scholarly journals Pain: More than Meets the Eye, an Atypical Case of Ocular Squamous Cell Carcinoma

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Jasmin Hundal ◽  
Madiha Ali ◽  
Kyle Ferguson ◽  
Norman Saffra ◽  
Benson Babu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Care Physicians ◽  
Excisional Biopsy ◽  
Eye Pain ◽  
History Of ◽  
Refractory Case ◽  
Hispanic Male

Introduction  Eye pain is common and initially managed by primary care physicians. In the rare refractory case or atypical appearance, consultation with ophthalmology is needed. Case presentationA 35-year-old Hispanic male patient with a history of pterygium presented with complaints of worsening left eye pain for months .Over the past two weeks, the patient had also noticed more redness and soreness that occurred all day.  He noticed darkening in the medial vision of his left eye, persistence of left eye pain and visual changes. An excisional biopsy of the lesion was performed.  The final biopsy reports revealed an ocular surface squamous cell carcinoma in situ arising from pterygium.DiscussionTopical application and injections of immunotherapy such as mitomycin C and 5-fluorouracil have been shown to be effective.  Recurrence is high and follow-up examination by ophthalmology is essential. 

scholarly journals A Case of Squamous Cell Carcinoma in Situ Occurred in the External Auditory Canal

2020 ◽  
Vol 63 (4) ◽  
pp. 176-179
Author(s):  
Seok Jung Hong ◽  
Moon Seung Baeg ◽  
Ji Hye Rhee ◽  
Hyun Sang Cho
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
External Auditory Canal ◽  
Carcinoma In Situ ◽  
English Literature ◽  
Clinical Manifestations ◽  
Excisional Biopsy ◽  
Wide Resection

Primary malignant lesions in the external auditory canal are rare. While squamous cell carcinoma is the most common of these lesions, there are also basal cell carcinoma, malignant melanoma and adenocarcinoma, etc. However, squamous cell carcinoma in situ of the external auditory canal is extremely rare since its first report in the English literature in 1953 and has not been reported in Korea. Its clinical manifestations are very similar to chronic ear disease. For treatment, local wide resection of the lesions is preferred. We recently encountered a 54-year-old female, who presented with intermittent irritating sensation in the external auditory canal. Otoscopic examination showed a scaly plaque with the irregular surface on the anteroinferior portion of the left external auditory canal. Excisional biopsy revealed a squamous cell carcinoma in situ. We report this very rare and unique case with a literature review.

scholarly journals Clear Cell Squamous Cell Carcinoma: Clinical and Histologic Parameters and a Review of the Literature

2020 ◽  
Vol 4 (2) ◽  
pp. 130
Author(s):  
Mathew Loesch ◽  
Stephen J Ganocy ◽  
Christine Jaworsky
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clear Cell ◽  
Review Of The Literature ◽  
History Of ◽  
Age Range ◽  
Anatomic Region ◽  
Clear Cell Change

Background: Clear cell squamous cell carcinoma (ccSCC) is an uncommon subtype of squamous cell carcinoma. This tumor subtype arises more commonly in elderly individuals and occurring greater upon sun-exposed areas of the body.Objective: To determine the age range and locations of ccSCC, and occurrence in men as compared with women.Methods: An observational study of ccSCC accessioned at a dermatopathology laboratory (Cleveland Skin Pathology, CSP) over an 18-month interval. Cases were retrieved and included based on a search of the terms “clear cell squamous cell carcinoma” in the diagnosis field of the CSP database and reviewed for accuracy and the degree of clear cell change in each lesion. Pathology requisition forms from these cases were used only to identify patients’ age, gender, and anatomic region of the ccSCC reviewed.Results: Of the 17,838 cases of in situ and invasive SCC, there were a total of 107 ccSCC, 77 in situ and 30 invasive (0.6% of total SCC). Of patients with ccSCC, 71% had a history of skin cancer, many (57.9%) in the same anatomic region. When the degree of clear cell change was evaluated there was no statistically significant increase of percentage clear cell change in tumors with age.Conclusions: Along with confirming past observations made with previous studies, our series shows that more men than women develop such tumors before 70 years of age, and more women than men after 70 years of age with men developing ccSCC on average 7 years earlier than women.

Use of In Situ Hybridization to Detect Human Papillomavirus in Head and Neck Squamous Cell Carcinoma Patients Without a History of Alcohol or Tobacco Use

2008 ◽  
Vol 132 (10) ◽  
pp. 1653-1656
Author(s):  
Walter T. Lee ◽  
Raymond R. Tubbs ◽  
Aysenur M. Teker ◽  
Joseph Scharpf ◽  
Marshall Strome ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
In Situ Hybridization ◽  
Alcohol Use ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
History Of ◽  
High Risk Hpv

Abstract Context.—Head and neck squamous cell carcinoma is commonly associated with tobacco and alcohol use. There are, however, a group of patients without a significant history of tobacco or alcohol use, and the etiology of these tumors is incompletely understood. Objective.—To examine tumors in this subpopulation for association with human papillomavirus (HPV) using newly available in situ hybridization probes. Design.—Between October 2004 and October 2005, 22 patients who did not use alcohol or tobacco were included. Formalin-fixed, paraffin-embedded tissue sections were used to perform in situ hybridization using newly available probe sets (Ventana Medical Systems, Tucson, Ariz). The slides were examined for the presence of integrated HPV using light microscopy. Positive and negative xenograft controls were run with the assay. Results.—The mean age of the patients was 64 years. There were 14 men and 8 women. The most common anatomic sites included tongue (n = 8), tonsil (n = 7), and larynx (n = 7). All cases and controls were successfully stained. Only 2 cases were positive for high-risk HPV, and both demonstrated an integrated pattern. Both cases were tumors of the tonsil. No cases were positive for low-risk HPV. Conclusions.—These results demonstrate that the new probe sets for HPV can be used very efficiently in clinical pathology material of head and neck squamous cell carcinoma. Our data show that high-risk HPV is an uncommon finding in head and neck squamous cell carcinoma from patients who do not have a history of tobacco or alcohol use; low-risk HPV was not seen in any case.

