scholarly journals Angioedema, a life-threatening adverse reaction to ACE-inhibitors

2019 ◽  
Vol 9 (36) ◽  
pp. 177-181
Author(s):  
Ramona Ungureanu ◽  
Elena Madalan
Keyword(s):  
Ace Inhibitors ◽  
Neck Region ◽  
Diagnostic Algorithm ◽  
Converting Enzyme ◽  
Drug Induced ◽  
Head And Neck Region ◽  
Specific Diagnosis ◽  
Frequent Form ◽  
The Face ◽  
Life Threatening

Abstract Angioedema with life-threatening site is one of the most impressive and serious reasons for presenting to the ENT doctor. Among different causes (tumors, local infections, allergy reactions), an important cause is the side-effect of the angiotensin converting enzyme (ACE) inhibitors drugs. ACE-inhibitors-induced angioedema is described to be the most frequent form of bradykinin-mediated angioedema presented in emergency and also one of the most encountered drug-induced angioedema. The edema can involve one or more areas of the head and neck region, the most affected being the face, the lips, the tongue, followed by the larynx, when it may determine respiratory distress and even death. There are no specific diagnosis tests available and the positive diagnosis of ACE-inhibitors-induced angioedema is an exclusion diagnosis. The authors performed a review of the most important characteristics of the angioedema caused by ACE-inhibitors and present their experience emphasizing the diagnostic algorithm.

scholarly journals Necrotizing Fasciitis of Face in Odontogenic Infection: A Rare Clinical Entity

2012 ◽  
Vol 3 (3) ◽  
pp. 261-264 ◽  
Author(s):  
GK Vivek ◽  
Ranjith Singh ◽  
GC Veena ◽  
Prappanna Arya
Keyword(s):  
Necrotizing Fasciitis ◽  
Subcutaneous Tissue ◽  
Neck Region ◽  
Odontogenic Infection ◽  
Clinical Entity ◽  
Rare Clinical Entity ◽  
Head And Neck Region ◽  
The Face ◽  
Life Threatening ◽  
Group A

ABSTRACT Necrotizing fasciitis is a progressive, life-threatening, bacterial infection of the skin, the subcutaneous tissue and the underlying fascia, in most cases caused by β-hemolytic group A Streptococcus. Only early diagnosis and aggressive therapy including broad spectrum antibiotics and surgical intervention can avoid systemic toxicity with a high mortality rate. This disease is commonly known to occur in the lower extremities and trunk, and only rarely in the head and neck region, the face being rarest finding. When located in the face necrotizing fasciitis is associated with severe cosmetic and functional complication due to the invasive nature, infection and often due to the necessary surgical treatment. In the following article, we present the successful diagnosis and management of an isolated facial necrotizing fasciitis as a consequence of odontogenic infection. How to cite this article Vivek GK, Singh R, Veena GC, Arya P. Necrotizing Fasciitis of Face in Odontogenic Infection: A Rare Clinical Entity. World J Dent 2012;3(3):261-264.

scholarly journals Postanesthetic Severe Oral Angioedema in Patient’s Taking Angiotensin-Converting Enzyme Inhibitor

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Acílio Marques ◽  
Carla Retroz-Marques ◽  
Sara Mota ◽  
Raquel Cabral ◽  
Matos Campos
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Angiotensin Converting Enzyme Inhibitor ◽  
Ace Inhibitors ◽  
Clinical Case ◽  
Enzyme Inhibitor ◽  
Converting Enzyme ◽  
Drug Induced ◽  
Life Threatening ◽  
Perioperative Safety ◽  
Improve Patient

Angiotensin-converting enzyme (ACE) inhibitors are the leading cause of a drug-induced angioedema. This occurrence is frequently underdiagnosed, but its relapse can be life-threatening. The authors’ intention in reporting this clinical case is to sound a warning about reviewing attitudes and surveillance to try to improve patient perioperative safety.

