scholarly journals HUBUNGAN KEPADATAN DERMATOPHAGOIDES SPP. DENGAN FREKUENSI SERANGAN ASMA PADA PENDERITA ASMA DI RS PARU JEMBER

2019 ◽  
Vol 19 (2) ◽  
Author(s):  
Denaneer Rahmadatu ◽  
Erma Sulistyaningsih ◽  
Dini Agustina
Keyword(s):  
House Dust ◽  
Random Sampling ◽  
Simple Random Sampling ◽  
Dermatophagoides Pteronyssinus ◽  
House Dust Mites ◽  
Inflammatory Disorder ◽  
Dust Mites ◽  
Dermatophagoides Farinae ◽  
Cross Sectional ◽  
Asthmatic Patients

Abstrak. Asma merupakan gangguan inflamasi kronik saluran napas yang bersifat hiperesponsif yang ditandai adanya gejala episodik berulang berupa mengi, sesak napas, dada terasa berat, dan batuk, terutama pada malam hari atau dini hari. Sekitar 50-80% asma disebabkan oleh tungau debu rumah (TDR), khususnya Dermatophagoides pteronyssinus dan Dermatophagoides farinae. Penelitian ini bertujuan untuk mengetahui apakah terdapat hubungan antara kepadatan Dermatophagoides spp. pada debu rumah dengan frekuensi serangan asma pada penderita asma di RS Paru Jember. Penelitian ini merupakan penelitian analitik observasional dengan desain penelitian cross-sectional. Sampel penelitian ini yaitu 30 penderita asma di RS Paru Jember yang diambil menggunakan teknik simple random sampling sesuai dengan kriteria inklusi dan eksklusi. Peneliti melakukan interview mengenai frekuensi serangan asma dalam tiga bulan terakhir, mengambil debu dari ruang tamu dan ruang tidur pada rumah penderita asma, dan mengidentifikasi tungau debu rumah (TDR) yang ditemukan pada debu. Hasil uji Pearson mendapatkan nilai p=0,011 dan nilai r=0,475 sehingga dapat disimpulkan bahwa terdapat hubungan bermakna antara kepadatan Dermatophagoides spp. dengan frekuensi serangan asma dengan kekuatan korelasi sedang pada penderita asma di RS Paru Jember. Kata Kunci: Dermatophagoides spp., Tungau Debu Rumah (TDR), Asma Abstract. Asthma is a chronic inflammatory disorder of the respiratory system characterized by recurrent episodes of wheezing, shortness of breath, chest tightness, and cough, particularly at night or early morning. About 50-80% of asthma is caused by house dust mite (HDM), especially Dermatophagoides pteronyssinus and Dermatophagoides farinae. This study aimed to investigate the correlation between the density of Dermatophagoides spp. and the frequency of asthma attacks in asthmatic patients at Jember Pulmonary Hospital. This study was an observational analytic study with a cross-sectional design. Respondents were 30 asthmatic patients at Jember Pulmonary Hospital matched with inclusion and exclusion criteria and chose by simple random sampling. Respondents were interviewed about the frequency of asthma attacks in the last three month,s and the hose dust from the living and sleeping rooms were collected for identification of house dust mites (HDM). The pearson test showed a value of p=0.011 and r=0.475. It can be concluded that there is a significant correlation with the moderate strenght between the density of Dermatophagoides spp. and the frequency of asthma attacks in the asthmatic patient at Jember Pulmonary Hospital. Keywords: Dermatophagoides spp., House Dust Mites (HDM), Asthma

scholarly journals TUNGAU DEBU RUMAH DI KELURAHAN RANOTANA WERU KECAMATAN WANEA KOTA MANADO

2013 ◽  
Vol 1 (2) ◽  
Author(s):  
Friska M. Kokali
Keyword(s):  
House Dust ◽  
Random Sampling ◽  
Simple Random Sampling ◽  
Cross Sectional Study ◽  
House Dust Mites ◽  
Living Room ◽  
Dust Mites ◽  
Cross Sectional ◽  
Dust Mite ◽  
Animal Dander

