scholarly journals Anthelmintic activity of praziquantel and Spilanthes acmella extract on an intestinal cestode parasite

2020 ◽  
Vol 70 (4) ◽  
pp. 551-560 ◽  
Author(s):  
Pawi Bawitlung Lalthanpuii ◽  
Zar Zokimi ◽  
Kholhring Lalchhandama
Keyword(s):  
Medicinal Plant ◽  
Comparative Study ◽  
Plant Extract ◽  
Anthelmintic Activity ◽  
Chloroform Extract ◽  
Main Body ◽  
Good Source ◽  
Cestode Parasite ◽  
Raillietina Echinobothrida ◽  
Spilanthes Acmella

AbstractSpilanthes acmella Murr., popularised as toothache plant, is a well-known culinary and medicinal plant for different purposes, but its use as an anthelmintic is apparently exclusive to the Mizo people of India and Myanmar. A chloroform extract of Spilanthes acmella Murr. was analysed in a single quadrupole GC-MS system, from which it was found that the major compound was an alkylamide, N-isobutyl-(2E,4Z,8Z,10E)-dodecatetraenamide. A comparative study was performed on the anthelmintic activity of the plant extract and praziquantel (PZQ) against an intestinal cestode, Raillietina echinobothrida. In terms of efficacy, PZQ was more potent, but the plant extract was also effective at all concentrations tested. PZQ caused severe shrinkage and folds of the tegument, constriction of the suckers, dislocation of spines and erosion of microtriches. The plant extract caused shrinkage and folds on the main body but not on the scolex. Damage on the suckers is more pronounced than in PZQ-treated cestodes. The spines were completely removed. The current findings indicate that S. acmella is a good source of compounds with anthelmintic activity.

Elaeagnus Angustifolia: a Promising Medicinal Plant for Cancer Theraby

2020 ◽  
Author(s):  
Islam Mohamed ◽  
Ahmed Moahmed ◽  
Mennatallah Abdelkader ◽  
Alaaeldin Saleh ◽  
Ala-Eddin Al-Moustafa
Keyword(s):  
Cell Proliferation ◽  
Oral Cancer ◽  
Medicinal Plant ◽  
Cancer Progression ◽  
Plant Extract ◽  
Cell Invasion ◽  
Elaeagnus Angustifolia ◽  
Flower Extract ◽  
Inhibition Of Angiogenesis ◽  
E Cadherin

Introduction: Elaeagnus angustifolia (EA) is a medicinal plant that has been used for centuries in treating many human diseases, in the Middle East, including fever, amoebic dysentery, gastrointestinal problems. However, the effect of EA plant extract on human cancer progression especially oral malignancy has not been investigated yet. Thus, first we examined the effect of EA flower extract on angiogenesis in ovo, and on selected parameters in human oral cancer cells. Materials and methods: Chorioallantoic membranes (CAMs) of chicken embryos at 3-7 days of incubation were used to assess the effect EAflower plant extract on angiogenesis. Meanwhile, cell proliferation, soft agar, cell cycle, cell invasion and cell wounding assays were performed to explore the outcome of EA plant extract on FaDu and SCC25 oral cancer cell lines. On the other hand, western blot analysis was carried out to evaluate E-cadherin and Erk1/Erk2 expression and activation, respectively, in FaDu and SCC25 under the effect of EA extract. Results: Our data show that EA extract inhibits cell proliferation and colony formation, in addition to the initiation of Scell cycle arrest and reductionof G1/G2 phases. In parallel, EA extract provokes differentiation to an epithelial phenotype “mesenchymal-epithelial transition: MET” which is the opposite of “epithelial-mesenchymal transition, EMT”: an important event in cell invasion and metastasis. Thus, EA extract causes a dramatic decrease in cell motility and invasion abilities of FaDu and SCC25 cancer cells in comparison with their controls. These changes are accompanied by an up-regulation of E-cadherin expression. The molecular pathway analysis of the EA flower extract reveals that it can inhibit the phosphorylation of Erk1/Erk2, which could be behind the inhibition of angiogenesis, the initiation of MET event and the overexpression of E-cadherin. Conclusions: Our findings indicate that EA plant extract can downgrade human oral cancer progression by the inhibition of angiogenesis and cell invasion via Erk1/Erk2 signaling pathways.

scholarly journals Isolation, Structure Elucidation, and Biological Activity of a New Alkaloid from Zanthoxylum rhetsa

2011 ◽  
Vol 6 (11) ◽  
pp. 1934578X1100601
Author(s):  
Karsten Krohn ◽  
Stephan Cludius-Brandt ◽  
Barbara Schulz ◽  
Mambatta Sreelekha ◽  
Pottachola Mohamed Shafi
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Medicinal Plant ◽  
Plant Extract ◽  
Structure Elucidation ◽  
Biologically Active ◽  
Reduction Product ◽  
Pharmacological Properties ◽  
Evergreen Tree

