scholarly journals Association of Vitamin D with Mild Cognitive Impairment and Alzheimer�s Dementia in Older Mexican Adults

2019 ◽  
Vol 71 (6) ◽  
Author(s):  
Sara G. Aguilar-Navarro ◽  
Alberto J. Mimenza-Alvarado ◽  
Gilberto A. Jiménez-Castillo ◽  
Leonardo A. Bracho-Vela ◽  
Sara G. Yeverino-Castro ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Mexican Adults

scholarly journals Serum vitamin D in patients with mild cognitive impairment and Alzheimer's disease

2018 ◽  
Vol 8 (3) ◽  
pp. e00936 ◽  
Author(s):  
Shinji Ouma ◽  
Midori Suenaga ◽  
Funda F. Bölükbaşı Hatip ◽  
Izzettin Hatip-Al-Khatib ◽  
Yoshio Tsuboi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vitamin D ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Serum Vitamin ◽  
Serum Vitamin D

Effects of commonly prescribed drugs on cognition and mild cognitive impairment in healthy elderly people

2019 ◽  
Vol 33 (8) ◽  
pp. 965-974 ◽  
Author(s):  
Teodoro del Ser ◽  
María-Ascensión Zea ◽  
Meritxell Valentí ◽  
Javier Olazarán ◽  
Jorge López-Álvarez ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cognitive Impairment ◽  
Information Processing ◽  
Mild Cognitive Impairment ◽  
Elderly People ◽  
Longitudinal Analyses ◽  
Negative Effects ◽  
Cross Sectional ◽  
Positive Effects ◽  
Healthy Elderly

Background:Chronic drug intake has been associated with negative and positive cognitive effects in elderly people, although subjacent conditions may be confounding factors.Aim:To study the effects on cognitive performance of commonly prescribed medications in a cohort of cognitively normal older adults.Methods:Medication intake was recorded during two years in 1087 individuals 70–85 years old, without neurological or psychiatric conditions. The influence of every drug, drug family and therapeutic group on six cognitive scores and on the conversion to mild cognitive impairment over two years was ascertained by cross-sectional and longitudinal analyses controlling for demographic and clinical variables.Results:Small effects of several drugs on information processing were found in cross-sectional analyses but only confirmed for a positive effect of vitamin D in case–control analyses. Longitudinal analyses showed no drug effects on the cognitive slopes. Several hypotensive drugs reduced, whereas bromazepam and glucose lowering drugs increased, the conversion rate to mild cognitive impairment with very small effects ( R2=0.3–1%).Conclusions:Cognitively healthy elderly individuals show minimal negative effects on information processing associated with chronic intake of some drugs probably related to the subjacent condition. Some drugs slightly affect the rate of conversion to mild cognitive impairment. Positive effects of vitamin D, chondroitin, atorvastatin and antihypertensive drugs, and negative effects of antidepressants and benzodiazepines, should be further explored in studies with longer follow-up.

scholarly journals Vitamin D deficiency is associated with reduced hippocampal volume and disrupted structural connectivity in patients with mild cognitive impairment

2018 ◽  
Vol 40 (2) ◽  
pp. 394-406 ◽  
Author(s):  
Mamun Al-Amin ◽  
DanaKai Bradford ◽  
Robert K. P. Sullivan ◽  
Nyoman D. Kurniawan ◽  
Yeonsil Moon ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Vitamin D Deficiency ◽  
Structural Connectivity ◽  
Hippocampal Volume

scholarly journals Longitudinal association of sarcopenia and mild cognitive impairment among older Mexican adults

2021 ◽  
Author(s):  
Aarón Salinas‐Rodríguez ◽  
Rosa Palazuelos‐González ◽  
Ana Rivera‐Almaraz ◽  
Betty Manrique‐Espinoza
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Longitudinal Association ◽  
Mexican Adults

Association of Vitamin D Receptor Polymorphisms with Amyloid-β Transporters Expression and Risk of Mild Cognitive Impairment in a Chilean Cohort

2020 ◽  
pp. 1-14
Author(s):  
Nohela B. Arévalo ◽  
Daniela P. Castillo-Godoy ◽  
Italo Espinoza-Fuenzalida ◽  
Nicole K. Rogers ◽  
Gonzalo Farias ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Vitamin D Receptor ◽  
Mononuclear Cells ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Mrna Levels ◽  
Vdr Gene ◽  
Vdr Polymorphisms

Background: Amyloid-β peptide (Aβ) deposition in Alzheimer’s disease (AD) is due to an imbalance in its production/clearance rate. Aβ is transported across the blood-brain barrier by LRP1 and P-gp as efflux transporters and RAGE as influx transporter. Vitamin D deficit and polymorphisms of the vitamin D receptor (VDR) gene are associated with high prevalence of mild cognitive impairment (MCI) and AD. Further, vitamin D promotes the expression of LRP1 and P-gp in AD-animal model brains. Objective: To associate VDR polymorphisms Apa I (rs7975232), Taq I (rs731236), and Fok I (rs2228570) with the risk of developing MCI in a Chilean population, and to evaluate the relationship of these polymorphisms to the expression of VDR and Aβ-transporters in peripheral blood mononuclear cells (PBMCs). Methods: VDR polymorphisms Apa I, Taq I, and Fok I were determined in 128 healthy controls (HC) and 66 MCI patients. mRNA levels of VDR and Aβ-transporters were evaluated in subgroups by qPCR. Results: Alleles A of Apa I and C of Taq I were associated with a lower risk of MCI. HC with the Apa I AA genotype had higher mRNA levels of P-gp and LRP1, while the expression of VDR and RAGE were higher in MCI patients and HC. For Fok I, the TC genotype was associated with lower expression levels of Aβ-transporters in both groups. Conclusion: We propose that the response to vitamin D treatment will depend on VDR polymorphisms, being more efficient in carriers of protective alleles of Apa I polymorphism.