Noma and Necrotizing Fasciitis of the Face and Neck

2021 ◽  
Author(s):  
Lauren E. Miller ◽  
David A. Shaye
Keyword(s):  
Soft Tissue ◽  
Necrotizing Fasciitis ◽  
Head And Neck ◽  
Subcutaneous Tissue ◽  
Neck Region ◽  
Superficial Fascia ◽  
Soft Tissue Infections ◽  
Head And Neck Region ◽  
Necrotizing Soft Tissue Infections ◽  
The Face

AbstractNecrotizing fasciitis (NF) is part of the class of necrotizing soft tissue infections characterized by rapid fascial spread and necrosis of the skin, subcutaneous tissue, and superficial fascia. If left untreated, NF can rapidly deteriorate into multiorgan shock and systemic failure. NF most commonly infects the trunk and lower extremities, although it can sometimes present in the head and neck region. This review provides an overview of NF as it relates specifically to the head and neck region, including its associated clinical features and options for treatment. Noma, a related but relatively unknown disease, is then described along with its relationship with severe poverty.

scholarly journals Chondroid syringoma of the upper lip: a rare entity

2020 ◽  
Vol 6 (10) ◽  
pp. 1900
Author(s):  
Ashiya Goel ◽  
Aman . ◽  
Vinny Raheja ◽  
Manisha Kumari
Keyword(s):  
Differential Diagnosis ◽  
Normal Tissue ◽  
Neck Region ◽  
Rare Entity ◽  
Upper Lip ◽  
Head And Neck Region ◽  
Chondroid Syringoma ◽  
The Face ◽  
Slow Growing

<p class="abstract"><span lang="EN-US">Chondroid syringomas are uncommon cutaneous neoplasms of sweat gland origin which are slow-growing, nontender, subcutaneous or intracutaneous in location and often occurring in the head and neck region. Chondroid syringoma should be considered in the differential diagnosis of any subcutaneous nodule over the face. The clinician may miss the diagnosis of this lesion and if it is suspected, tumour should be excised with a margin of normal tissue and regular follow up should be done.</span></p>

Clinical presentation and treatment of melioidosis in the head and neck region

2018 ◽  
Vol 132 (9) ◽  
pp. 827-831 ◽  
Author(s):  
K Mahawerawat ◽  
P Kasemsiri
Keyword(s):  
Early Diagnosis ◽  
Confidence Interval ◽  
Head And Neck ◽  
Clinical Presentation ◽  
Neck Region ◽  
Oral Antibiotic ◽  
Head And Neck Region ◽  
Indirect Haemagglutination ◽  
Appropriate Treatment ◽  
Life Threatening

AbstractBackgroundAlthough melioidosis in the head and neck region is uncommon, it is a potentially life-threatening infection. Thus, early diagnosis and proper management are very important.ObjectivesTo report the clinical presentation and management of melioidosis in the head and neck.MethodA retrospective study was conducted from 1 January 2013 to 31 October 2016 in Mukdahan Hospital, Thailand. Case records of patients who had presented with culture-positive melioidosis were analysed.ResultsMedical records of 49 patients (23 males and 26 females) were analysed. Patients ranged in age from 1 to 75 years. Clinical presentations included 22 parotid abscesses, 16 neck abscesses and 11 suppurative lymphadenitis cases. Only 35 patients (71 per cent) had high indirect haemagglutination assay titres of ≥ 1:160 (95 per cent confidence interval = 45.35–88.28). Almost half of the patients received intravenous ceftazidime and subsequently oral co-trimoxazole. Oral antibiotic regimens were prescribed for mild localised melioidosis. Overall, 95.65 per cent of patients were in remission and no relapses were observed (95 per cent confidence interval = 85.47–98.80).ConclusionCareful clinical correlation and proper investigation are required to establish an early diagnosis of melioidosis and to initiate appropriate treatment.

