scholarly journals Comparison of Type I Error of some Non-Parametric Tests on Multiple Regression Models Coefficients

2015 ◽  
Vol 11 (7) ◽  
pp. 5426-5443
Author(s):  
Ali Shadrokh

Various non-parametric methods have been used to perform hypothesis test on multiple regression coefficients. In this article, at first the most important methods which has been introduced from other statisticians as proper methods, such as Kennedy, Freedman and Lane, and modified Kennedy, are explained and then, Freedman and Lane (Huh-John) method will be modified in the form of Kennedy method; finally, all aforementioned methods will be compared as simulating. At last, we look for a method that done best. So, Huh-John (2001) modify the method of Kennedy which was proposed in 1995 and showed by simulation that is called modified Huh-John method; and it has less type I error. On the other hand, Anderson as simulation (1991) and Schadrekh as theory (2011) had shown that Freedman& Lane method has lower type I error in comparison with Kennedy method. We did some modification on Freedman and Lane method that Huh-John had done on Kennedy method and compared this modified method with Freedman and Lane and Huh-John method. We conclude that Freedman and Lane modified method often has lower type I error estimation and higher power than Freedman& Lane and Huh-John method.

Author(s):  
Judith H. Parkinson-Schwarz ◽  
Arne C. Bathke

AbstractIn this paper, we propose a new non-parametric test for equality of distributions. The test is based on the recently introduced measure of (niche) overlap and its rank-based estimator. As the estimator makes only one basic assumption on the underlying distribution, namely continuity, the test is universal applicable in contrast to many tests that are restricted to only specific scenarios. By construction, the new test is capable of detecting differences in location and scale. It thus complements the large class of rank-based tests that are constructed based on the non-parametric relative effect. In simulations this new test procedure obtained higher power and lower type I error compared to two common tests in several settings. The new procedure shows overall good performance. Together with its simplicity, this test can be used broadly.


2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Zhongliang Zhu ◽  
Guangyu Yang ◽  
Zhenzhen Pang ◽  
Jiawei Liang ◽  
Weizhong Wang ◽  
...  

Abstract Background The aim of this study was to establish a regression equation model of serum bone metabolism markers. We analyzed the diagnostic value of bone metastases in lung cancer and provided laboratory evidence for the early clinical treatment of bone metastases in lung cancer. Methods A total of 339 patients with non-metastatic lung cancer, patients with lung cancer with bone metastasis, and patients with benign lung disease who were treated in our hospital from July 2012 to October 2015 were included. A total of 103 patients with lung cancer in the non-metastatic group, 128 patients with lung cancer combined with bone metastasis group, and 108 patients with benign lung diseases who had nontumor and nonbone metabolism-related diseases were selected as the control group. Detection and analysis of type I collagen carboxyl terminal peptide β-special sequence (β-CTX), total type I procollagen amino terminal propeptide (TPINP), N-terminal-mid fragment of osteocalcin (N-MID), parathyroid hormone (PTH), vitamin D (VitD3), alkaline phosphatase (ALP), calcium (CA), phosphorus (P), cytokeratin 19 fragment (F211), and other indicators were performed. Four multiple regression models were established to determine the best diagnostic model for lung cancer with bone metastasis. Results Analysis of single indicators of bone metabolism markers in lung cancer was performed, among which F211, β-CTX, TPINP, and ALP were significantly different (P < 0.05). The ROC curve of each indicator was less than 0.712. Based on the multiple regression models, the fourth model was the best and was much better than a single indicator with an AUC of 0.856, a sensitivity of 70.0%, a specificity of 91.0%, a positive predictive value of 82.5%, and a negative predictive value of 72.0%. Conclusion Multiple regression models of bone metabolism markers were established. These models can be used to evaluate the progression of lung cancer and provide a basis for the early treatment of bone metastases.


2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 10-11
Author(s):  
Esther D McCabe ◽  
Mike E King ◽  
Karol E Fike ◽  
Maggie J Smith ◽  
Glenn M Rogers ◽  
...  

