scholarly journals Blood coagulation in the 21st century: existing knowledge, current strategies for treatment and perspective

2020 ◽  
Vol 19 (1) ◽  
pp. 139-157
Author(s):  
N. A. Podoplelova ◽  
V. B. Sulimov ◽  
I. S. Ilin ◽  
A. S. Tashilova ◽  
M. A. Panteleev ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Blood Clotting ◽  
Coagulation Factors ◽  
New Drugs ◽  
Coagulation System ◽  
Modern World ◽  
Blood Coagulation Factors ◽  
Clotting System ◽  
Normal Hemostasis

Disorders in the blood coagulation system are the leading cause of death and disability in the modern world. So the search for new drugs that can prevent pathological thrombosis, while not affecting normal hemostasis, becomes more relevant than ever. Recent studies has been a revolution in the understanding of the principles of work and the regulation of blood coagulation. In addition, new, more effective approaches to drug development have now appeared. For example computer simulation methods that can significantly reduce the time and resources spent on the search for new candidate molecules. In the review, the blood clotting system, the molekular mechanisms of thrombosis, the role of blood coagulation factors Xa and XIa, and the urgency of developing new inhibitors of these targets are shown, and the most interesting inhibitors of factors Xa and XIa are presented.

Tissue Factor: An Enzyme Cofactor and a True Receptor

2001 ◽  
Vol 86 (07) ◽  
pp. 66-74 ◽  
Author(s):  
James Morrissey
Keyword(s):  
Tissue Factor ◽  
Blood Clotting ◽  
Factor Viia ◽  
Clotting System ◽  
New Knowledge ◽  
The Subject ◽  
Normal Hemostasis ◽  
Thrombotic Diseases ◽  
Near Future

SummaryTissue factor is considered to be the physiologic trigger of the blood clotting system in normal hemostasis and in many – perhaps most – thrombotic diseases. A wealth of new knowledge is available regarding the structure and assembly of the TF:VIIa complex and the role of factor VIIa and tissue factor in hypercoagulable states. The exciting recent finding that tissue factor can function as a signaling receptor, and suggestions that tissue factor may have important, non-hemostatic roles, will be the subject of much additional study in the near future.

Investigation on Carbohydrate Residues Involved in the Blood Coagulation Mechanism Using Lectins

1979 ◽  
Author(s):  
H.J. Klein ◽  
E. Wenzel ◽  
B. Podolsak
Keyword(s):  
Blood Coagulation ◽  
Room Temperature ◽  
Coagulation Factors ◽  
Inhibitory Influence ◽  
Blood Coagulation Factors ◽  
Clotting System ◽  
Global Test ◽  
Coagulation Mechanism ◽  
Strongly Connected ◽  
Blood Coagulation Mechanism

Decline in the activity of blood coagulation factors of titrated pooled human plasma (in%) after incubation with lectins (final concentration 1mg/ml, 15 min.at room temperature):The inhibitory influence of lectins could be prevented by adding specific carbohydrates. Taking the specificity of lectins into account, one could assume that carbohydrate residue Ac-D-gluc. has a prominent influence on clotting activity of FXII and VIII.F-v-activity also seems to be strongly connected with glucosyl or mannosyl residues. Also PTT, as global test for the “intrinsic clotting system” was remarkably prolonged(6x)with WGL (not shown on the table).It is striking that FVII activity is not inhibited by the lectins examined. This raises the question, whether carbon.resid.take part in”extrinsic clotting” at all.

