◽  
Term Care ◽  
Cerebrovascular Complications ◽  
Guillain Barré ◽  
Neurological Pathology ◽  
Degree Of Severity

COVID-19 disease has spread around the world since December 2019. Neurological symptoms are part of its clinical spectrum. Objective: To know the neurological manifestations in patients infected by COVID-19 in Argentina. Methods: Multicenter study conducted in adults, from May 2020 to January 2021, with confirmed COVID-19 and neurological symptoms. Demographic variables, existence of systemic or neurological comorbidities, the form of onset of the infection, alteration in complementary studies and the degree of severity of neurological symptoms were recorded. Results: 817 patients from all over the country were included, 52% male, mean age 38 years, most of them without comorbidities or previous neurological pathology. The first symptom of the infection was neurological in 56.2% of the cases, predominantly headache (69%), then anosmia / ageusia (66%). Myalgias (52%), allodynia / hyperalgesia (18%), and asthenia (6%) were also reported. 3.2% showed diffuse CNS involvement such as encephalopathy or seizures. 1.7% had cerebrovascular complications. Sleep disorders were observed in 3.2%. 6 patients were reported with Guillain Barre (GBS), peripheral neuropathy (3.4%), tongue paresthesia (0.6%), hearing loss (0.4%), plexopathy (0.3%). The severity of neurological symptoms was correlated with age and the existence of comorbidities. Conclusions: Our results, similar to those of other countries, show two types of neurological symptoms associated with COVID-19: some potentially disabling or fatal such as GBS or encephalitis, and others less devastating, but more frequent such as headache or anosmia that demand increasingly long-term care.

scholarly journals Three-month outcomes in hospitalized COVID-19 patients

2020 ◽  
Author(s):  
Jude PJ Savarraj ◽  
Angela B Burkett ◽  
Sarah N Hinds ◽  
Atzhiry S Paz ◽  
Andres Assing ◽  
...  
Keyword(s):  
Public Health ◽  
Hospitalized Patients ◽  
Neurological Symptoms ◽  
Cognitive Symptoms ◽  
Neurologic Outcomes ◽  
Pain Symptoms

AbstractCOVID-19 is an ongoing pandemic with a devastating impact on public health. Acute neurological symptoms have been reported after a COVID-19 diagnosis, however there is no data available on the long-term neurological symptoms. Using a prospective registry of hospitalized COVID-19 patients, we assessed the neurological assessments (including functional, cognitive and psychiatric assessments) of several hospitalized patients at 3 months. Our main finding is that 71% of the patients still experienced neurological symptoms at 3 months and the most common symptoms being fatigue (42%) and PTSD (29%). 64% of the patients report pain symptoms we well. Cognitive symptoms were found in 12%. Our preliminary findings suggests the importance of investigating long-term and rationalizes the need for further studies investigating the neurologic outcomes after COVID-19.

scholarly journals An Analytical-Predictive Model for Measuring the Efficiency and Effectiveness of Public Health Services

2020 ◽  
Vol 13 (1) ◽  
pp. 203-211
Author(s):  
Neda Vitezić ◽  
Antonija Petrlić
Keyword(s):  
Public Health ◽  
Health Services ◽  
Predictive Model ◽  
Balanced Scorecard ◽  
Data Envelopment ◽  
Public Health Services ◽  
Measuring Efficiency ◽  
Efficiency And Effectiveness ◽  
Public Health Institutions