Abstract The objective was to determine effect of trucking distance on sale price of beef calf and feeder cattle lots sold through Superior Livestock Video Auctions from 2010 through 2018. Data analyzed were collected from 211 livestock video auctions. There were 42,043 beef calf lots and 19,680 feeder cattle lots used in these analyses. Six states (Colorado, Iowa, Kansas, Nebraska, Oklahoma, and Texas) of delivery comprised 70% of calf lots and 83% of feeder cattle lots and were used in these analyses. All lot characteristics that could be accurately quantified or categorized were used to develop multiple regression models that evaluated effects of independent factors using backwards selection. A value of P &lt; 0.05 was used to maintain a factor in the final models. Based upon reported state of origin and state of delivery, lots were categorized into one of the following trucking distance categories: 1) Within-State, 2) Short-Haul, 3) Medium-Haul, and 4) Long-Haul. Average weight and number of calves in lots analyzed was 259.2 ± 38.4 kg BW and 100.6 ± 74.3 head, respectively. Average weight and number of feeder cattle in lots analyzed was 358.4 ± 34.3 kg BW and 110.6 ± 104.1 head, respectively. Beef calf lots hauled Within-State sold for more ($169.24/45.36 kg; P &lt; 0.0001) than other trucking distance categories (Table 1). Long-Haul calf lots sold for the lowest (P &lt; 0.0001) price ($166.70/45.36 kg). Within-State and Short-Haul feeder cattle lots sold for the greatest (P &lt; 0.0001) price ($149.96 and $149.81/45.36 kg, respectively; Table 2). Long-Haul feeder cattle lots sold for the lowest (P &lt; 0.0001) price, $148.43/45.36 kg. These results indicate there is a price advantage for lots expected to be hauled shorter distances, likely because of cost and risk associated with transportation.


Grana ◽  
2005 ◽  
Vol 44 (2) ◽  
pp. 108-114 ◽  
Author(s):  
José Manuel Angosto ◽  
Stella Moreno‐Grau ◽  
Javier Bayo ◽  
Belén Elvira‐Rendueles

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Alvin S Das ◽  
Elif Gokcal ◽  
Robert W Regenhardt ◽  
Andrew Warren ◽  
Kristin Schwab ◽  
...  

Introduction: High burdens of basal ganglia-perivascular spaces (BG-PVS) are often attributed to underlying hypertensive cerebral small vessel disease (HTN-CSVD). Although PVS are thought to arise from decreased perivascular drainage related to changes in arterial pulsatility, the contribution of pulsatility changes from nonvalvular atrial fibrillation (NVAF) has not been studied. Hypothesis: We hypothesized that NVAF patients have a higher burden of BG-PVS than HTN-CSVD patients, possibly through hemodynamic factors related to NVAF. Methods: Through an observational single-center study of consecutive stroke patients, we compared BG-EPVS severity between 136 patients with NVAF-related ischemic stroke (NVAF-IS) and 107 patients with HTN-CSVD-related intracerebral hemorrhage (HTN-ICH) without NVAF. Within the NVAF cohort, we also built multiple regression models to evaluate independent effects of NVAF-related factors on BG-PVS. All multiple regression models were adjusted for age, hypertension, sex, and neuroimaging markers of CSVD (extent of white matter hyperintensities (WMH), presence of lacunes, and cerebral microbleeds). Results: Patients with NVAF-IS were older than patients with HTN-ICH (75 + 12 vs. 64 + 13, p < 0.0001); however, there was no difference in sex between groups ( p = 0.6). Severe BG-PVS (defined as > 20 PVS in the BG) were found in 42.6% of NVAF-IS patients vs. 8.4% of HTN-ICH ( p < 0.0001). Even after multivariate adjustment, the presence of NVAF remained significantly related to BG-PVS ( p = 0.001). Within the NVAF cohort, CHA2DS2-VASc was associated with the presence of severe BG-PVS ( p = 0.003) despite controlling for other covariates. When CHA2DS2-VASc was replaced with its individual components in the same regression model, congestive heart failure (CHF, p = 0.017), WMH burden ( p = 0.009), and age ( p = 0.02) were found to be predictors of severe BG-PVS. Conclusions: Severe BG-PVS were significantly more common in NVAF patients compared to HTN-CSVD patients. NVAF-related features (CHA2DS2-VASc score) and CHF were associated with higher burdens of BG-PVS. These findings suggest that NVAF might play a role in the development of BG-PVS, conceivably through hemodynamic factors.


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