The Role of Apolipoprotein (A) In Pathogenesis and Clinical Course of Deep Venous Thrombosis

2015 ◽  
Vol 86 (11) ◽  
Author(s):  
Marek Chrapko ◽  
Adam Skwarzyński ◽  
Wacław Karakuła ◽  
Tomasz Zubilewicz
Keyword(s):  
Risk Factors ◽  
Pulmonary Embolism ◽  
Serum Level ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Clinical Course ◽  
Newly Diagnosed ◽  
Apolipoprotein A ◽  
Duplex Doppler

AbstractDeep venous thrombosis is widespread disease, which complications, like: pulmonary embolism and postphlebitis syndrome areimportant social problem. There are many well-known and accurately described risk factors, though in many cases etiology remains unexplained. Further research into causes of deep venous thrombosis seem to be fully justified.was the evaluation of the influence of apolipoprotein (a) serum level in patients with deep venous thrombosis and the changes of its concentration during the treatment.26 patients with newly diagnosed deep venous thrombosis (DVT) were enrolled to the study. Diagnosis of DVT was established by use of physical examination and duplex Doppler. Measurements of apolipoprotein (a) and D-dimers serum level were recorded on the following days, starting from the day of the initial diagnosis: 1, 7, 14 and 84.Statistically significant increase of the level of serum apolipoprotein (a) has been found during properly conducted treatment.Alterations of the concentration of serum apoliprotein (a) during the deep venous thrombosis treatment, indicates the involvement of apolipoprotein (a) in pathogenesis of deep venous thrombosis.

scholarly journals Upper extremity deep venous thrombosis: risk factors, diagnosis, treatment

2016 ◽  
Vol 11 (1) ◽  
pp. 28-32
Author(s):  
Camelia C. DIACONU ◽  
◽  
Mădălina ILIE ◽  
Mihaela Adela IANCU ◽  
◽  
...  
Keyword(s):  
Risk Factors ◽  
Pulmonary Embolism ◽  
High Risk ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Upper Extremity ◽  
Brachiocephalic Vein ◽  
Risk Of Death ◽  
Thrombosis Risk ◽  
Effort Thrombosis

Upper extremity deep venous thrombosis is a condition with increasing prevalence, with high risk of morbidity and mortality, due to embolic complications. In the majority of the cases, thrombosis involves more than one venous segment, most frequently being affected the subclavian vein, followed by internal jugular vein, brachiocephalic vein and basilic vein. Upper extremity deep venous thrombosis in patients without risk factors for thrombosis is called primary deep venous thrombosis and includes idiopathic thrombosis and effort thrombosis. Deep venous thrombosis of upper extremity is called secondary when there are known risk factors and it is encountered mainly in older patients, with many comorbidities. The positive diagnosis is established only after paraclinical and imaging investigations, ultrasonography being the most useful diagnostic method. The most important complication, with high risk of death, is pulmonary embolism. Treatment consists in anticoagulant therapy, for preventing thrombosis extension and pulmonary embolism.

scholarly journals Duplex doppler ultrasonography in the diagnosis of deep venous thrombosis of the lower extremities

2006 ◽  
Vol 59 (1-2) ◽  
pp. 11-14 ◽  
Author(s):  
Viktorija Vucaj-Cirilovic ◽  
Kosta Petrovic ◽  
Olivera Nikolic ◽  
Viktor Till ◽  
Dijana Niciforovic ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Doppler Ultrasonography ◽  
Varicose Veins ◽  
Color Doppler ◽  
Lower Extremities ◽  
Postthrombotic Syndrome ◽  
Duplex Doppler ◽  
Age Range

Introduction. The aim of this study was to investigate the role of duplex Doppler ultrasonography in diagnosis of deep venous thrombosis (DVT) of the lower extremities. Material and methods. During a 2-year period, 860 patients were examined by duplex Doppler sonography. Among these, 619(72%) were women and 241 (28%) men, with the age-range of 16-91; (mean 56,2) years. Siemens Versa Pro color doppler was used, with 7MHz transducers. Findings were categorized into four categories: 1. deep venous thrombosis (DVT); 2. pathology predominantly related to superficial veins without DVT; 3. pathology of superficial and deep veins; 4. normal findings. Results. 185 (21%) patients had DVT, 366 (42.5%) patients had pre?dominant pathology of superficial veins: postthrombotic syndrome, superficial thrombophlebitis and varicose veins. 128 (14.9%) patients had pathology of superficial and deep veins. Normal findings were found in 181 (21.1%) patients. Conclusions. Various vascular and nonvascular diseases may mimic deep venous thrombosis, and that is why US should be used whenever possible to avoid unnecessary anticoagulant therapy. .