scholarly journals Anatomical Variation of Facial Artery Branch: A Case Report

2018 ◽  
Vol 35 (04) ◽  
pp. 218-220
Author(s):  
Guilherme Brasil ◽  
Josete Mazon
Keyword(s):  
Case Report ◽  
Anatomical Variation ◽  
Neck Region ◽  
Facial Artery ◽  
Invasive Procedures ◽  
Head And Neck Region ◽  
Face Region ◽  
The Face ◽  
Artery Branch ◽  
Anomalous Branch

Introduction The facial artery and its branches are the major vessels that supply blood to the face region. This artery and its branches can present variations in path and branching pattern and thus complicate the location of these arteries during invasive procedures. There is still a great need to inform and clarify the variant or unusual organization of the display of these arteries. Case Report During the dissection of the head and neck region of a cadaver, an anomalous branch of the unilateral facial artery was observed in the superior labial artery. Conclusion The lack of knowledge about the possible pathways of the facial artery and its branches can lead to errors in surgical procedures or fillers, causing severe complications to the facial structures.

scholarly journals Role of sclerotherapy in management of low flow vascular malformations

2021 ◽  
Vol 8 (4) ◽  
pp. 1234
Author(s):  
Manpreet Kaur ◽  
Parul Sachdeva ◽  
Rajan Syal ◽  
Savijot Singh
Keyword(s):  
Head And Neck ◽  
Vascular Malformations ◽  
Neck Region ◽  
Low Flow ◽  
Vascular Lesions ◽  
Surgical Removal ◽  
Complete Regression ◽  
Head And Neck Region ◽  
Life Threatening

Background: Low flow vascular malformations are most common in the head and neck region. Only symptomatic malformations require treatment. Sclerotherapy followed by surgery was considered the gold standard treatment but in the head and neck region, it may produce cosmetic and physiological defects. In the present study, multiple injections of sclerotherapy with 3% sodium tetradecyl sulphate was used for the treatment of low flow vascular malformations.Methods: Twenty cases of low flow vascular malformations of the oral cavity who presented in the outpatient department of ESIC Model Hospital, Ludhiana from 2014-2016 were selected for the study. Only significantly sized (>4 cm) and easily accessible lesions were included. Staged sequential sclerotherapy with 3% STS under strict fluoroscopy control was used as the sole treatment.Results: A total of 20 patients were taken of which, 25% required three sessions, 65% five to six sessions each and 10% required eight sessions each. All patients showed good results with complete regression and no mucosal ulceration.Conclusions: Staged sequential sclerotherapy with 3% STS should be the treatment of choice in low flow vascular lesions involving mucosal and cutaneous structures of head and neck region especially anterior two-thirds of tongue, palate, gingiva, buccal mucosa and lips. Surgical removal may affect critical neurovascular structures and cause cosmetic deformity. So the removal is advisable in life-threatening conditions, lesions requiring general anaesthesia and single sitting removal.

scholarly journals Efficacy of Sirolimus in Patients Requiring Tracheostomy for Life-Threatening Lymphatic Malformation of the Head and Neck: A Report From the European Reference Network

2021 ◽  
Vol 9 ◽  
Author(s):  
Annegret Holm ◽  
Maroeska te Loo ◽  
Leo Schultze Kool ◽  
Päivi Salminen ◽  
Veronica Celis ◽  
...  
Keyword(s):  
Head And Neck ◽  
Insertion Site ◽  
Neck Region ◽  
Reference Network ◽  
Efficacy And Safety ◽  
Duration Of Treatment ◽  
Lymphatic Malformations ◽  
Head And Neck Region ◽  
European Reference Network ◽  
Life Threatening

