scholarly journals Type 2 Diabetes and Hashimoto Thyroiditis-Possible Associations and Clinical Correlations - Preliminary Results

2018 ◽  
Vol 25 (3) ◽  
pp. 297-301
Author(s):  
Oana-Andreea Parlițeanu ◽  
Dan Mircea Cheța
Keyword(s):  
Type 2 Diabetes ◽  
Hashimoto Thyroiditis ◽  
Primary Objective ◽  
Observational Research ◽  
Diabetes Group ◽  
Metabolic Component ◽  
Prevalence Of Obesity ◽  
Clinical Correlations

Abstract Background and aims: The primary objective is to evaluate the possible relationship between Type 2 Diabetes (T2DM) and Hashimoto Thyroiditis (HT), since the only correlation described until now is between Type 1 Diabetes and HT based on the autoimmune mechanism. The secondary end-point is to evaluate if there is a correlation between the characteristics of Type 2 Diabetes and autoimmune thyroiditis and if the metabolic component may be a factor of association. Material and method: We designed a retrospective, observational research, enrolling patients from “Sanamed” Hospital from Bucharest. Between 2016 and 2017 in our clinic a number of 150 patients were enrolled, in the following groups: 50 only with T2DM, 50 only with HT and 50 with both T2DM and HT. Results: The main observations of the study were the following: the prevalence of obesity was higher in patients with T2DM (p<0.001) than in the group with HT (p<0.001); Dyslipidemia was higher in the HT group (p<0.001) than in the group of T2DM (p<0.001); Ischemic cardiac disease was more frequent in the HT group (p<0.001) than in the Diabetes group (p<0.001); in the group that had both T2DM and HT, the HbA1c was correlated with pre-existing Thyroid pathology (p<0.001), also Dyslipidemia was associated with hepatic steatosis (p<0.001). Conclusions: After assessing all the parameters we have reached the conclusion that there is an association between the characteristics of T2DM and HT, as well as an interaction between these two diseases, considering their metabolic component.

scholarly journals SUN-655 Helicobacter Pylori Infection Is Not Associated with Diabetes Among a Cohort of Diabetic Patients in Alexandria City, Egypt

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Mohamed Fahmy Amara
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Helicobacter Pylori ◽  
Diabetic Retinopathy ◽  
Diabetic Nephropathy ◽  
Helicobacter Pylori Infection ◽  
Diabetes Group ◽  
Significant Difference

Abstract Abstract: Helicobacter Pylori infection is one of the most common bacterial infections in Egypt. A mounting body of evidence suggests the association of H Pylori infection with diabetes. H.Pylori is implicated in increasing insulin resistance and promoting chronic inflammation, resulting in the development of diabetes. This study aimed to estimate the prevalence of H.Pylori infection among a cohort of patients with diabetes in Alexandria city, Egypt and the possible role of this condition in the control of the glycemic profile. We also investigated the correlation between H.pylori infection and the presence of diabetes-related complications (diabetic nephropathy and retinopathy). The study was conducted on 300 subjects classified into three groups; Group (I): 100 patients with type 2 diabetes, Group (II): 100 subjects with type 1 diabetes, Group (III): 100 non-diabetic control subjects. Participants were subjected to detailed history taking and thorough clinical examination. Routine laboratory investigations were done, including HbA1c and fasting plasma glucose. Stool antigen test, on- site Helicobacter Pylori Ag Rapid Test-cassette was done. The mean duration of diabetes in type 2 diabetes was 8.18±5.87 years, while the mean duration in type 1 was 4.88± 3.02 years, which was statistically significante (p&lt; 0.05). The results of the presented study showed that there was no significant difference in the prevalence of Helicobacter Pylori infection between type 1 and type 2 patients with diabetes (31% Vs 38%, p=0.298), moreover; after adjustment for age, there was no significant difference in the prevalence of Helicobacter Pylori infection among either group with diabetes (Group 1 and group 2) compared to the control group, (p= 0.756 and 0.066) respectively. There was no statistically significant association between the presence of Helicobacter Pylori infection in both type 1 and type 2 diabetes, and an elevated HbA1c level above 6.5%.(p= 0.772 and p=0.524) respectively. The prevalence of diabetic nephropathy in patients with type 2 and type 1 diabetes was 5% and 3% respectively, which was non-statistically significant (p=0.721). While the prevalence of diabetic retinopathy was 11% among patients with type 2 compared to 1% among patients with type 1 diabetes, which was statistically significant (p=0.003). There was no statistically significant correlation between Helicobacter Pylori infection and the presence of diabetic nephropathy or diabetic retinopathy. Helicobacter Pylori infection was not associated with diabetes and did not affect the HbA1c level. Helicobacter Pylori infection was not correlated to the presence of either diabetic nephropathy or diabetic retinopathy among both patients with type 2 and type 1 diabetes. Nothing to Disclose: MA, MM, AH No Sources of Research Support

Diabetic Retinopathy in Relation with eGDR Value in Patients with Type 1 Diabetes Mellitus

2019 ◽  
Vol 70 (4) ◽  
pp. 1434-1438
Author(s):  
Diana Clenciu ◽  
Tiberiu Stefanita Tenea Cojan ◽  
Anda Lorena Dijmarescu ◽  
Cristina Gabriela Ene ◽  
Dragos Virgil Davitoiu ◽  
...  
Keyword(s):  
Public Health ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Type 1 Diabetes Mellitus ◽  
Childhood And Adolescence ◽  
Prevalence Of Obesity

