scholarly journals Application of molecularly imprinted polymer designed for the selective extraction of ketoprofen from wastewater

Water SA ◽  
2018 ◽  
Vol 44 (3 July) ◽  
Author(s):  
Lawrence Mzukisi Madikizela ◽  
Silindile Senamile Zunngu ◽  
Nomchenge Yamkelani Mlunguza ◽  
Nikita Tawanda Tavengwa ◽  
Phumlane Selby Mdluli ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Selective Extraction ◽  
Bulk Polymerization ◽  
Selectivity Coefficient ◽  
Dynamics Simulation ◽  
Maximum Adsorption Capacity ◽  
Order Kinetic ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

A molecularly imprinted polymer (MIP) that is selective to ketoprofen was synthesized and applied in the adsorption of the target compound from water. The MIP was synthesized using a bulk polymerization method at high temperatures (60–80°C), where ketoprofen, 2-vinylpyridine, ethylene glycol dimethacrylate, toluene and 1,1´-azobis(cyclohexanecarbonitrile) were used as template, functional monomer, cross-linker, porogen and initiator, respectively. Non-imprinted polymer (NIP) was synthesized similarly to the MIP but in the absence of ketoprofen. From molecular dynamics simulation, the nature of interactions that occurred between the template and the functional monomer were found to be based on hydrogen bonding. This was confirmed experimentally, where a high extraction efficiency of ≥ 90% was obtained at acidic conditions (pH 5) due to the protonation of ketoprofen. A contact time of 45 min was sufficient for the maximum adsorption of ketoprofen from 10 mL spiked water using 8 mg of the adsorbent. MIP showed greater selectivity than NIP by achieving a relative selectivity coefficient of 7.7 towards ketoprofen in the presence of structurally related pharmaceuticals. Furthermore, the order of sorption onto the MIPs from water was ketoprofen > fenoprofen > gemfibrozil. From a modelling perspective, the Langmuir adsorption isotherm and pseudo-second-order kinetic model gave the best fit, with maximum adsorption capacity of 8.24 mg·g−1 and sorption rate constant of 0.25 mg·g−1·min−1 for MIP. This was translated to chemisorption of ketoprofen onto the homogeneous MIP binding sites. This work demonstrated the great potential of MIP in selective recognition of ketoprofen from wastewater relative to closely related compounds.

scholarly journals Removal of bisphenol A from aqueous media using a highly selective adsorbent of hybridization cyclodextrin with magnetic molecularly imprinted polymer

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
S. Mamman ◽  
F. B. M. Suah ◽  
M. Raaov ◽  
F. S. Mehamod ◽  
S. Asman ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Molecularly Imprinted Polymer ◽  
Binding Capacity ◽  
Bulk Polymerization ◽  
Resonance Spectroscopy ◽  
Template Molecule ◽  
Order Kinetic ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Magnetic Molecularly Imprinted Polymer

In this study, a unique magnetic molecularly imprinted polymer (MMIP) adsorbent towards bisphenol A (BPA) as a template molecule was developed by bulk polymerization using β-cyclodextrin (β-CD) as a co-monomer with methacrylic acid (MAA) to form MMIP MAA–βCD as a new adsorbent. β-CD was hybridized with MAA to obtain water-compactible imprinting sites for the effective removal of BPA from aqueous samples. Benzoyl peroxide and trimethylolpropane trimethacrylate were used as the initiator and cross-linker, respectively. The adsorbents were characterized by Fourier transform infrared spectroscopy, scanning electronic microscopy, transmission electron microscopy, vibrating sample magnetometer, Brunauer–Emmett–Teller and X-ray diffraction. 1 H nuclear magnetic resonance spectroscopy was used to characterize the MAA–βCD and BPA–MAA–βCD complex. Several parameters influencing the adsorption efficiency of BPA such as adsorbent dosage, pH of sample solution, contact time, initial concentrations and temperature as well as selectivity and reusability study have been evaluated. MMIP MAA–βCD showed significantly higher removal efficiency and selective binding capacity towards BPA compared to MMIP MAA owing to its unique morphology with the presence of β-CD. The kinetics data can be well described by the pseudo second-order kinetic and Freundlich isotherm and Halsey models best fitted the isotherm data. The thermodynamic studies indicated that the adsorption reaction was a spontaneous and exothermic process. Therefore, MMIP based on the hybrid monomer of MAA–βCD shows good potential of a new monomer in molecularly imprinted polymer preparation and can be used as an effective adsorbent for the removal of BPA from aqueous solutions.

Molecularly imprinted polymer for selective extraction and simultaneous determination of four tropane alkaloids from Przewalskia tangutica Maxim. fruit extracts using LC-MS/MS

RSC Advances ◽  
2015 ◽  
Vol 5 (115) ◽  
pp. 94997-95006 ◽  
Author(s):  
Shaomei Zeng ◽  
Yongxin She ◽  
Bining Jiao ◽  
Guangyang Liu ◽  
Jing Wang ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Molecularly Imprinted Polymer ◽  
Tropane Alkaloids ◽  
Selective Extraction ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Fruit Extracts ◽  
Przewalskia Tangutica

A class-specific molecularly imprinted polymer (MIP) for selectively extracting four tropane alkaloids has been prepared using anisodine, methacrylic, and trimethylolpropane trimethacrylate as template, functional monomer and crosslinker, respectively.

scholarly journals Performance Evaluation of Molecularly Imprinted Polymer using Propanol as Porogen for Atenolol Recognition in Human Serum