scholarly journals Isolated corneal squamous cell carcinoma in a patient with unilateral dry eye symptoms

2014 ◽  
Vol 14 (1) ◽  
pp. 31-35
Author(s):  
Siamak Zarei Ganavati ◽  
Alireza Eslampoor ◽  
Mehdi Farzadnia ◽  
Jafari Habib
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Dry Eye ◽  
Squamous Cell ◽  
Excisional Biopsy ◽  
Corneal Injury ◽  
History Of ◽  
Eye Symptoms ◽  
Short Time ◽  
Dry Eye Symptoms

The aim of this study was to report a case of isolated corneal squamous cell carcinoma in a patient with unilateral dry eye symptoms. The case was a 48 years old man with history of thermal corneal injury on his left eye two years ago with decreased visual acuity and dry eye symptoms a short time after, which was treated with the diagnosis of dry eye and had no improvement in symptoms. Examination revealed hypertrophy of near total corneal epithelium, without limbal and conjunctival involvement. The surface of the lesion was irregular with punctate epithelial erosions. The patient was underwent excisional biopsy which was revealed severe corneal dysplasia (carcinoma in situ). After excision, the patient was treated with Fluorouracil and there was no sign of recurrence till the time of last follow-up examination. Dry eye symptoms were disappeared completely. We conclude that, in the case of unilateral chronic dry eye which was resistant to the treatment with signs of corneal epithelial involvement, isolated corneal neoplasia should be considered even without limbal or conjunctival involvement.

Primary squamous cell carcinoma of the ampulla of Vater: management and review of the literature

2021 ◽  
Vol 14 (1) ◽  
pp. e236477
Author(s):  
Subhash Soni ◽  
Poonam Elhence ◽  
Vaibhav Kumar Varshney ◽  
Sunita Suman
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Survival Rates ◽  
Ampulla Of Vater ◽  
Metallic Stent ◽  
Biological Behaviour ◽  
Curative Intent ◽  
Term Survival ◽  
History Of

Squamous cell carcinoma (SCC) of the ampulla of Vater is a rare pathology and only few cases are reported in the literature. With limited experience of primary SCC in the ampulla of Vater, its biological behaviour, prognosis and long-term survival rates are not well known. A 38-year-old woman presented with a history of painless progressive jaundice for which self-expending metallic stent was placed 3 years back. She was evaluated and initially diagnosed as probably periampullary adenocarcinoma. She underwent pancreaticoduodenectomy and histopathology with immunohistochemistry was suggestive of SCC of ampulla of Vater. She received adjuvant chemotherapy and doing well with no recurrence after 1 year of follow-up. In conclusion, SCC of the ampulla is an unusual pathology that should be kept as a differential diagnosis for periampullary tumours. Surgical treatment with curative intent should be performed whenever feasible even in the setting of bulky tumour to improve the outcome.

scholarly journals Cutaneous squamous cell carcinoma arising in hidradenitis suppurativa: A case report

2019 ◽  
Vol 7 ◽  
pp. 2050313X1984735 ◽  
Author(s):  
Catherine F Roy ◽  
Simon F Roy ◽  
Feras M Ghazawi ◽  
Erica Patocskai ◽  
Annie Bélisle ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hidradenitis Suppurativa ◽  
Rare Complication ◽  
Excisional Biopsy ◽  
Necrosis Factor Alpha ◽  
Spindle Cells ◽  
Poorly Differentiated ◽  
Well Differentiated

We present a case of a 64-year-old man who presented with a rapidly growing tumor in the left buttock and intergluteal cleft area, which was affected by hidradenitis suppurativa. The patient was on tumor necrosis factor-alpha inhibitors for hidradenitis suppurativa for 2 years prior to the development of the mass. Initial biopsy of the mass showed a well-differentiated squamous cell carcinoma with spindle cells and positive epithelial immunomarkers. Subsequent excisional biopsy of the tumor showed an infiltrating poorly differentiated squamous cell carcinoma composed of islands of atypical sarcomatoid spindle cells. Squamous cell carcinoma arising in hidradenitis suppurativa is a rare complication which may occur secondary to chronic inflammation and epidermal hyperproliferation in hidradenitis suppurativa–affected areas.

scholarly journals Leiomyosarcoma of the Tracheostomy Site in a Patient with History of Laryngeal Squamous Cell Carcinoma

2021 ◽  
pp. 912-917
Author(s):  
Zainub Ajmal ◽  
Abdul Moiz Khan ◽  
Lezah McCarthy ◽  
Allison Lupinetti ◽  
Syed Mehdi
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
English Literature ◽  
Neck Region ◽  
Multiple Risk Factors ◽  
History Of ◽  
Rare Malignancy

Leiomyosarcoma (LMS) of the trachea is an extremely rare malignancy with only a few reported cases in English literature. As such the diagnosis can be frequently missed or delayed. We present a case of a 69-year-old male who underwent tracheostomy for airway obstruction secondary to glottic squamous cell carcinoma and treated definitely with radiation therapy. Subsequently, the patient developed LMS of the tracheostomy site. The case further details multiple risk factors that could contribute to development of LMS including radiation exposure, prior malignancy, and chronic inflammation. These risk factors have been well established for LMS in other sites but less so in the head and neck region, which is the subject of our discussion. We also review the current guidelines for head and neck as well as limb sarcomas and discussed role of surgery or radiation and their accompanying challenges in management of this rare malignancy.

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