The Evaluation of the Role of the Kallikrein-Kinin Systems with Coagulation Factors During Pregnancy Delivery and Pueriperium

1979 ◽  
Author(s):  
Suzuki Shigenori
Keyword(s):  
Blood Coagulation ◽  
Factor Xiii ◽  
Coagulation Factors ◽  
Point Of View ◽  
Individual Factors ◽  
Rat Uterus ◽  
Blood Coagulation Factors ◽  
Full Explanation ◽  
Pregnancy And Delivery

(Purpose) While it is a well-known fact that the majority of blood coagulation factors are increasing in the latter half of Pregnancy and Delivery, the correlation between Kallikrein-Kinin Systems and Coagulation fretors has not yet been brought to a full explanation. From this point of view, Kininogens and individual coagulation factors were hereby determined in order to clarify the state of hypercoagulability and DIC during Pregnancy and Delivery.(Method) 1) In 20 normal cases from Pregnancy through to Delivery and Pueriperium and 10 cases of DIC, Kininogen were measured with the method of Bioassay using Rat-Uterus. (DINIZ Method) 2) The slate of hypercoagulability in the background of DIC was evaluated by determining many coagulation-factors including Contact Factors.(Results) 1) In the latter hair of the period or gestation, individual factors (excluding Factor XIII) were increasing, especially before Delivery. 2) The high levels or the kininogen in plasma were proved during Pregnancy and before Delivery(8.4 ± 3.4 μg/ml) than that of nonpregnancy (4.3 ± 2.1 μrg/ml) as well as many other coagulation factors. 3) In the cases of DIC, the extrectly low level of Kininogen (2.2± 1.4 μg/ml) were proved.(Conclusion) The levels of Kininogen seems to play an important role in the mechanismus of DIC which start before and immediately after Delivery.

scholarly journals Changes in the blood coagulation system that determine postoperative complications in patients with non-tumor mechanical jaundice

2021 ◽  
Vol 180 (2) ◽  
pp. 12-20
Author(s):  
V. E. Fedorov ◽  
B. S. Kharitonov ◽  
A. D. Aslanov ◽  
O. E. Logvina ◽  
M. S. Narizhnaya
Keyword(s):  
Postoperative Complications ◽  
Blood Coagulation ◽  
Blood Platelets ◽  
Coagulation Factors ◽  
Coagulation System ◽  
Thrombin Time ◽  
Blood Coagulation Factors ◽  
Blood Coagulation System ◽  
Normal Limits ◽  
Prothrombin Index

The OBJECTIVE was to study the features of changes in the blood coagulation system that contribute to the development of postoperative complications in patients depending on the stage of non-tumor mechanical jaundice at admission.METHODS AND MATERIALS. A total of 537 patients with mechanical jaundice were examined and changes in the blood coagulation system were analyzed. Vascular-platelet hemostasis was characterized by the following tests: capillary resistance, the number of desquamated endothelial cells, the number of blood platelets. Plasma hemostasis was analyzed using activated partial thromboplastin time, plasma soluble fibrin level, thrombin time, prothrombin ratio, prothrombin index, and fibrinogen blood level. Then, XIIa-dependent fibrinolysis in the blood and the level of the fibrin D-dimer in the blood plasma were determined.RESULTS. It was found that in the first stage of mechanical jaundice, with cholestasis, there were no changes in blood coagulation system that go beyond the normal limits. In the second stage, during cytolysis of hepatocytes, hyperbilirubinemia and hypertransaminasemia contribute to the activation of platelet first, and then plasma hemostasis. In the third stage (cholangitis), the death of endotheliocytes increases and there is a deficiency of blood coagulation factors due to their consumption and increased fibrinolysis.CONCLUSION. In the stage of cholestasis in patients with non-tumors mechanical jaundice, the parameters of the coagulation system remain within the reference values. In the stage of cytolysis, as endotheliotoxicosis increases, platelet and plasma hemostasis begins to activate, which can lead to thrombosis and thromboembolism in vital organs. In the stage of cholangitis, further activation of plasma hemostasis causes hemorrhagic syndrome. The occurrence of the described disorders in blood coagulation system with the progression of MJ dictates the need to monitor the changes in the blood coagulation system and their correction for the prevention of intra-and postoperative complications.

