Use of Concrete Reinforcement to Control Content of Verbal Initiations in Group Therapy with Adolescents

1976 ◽  
Vol 38 (3_suppl) ◽  
pp. 1051-1057 ◽  
Author(s):  
Stanley Zweback
Keyword(s):  
Group Therapy ◽  
Basic Structure ◽  
Class Ii ◽  
Token Economy ◽  
Class I ◽  
Group Members ◽  
Verbal Initiations ◽  
Group Member ◽  
Economy System ◽  
Concrete Reinforcement

Tokens in the form of ½-in. diameter metal washers were used with 8 hospitalized adolescents in group therapy to reinforce two classes of verbalization content. Class I verbalizations were statements of group members' own problems, while Class II verbalizations were statements which dealt with problems of fellow group members. Baseline frequencies of emission of both content classes were collected. During the first and third experimental phases Class I verbalizations were reinforced, with Class II verbalizations reinforced only during Phase II. Reinforcement was administered on a variable ratio 3 (VR 3) schedule, so that an average of one token was received by a group member for every three emitted verbalizations subject to reinforcement during a given session. Tokens earned in therapy were used to purchase a variety of items and privileges within the basic structure of a token economy system. Results clearly supported the hypothesis that the content of verbalizations in group therapy could be controlled through the differential use of concrete reinforcement.

Electron microscopy analysis of degenerating pancreatic ß cells in transgenic mice expressing the MHC Class I antigen Dd

1990 ◽  
Vol 48 (3) ◽  
pp. 548-549
Author(s):  
T. A. Stewart ◽  
D. Liggitt ◽  
S. Pitts ◽  
L. Martin ◽  
M. Siegel ◽  
...  
Keyword(s):  
Type I Diabetes ◽  
Disease Process ◽  
Class Ii ◽  
Class I ◽  
Type I ◽  
Aberrant Expression ◽  
Mhc Molecules ◽  
Endogenous Insulin ◽  
Class Ii Mhc ◽  
Ifn Γ

Insulin-dependant (Type I) diabetes mellitus (IDDM) is a metabolic disorder resulting from the lack of endogenous insulin secretion. The disease is thought to result from the autoimmune mediated destruction of the insulin producing ß cells within the islets of Langerhans. The disease process is probably triggered by environmental agents, e.g. virus or chemical toxins on a background of genetic susceptibility associated with particular alleles within the major histocompatiblity complex (MHC). The relation between IDDM and the MHC locus has been reinforced by the demonstration of both class I and class II MHC proteins on the surface of ß cells from newly diagnosed patients as well as mounting evidence that IDDM has an autoimmune pathogenesis. In 1984, a series of observations were used to advance a hypothesis, in which it was suggested that aberrant expression of class II MHC molecules, perhaps induced by gamma-interferon (IFN γ) could present self antigens and initiate an autoimmune disease. We have tested some aspects of this model and demonstrated that expression of IFN γ by pancreatic ß cells can initiate an inflammatory destruction of both the islets and pancreas and does lead to IDDM.

Pictish Horse Carvings

1991 ◽  
Vol 17 (1) ◽  
pp. 53-62
Author(s):  
Irene Hughson
Keyword(s):  
Class Ii ◽  
Class I ◽  
Early Historic Period ◽  
High Quality ◽  
Historic Period ◽  
Agricultural Economy ◽  
Different Types ◽  
Early Historic

Summary This paper examines the horse carvings to be found on Class I and Class II Pictish sculptured stones and considers their reliability as evidence of the sort of horses and ponies that would have existed in the Early Historic Period. An attempt is made to show that the availability in Britain of good sized, high quality riding horses during that period is not inconsistent with what is known of the development and distribution of different types of horses in pre-hislory. The importance of horses and ponies in Early Historic societies is stressed and inferences drawn about the agricultural economy that could support horses and the skilled specialists required to look after them.

MHC Sınıf I ve MHC Sınıf II Gen Düzenlenmesi

2020 ◽  
Vol 8 (3) ◽  
pp. 144-156
Author(s):  
Şule KARATAŞ ◽  
Fatma SAVRAN OĞUZ
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Gene Regulation ◽  
Mhc Class I ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Class I ◽  
Mhc Molecules ◽  
Class Ii Mhc ◽  
Regulation Mechanisms

Introduction: Peptides obtained by processing intracellular and extracellular antigens are presented to T cells to stimulate the immune response. This presentation is made by peptide receptors called major histocompatibility complex (MHC) molecules. The regulation mechanisms of MHC molecules, which have similar roles in the immune response, especially at the gene level, have significant differences according to their class. Objective: Class I and class II MHC molecules encoded by MHC genes on the short arm of the sixth chromosome are peptide receptors that stimulate T cell response. These peptides, which will enable the recognition of the antigen from which they originate, are loaded into MHC molecules and presented to T cells. Although the principles of loading and delivering peptides are similar for both molecules, the peptide sources and peptide loading mechanisms are different. In addition, class I molecules are expressed in all nucleated cells while class II molecules are expressed only in Antigen Presentation Cells (APC). These differences; It shows that MHC class I is not expressed by exactly the same transcriptional mechanisms as MHC class II. In our article, we aimed to compare the gene expressions of both classes and reveal their similarities and differences. Discussion and Conclusion: A better understanding of the transcriptional mechanisms of MHC molecules will reveal the role of these molecules in diseases more clearly. In our review, we discussed MHC gene regulation mechanisms with presence of existing informations, which is specific to the MHC class, for contribute to future research. Keywords: MHC class I, MHC class II, MHC gene regulation, promoter, SXY module, transcription

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