Abstract: Dust compossed of destrimen particles from hair, dirt, animal dander, food scraps, pollen, squama, bacteria, fungi and small insects. House dust mites which commonly found on carpet, mattress, pillow and other house furniture with moise enviroment. The goal of this research was to find out the density of  house dust mites and to know the species of  house dust mites in Ranotana Weru. Methods: The study is descriptif survey with cross sectional study design for two month’s which in November-December 2012. The sample which in collected from the house will be selected by the simple random sampling technic. The size of the sample will be determine using of the Snecdor Cochcran. Results: The results there is 5 species of house dust mites which is Dermatophagoides spp, Glycyphagus destructor, Acarus spp, Cheyletus spp, Tarsonemus spp. The density of the house dust mites in Ranotana Weru  is low. Conclusion: There are five  species of house dust mites are found in Ranotana Weru. The density of the house dust mites in Ranotana Weru  is low. The most common found in Ranotana Weru is the Acarus spp in the bedroom and the living room, but mostly ini the living room. Keywords: Species, density, house dust mite.    Abstrak: Debu terdiri atas partikel destrimen yang berasal dari rambut, daki, bulu binatang, sisa makanan, serbuk sari, skuama, bakteri, jamur dann serangga kecil. Di dalam debu rumah terdapat tungau debu rumah ( TDR ) yang banyak ditemukan pada rumah yang lembab, kasur, bantal, guling, karpet serta berbagai perabot rumah yang lain. Tujuan Penelitian ini adalah untuk mengetahui kepadatan TDR dan jenis TDR yang ditemukan dikelurahan Ranotana Weru Kecamatan Wanea Kota Manado. Metode: Penelitian menggunakan metode survey deskriptif dilakukan secara potong lintang (cross sectional) selama 2 bulan yakni bulan November - Desember 2012 di Kelurahan Ranotana Weru. Sampel penelitian yakni debu yang dikumpulkan dari kasur, sofa, lantai  ruangan-ruangan serta perabotan yang ada pada rumah penduduk dipilih oleh peneliti menggunakan teknik Simple random sampling. Besar sampel ditentukan dengan menggunakan  rumus Snecdor Cochran. Hasil: Penelitian ini ditemukan 5 spesies tungau debu rumah yakni Dermatophagoides spp, Glycyphagus destructor, Acarus spp, Cheyletus spp, Tarsonemus spp. Kepadatan tungau debu di kelurahan Ranotana Weru rendah. Simpulan: Ada lima jenis tungau debu rumah yang ditemukan di kelurahan Ranotana Weru, tungau debu rumah Acarus spp paling banyak ditemukan di ruang tidur maupun di ruang keluarga, tungau debu rumah jenis Acarus spp lebih dominan ditemukan pada ruang keluarga dibanding ruang tidur, kepadatan tungau debu rumah di Kelurahan Ranotana Weru Kecamatan Wanea cukup rendah. Kata Kunci: Jenis, Kepadatan, Tungau debu.

scholarly journals Jenis dan kepadatan tungau debu rumah di Kelurahan Kleak Kecamatan Malalayang Kota Manado

2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Yohanes A. Hohakay ◽  
Greta J. P. Wahongan ◽  
Janno B. B. Bernadus
Keyword(s):  
House Dust ◽  
Random Sampling ◽  
Simple Random Sampling ◽  
Cross Sectional Study ◽  
House Dust Mites ◽  
Dust Mites ◽  
Cross Sectional ◽  
Dominant Type ◽  
Humid Environment ◽  
Dust Mite