Type 1 diabetes mellitus (T1DM) is a chronic disease which represents a major issue for public health. Type 1 diabetes is occurred most frequently in childhood and adolescence, although in recent years due to the increase in the prevalence of obesity in this category of population has been registered a growing number of cases of type 2 diabetes among children and adolescents (1, 2).

scholarly journals Humoral immune response to Covid-19 vaccination in diabetes: age-dependent but independent of type of diabetes and glycaemic control-the prospective COVAC-DM cohort study

2021 ◽  
Author(s):  
Caren Sourij ◽  
Norbert Joachim Tripolt ◽  
Faisal Aziz ◽  
Felix Aberer ◽  
Patrick Forstner ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Immune Response ◽  
Type 1 Diabetes ◽  
Cohort Study ◽  
Glycaemic Control ◽  
Healthy Controls ◽  
Diabetes Group ◽  
Antibody Levels

Aims: Immune response to COVID-19 vaccination and a potential impact of glycaemia on antibody levels in people with diabetes remains unclear. We investigated the seroconversion following first and second COVID-19 vaccination in people with type 1 and type 2 diabetes in relation to glycaemic control prior to vaccination and analysed the response in comparison to individuals without diabetes. Materials and Methods: This prospective, multicenter cohort study analysed people with type 1 and type 2 diabetes, well (HbA1c<7.5% or <58 mmol/mol) or insufficiently (HbA1c≥7.5% or ≥58 mmol/mol) controlled and healthy controls. Roche's Elecsys anti-SARS-CoV-2 S was used to quantify anti-spike protein antibodies 7-14 days after the first and 14-21 days after the second vaccination. Results: 86 healthy controls and 161 participants with diabetes were enrolled, 150 (75 with type 1 diabetes and 75 with type 2 diabetes) were eligible for the analysis. After the first vaccination, only 52.7% in the type 1 diabetes group and 48.0% in the type 2 diabetes group showed antibody levels above the cut-off for positivity. Antibody levels after the second vaccination were similar in people with type1, type 2 diabetes and healthy controls if adjusted for age, sex and multiple testing (p>0.05). Age (r=-0.45, p<0.001) and glomerular filtration rate (r=0.28, p=0.001) were significantly associated with antibody response. Conclusions: Anti-SARS-CoV-2 S antibody levels after the second vaccination were comparable in healthy controls, people with type 1 and type 2 diabetes, irrespective of glycaemic control. Age and renal function correlated significantly with the extent of antibody levels.

scholarly journals Association of diabetes type and chronic diabetes complications with early exit from the labour force: register-based study of people with diabetes in Finland

Diabetologia ◽  
2021 ◽  
Author(s):  
Olli Kurkela ◽  
Leena Forma ◽  
Pirjo Ilanne-Parikka ◽  
Jaakko Nevalainen ◽  
Pekka Rissanen
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Diabetes Complications ◽  
Labour Force ◽  
Diabetes Group ◽  
Productivity Costs ◽  
Early Exit ◽  
The Difference

Abstract Aims/hypothesis Diabetes and diabetes complications are a cause of substantial morbidity, resulting in early exits from the labour force and lost productivity. The aim of this study was to examine differences in early exits between people with type 1 and 2 diabetes and to assess the role of chronic diabetes complications on early exit. We also estimated the economic burden of lost productivity due to early exits. Methods People of working age (age 17–64) with diabetes in 1998–2011 in Finland were detected using national registers (Ntype 1 = 45,756, Ntype 2 = 299,931). For the open cohort, data on pensions and deaths, healthcare usage, medications and basic demographics were collected from the registers. The outcome of the study was early exit from the labour force defined as pension other than old age pension beginning before age 65, or death before age 65. We analysed the early exit outcome and its risk factors using the Kaplan–Meier method and extended Cox regression models. We fitted linear regression models to investigate the risk factors of lost working years and productivity costs among people with early exit. Results The difference in median age at early exit from the labour force between type 1 (54.0) and type 2 (58.3) diabetes groups was 4.3 years. The risk of early exit among people with type 1 diabetes increased faster after age 40 compared with people with type 2 diabetes. Each of the diabetes complications was associated with an increase in the hazard of early exit regardless of diabetes type compared with people without the complication, with eye-related complications as an exception. Diabetes complications partly but not completely explained the difference between diabetes types. The mean lost working years was 6.0 years greater in the type 1 diabetes group than in the type 2 diabetes group among people with early exit. Mean productivity costs of people with type 1 diabetes and early exit were found to be 1.4-fold greater compared with people with type 2 diabetes. The total productivity costs of incidences of early exits in the type 2 diabetes group were notably higher compared with the type 1 group during the time period (€14,400 million, €2800 million). Conclusions/interpretation We found a marked difference in the patterns of risk of early exit between people with type 1 and type 2 diabetes. The difference was largest close to statutory retirement age. On average, exits in the type 1 diabetes group occurred at an earlier age and resulted in higher mean lost working years and mean productivity costs. The potential of prevention, timely diagnosis and management of diabetes is substantial in terms of avoiding reductions in individual well-being and productivity. Graphical abstract

Type 2 Diabetes Overtakes Type 1 in Hispanic Girls

2008 ◽  
Vol 38 (15) ◽  
pp. 18
Author(s):  
SHERRY BOSCHERT
Keyword(s):  
Type 2 Diabetes
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