scholarly journals Depression and Quality of Life in People with Systemic Lupus Erythematosus

2018 ◽  
Vol 33 (3) ◽  
Author(s):  
Fitria Maharani Harsono Putri ◽  
Magdalena S. Halim
Keyword(s):  
Quality Of Life ◽  
Systemic Lupus Erythematosus ◽  
Body Image ◽  
Lupus Erythematosus ◽  
Additional Data ◽  
Demographic Factors ◽  
Systemic Lupus ◽  
Significant Difference ◽  
The Relationship

The aim of this research was to determine the relationship between depression and some aspects of the quality of life. As additional data, the researchers sought connections between demographic factors and the quality of life. This research used measurement implements in the form of the Beck Depression Inventory-II (BDI-II) and the LupusQoL. The participants involved in the research were 49 females aged between 18 and 45 years. The results of the research indicated that depression has a significant relationship with all aspects of quality of life, with the exception of the aspect of body image. The greater the depression, the worse the quality of life. Conversely, the lighter the depression, the better the quality of life. Besides this, the research also indicated a significant difference in aspects of the quality of life, on the basis of demographic factors. The conclusion from the research is that depression is an important matter for attention. By overcoming depression, a number of aspects of the quality of life of people with Lupus/SLE may be improved.

Body image mediates the impact of pain on depressive symptoms in patients with systemic lupus erythematosus

Lupus ◽  
2019 ◽  
Vol 28 (9) ◽  
pp. 1148-1153
Author(s):  
S Gholizadeh ◽  
D R Azizoddin ◽  
S D Mills ◽  
G Zamora ◽  
H M K Potemra ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systemic Lupus Erythematosus ◽  
Body Image ◽  
Depressive Symptoms ◽  
Lupus Erythematosus ◽  
Urban Region ◽  
Systemic Lupus ◽  
Related Quality ◽  
The Relationship

Objective Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with treatment manifestations that can cause changes in appearance, including skin rashes, alopecia, vitiligo, and scars. SLE has been shown to adversely impact body image outcomes, and previous research has identified that greater disease activity is associated with worse body image outcomes which, in turn, are associated with greater depressive symptoms. For patients with SLE who also experience significant pain, poor body image outcomes may further compromise wellbeing and lead to greater depressive symptoms. The role of pain in body image has not been explored in SLE. Thus, the present study examined whether body image (specifically, body image-related quality of life) serves as a mediator of the relationship between pain and depressive symptoms among patients with SLE. Methods Multiple mediation analysis was used to examine the hypothesis that body image-related quality of life mediates the relationship between pain and depressive symptoms in a sample of patients with SLE ( N = 135) from an urban region in Los Angeles, California. Results The sample was predominately female (92.6%) with a mean disease duration of approximately 17 years. Approximately one-quarter of the sample had elevated depressive symptoms. Body image-related quality of life was a significant mediator in the relationship between pain and depressive symptoms. The model accounted for 51% of the total variance in depressive symptoms ( R2 = 0.51). Conclusion This cross-sectional study suggested that body image-related quality of life may mediate the effects of pain on depressive symptoms among patients with SLE.

Prolonged clinical remission and low disease activity statuses are associated with better quality of life in systemic lupus erythematosus

Lupus ◽  
2019 ◽  
Vol 28 (10) ◽  
pp. 1189-1196 ◽  
Author(s):  
N Poomsalood ◽  
P Narongroeknawin ◽  
S Chaiamnuay ◽  
P Asavatanabodee ◽  
R Pakchotanon
Keyword(s):  
Quality Of Life ◽  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Clinical Remission ◽  
Life Questionnaire ◽  
Systemic Lupus ◽  
Low Disease Activity ◽  
Significant Difference

Objective The objective of this study was to determine the association between disease activity status and health-related quality of life (HRQoL) in systemic lupus erythematosus (SLE) patients. Methods SLE patients in an out-patient clinic during the previous 12 months were included in the study. The Systemic Lupus Erythematosus-specific Quality-of-Life questionnaire (SLEQoL) was administered at the last visit. Disease activity status was determined retrospectively during the previous year. The categories of disease activity status were defined as: clinical remission (CR): clinical quiescent disease according to Systemic Lupus Erythematosus Disease Activity Index 2000, prednisolone ≤ 5 mg/day; low disease activity (LDA): SLEDAI-2K (without serological domain) ≤ 2, prednisolone ≤ 7.5 mg/day; and non-optimally controlled status: for those who were not in CR/LDA. Immunosuppressive drugs (maintenance dose) and antimalarials were allowed. Prolonged CR or LDA was defined as those with sustained CR or LDA for at least one year. The association between disease activity status and HRQoL was assessed by using regression analysis adjusting for other covariates. Results Of 237 SLE patients, 100 patients (42.2%) achieved prolonged CR, 46 patients (19.4%) achieved prolonged LDA and 91 patients (38.4%) were not in CR/LDA. Non-CR/LDA patients had significantly higher total SLEQoL score and in all domains compared to CR/LDA patients. No significant difference in SLEQoL domain scores was found between CR and LDA groups. Multivariable analysis revealed that non-CR/LDA was positively associated with SLEQoL score compared with CR/LDA (β 20.02, 95% confidence interval (CI) 6.81–33.23, p < 0.003). Moreover, non-CR/LDA was at a higher risk of impaired QoL (SLEQoL score > 80) compared with CR (hazard ratio 3.8; 95% CI 1.82–7.95; p < 0.001). However, there was no significant difference between CR and LDA in terms of SLEQoL score or impaired QoL. Other factors associated with higher SLEQoL score were damage index (β 9.51, 95% CI 3.52–15.49, p = 0.002) and anemia (β 24.99, 95% CI 5.71–44.27, p = 0.01). Conclusion Prolonged CR and LDA are associated with better HRQoL in SLE patients and have a comparable effect. Prolonged CR or optional LDA may be used as the treatment goal of a treat to target approach in SLE.

