FV Leiden Mutation and Deep Venous Thrombosis in Vojvodina: A Case-Control Study

FV Leiden Mutation and Deep Venous Thrombosis in Vojvodina: A Case-Control StudyBetween September 2007 and February 2010, the occurrence of symptomatic deep venous thrombosis (DVT) was investigated in a cohort of 79 consecutive patients. A case-control study inclu ded 71 healthy controls matched with cases for sex and age. The prevalence of factor V G1691A mutation genotype was analyzed. Eighteen cases (22.79%; 95% confidence interval (CI) 13.53% to 32.03%) and four controls (5.63%; 95% CI 0.27% to 10.99%) were heterozygous carriers of FV Leiden (p= 0.025). The odds ratio for DVT was 4.94 (95% CI 1.58 to 15.42) and the relative risk 4.04 (95% CI 1.44-11.38) compared with FV 1691G carriers. Four cases were homozygous carriers of FV Leiden, giving a prevalence of 5.06% (95% CI 0.23 to 9.89%) and no controls, therefore OR and RR calculation was based on the prevalence of homozygotes in the general Caucasian population. The OR for DVT was 47.28 (95% CI 0.04 - 52167.3) and the RR 45.57 (95% CI 0.04 to 49540.77; p=0.025) compared with FV 1691 G carriers. Our study confirms that factor V Leiden carriers in Vojvodina, as in similar studies previously carried out in other populations, have an increased risk of developing DVT. The evaluated risk of DVT in heterozygous carriers of the mutation is four- to five-fold higher, whereas for homozygous carriers it is 45- to 48-fold higher than in non-carriers. These results confirm that patients with DVT and their relatives should undergo screening for FV Leiden mutation.

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A Case Control Study on the Contribution of Factor V-Leiden, Prothrombin G20210A, and MTHFR C677T Mutations to the Genetic Susceptibility of Deep Venous Thrombosis

Journal of Thrombosis and Thrombolysis ◽

10.1007/s11239-005-1313-x ◽

2005 ◽

Vol 19 (3) ◽

pp. 189-196 ◽

Cited By ~ 36

Author(s):

Wassim Y. Almawi ◽

Hala Tamim ◽

Raghid Kreidy ◽

Georgina Timson ◽

Elias Rahal ◽

...

Keyword(s):

Venous Thrombosis ◽

Deep Venous Thrombosis ◽

Genetic Susceptibility ◽

Case Control Study ◽

Factor V Leiden ◽

Mthfr C677t ◽

Case Control ◽

Prothrombin G20210a ◽

Factor V ◽

Control Study

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A case control study of deep venous thrombosis in relation to factor V G1691A (Leiden) and A4070G (HR2 Haplotype) polymorphisms

Experimental and Molecular Pathology ◽

10.1016/j.yexmp.2007.04.006 ◽

2007 ◽

Vol 83 (3) ◽

pp. 480-483 ◽

Cited By ~ 7

Author(s):

Lobna Bouaziz-Borgi ◽

Philipe Nguyen ◽

Nathalie Hezard ◽

Umayya Musharrafieh ◽

Wassim Y. Almawi ◽

...

Keyword(s):

Venous Thrombosis ◽

Deep Venous Thrombosis ◽

Case Control Study ◽

Case Control ◽

Factor V ◽

Factor V G1691a ◽

Control Study

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Risk of pulmonary embolism and deep venous thrombosis in patients with asthma: a nationwide case−control study from Sweden

European Respiratory Journal ◽

10.1183/13993003.01014-2016 ◽

2017 ◽

Vol 49 (2) ◽

pp. 1601014 ◽

Cited By ~ 11

Author(s):

Bengt Zöller ◽

Mirnabi Pirouzifard ◽

Ashfaque A. Memon ◽

Jan Sundquist ◽

Kristina Sundquist

Keyword(s):

Pulmonary Embolism ◽

Venous Thrombosis ◽

Deep Venous Thrombosis ◽

Case Control Study ◽

Conditional Logistic Regression ◽

Case Control ◽

Increased Risk ◽

Using Data ◽

Population Controls ◽

Control Study

Asthma is associated with an increased risk of pulmonary embolism (PE) but little is known about whether asthma is associated with an increased risk of deep venous thrombosis (DVT). The aim in this study was to determine the risk of the first event of PE, DVT or a combination of PE and DVT in patients with asthma.We conducted this nationwide case–control study using data from Swedish nationwide registries. We included 114 366 Swedish-born patients with a first hospital diagnosis of PE, 76 494 patients with DVT and 6854 patients with both PE and DVT in Sweden between 1981 and 2010. We also included five age-, sex- and education-matched population controls. All previous hospital diagnoses of asthma were identified. Conditional logistic regression was used to compute odds ratios with adjustment for potential confounders.Asthma was associated with an adjusted odds ratio for PE of 1.43 (95% CI 1.37–1.50), for DVT of 1.56 (95% CI 1.47–1.65) and for combined PE and DVT of 1.60 (95% CI 1.32–1.93). Asthma was associated with an increased risk of PE, DVT and combined PE and DVT.Thus, the inflammation conferred by asthma seems to have systemic (and not just local) prothrombotic effects with increased risk of both DVT and PE.