Background: The main function of public health services is to improve people’s health and therefore, efficiency and effectiveness are constantly a subject of various world-wide research works. Today, in the era of digitalization, when numerous data are created and built, it is much easier to develop and implement a measurement system. It is possible to quickly use a wide variety of accurate and reliable data, aiming to create different measures that will help in the assessment and the decision-making process. For a long time, public health services have been facing a problem of finding an appropriate solution for measuring efficiency and effectiveness. Objective: The aim of this research is to find an appropriate analytical-predictive model for measuring efficiency and effectiveness of public health institutes. Public health is oriented to monitoring, analysis, and evaluation of the health of a population i.e., prevention activities. It is a complex and interdependent process of different realisation of services, programmes, and activities the results of which are sometimes visible only after a long period of time. Therefore, the results of their activities should be evaluated using an appropriate performance measurement system. Methods: The adjusted Balanced Scorecard (BSC) combined with the non-parametric Data Envelopment Analysis (DEA) technique is used to help identify the possibilities for improving the efficiency and effectiveness of public health service activities. Results: The result of this study is the proposed Analytical-Predictive Model (APE) that uses Balanced Scorecard combined with Data Envelopment Analysis to measure relative and technical efficiency as well as long-term effectiveness. The model used DEA as a benchmark for targets set in each perspective within the BSC. Using the BSC model, we selected the goals and common indicators for all DMUs, and using DEA, we identified relative efficiency of the DMUs. Efficient DMUs are considered a benchmark and used as targets for measuring effectiveness. Conclusion: This research has confirmed the appropriateness of the combination of BSC and DEA methods for measuring efficiency and effectiveness of public health institutions. To be able to measure and predict the long-term effectiveness of the activities and programmes, we had to combine the realised outputs and the set outcomes. The implementation of the APE model in the institutes of public health will contribute to the improvement of analysis, forecast, and optimisation of all their activities. The model is applicable to other public health institutions.

scholarly journals COVID-19 severity impacts on long-term neurological manifestation after hospitalisation

2021 ◽  
Author(s):  
Andrea Pilotto ◽  
Viviana Cristillo ◽  
Stefano Cotti Piccinelli ◽  
Nicola Zoppi ◽  
Giulio Bonzi ◽  
...  
Keyword(s):  
Cognitive Deficits ◽  
Clinical Status ◽  
Neurological Symptoms ◽  
Neurological Manifestations ◽  
Neurological Abnormalities ◽  
Clinical Investigations ◽  
Infection Disease ◽  
Infection Parameters

ABSTRACTBackgroundPreclinical and clinical investigations have argued for nervous system involvement in SARS-CoV-2 infection and for long term sequalae including neurological manifestationsMethodsa sample of 208 previously hospitalized COVID-19 patients, 165 patients were re-assessed at 6 months according to a structured standardized clinical protocol. Premorbid comorbidities and clinical status, severity of COVID-19 disease, complications during and after hospitalization were recorded.ResultsAt 6-month follow-up after hospitalisation due to COVID-19 disease, patients displayed a wide array of neurological symptoms, being fatigue (34%), memory/attention (31%), and sleep disorders (30%) the most frequent. Subjects reporting neurological symptoms were affected by more severe respiratory SARS-CoV-2 infection parameters during hospitalisation. At neurological examination, 37.4% of patients exhibited neurological abnormalities, being cognitive deficits (17.5%), hyposmia (15.7%) and postural tremor (13.8%) the most common. Patients with cognitive deficits at follow-up were comparable for age, sex and pre-admission comorbidities but experienced worse respiratory SARS-CoV-2 infection disease and longer hospitalisation.Conclusionslong term neurological manifestations after hospitalization due to COVID-19 infection affects one third of survivors. Multiple neurological abnormalities including mild cognitive impairment are associated with severity of respiratory SARS-CoV-2 infection.

scholarly journals Pain and Other Neurological Symptoms Are Present at 3 Months After Hospitalization in COVID-19 Patients

2021 ◽  
Vol 2 ◽  
Author(s):  
Jude P. J. Savarraj ◽  
Angela B. Burkett ◽  
Sarah N. Hinds ◽  
Atzhiry S. Paz ◽  
Andres Assing ◽  
...  
Keyword(s):  
Public Health ◽  
Neurological Function ◽  
Hospitalized Patients ◽  
Neurological Symptoms ◽  
Cognitive Symptoms ◽  
Long Term Outcomes ◽  
Neurologic Outcomes ◽  
Pain Symptoms

COVID-19 is an ongoing pandemic with a devastating impact on public health. Acute neurological symptoms have been reported after a COVID-19 diagnosis, however, the long-term neurological symptoms including pain is not well established. Using a prospective registry of hospitalized COVID-19 patients, we assessed pain and neurological function (including functional, cognitive and psychiatric assessments) of several hospitalized patients at 3 months. Our main finding is that 60% of the patients report pain symptoms. 71% of the patients still experienced neurological symptoms at 3 months and the most common symptoms being fatigue (42%) and PTSD (25%). Cognitive symptoms were found in 12%. Our preliminary findings suggests the importance of investigating long-term outcomes and rationalizes the need for further studies investigating the neurologic outcomes and symptoms of pain after COVID-19.

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