Demographic and Clinical Profile of Patients with Mild Cognitive Impairment Seen at St. Luke’s Medical Center-Global City Memory Service

2021 ◽  
pp. 1-7
Author(s):  
Christianne V. Mojica ◽  
Justine Megan F. Yu ◽  
Encarnita R. Ampil ◽  
Jon Stewart H. Dy ◽  
Erickson F. Torio ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Vitamin B12 ◽  
The Philippines ◽  
Clinical Profile ◽  
Dynamic State ◽  
Disease Assessment ◽  
Published Data ◽  
Vitamin D Levels

<b><i>Introduction:</i></b> Mild cognitive impairment (MCI) is a dynamic state, which has evolved into a highly defined condition due to its association with dementia syndromes. There are no published data on the demographic and clinical characteristics of MCI in the Philippines. These data will help in defining the population at risk for the condition and in modifying the factors for its prevention. <b><i>Methods:</i></b> From 2010 to 2019, 434 subjects were diagnosed with MCI based on the criteria published by the International Working Group on MCI last 2004. The demographic profile, vascular risk factors, and levels of Vitamin B12, Vitamin D, and homocysteine were reviewed. Results of neuropsychological tests, such as Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), Mini-Mental State Exam (MMSE), and Montreal Cognitive Assessment (MoCA), were collected. The Fazekas score of the cranial magnetic resonance imaging of patients was also considered. <b><i>Results:</i></b> The median age was 72 years [34–97] with 58.3% females. The median years of education were 14 [4–28]. Median ADAS-Cog, MMSE, and MoCA scores were 11.3 [0–27.67], 27 [13–30], and 21 [7–30], respectively. Hypertension and dyslipidemia were present in 66.8% and 64.1%, respectively. Normal homocysteine, Vitamin B12, and Vitamin D levels were found in 64.2%, 59.8%, and 48.8%, respectively. The median Fazekas score was 1 (59.4%). <b><i>Conclusion:</i></b> This is the first study to document the demographic and clinical profile of Filipinos with MCI in a clinical setting. This review serves as a foundation for increased understanding of MCI with the ultimate goal of controlling the factors which may impact its prevention.

Vitamin D Increases Aβ140 Plasma Levels and Protects Lymphocytes from Oxidative Death in Mild Cognitive Impairment Patients

2018 ◽  
Vol 15 (6) ◽  
pp. 561-569 ◽  
Author(s):  
Carol D. SanMartín ◽  
Mauricio Henriquez ◽  
Carlos Chacon ◽  
Daniela P. Ponce ◽  
Felipe Salech ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Plasma Levels ◽  
Vitamin D Supplementation ◽  
Cognitive Status ◽  
Clinical Dementia Rating ◽  
Vitamin D Levels ◽  
Increased Susceptibility

Background: Mild cognitive impairment (MCI) has an increased rate of progression to dementia. Alterations of some metabolic factors, such as deficiency of vitamin D, are a risk factor for cognitive deterioration. Vitamin D is involved in the clearance of β-amyloid (Aβ) from the brain. We have reported that lymphocytes from Alzheimer's disease (AD) patients have an increased susceptibility to oxidative death by H2O2 exposure, but currently it is unknown if this characteristic is modifiable in vivo. Objective: To determine if correction of low vitamin D levels protects lymphocytes from oxidative death and increases Aβ1-40 plasma levels in MCI and very early AD (VEAD) patients. Method: Sixteen MCI, 11 VEAD and 25 healthy control (HC) voluntaries were evaluated with the Clinical Dementia Rating (CDR), Montreal Cognitive assessment (MoCA), and Memory Index score (MIS). Lymphocyte death was measured by flow cytometry after 20h exposure to H2O2. In patients with low levels of vitamin D -11 MCI, 9 VEAD and 20 HC- lymphocyte H2O2-death, plasma Aβ1-40 levels and cognitive status were evaluated pre- and post-vitamin D supplementation for 6 months. Results: Lymphocytes from MCI and VEAD patients showed increased susceptibility to oxidative death at study entry. In MCI, but not VEAD patients, lymphocyte susceptibility to death and Aβ1-40 levels plasma levels improved after 6 months of vitamin D supplementation. In addition, cognitive status on follow-up (18 months) improved in MCI patients after vitamin D supplementation. Conclusion: Vitamin D supplementation may be beneficial in MCI. The lack of effect in VEAD may be due to a more advanced stage or different characteristics of the neurodegenerative process.

Vitamin D as a possible biomarker of mild cognitive impairment in parkinsonians

2020 ◽  
pp. 1-5
Author(s):  
Gabriella Santangelo ◽  
Simona Raimo ◽  
Roberto Erro ◽  
Marina Picillo ◽  
Marianna Amboni ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment

Relationship between the levels of vitamin D in elderly adults with mild cognitive impairment and dementia in a tertiary care hospital

2019 ◽  
Vol 405 ◽  
pp. 371
Author(s):  
A. Mimenza ◽  
S. Aguilar Navarro ◽  
L. Bracho Vela ◽  
A. Zamudio Cruz ◽  
F. Hernandez Contreras ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Elderly Adults
Sign in / Sign up

Export Citation Format

Share Document