Abstract: House dust mites in house dust have cosmopolitan distribution. House mites live from eating the remaining cask of human skin scale and grow in a humid environment. Mites are commonly found in beds, carpets, and clothes. This study was aimed to obtain the types and density of dust mites in Kelurahan Kleak Kecamatan Malalayang Manado. This was a descriptive study with a cross sectional study conducted from October to January 2015. Samples of dust were collected from bed, bedroom floor, and sofa in residential houses by using technique simple random sampling. The results showed that there were 5 dust mite samples from Pyroglyphidae, Glycyphagidae, Acaridae, Cheyletidae, and Chortoglyphidae families. Density of house dust mites was 199 mites/13.46 g of dust. The most dominant type of dust mites was the Glycyphagidae family and the highest percentage of its population was in the bedroom floor meanwhile the most dominant population in bed was the Pyroglyphidae family. Conclusion: There were 5 dust mite families- Pyroglyphidae, Glycyphagidae, Acaridae, Cheyletidae, and Chortoglyphidae with the density of 199 mites/13.46 g of dust. The most frequently found mites was the Glycyphagidae family.Keywords: dust mites, types, densityAbstrak: Tungau debu rumah (TDR) terdapat dalam debu rumah dan berdistribusi kosmopolit. Tungau debu hidup dengan memakan sisa skuama kulit manusia dan bertumbuh dalam lingkungan yang lembab. Tungau biasanya ditemukan di tempat tidur, karpet, dan pakaian. Penelitian ini bertujuan untuk mengetahui jenis dan kepadatan TDR yang ditemukan di Kelurahan Kleak Kecamatan Malalayang Kota Manado. Jenis penelitian ialah deskriptif dengan desain potong lintang yang dilakukan selama bulan Oktober sampai Januari 2015. Sampel penelitian yaitu sampel debu yang dikumpulkan dari tempat tidur, lantai kamar tidur, dan sofa yang ada di perumahan penduduk dengan menggunakan teknik simple random sampling. Hasil penelitian mendapatkan 5 jenis TDR dari famili Pyroglyphidae, Glycyphagidae, Acaridae, Cheyletidae, dan Chortoglyphidae. Kepadatan TDR yaitu 199 tungau/13,46 gr debu. Jenis tungau debu yang paling dominan yaitu dari famili Glycyphagidae dengan populasi tertinggi pada lantai kamar tidur sedangkan populasi paling dominan pada tempat tidur yaitu famili Pyroglyphidae. Simpulan: Di Kelurahan Kleak Kecamatan Malalayang Kota Manado terdapat 5 jenis TDR dari famili Pyroglyphidae, Glycyphagidae, Acaridae, Cheyletidae, dan Chortoglyphidae dengan kepadatan TDR yaitu 199 tungau/13,46 gr debu. Jenis TDR yang paling sering ditemukan ialah famili GlycyphagidaeKata kunci: tungau debu rumah, jenis, kepadatan

scholarly journals JENIS DAN KEPADATAN TUNGAU DEBU RUMAH PADA BEBERAPA HABITAT DI RUMAH PENDERITA PENYAKIT ALERGI

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Wiska F. Ponggalunggu ◽  
Victor D. Pijoh ◽  
Greta J. P. Wahongan
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Allergic Diseases ◽  
Dermatophagoides Pteronyssinus ◽  
House Dust Mites ◽  
Dust Mites ◽  
Dermatophagoides Farinae ◽  
Cross Sectional ◽  
Dust Mite ◽  
Euroglyphus Maynei