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Factor V Leiden mutation and high FVIII are associated with an increased risk of VTE in women with breast cancer during adjuvant tamoxifen — Results from a prospective, single center, case control study

European Journal of Internal Medicine ◽

10.1016/j.ejim.2014.12.015 ◽

2015 ◽

Vol 26 (1) ◽

pp. 63-67 ◽

Cited By ~ 8

Author(s):

Mirjana Kovac ◽

Zeljko Kovac ◽

Zorica Tomasevic ◽

Slavko Vucicevic ◽

Valentina Djordjevic ◽

...

Keyword(s):

Breast Cancer ◽

Case Control Study ◽

Factor V Leiden ◽

Case Control ◽

Adjuvant Tamoxifen ◽

Factor V ◽

Single Center ◽

Factor V Leiden Mutation ◽

Increased Risk ◽

Control Study

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An unfavorable combination of factor V Leiden with age, weight, and blood group causes high risk of pregnancy-associated venous thrombosis—a population-based nested case-control study

Thrombosis Research ◽

10.1016/j.thromres.2006.04.001 ◽

2007 ◽

Vol 119 (4) ◽

pp. 423-432 ◽

Cited By ~ 17

Author(s):

Leena Hiltunen ◽

Anna Rautanen ◽

Vesa Rasi ◽

Risto Kaaja ◽

Juha Kere ◽

...

Keyword(s):

High Risk ◽

Venous Thrombosis ◽

Blood Group ◽

Case Control Study ◽

Factor V Leiden ◽

Population Based ◽

Case Control ◽

Factor V ◽

Nested Case Control ◽

Control Study

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Factor V Leiden, FII G20210A, MTHFR C677T mutations as risk factors for venous thrombosis during pregnancy and puerperium

Vojnosanitetski pregled ◽

10.2298/vsp0503201d ◽

2005 ◽

Vol 62 (3) ◽

pp. 201-205 ◽

Cited By ~ 9

Author(s):

Valentina Djordjevic ◽

Ljiljana Rakicevic ◽

Milos Spasic ◽

Predrag Miljic ◽

Danijela Mikovic ◽

...

Keyword(s):

Risk Factors ◽

Venous Thrombosis ◽

Deep Venous Thrombosis ◽

Factor V Leiden ◽

Mthfr C677t ◽

First Episode ◽

Factor V ◽

G20210a Mutation ◽

Fv Leiden ◽

Heterozygous Carriers

Background. Venous thrombosis is the most common cause of obstetric morbidity and mortality during pregnancy and puerperium. The incidence of pregnancy associated venous thrombosis varies from 1 in 1000 to 1 in 2000 deliveries. Factor V G1691A (FV Leiden), FII G20210A and MTHFR C677T mutations are the most common genetic risk factors for thromboembolism. The aim of this study was to establish the presence of these risk factors in a group of women with an episode of deep venous thrombosis during pregnancy or puerperium. Methods. The study was carried in a group of 45 women with the first episode of deep venous thrombosis during pregnancy or puerperium. The patients with antiphospholipid antibodies, antithrombin III, protein C or protein S deficiency, and autoimmune and malignant diseases were excluded from the study. FV Leiden, FII G20210A, and MTHFR C677T mutations were detected by polymerase chain reaction, followed by digestion with specific restriction enzymes. Results. Twenty heterozygous carriers of the FV Leiden mutation and one homozygous carrier were detected, which represents the frequencies of 44.4% and 2.2%, respectively. For the FII G20210A mutation, six heterozygous carriers were identified, giving the frequency of 13.3%. The MTHFR C677T mutation was observed in 31 patients (22 heterozygous and 9 homozygous carriers) which represents the frequencies of 48.9% and 20%, respectively. Conclusion. Our study suggested that the obligatory testing for FV Leiden and FII G20210A mutations was strongly recommended in women with history of venous thrombosis during pregnancy and puerperium. We found a slight effect of MTHFR 677T allele, but it should be considered in association with other risk factors.

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