scholarly journals Effect of training on health outcome including fatigue, depression and quality of life in patients with systemic lupus erythromatosus

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Manal K. Youssef
Keyword(s):  
Quality Of Life ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Depression Scale ◽  
Post Treatment ◽  
Step Test ◽  
Walk Test ◽  
Systemic Lupus ◽  
Significant Difference

Abstract Background Systemic lupus erythematosus is an inflammatory condition that causes significant tissue damage and inflammation, and is more common in women. Despite the fact that medical treatment seeks to prevent flare-ups and organ damage, up to 50% of patients believe their wellbeing is suboptimal due to unmet needs like exhaustion and pain. The aim of the new systemic lupus erythematosus treatment guidelines is to improve people's quality of life. In people with systemic lupus erythematosus, fatigue is associated with reduced health, exercise capacity, muscle strength, and impairment. The aim of the study is to compare the effects of strengthening exercise on fatigue, depression, and quality of life in patients with systemic lupus erythematosus compared to the control sedentary group. This study included 20 patients with systemic lupus erythematosus from the department of internal medicine, compared to 25 control patients. Both groups had been treated with strengthening exercises for three months. Self-rating depression scale, quality of life questioner, fatigue severity scale, 6 min’ walk test, 2 min step test and body mass index (BMI). All parameters were measured before and after 3 months of treatment. Results Analysis of data showed that systemic lupus erythematosus has more depression and fatigue than sedentary control. After exercises, both groups have a significant difference between pre and post treatment, but still have a difference between both groups. Both groups have a significant difference between pre and post treatment in 6-min walk test, 2-min step test, and quality of life measured by SF-36. No significant difference was found between both groups pre and post treatment in BMI, although each group has a significant difference between pre and post treatment BMI. Conclusions Exercises are very important in the management of systemic lupus erythematosus. They help to decrease fatigue, depression, and improve quality of life.

The Relationship Between Renal Activity and Quality of Life in Systemic Lupus Erythematosus

2009 ◽  
Vol 36 (5) ◽  
pp. 947-952 ◽  
Author(s):  
SIMONE APPENZELLER ◽  
ANN E. CLARKE ◽  
PANTELIS PANOPALIS ◽  
LAWRENCE JOSEPH ◽  
YVAN ST. PIERRE ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systemic Lupus Erythematosus ◽  
Renal Disease ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Entire Study ◽  
Function Subscale ◽  
The Relationship

Objective.To evaluate the relationship between renal activity and quality of life (QOL) in patients with systemic lupus erythematosus (SLE).Methods.Three hundred eighty-six patients completed annual Medical Outcomes Study Short Form-36 questionnaires and physicians completed the SLE Disease Activity Index and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index. Concurrent association between renal activity and QOL was evaluated through regression models that adjusted for demographics and nonrenal disease activity and nonrenal damage. To characterize the longitudinal relationship between change in renal activity and change in QOL, all renal activity and QOL data over the entire study were used to estimate a linear trend within each individual patient through hierarchical modeling.Results.In the regression model that assessed the association between renal activity and QOL, on average, each additional renal activity item fulfilled was associated with a 2.04-unit (95% CI 0.88, 3.24) decrease in the physical function subscale, a 5.28-unit (95% CI 2.76, 7.76) decrease in the role-physical subscale, a 2.24-unit (95% CI 0.72, 3.80) decrease in the social function subscale, and a 1.16-unit (95% CI 0.60, 1.72) decrease in the physical component summary score. In the hierarchical model, no association was observed between changes in renal activity and QOL.Conclusion.Patients with SLE and active renal disease concurrently experience a slightly poorer QOL than those without renal disease, especially in the physical domains. Because the confidence intervals were wide, we could not accurately estimate whether a longitudinal change in renal activity was associated with a change in QOL.

scholarly journals Quality of Life in Patient with Systemic Lupus Erythematosus (SLE)

2016 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Irma Yanih
Keyword(s):  
Quality Of Life ◽  
Systemic Lupus Erythematosus ◽  
Body Image ◽  
Physical Health ◽  
Lupus Erythematosus ◽  
Emotional Health ◽  
Intimate Relationship ◽  
Nutrition Status ◽  
Systemic Lupus

The number of patient with Systemic Lupus Erythematosus (SLE) was keep growing. SLE attacked many women and developed between the age of 15-45. The treatment which used by patient with SLE just for reduced or faded the symptoms that occurred. It couldn’t heals the patient properly yet, so that sometimes that symptoms would occur again. The object of this study were to see the quality of life from 13 patient SLE in 8 domain from Quality of Life (QoL) such as physical health, emotional health, body image, pain, planning, fatigue intimate relationship and burden to others. This study was a study case in 13 patient with SLE which lived in Surabaya and a member of Lupus Indonesia Foundation branch Surabaya. Primary data were collected by interview using LupusQoL questionnaire and the weight was measured by digital weight scales. In this study, there were 13 woman patient with SLE in the age between 15–40 years old with highly educated and having normal nutrition status. They usually work and having monthly income > Rp 1,740,000, were suffer SLE for more than 5 years and having good knowledge in Lupus and SLE. This study showed a good value quality of life in patient with SLE at 3 domain. That were body image, intimate relationship and physical health domain. Some patients had a bad even worse quality in pain, fatigue and burden to others domain. Some of patients with SLE had a good quality of life except pain, fatigue, and burden to others domain. Keywords: Quality of Life (QoL), Systemic Lupus Erythematosus (SLE), desease duration

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