Abstract. House dust mites are the most found allergens in homes scattered throughout the world that associated with allergic manifestations in the respiratory tract and skin, such as bronchial asthma, allergic rhinitis and atopic dermatitis. The most common house dust mite is from the family Pyroglyphidae, four of which have a close relationship with the incidence of allergy: Dermatophagoides pteronyssinus, Dermatophagoides farinae, Dermatophagoides microceras, and Euroglyphus maynei. This study aims to determine the type and density of house dust mites in several habitats in the homes of people with allergic diseases. This study is a descriptive study using cross-sectional method. Samples were dust in allergic patient’s home in Malalayang I, taken from three habitats, namely bed (mattress and bed linen), bedrooms floor and sofa, as many as 96 samples. Of the 96 samples, there are 60 samples positive of dust mites and 36 negative samples. This study found 157 mites (124 adults and 33 larvae mites). Of the 124 adult mites were identified, there are 122 from order Astigmata with the dominant species is Dermatophagoides pteronyssinus, and two others of the order Prostigmata. In each habitat that is in the bed (mattress and bed linen), bedrooms floor and sofa, Pyroglyphidae is the most prevalent.Keywords: house dust mite, allergiesAbstrak. Tungau debu rumah (TDR) adalah alergen dalam rumah terbanyak yang tersebar di seluruh dunia yang dikaitkan dengan manifestasi alergi pada saluran pernapasan dan kulit, seperti asma bronkial, rinitis alergi dan dermatitis atopik. TDR yang paling sering ditemukan adalah dari famili Pyroglyphidae, empat di antaranya memiliki hubungan yang erat dengan kejadian alergi: Dermatophagoides pteronyssinus, Dermatophagoides farinae, Dermatophagoides microceras, dan Euroglyphus maynei. Penelitian ini bertujuan untuk mengetahui jenis dan kepadatan tungau debu rumah pada beberapa habitat di rumah penderita penyakit alergi. Penelitian ini adalah penelitian deskriptif dengan menggunakan metode cross-sectional. Sampel penelitian adalah debu di rumah penderita alergi di Kelurahan Malalayang I yang diambil dari 3 habitat, yaitu tempat tidur (kasur dan sprei), lantai kamar tidur, dan sofa sebanyak 96 sampel. Dari 96 sampel, 60 sampel positif tungau debu dan 36 sampel negatif. Pada penelitian ini ditemukan 157 tungau (124 tungau dewasa dan 33 larva). Dari 124 tungau dewasa yang terindentifikasi, dari ordo Astigmata sebanyak 122 dengan spesies yang dominan adalah Dermatophagoides pteronyssinus, dan dua lainnya dari ordo Prostigmata. Pada masing-masing habitat yaitu di tempat tidur (kasur dan sprei), lantai kamar tidur dan sofa, famili Pyroglyphidae paling banyak ditemukan.Kata kunci: tungau debu rumah, alergi

scholarly journals JENIS DAN KEPADATAN TUNGAU DEBU RUMAH DI KELURAHAN MALALAYANG DUA KECAMATAN MALALAYANG KOTA MANADO

2015 ◽  
Vol 3 (3) ◽  
Author(s):  
Kadek A.W. Widiastawan ◽  
Greta J. P. Wahongan ◽  
Janno B. B. Bernadus
Keyword(s):  
House Dust ◽  
Random Sampling ◽  
Sampling Method ◽  
Simple Random Sampling ◽  
Allergic Diseases ◽  
House Dust Mites ◽  
Dust Mites ◽  
Atopic Diseases ◽  
Cross Sectional ◽  
Cross Sectional Design

Abstract: Mites have an important role as a source of allergens in allergic diseases such as asthma, rhinitis, and other atopic diseases. House dust mites (HDMs) are found mainly in the bed, carpet, and floor. HDMs have an important role as the source of house dust allergens. It is important to identify the types of HDMs in an area to determine the nature of HDM allergens. This study aimed to determine the types and density of HDMs in the Malalayang Dua Manado. This was a descriptive study with a cross-sectional design. Samples of dust were collected from houses at Malalayang Dua by simple random sampling method. Of 96 samples of house dust, there were 82 positive mite and 14 negative mite samples. A total of 216 mites were obtained in samples of HDMs. The most abundant was Pyroglyphidae family (107 mites), followed by Glycyphagidae (51 mites) dan Cheyletidae (6 mites) families. The densities of HDMs were di 36.92 mites/g dust on beds, 15.94 mites/g dust on the sofas, and 11.41 mites/g dust on the bedroom floors with an average 21.42 mites/g dust. Conclusion: In Malalayang Dua, there were 3 types of house dust mites as follows: Pyroglyphidae (the most), Glycyphagidae, and Cheyletidae families. The highest density of house dust mites was in the dust on beds meanwhile the lowest one was in the dust on bedroom floors.Keywords: types, density, house dust mitesAbstrak: Tungau memiliki peranan sebagai sumber alergen penting pada penyakit alergi seperti asma, rinitis, dan penyakit atopik lainnya. Tungau debu rumah (TDR) ditemukan terutama di tempat tidur, karpet, dan lantai dan berperan sebagai sumber alergen debu rumah. Identifikasi jenis TDR di suatu wilayah diperlukan untuk mengetahui sifat alergen TDR di wilayah tersebut. Penelitian ini bertujuan untuk mengetahui jenis dan kepadatan TDR di Kelurahan Malalayang Dua Kecamatan Malalayang Kota Manado. Penelitian ini menggunakan metode deskriptif dengan desain potong lintang. Sampel penelitian berupa debu dikumpulkan dari rumah-rumah penduduk dengan menggunakan metode simple random sampling. Dari 96 sampel debu rumah pada penelitian ini didapatkan 82 sampel positif tungau dan 14 negatif. Sebanyak 216 tungau didapatkan dari sampel debu rumah dengan jenis tungau terbanyak berasal dari famili Pyroglyphidae (107 tungau), diikuti famili Glycyphagidae (51 tungau) dan famili Cheyletidae (6 tungau). Kepadatan TDR di tempat tidur 36,92 tungau/g debu, di sofa 15,94 tungau/g debu, dan di lantai kamar tidur 11,41 tungau/g debu dengan rerata 21,42 tungau/g debu. Simpulan: Dari hasil penelitian di Kelurahan Malalayang Dua didapatkan 3 jenis tungau yaitu famili Pyroglyphidae (terbanyak), famili Glycyphagidae dan famili Cheyletidae. Tingkat kepadatan TDR tertinggi pada sampel debu tempat tidur dan terendah di lantai kamar tidur.Kata kunci: jenis, kepadatan, tungau debu rumah