A Re-Appraisal of the Role of Blood Coagulation and Platelets in the Generalized Shwartzman Phenomenon

1966 ◽  
Vol 15 (03/04) ◽  
pp. 519-538 ◽  
Author(s):  
J Levin ◽  
E Beck
Keyword(s):  
Blood Coagulation ◽  
The State ◽  
Coagulation System ◽  
Renal Lesions ◽  
Intravascular Coagulation ◽  
Renal Glomeruli ◽  
Coagulation Mechanism ◽  
Shwartzman Phenomenon ◽  
Do So

SummaryThe role of intravascular coagulation in the production of the generalized Shwartzman phenomenon has been evaluated. The administration of endotoxin to animals prepared with Thorotrast results in activation of the coagulation mechanism with the resultant deposition of fibrinoid material in the renal glomeruli. Anticoagulation prevents alterations in the state of the coagulation system and inhibits development of the renal lesions. Platelets are not primarily involved. Platelet antiserum produces similar lesions in animals prepared with Thorotrast, but appears to do so in a manner which does not significantly involve intravascular coagulation.The production of adrenal cortical hemorrhage, comparable to that seen in the Waterhouse-Friderichsen syndrome, following the administration of endotoxin to animals that had previously received ACTH does not require intravascular coagulation and may not be a manifestation of the generalized Shwartzman phenomenon.

Natural Oestrogen in the Female Climacteric - Influence on Blood Coagulation and Fibrinolysis

1978 ◽  
Vol 40 (02) ◽  
pp. 532-541 ◽  
Author(s):  
Anders Lagrelius ◽  
Nils-Olov Lunell ◽  
Margareta Blombäck
Keyword(s):  
Blood Coagulation ◽  
Antithrombin Iii ◽  
Coagulation Factors ◽  
Control Group ◽  
Blood Coagulation Factors ◽  
Excessive Bleeding ◽  
Oestrone Sulphate ◽  
Menopausal Women ◽  
History Of ◽  
Coagulation And Fibrinolysis

SummaryThe aim of the present study was to investigate the effect on blood coagulation and fibrinolysis of a natural oestrogen preparation, piperazine oestrone sulphate, prospectively in menopausal women. Scopolamine was given to the control group.The women were investigated before and during treatment with regard to factors VIII, VII, X, V, fibrinopeptide A, antithrombin III, plasminogen, rapid antiplasmin and α1-antitrypsin. There was no significant change towards hypercoagulability or decreased fibrinolysis in any group. In the oestrogen group, however, a tendency towards an increased level of plasminogen and a decreased level of antiplasmin was demonstrated. In the scopolamine group there was an unexpected fall in factors X and V and also in plasminogen and α1,-antitrypsin. A low level of some blood coagulation factors in some of the women before treatment is somewhat astonishing; none of them had any history of excessive bleeding.

STEROIDSTRUKTUR UND LEBERTOXIZITÄT

1967 ◽  
Vol 54 (1) ◽  
pp. 73-84 ◽  
Author(s):  
H. L. Krüskemper ◽  
G. Noell
Keyword(s):  
Alkaline Phosphatase ◽  
Liver Function ◽  
Blood Coagulation ◽  
Electrophoretic Pattern ◽  
Coagulation Factors ◽  
Blood Coagulation Factors ◽  
Methyl Group ◽  
Liver Functions ◽  
Male Subjects ◽  
Androstane Derivatives

ABSTRACT In male subjects investigations have been carried out regarding the effect of C1- and C17-methylated androstane derivatives (20 mg per day, orally, two weeks) on liver functions (parameters: activities of GPT, GOT, alkaline phosphatase and cholinesterase in serum; electrophoretic pattern; blood coagulation factors V, VII, X and prothrombin; BSP-retention). In addition to the well known hepatotropic action of 17α-alkylated C-19-steroids a quasi-axial 1α-methyl configuration (in 1α-methylandrost-2-en-17β-ol) definitely increased BSP-retention and several coagulation factors. These steroid effects decreased gradually when a methyl group was introduced in C1 equatorially (1-methylandrost-1-en-17β-ol-3-one) or quasi-equatorially (1β-methylandrost-2-en-17β-ol), the latter compound completely lacking from any influence on parameters of liver function under investigation.

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