Several biologically active alkaloids (1-4, 6), including a new quinazoline-6-carboxylic acid (1), were isolated from the medicinal plant Zanthoxylum rhetsa, an evergreen tree, native to subtropical areas. Whereas the pharmacological properties of the plant extract and single constituents have been widely tested, we now show that all of the metabolites have antialgal activities, all but 6 are antibacterial, and 6 and the reduction product 5 (derived from 4) are also antifungal.

scholarly journals Medicinal plant knowledge in Caribbean Basin: a comparative study of Afrocaribbean, Amerindian and Mestizo communities

2015 ◽  
Vol 11 (1) ◽  
pp. 18 ◽  
Author(s):  
Wendy Torres-Avilez ◽  
Martha Méndez-González ◽  
Rafael Durán-García ◽  
Isabelle Boulogne ◽  
Lionel Germosén-Robineau
Keyword(s):  
Medicinal Plant ◽  
Comparative Study ◽  
Caribbean Basin ◽  
Plant Knowledge ◽  
Medicinal Plant Knowledge

Effects of the folk medicinal plant extract Ankaferd Blood Stopper®on the ocular surface

2011 ◽  
Vol 30 (4) ◽  
pp. 280-285 ◽  
Author(s):  
Atilla Alpay ◽  
Cenk Evren ◽  
Sibel Bektaş ◽  
Sılay Canturk Ugurbas ◽  
Suat Hayri Ugurbas ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Plant Extract ◽  
Ocular Surface ◽  
Ankaferd Blood Stopper

scholarly journals Effect of Medicinal Plant Extract Incorporated Carrageenan Based Films on Shelf-Life of Chicken Breast Meat

2013 ◽  
Vol 33 (1) ◽  
pp. 53-57 ◽  
Author(s):  
Kuk-Hwan Seol ◽  
Beom-Jin Joo ◽  
Hyoun Wook Kim ◽  
Oun-Ki Chang ◽  
Jun-Sang Ham ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Shelf Life ◽  
Plant Extract ◽  
Chicken Breast ◽  
Breast Meat ◽  
Chicken Breast Meat

scholarly journals Anti-Inflammatory Activity and Composition ofSenecio salignusKunth

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Cuauhtemoc Pérez González ◽  
Roberto Serrano Vega ◽  
Marco González-Chávez ◽  
Miguel Angel Zavala Sánchez ◽  
Salud Pérez Gutiérrez
Keyword(s):  
Medicinal Plant ◽  
Methanol Extract ◽  
Chloroform Extract ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Active Fraction ◽  
Ear Edema ◽  
Methanol Extracts ◽  
Anti Inflammatory ◽  
Inflammatory Effect

We investigated the anti-inflammatory activity ofSenecio salignus. This medicinal plant is often used in Mexico for the treatment of fever and rheumatism. Chloroform and methanol extracts of the plant were tested on 12-O-tetradecanoylphorbol-13-acetate- (TPA-) induced edema in mice ears. The methanol extract of the plant inhibited edema by36±4.4% compared with the control, while the chloroform extract exhibited an even greater level of inhibition (64.1%). The chloroform extract was then fractionated, and the composition of the active fraction was determined by GC-MS. The anti-inflammatory activity of this fraction was then tested on TPA-induced ear edema in mice, and we found that the active fraction could inhibit edema by 46.9%. The anti-inflammatory effect of the fraction was also tested on carrageenan-induced paw edema in rats at doses of 100 mg/kg; a58.9±2.8% reduction of the edema was observed 4 h after administration of carrageenan, and the effect was maintained for 5 h.

scholarly journals Icacina trichantha, A Tropical Medicinal Plant

2016 ◽  
Vol 11 (7) ◽  
pp. 1934578X1601100
Author(s):  
Chun-Tao Che ◽  
Ming Zhao ◽  
Brian Guo ◽  
Michael M. Onakpa
Keyword(s):  
Chemical Composition ◽  
Animal Models ◽  
Chemical Analysis ◽  
Medicinal Plant ◽  
West Africa ◽  
Pharmacological Properties ◽  
Good Source ◽  
Pharmacological Activities

This is a review on the pharmacological properties and chemical composition of Icacina trichantha (Icacinaceae), a food and medicinal plant native to West Africa. The tuber is a good source of nutrients such as starch; it also exhibits a variety of pharmacological activities in animal models. Chemical analysis has revealed the presence of a series of unusual pimarane-type diterpenes.

scholarly journals In Vivo Hemostatic Effect of the Medicinal Plant Extract Ankaferd Blood Stopper in Rats Pretreated With Warfarin

2008 ◽  
Vol 15 (3) ◽  
pp. 270-276 ◽  
Author(s):  
Handan S. Cipil ◽  
Ali Kosar ◽  
Arif Kaya ◽  
Burak Uz ◽  
Ibrahim C. Haznedaroglu ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Plant Extract ◽  
Hemostatic Effect ◽  
Ankaferd Blood Stopper
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