The Influence of Indoor Environmental Factors on the Prevalence of House Dust Mites as Aeroallergens in Bandar Abbas Student Dormitories, South of Iran, 2019

2021 ◽  
Author(s):  
Mehdi Zare ◽  
Mehdi Hassani-Azad ◽  
Moussa Soleimani-Ahmadi ◽  
Raziea Majnoon
Keyword(s):  
Environmental Factors ◽  
House Dust ◽  
Dermatophagoides Pteronyssinus ◽  
House Dust Mites ◽  
Dust Mites ◽  
Dermatophagoides Farinae ◽  
Floor Covering ◽  
The Mean ◽  
Bandar Abbas ◽  
Cheyletus Malaccensis

Abstract This study was conducted to determine the influence of environmental factors on the prevalence of house dust mites in student dormitories of Bandar Abbas city. In this study, 64 dust samples were collected from seven randomly selected dormitories located in various areas of the Bandar Abbas. The collected mites were isolated and mounted in Hoyer’s medium and identified using a morphological key. The associations between the environmental factors and the density of house dust mites were investigated. In total, 1,093 adult mites were collected and identified. They consisted of four species including Dermatophagoides pteronyssinus Trouessart (57.6%), Dermatophagoides farinae Hughes (24.3%) and Dermatophagoides evansi Fain (14.9%) (Acari: Pyroglyphidae), and Cheyletus malaccensis Oudemans (3.2%) (Acari: Cheyletidae). All of the dormitories were contaminated by more than one house dust mites species and the mean density of house dust mites in dormitories was 8.3 ± 0.2 mites/g of dust. There was a significant relationship between average house dust mites density and some of environmental factors such as relative humidity, temperature, floor covering type, and number of occupants (P < 0.05). Results of this study revealed that two major allergenic dust mites, D. pteronyssinus and D. farinae, were the most prevalent and collected from all of dormitories and some of indoor environmental factors found to influence mites’ population.

scholarly journals IgE-dependent reactivity of canine sera from three regions of Poland

2020 ◽  
Vol 76 (06) ◽  
pp. 6410-2020
Author(s):  
BARTOSZ JANIA ◽  
MARTA DOPIERAŁA ◽  
EWA WÓJCIK ◽  
KATARZYNA RYMUZA ◽  
KATARZYNA ANDRASZEK
Keyword(s):  
House Dust ◽  
Genetic Predisposition ◽  
Dermatophagoides Pteronyssinus ◽  
House Dust Mites ◽  
Allergic Reactions ◽  
Dust Mites ◽  
Dermatophagoides Farinae ◽  
Acarus Siro ◽  
Study Support ◽  
Health Complications

