scholarly journals The side effects (cytogenetics ) of Methotrexate drug on male germ cells of Mus musculus

2011 ◽  
Vol 5 (1) ◽  
pp. 59-68
Author(s):  
Abbas A. Mohammed ◽  
Ali A. Al-Temimi ◽  
Ahmed Abdul Amier Hussain Al-Amiery
Keyword(s):  
Chromosomal Aberration ◽  
Germ Cells ◽  
Mus Musculus ◽  
Atomic Charge ◽  
Inhibitory Effect ◽  
Sperm Head ◽  
Male Germ Cells ◽  
Equal Rate ◽  
The Relationship ◽  
High Inhibitory Effect

In this study three doses (0.01, 0.02, 0.04) mgkg B.W of methotrexate drug which used, in the treatment of bladder cancer, were investigate in male germ cells of Mus musculus. Five tests were considered (mitotic index, chromosomal central associated, micronuclei, chromosomal aberration and sperm–head abnormalities). The results showed that,s these doses were presentel with high inhibitory effect of cell division, as well as, they induced significantly higher number of chromosomal central associated, micronuclei, chromosomal aberration and sperm head abnormalities especially after (21, 35) days after treatment at equal rate in control. We study the relationship between the structures of drug with it medical effect by study the atomic charge of each atom of drug and adenine, guanine, cytosine and uracil.

scholarly journals Cell inclusions in the oogenesis of scorpions

1925 ◽  
Vol 98 (687) ◽  
pp. 44-58 ◽  
Keyword(s):  
Germ Cells ◽  
Yolk Formation ◽  
Male Germ Cells ◽  
The Past ◽  
The Relationship

Although the very remarkable mitochondria of the male germ cells of scorpions have attracted in the past a number of workers (12 and 13), no work had so far been undertaken on the female germ cells. In the present work two different groups of scorpions, with and without ordinary yolk in their oocytes, were selected for study in the hope that some light might be thrown on the relationship between the nucleus and yolk formation. Euscorpius napoli and Buthus judaicus were selected as the representatives of those forms whose oocytes contain ordinary yolk, and Palamnœus fulvipes madraspatensis and Palamnœus swammerdami as the representatives of forms without any such yolk.

Ultrastructure and the relationship between the nucleolus and the nucleolar organizer region in Orthoptera male germ cells

1985 ◽  
Vol 27 (2) ◽  
pp. 186-191 ◽  
Author(s):  
P. Esponda ◽  
J. S. Rufas ◽  
S. Fonzo ◽  
J. Gosálvez
Keyword(s):  
Germ Cells ◽  
Organizer Region ◽  
Nucleolar Organizer Region ◽  
Nucleolar Organizer ◽  
Serial Sections ◽  
Male Germ Cells ◽  
Fibrillar Center ◽  
Nucleolar Organizers ◽  
The Relationship

The ultrastructure of the nucleolus and the nucleolar organizer region, together with the relationships they maintain, are described in male germ cells of two species of grasshoppers. The nucleolus is multiple and appears related to a fibrillar center which seems to represent only a nontranscribing part of the organizer region. By means of serial sections, a particular relationship among the fibrillar center, the rDNA loops, and the nucleolar masses is suggested.Key words: ultrastructure, nucleolar organizers, nucleolus, Orthoptera.

scholarly journals NANOS2 suppresses the cell cycle by repressing mTORC1 activators in embryonic male germ cells

iScience ◽  
2021 ◽  
pp. 102890
Author(s):  
Ryuki Shimada ◽  
Hiroko Koike ◽  
Takamasa Hirano ◽  
Yuzuru Kato ◽  
Yumiko Saga
Keyword(s):  
Cell Cycle ◽  
Germ Cells ◽  
Male Germ Cells

scholarly journals The inhibitory effect of melatonin on human prostate cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Dexin Shen ◽  
Lingao Ju ◽  
Fenfang Zhou ◽  
Mengxue Yu ◽  
Haoli Ma ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Clinical Trials ◽  
Theoretical Basis ◽  
Inhibitory Effect ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Anti Oxidant ◽  
Androgen Depletion ◽  
The Relationship ◽  
Future Utilization

AbstractProstate cancer (PCa) is one of the most commonly diagnosed human cancers in males. Nearly 191,930 new cases and 33,330 new deaths of PCa are estimated in 2020. Androgen and androgen receptor pathways played essential roles in the pathogenesis of PCa. Androgen depletion therapy is the most used therapies for primary PCa patients. However, due to the high relapse and mortality of PCa, developing novel noninvasive therapies have become the focus of research. Melatonin is an indole-like neurohormone mainly produced in the human pineal gland with a prominent anti-oxidant property. The anti-tumor ability of melatonin has been substantially confirmed and several related articles have also reported the inhibitory effect of melatonin on PCa, while reviews of this inhibitory effect of melatonin on PCa in recent 10 years are absent. Therefore, we systematically discuss the relationship between melatonin disruption and the risk of PCa, the mechanism of how melatonin inhibited PCa, and the synergistic benefits of melatonin and other drugs to summarize current understandings about the function of melatonin in suppressing human prostate cancer. We also raise several unsolved issues that need to be resolved to translate currently non-clinical trials of melatonin for clinic use. We hope this literature review could provide a solid theoretical basis for the future utilization of melatonin in preventing, diagnosing and treating human prostate cancer.

scholarly journals ELECTRON MICROSCOPE STUDIES ON THE DICTYOSOMES AND ACROBLASTS IN THE MALE GERM CELLS OF THE CRICKET

1956 ◽  
Vol 2 (4) ◽  
pp. 123-128 ◽  
Author(s):  
H. W. Beams ◽  
T. N. Tahmisian ◽  
R. L. Devine ◽  
Everett Anderson
Keyword(s):  
Electron Microscope ◽  
Golgi Apparatus ◽  
Electron Micrographs ◽  
Germ Cells ◽  
Light Microscope ◽  
Golgi Body ◽  
Duplex Structure ◽  
Male Germ Cells ◽  
Secondary Spermatocyte ◽  
A Chain

The dictyosome (Golgi body) in the secondary spermatocyte of the cricket appears in electron micrographs as a duplex structure composed of (a) a group of parallel double-membraned lamellae and (b) a group of associated vacuoles arranged along the compact lamellae in a chain-like fashion. This arrangement of ultramicroscopic structure for the dictyosomes is strikingly comparable to that described for the Golgi apparatus of vertebrates. Accordingly, the two are considered homologous structures. Associated with the duplex structure of the dictyosomes is a differentiated region composed of small vacuoles. This is thought to represent the pro-acrosome region described in light microscope preparations. In the spermatid the dictyosomes fuse, giving rise to the acroblast. Like the dictyosomes, the acroblasts are made up of double-membraned lamellae and associated vacuoles. In addition, a differentiated acrosome region is present which, in some preparations, may display the acrosome vacuole and granule. Both the dictyosomes and acroblasts are distinct from mitochondria.

scholarly journals Male germ cells and photoreceptors, both dependent on close cell–cell interactions, degenerate upon ClC-2 Cl− channel disruption

2001 ◽  
Vol 20 (6) ◽  
pp. 1289-1299 ◽  
Author(s):  
Michael R. Bösl ◽  
Valentin Stein ◽  
Christian Hübner ◽  
Anselm A. Zdebik ◽  
Sven-Eric Jordt ◽  
...  
Keyword(s):  
Germ Cells ◽  
Cell Interactions ◽  
Male Germ Cells ◽  
Cl Channel ◽  
Cell Cell
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