Extensive lymphatic malformations (LMs) of the head and neck region may require tracheostomy to secure the airway. Treatment of these life-threatening LMs is usually multimodal and includes sclerotherapy and surgery, among others. Recently, systemic therapy with sirolimus has been introduced as an effective treatment for venous and lymphatic malformations; its efficacy and safety profile in patients with extensive LM requiring tracheostomy are, however, as yet not fully known. We performed a retrospective, multicenter review and identified 13 patients with an extensive LM of the head and neck region, who previously underwent placement of tracheostomy and subsequently received sirolimus treatment with the aim to improve the local respiratory situation and remove the tracheostomy. Under sirolimus therapy, tracheostomy could be reversed in 8/13 (62%) patients, a further 2/13 (15%) patients improved markedly, and removal of the tracheostomy was planned at the time of writing, while 3/13 (23%) patients showed insufficient or absent response to sirolimus, rendering tracheostomy reversal not feasible. The median duration of sirolimus treatment until removal of tracheostomy was 18 months (range, 8 months to 5.6 years). Adverse events of sirolimus therapy were common [10/13 (77%) patients], yet the majority of these were mild [9/10 (90%) patients] and only one severe adverse event was recorded, with ulceration and necrosis at a catheter insertion site. In conclusion, sirolimus can be considered an effective and safe salvage treatment in patients with extensive LM even after placement of a tracheostomy, as closure of the latter was possible in the majority of patients (62%) of our retrospective cohort. A better understanding of when to start sirolimus therapy, of the duration of treatment, and of factors allowing the prediction of treatment response will require further investigation.

Republished: Treatment of hemorrhagic head and neck lesions by direct puncture and n-BCA embolization

2018 ◽  
Vol 10 (10) ◽  
pp. e25-e25
Author(s):  
Gerard Deib ◽  
Amgad El Mekabaty ◽  
Philippe Gailloud ◽  
Monica Smith Pearl
Keyword(s):  
Head And Neck ◽  
Transarterial Embolization ◽  
Neck Region ◽  
Effective Alternative ◽  
Direct Puncture ◽  
Head And Neck Region ◽  
Life Threatening ◽  
Anatomic Variants ◽  
Endovascular Approach ◽  
Vessel Tortuosity

Life-threatening bleeding in the head and neck region requires urgent management. These hemorrhagic lesions, for example, a ruptured pseudoaneurysm, are often treated by transarterial embolization (TAE), but prior intervention or surgery, inflammation, anatomic variants, and vessel tortuosity may render an endovascular approach challenging, time-consuming, and sometimes impossible. We report two cases of severe head and neck hemorrhages successfully embolized with n-butyl cyanoacrylate via direct puncture, and propose this approach as a fast, safe, and effective alternative to TAE.

scholarly journals ACE2 Protein Landscape in the Head and Neck Region: The Conundrum of SARS-CoV-2 Infection

Biology ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 235 ◽  
Author(s):  
Géraldine Descamps ◽  
Laurine Verset ◽  
Anne Trelcat ◽  
Claire Hopkins ◽  
Jérome R. Lechien ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Head And Neck ◽  
Neck Region ◽  
Converting Enzyme ◽  
Upper Aerodigestive Tract ◽  
Immunohistochemical Expression ◽  
Vocal Cords ◽  
Head And Neck Region ◽  
Angiotensin Converting Enzyme 2 ◽  
Histological Location

The coronavirus pandemic raging worldwide since December 2019 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which invades human cells via the angiotensin-converting enzyme 2 (ACE2) receptor. Although it has already been identified in many organs, ACE2 expression remains largely unknown in the head and neck (HN) sphere. Thus, this study aims to investigate its protein expression in several sites of the upper aerodigestive tract in order to highlight potential routes of infection. We compared ACE2 immunohistochemical expression between 70 paraffin-embedded specimens with two different antibodies and reported the quantified expression in each histological location. Surprisingly, we obtained different results depending on the antibody, an absence of labeling having been observed with a monoclonal antibody raised against the extracellular domain, whereas the polyclonal, against the cytoplasmic part of the protein, revealed enriched ACE2 expression, particularly in sinuses, vocal cords, salivary glands and oral cavity epithelial cells. The interpretation of these discordant results has brought several exciting lines of reflection. In conclusion, this study provides possible routes of entry for the SARS-CoV-2 in HN region and, above all, has led us to encourage caution when studying the ACE2 expression which is currently at the center of all attention.

Sign in / Sign up

Export Citation Format

Share Document