Allergies in dogs have become a relatively frequent topic of discussion in veterinary surgeries. Many dogs, both purebred and of mixed breeds, are diagnosed for allergies. Allergies have many causes, from genetic predisposition to the environmental conditions in which the animal lives. Allergies in dogs are troublesome because they can lead to serious health complications when diagnosed late or left untreated. The results of the study support the hypothesis that the percentage of allergies to individual allergens varied by region (Tab. 4). Differences were observed in the case of Dermatophagoides pteronyssinus and Dermatophagoides farinae house dust mites, Acarus siro, and Tyrophagus. The remaining allergens caused allergic reactions in similar percentages of dogs from northern, central and southern Poland.

scholarly journals House Dust Mites in One of Indonesian Detention Center in 2020

Biomedika ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 98-103
Author(s):  
Ajrina Malia ◽  
Makhabbah Jamilatun ◽  
Aminah Aminah
Keyword(s):  
House Dust ◽  
Descriptive Study ◽  
Dermatophagoides Pteronyssinus ◽  
House Dust Mites ◽  
Dust Mites ◽  
Dermatophagoides Farinae ◽  
Detention Center ◽  
Home Furnishings ◽  
Dust Mite ◽  
Flotation Method

House dust mite was one of the most common allergens in homes around the world and associated with manifestations of allergies of skin and respiratory tract such as bronchial asthma, allergic rhinitis, and atopic dermatitis. This arthropod was commonly found on carpets, mattresses, children's toys, and other home furnishings. This study was aimed to identify and quantify the number of Dermatophagoides spp in Detention Center. This descriptive study was conducted using flotation method on 52 samples of mattress dust collected in February 2020. The results showed that 49 out of 52 mattress dust samples were positive of Dermatophagoidesspp..Of all Dermatophagoides spp, there were Dermatophagoides pteronyssinus (71.2%) and Dermatophagoides farinae (28.8%). In conclusion, this study found two species of Dermatophagoides spp. in Detention Center and suggested that the fascility maintain the cleanliness of the mattress by drying the mattress and changing the sheets at least once a week.

scholarly journals SURVEI PERILAKU MASYARAKAT TERHADAP POPULASI TUNGAU DEBU RUMAH DI SEKITAR RUMAH PENDUDUK KELURAHAN MALALAYANG SATU KECAMATAN MALALAYANG KOTA MANADO

2015 ◽  
Vol 3 (3) ◽  
Author(s):  
Mikhael Abraham ◽  
Victor Pijoh ◽  
John Runtuwene
Keyword(s):  
House Dust ◽  
Random Sampling ◽  
Sampling Method ◽  
Simple Random Sampling ◽  
House Dust Mites ◽  
Average Score ◽  
Dust Mites ◽  
The Public ◽  
Dust Mite ◽  
Level Of Knowledge

