Safety of reduced-dosage ketoprofen for long-term oral administration in healthy dogs

Abstract OBJECTIVE To evaluate the effects of long-term (30-day) oral administration of melatonin on tear production, intraocular pressure (IOP), and concentration of melatonin in the tears and serum of healthy dogs. ANIMALS 20 healthy sexually intact adult male dogs. PROCEDURES 10 dogs were given melatonin (0.3 mg/kg, PO, q 24 h, administered in food at 9 am), and 10 dogs were given a placebo. Tear and serum melatonin concentrations, IOP, and tear production (determined with a Schirmer tear test) were recorded before (baseline) and 30 minutes, 3 hours, and 5 hours after administration of melatonin or the placebo on day 1 and 30 minutes after administration of melatonin or the placebo on days 8, 15, and 30. RESULTS Data collection time had significant effects on tear production, IOP, and tear melatonin concentration but not on serum melatonin concentration. Treatment (melatonin vs placebo) had a significant effect on tear melatonin concentration, but not on tear production, IOP, or serum melatonin concentration; however, tear melatonin concentration was significantly different between groups only 30 minutes after administration on day 1 and not at other times. CLINICAL RELEVANCE In healthy dogs, long-term administration of melatonin at a dosage of 0.3 mg/kg, PO, every 24 hours did not have any clinically important effects on tear production, IOP, or serum or tear melatonin concentrations.

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Effect of Long-term Oral Administration of an Immunostimulant Diet on Innate Immunity in Sea Bass (Dicentrarchus labrax)

Journal of Veterinary Medicine Series B ◽

10.1046/j.1439-0450.2000.00412.x ◽

2000 ◽

Vol 47 (10) ◽

pp. 745-751 ◽

Cited By ~ 43

Author(s):

M. Bagni ◽

L. Archetti ◽

M. Amadori ◽

G. Marino

Keyword(s):

Innate Immunity ◽

Oral Administration ◽

Dicentrarchus Labrax ◽

Sea Bass

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Efficacy and Safety of Long-Term Low-Dose Clarithromycin in Patients With Refractory Chronic Sinusitis After Endoscopic Sinus Surgery: A Prospective Clinical Trial

Ear Nose & Throat Journal ◽

10.1177/01455613211032020 ◽

2021 ◽

pp. 014556132110320

Author(s):

Han Chen ◽

Bing Zhou ◽

Qian Huang ◽

Cheng Li ◽

Yubin Wu ◽

...

Keyword(s):

Oral Administration ◽

Nasal Cavity ◽

Endoscopic Sinus Surgery ◽

Low Dose ◽

Continuous Treatment ◽

Sinus Surgery ◽

Efficacy And Safety ◽

Endoscopic Findings ◽

Before And After

Objective: To observe the efficacy and safety of postoperative long-term low-dose oral administration of clarithromycin in patients with refractory chronic rhinosinusitis (RCRS), to explore the characteristics of postoperative microbiota in the nasal cavity in patients with RCRS, and to compare the differences and changes in microbiota in the nasal cavity before and after medication. Methods: This was a prospective, self-controlled study. Eighteen patients with RCRS who had persistent symptoms after endoscopic sinus surgery and standard therapy with normal immunoglobulin E and eosinophil level were included. Low dose (250 mg, once daily) clarithromycin was orally administrated for 12 weeks. Symptom severity and endoscopic findings were evaluated before, after 4 weeks, and 12 weeks of treatment, and nasal cavity microbiota was analyzed simultaneously. Results: A total of 18 patients with RCRS were enrolled and 17 patients completed the study. Four weeks after oral administration of clarithromycin, significant improvement was observed in subjective symptoms including nasal congestion, rhinorrhea, postnasal drip, and general discomfort, as well as endoscopic findings including general surgical cavity condition, rhinedema, and rhinorrhea ( P < .05). After continuous treatment to the 12th week, symptoms showed significant improvement compared with baseline, and endoscopic score showed significant improvement compared with both baseline and 4 weeks after treatment. Analysis of middle nasal meatus flora revealed a significant decrease of Streptococcus pneumoniae after 12 weeks of clarithromycin treatment ( P < .05), while the richness, composition, and diversity were similar before and after treatment. Patients enrolled experienced no adverse drug reaction or allergic reaction, nor clinical significant liver function impairment observed. Conclusion: Postoperative low-dose long-term oral administration of clarithromycin in patients with RCRS can improve the clinical symptoms and facilitate the mucosal epithelialization, with good tolerance and safety. The efficacy of clarithromycin in patients with RCRS may be related to its regulatory effect on nasal cavity microbiota.

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1,25-Dihydroxycholecalciferol: Oral Administration and Sterol Levels in the Long-Term Management of Idiopathic Hypoparathyroidism in Children

Vitamin D - Biochemical, Chemical and Clinical Aspects Related to Calcium Metabolism ◽

10.1515/9783112327203-147 ◽

1977 ◽

pp. 827-830

Keyword(s):

Oral Administration ◽

Term Management

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Increase in serum 7S domain of type IV collagen and N-terminal propeptide of type III procollagen levels with normal serum transaminase levels after long-term oral administration of Tegaful-Uracil

Hepatology Research ◽

10.1016/s1386-6346(02)00026-8 ◽

2002 ◽

Vol 24 (2) ◽

pp. 184-191 ◽

Cited By ~ 2

Author(s):

T Suou

Keyword(s):

Oral Administration ◽

Type Iv Collagen ◽

Normal Serum ◽

Serum Transaminase ◽

Type Iii ◽

Type Iv ◽

Type Iii Procollagen

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Effects of long-term oral administration of silver nanoparticles on the cognitive functions of mammals

Токсикологический вестник ◽

10.36946/0869-7922-2021-29-6-33-38 ◽

2021 ◽

Vol 29 (6) ◽

pp. 33-38

Author(s):

Anna Alexandrovna Antsiferova ◽

Marina Yurievna Kopaeva ◽

Vyacheslav Nikolaevich Kochkin ◽

Pavel Konstantinovich Kashkarov

Keyword(s):

Silver Nanoparticles ◽

Oral Administration ◽

Dietary Supplement ◽

Cognitive Functions ◽

High Demand ◽

Gastrointestinal Infections ◽

Impaired Cognitive Function ◽

Potential Risks ◽

The Brain

Introduction. Since the beginning of the XXI century, silver nanoparticles have been widely used in various industries, medicine and pharmaceuticals due to their pronounced antibacterial, antiviral and fungicidal properties. In connection with such a high demand for the use of silver nanoparticles, it is very important to understand the associated potential risks from their use. Materials and methods. In the course of the work, there has been a study of the effects of the long-term oral administration of a commercially produced dietary supplement based on silver nanoparticles with a size of 34 nm and stabilized with polyvinylpyrrolidone in an amount of 50 μg/day/animal on the cognitive functions of C57Bl/6 mice, as well as their accumulation in the brain by the method of instrumental neutron activation analysis. The dietary supplement used is recommended for people as a treatment for gastrointestinal infections. Results. It was found that after 180 days of administration, silver nanoparticles impair long-term contextual memory, and over time, the content of silver in the brain increases. Conclusion. Presumably impaired cognitive function with accumulation of silver in the brains of mice. This poses the risk of prolonged oral use of the silver nanoparticles.

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