ACUTE CORONARY SYNDROME: A SEA CHANGE IN OUR UNDERSTANDING OF PATHOGENESIS AND WAY OF TREATMENT? (PART II)

The second part of review highlights the role of residual lipid and thrombotic risks in coronary heart disease patients and possible ways of its correction. The results of randomized clinical trials dedicated to the efficacy of new class of hypolipidemic drug (PCSK‑9 inhibitors) in acute coronary syndrome setting are discussed. Recently published new guidelines of European Society of Cardiology on acute coronary syndrome management are also highlighted.

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ACUTE CORONARY SYNDROME: A SEA CHANGE IN OUR UNDERSTANDING OF PATHOGENESIS AND WAY OF TREATMENT? (PART I)

EMERGENCY MEDICAL CARE ◽

10.24884/2072-6716-2019-20-2-67-73 ◽

2019 ◽

Vol 20 (2) ◽

pp. 67-73

Author(s):

V. I. Shalnev

Keyword(s):

Coronary Heart Disease ◽

Clinical Trials ◽

Acute Coronary Syndrome ◽

Heart Disease ◽

Randomized Clinical Trials ◽

Modern Approach ◽

Coronary Syndrome ◽

Inflammatory Pathways

The article highlights the hypothesis of the inflammatory pathways in pathogenesis of atherothrombosis and the conception of residual inflammatory risk in coronary heart disease patients. Modern approach to the correction of inflammatory risk by immune-modulating therapy in acute coronary syndrome setting is discussed. The results of most significant randomized clinical trials dedicated to this problem are also highlighted.

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Acute coronary syndrome: how to reduce the residual inflammatory risk?

Russian Journal of Cardiology ◽

10.15829/1560-4071-2020-2-3720 ◽

2020 ◽

Vol 25 (2) ◽

pp. 113-118

Author(s):

V. I. Shalnev

Keyword(s):

Coronary Artery Disease ◽

Clinical Trials ◽

Acute Coronary Syndrome ◽

Coronary Artery ◽

Randomized Clinical Trials ◽

Clinical Course ◽

Coronary Syndrome ◽

Inflammatory Drugs ◽

Artery Disease

Inflammatory mediators play an important role in the pathogenesis of acute coronary syndrome (ACS). The results of experimental and randomized clinical trials on the role of various inflammation inhibitors in the treatment of coronary artery disease (CAD), in particular CANTOS and COLCOT, mark a new stage that can significantly change the clinical course and outcomes of the disease. We analyze our own experience in studying this problem. There are much prospects for the use of immunomodulatory and anti-inflammatory drugs reducing the residual inflammatory risk, but additional studies are needed to determine their role in the treatment of CAD.

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Is there life after acute coronary syndrome?

Medicine of Ukraine ◽

10.37987/1997-9894.2021.4(250).238121 ◽

2021 ◽

pp. 30-32

Author(s):

A. V. Yagensky

Keyword(s):

Coronary Heart Disease ◽

Acute Coronary Syndrome ◽

Heart Disease ◽

Blood Vessels ◽

Low Density Lipoproteins ◽

Atherosclerotic Plaques ◽

Low Density ◽

Pathogenetic Mechanism ◽

Coronary Syndrome

The role of coronary heart disease and acute coronary syndrome in the structure of morbidity and mortality of the population of Ukraine cannot be overestimated. The main pathogenetic mechanism of corticosteroids is atherothrombosis, the influence of which is the basis of treatment of patients with coronary heart disease with or without corticosteroids. The effect on the progression of atherothrombosis is possible due to statins, due to slowing the growth of atherosclerotic plaques in blood vessels by reducing the level of low-density lipoproteins in the blood.

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Role of thyroid hormones in coronary heart disease

Bulgarian Cardiology ◽

10.3897/bgcardio.26.e55099 ◽

2020 ◽

Vol 26 (3) ◽

pp. 26-31

Author(s):

Boris Yosifov ◽

Plamen Gatzov

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Coronary Heart Disease ◽

Acute Coronary Syndrome ◽

Heart Disease ◽

Sudden Cardiac Death ◽

Thyroid Hormones ◽

Cardiac Death ◽

Coronary Syndrome

The coronary heart disease is one of the leading causes for sudden cardiac death, cardiovascular morbidity and disability. The main risk factors, such as diabetes mellitus, arterial hypertension, dyslipidaemia, have been extensively studied and researched to this day. In the background, however, are some of the most common endocrinological diseases and abnormalities, mainly those related to thyroid hormones. The purpose of this review is to look at the role of thyroid pathology and hormones in the development of coronary heart disease, as well as their place as a prognostic marker in acute coronary syndrome.

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