Abstract: Dust contains a variety of air-borne particles that spread in the air. The house dust contains house dust mites which are found most in the furniture of the house. House dust mites can be a serious problem for human health. The temperature and moisture of Manado is suitable for the breeding of house dust mites. This study aimed to determine the behavior of the public towards the house dust mites population around the residential houses in subdistrict Malalayang Satu district Malalayang Manado. This was a descriptive study with using questionnaire. Samples were 100 people obtained by simple random sampling method. This study was conducted in November – December 2012. The results showed that the average level of knowledge of the population was in good category with a score of 4.77 points (maximum 8 points). Respondents’ attitude is categorized as good with the average score of 20,01 points (maximum 21 points). Respondent’s action is categorized as good with average score of 7.04 points (maximum 10 points). Conclusion: Knowledge, attitude, and action of people in subdistrict Malalayang Satu Malalayang Manado belonged to good category.Keywords: house dust mite, behaviourAbstrak: Debu merupakan gabungan dari bermacam-macam partikel yang menyebar di udara. Di dalam debu rumah terdapat tungau debu rumah (TDR) yang banyak ditemukan pada perabot-perabot rumah. TDR dapat menjadi masalah serius bagi kesehatan manusia. Suhu dan kelembaban kota Manado cukup ideal bagi perkembangbiakan TDR. Penelitian ini bertujuan untuk mengetahui perilaku masyarakat terhadap populasi TDR di sekitar rumah penduduk kelurahan Malalayang Satu kecamatan Malalayang Manado. Penelitian ini menggunakan metode deskriptif dengan kuesioner. Sampel penelitian berjumlah 100 orang yang diambil berdasarkan simple random sampling. Penelitian dilakukan di kelurahan Malalayang Satu kecamatan Malalayang Manado pada bulan November – Desember 2012. Hasil penelitian memperlihatkan bahwa rata-rata tingkat pengetahuan penduduk masuk dalam kategori baik dengan skor 4,77 poin (maksimal 8 poin). Sikap responden dikategorikan baik dengan skor rata-rata 20,01 poin (maksimal 21 poin). Tindakan responden dikategorikan baik dengan skor rata-rata 7,04 poin (maksimal 10 poin). Simpulan: Pengetahuan, sikap, dan tindakan masyarakat kelurahan Malalayang Satu kecamatan Malalayang kota Manado termasuk kategori baik.Kata kunci: tungau debu rumah, perilaku

scholarly journals 96 Sublingual allergen-specific immunotherapy in pediatric patients: biomarkers and molecular allergy diagnostics as predictors of therapeutic success

2020 ◽  
Vol 25 (Supplement_2) ◽  
pp. e40-e40
Author(s):  
Lala Allahverdiyeva ◽  
G E Agaragimova ◽  
Veronica Mugarab Samedi
Keyword(s):  
House Dust ◽  
Pediatric Patients ◽  
Specific Immunotherapy ◽  
Dermatophagoides Pteronyssinus ◽  
House Dust Mites ◽  
Healthy Children ◽  
Dust Mites ◽  
Dermatophagoides Farinae ◽  
Allergen Specific Immunotherapy ◽  
Molecular Allergy

Abstract Background Efficacy of allergen-specific immunotherapy (ASIT) in patients with asthma could be significantly enhanced when physicians have an opportunity to identify those who are most likely to respond, determine when to stop treatment, and predict relapse. Thus, molecular allergy diagnostic is an effective tool that could help to individualize the diagnosis and treatment of asthma by accurate detection of the causative and cross-reactive allergens in pediatric patients. Cytokines are known as reliable diagnostic and prognostic biomarkers for asthma and can be used to evaluate the therapeutic effect. Objectives To evaluate the roles of molecular allergy diagnostic and biomarkers (L-10, IFNγ и TGFβ) as predictors of ASIT efficacy in pediatric patients with asthma. Design/Methods Eighty children aged 5 to 18 years with mild and moderate atopic bronchial asthma were included in the study. Sixty-eight out of 80 (85%) were found to have sensitization to house dust mites Dermatophagoides Pteronyssinus and/or Dermatophagoides Farinae. All these patients underwent molecular diagnostics using ImmunoCAP (Phadia 100) to determine the major (r Der p1, r Der p 2) and minor allergens (r Der p10) of the house dust mites. Twenty-eight patients with mild and moderate asthma were found to have a high sensitivity to these allergens and received SLIT with a mixture of house dust mites (Dermatophagoides Pteronyssinus and/or Dermatophagoides Farinae). To compare the efficacy of SLIT, we evaluated the severity of asthma clinical symptoms on a point scale from 0 to 3, and biomarker levels (IL-10, IFNγ и TGFβ) before and 6 months after SLIT. Twelve healthy children were included in the study as a reference group. Results At the beginning of the study, the average daily score in the SLIT group of 2.5 ± 0.7, and after 6 months of treatment, it decreased to 0.5 ± 0.2. The levels of biomarkers were markedly decreased prior to the treatment, especially TGFβ levels, and normalized at the end of treatment (Tab.1). Conclusion These findings support the efficacy of molecular diagnosis to determine the efficacy of allergen-specific immunotherapy in patients with asthma.

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