Deep venous thrombosis in the clinical course of pulmonary embolism

2018 ◽  
Vol 34 (7) ◽  
pp. 453-458
Author(s):  
Natalia Stoeva ◽  
Milena Staneva ◽  
Galina Kirova ◽  
Rumiana Bakalova
Keyword(s):  
Pulmonary Embolism ◽  
Mortality Rate ◽  
Pulmonary Artery ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Clinical Presentation ◽  
Clinical Course ◽  
Clinical Signs ◽  
Arterial Blood ◽  
Severe Clinical Presentation

Objectives The aim of the study is to find how concomitant deep venous thrombosis (DVT) changes the clinical course of pulmonary embolism. Methods Three hundred and five patients with pulmonary embolism were examined and grouped into DVT and non-DVT groups. Both groups were compared with regard to demography, predisposing factors, clinical signs, thrombotic burden, and one-month mortality rate. Results The patients with DVT had a more severe clinical presentation: higher heart rate (94.80 ± 18.66 beats per minute versus 87.9 ± 13.90 in the non-DVT group, p = 0.00033), more hemodynamic instability (11.35% versus 3.05% in the non-DVT group, p = 0.005), and less pCO2 in arterial blood gases (30.81 ± 7.94 mmHg versus 32.59 ± 7.35 mmHg in the non-DVT group, p = 0.049). The DVT group had heavier thrombotic burden in pulmonary artery, measured by Mastora score. The one-month mortality rate did not differ statistically between groups. Conclusions Patients with symptomatic pulmonary embolism and concomitant DVT have heavier thrombotic burden in the pulmonary artery and more severe clinical presentation compared to those without DVT, but a similar one-month mortality rate.

Risk factors for presence and severity of pulmonary embolism in patients with deep venous thrombosis

2018 ◽  
Vol 6 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Nancy Huynh ◽  
Wassim H. Fares ◽  
Kirstyn Brownson ◽  
Anand Brahmandam ◽  
Alfred I. Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pulmonary Embolism ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis

Venographic Studies on the Role of Valve Pockets in Thrombogenesis with Clinical Comments

1975 ◽  
Author(s):  
L. Diener ◽  
J.L.E. Ericsson ◽  
F. Lund
Keyword(s):  
Pulmonary Embolism ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Contrast Medium ◽  
Lower Limbs ◽  
Fatal Pulmonary Embolism ◽  
Early Type ◽  
Clinical Series ◽  
Good Agreement

In postmortem exploration of the veins of the lower limbs for studies of the frequency and significance of thromboembolism intraosseous venography with injection of contrast medium into the calcaneus was performed followed by complete dissection of the leg veins. A good agreement was found between venographic results and dissection findings. Out of the 596 legs examined, deep venous thrombosis was found in 229 (38%). In 32 of the lower limbs (5.4%) a definite localization and adherence of thrombi to valve pockets was noted. Altogether, 37 such thrombi were encountered. In addition 9 small thrombi of early type were found floating freely in the venous lumen just above a pocket. Microscopically the thrombi showed the greatest degree of organization at the bottom of the valve pocket speaking for this localization as the origin of formation. This is in accordance with the fact that stasis of blood would be most pronounced at the bottom of valve pockets as shown by retention of contrast medium in pockets in clinical venography. In a clinical series of venographies performed after hip surgery several thrombi located to valve pockets were found. Some of these thrombi had proximally free floating tails forming a potential menace of fatal pulmonary embolism.

Risk Factors for Deep Venous Thrombosis and Pulmonary Embolism are Different in Both Blunt and Penetrating Trauma

2017 ◽  
Vol 225 (4) ◽  
pp. e184-e185
Author(s):  
Charles A. Karcutskie ◽  
Sarah A. Eidelson ◽  
Jonathan P. Meizoso ◽  
Carl I. Schulman ◽  
Nicholas Namias ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pulmonary Embolism ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Penetrating Trauma
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