2018 ◽  
Vol 6 (1) ◽  
pp. 27
Author(s):  
Meilia Suherman ◽  
Ike Susanti ◽  
Driyanti Rahayu ◽  
Rimadani Pratiwi ◽  
Aliya Nur Hasanah
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Solid Phase ◽  
Therapeutic Index ◽  
Selective Extraction ◽  
Bulk Polymerization ◽  
Precipitation Polymerization ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
As Doping ◽  
Recovery Percentage

Atenolol is a cardiovascular drug that has a narrow therapeutic index with long-term use and it’s often used as doping. Atenolol has a small concentration in human boby and it’s in  biological matrix (serum) so in the testing need a selective extraction so  the analyte can be pra-concentration and removed from matrix. Two molecularly imprinted polymers (MIPs) on propanol as porogen  have been made with two different methods i.e. bulk polymerization and precipitation polymerization. The polymer was made using atenolol as a template, methacrylic acid as a functional monomer, and ethylene glycol dimethacrylate as a crosslinker. Prformance evaluations showed that polymers from bulk polymerization provide better performance than polymers from precipitation polymerization when tested against standard solution. However, this sorbent has low  recovery percentage after applied into serum sample and could not be used as alternative for atenolol extraction in human serum.Key words: Molecularly imprinted polymer, Atenolol, Solid Phase Extraction, Preparation  method, propanol.

Preparation of Nanosized Molecularly Imprinted Polymer Spheres for Atrazine

2012 ◽  
Vol 463-464 ◽  
pp. 1473-1478
Author(s):  
Rong Xie ◽  
Wen Jun Gui ◽  
Guo Nian Zhu
Keyword(s):  
Surface Area ◽  
Molecularly Imprinted Polymer ◽  
Binding Capacity ◽  
Bulk Polymerization ◽  
Precipitation Polymerization ◽  
Cross Linking ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Polymer Spheres

A novel nanosized molecularly imprinted polymer spheres for atrazine was synthesized in present assay, as an alternative to the biological antibodies. Both precipitation polymerization and bulk polymerization were performed. Various combinations of template, functional monomer, and cross-linking monomer and porogenic diluents were carried out to optimize the best one. The nanosized MIPs exhibit larger surface area and better binding capacity than traditional polymers, the best binding capacity and imprinted factor for atrazine were 95.75% and 1.83 respectively.

scholarly journals A Molecularly Imprinted Polymer for Selective Extraction of Phenolic Acids from Human Urine

2021 ◽  
Vol 11 (4) ◽  
pp. 1577
Author(s):  
Marco Mora-Granados ◽  
David González-Gómez ◽  
Jin Su Jeong ◽  
Alejandrina Gallego-Picó
Keyword(s):  
Phenolic Acids ◽  
Molecularly Imprinted Polymer ◽  
Human Urine ◽  
Limit Of Detection ◽  
Ph Dependence ◽  
Selective Extraction ◽  
Screening Methods ◽  
Specific Method ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

Studies for monitoring the bioavailability of dietary flavonoid compounds generate great interest. Among them, low-molecular-weight phenolic acids, secondary metabolites present in colonic catabolism and urinary excretion, have been proposed as biomarkers of polyphenol intake. Using 4-hydroxyphenylacetic acid as a template, a molecularly imprinted polymer (MIP) was synthesized for selective extraction of these hydroxylated metabolites from human urine samples and posterior analysis in an HPLC-DAD-MS system. Polymers were characterized by Scanning electron microscopy (SEM), Attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR), Brunauer-Emmett-Teller (BET) method, and binding experiments. MIP presents specific recognition ability for template and analogues molecules. This capacity of recognition and the pH dependence of the binding strength was also studied. The method was validated over a concentration range of 0.25–40 mg/L, r2 > 0.995. In the optimized conditions, the recovery value was 94% with RSD 1.2%. The Limit of Detection (LOD) and Limit of Quantification (LOQ) were 1.22 and 3.69 mg/L, respectively. In our knowledge, it is the first time that this methodology is applied to analyze urinary catabolites of the polyphenol compound and to provide a specific method and simple analysis alternative. The selective extraction of these metabolites improves the application and results obtained by other less sensitive analysis methods than the validation method. It also facilitates the development of new screening methods.

Selective extraction of progesterone hormones from environmental and biological samples using a polypyrrole molecularly imprinted polymer and determination by gas chromatography

2016 ◽  
Vol 8 (8) ◽  
pp. 1813-1827 ◽  
Author(s):  
A. Nezhadali ◽  
Z. Es’haghi ◽  
A. Khatibi
Keyword(s):  
Gas Chromatography ◽  
Molecularly Imprinted Polymer ◽  
Biological Samples ◽  
Selective Extraction ◽  
Chemical Oxidation ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Batch Extraction ◽  
Environmental And Biological Samples

A Molecularly Imprinted Polymer (MIP) was chemically prepared for the selective batch extraction of progesterone (PGN) hormones by chemical oxidation of pyrrole using FeCl3.

Molecularly Imprinted Polymer for Selective Extraction of Tartaric Acid

2018 ◽  
Vol 73 (9) ◽  
pp. 855-861 ◽  
Author(s):  
Z. Ghasempour ◽  
M. Alizadeh-Khaledabad ◽  
M. R. Vardast ◽  
M. Rezazad-Bari
Keyword(s):  
Tartaric Acid ◽  
Molecularly Imprinted Polymer ◽  
Selective Extraction ◽  
Imprinted Polymer ◽  
Molecularly Imprinted
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