scholarly journals Psoriasiform Secondary Syphilis: A Pitfall in Diagnosis

2021 ◽  
Vol 7 (1) ◽  
pp. 1-3
Author(s):  
Satiti Retno Pudjiati ◽  
Keyword(s):  
High Titer ◽  
Seborrheic Dermatitis ◽  
Immune Deficiency Syndrome ◽  
Skin Lesions ◽  
Deficiency Syndrome ◽  
Secondary Syphilis ◽  
Penicillin G ◽  
Serological Examination ◽  
Benzathine Penicillin G ◽  
The Face

Secondary syphilis in Acquired Immune Deficiency Syndrome (AIDS) patient’s have variety of skin manifestations. Failure to recognize the manifestations of secondary syphilis can cause delaying the therapy. The recognition of the characteristics of skin lesions as well as serology examination and histopathology help the physicians for making the diagnosis. A 24-year-old male who was diagnosed with HIV previously came with chief complaint of scaly red plaques on the palms and soles. The similar lesions were also notedover the face especially the perioral region.Patient also noted to have also alopecia on the eyebrows and eyelashes. Patient was diagnosed with psoriasis vulgaris from previous physician and treated with unknown therapy. Serological examination revealed reactive TPHA and high titer of VDRL. Skin biopsy was done and it has features of psoriasis but without pathognomonic signs. The patient then was treated with single dose of benzathine penicillin G 2,4 million units which provided excellent improvement.Secondary syphilis is called "great imitator" because of its broad manifestations. It has been widely reported that secondary syphilis has been misdiagnosed as psoriasis and seborrheic dermatitis. Characteristics of the lesion, serological examination and histopathology play significant role in establishing the diagnosis.

scholarly journals An AIDS Patient With Recurrent Multiple Skin Crusted Ulcerations

2020 ◽  
Author(s):  
Yu Wang ◽  
Ying Wen
Keyword(s):  
Immune Deficiency ◽  
Clinical Manifestations ◽  
Immune Deficiency Syndrome ◽  
Acquired Immune Deficiency Syndrome ◽  
Skin Lesions ◽  
Deficiency Syndrome ◽  
Secondary Syphilis ◽  
Doxycycline Treatment ◽  
Immunodeficiency Virus ◽  
Acquired Immune Deficiency

Abstract Background:Malignant syphilis is considered a rare disease, more commonly affecting individuals with poor immunity. We report a case of acquired immune deficiency syndrome with Repeated crusted ulcerations. Our report shows the typical skin lesions of malignant syphilis and a reinfection with the same rashes. Case presentation:A 22-year-old homosexual male was admitted to hospital for fever and ulcerations with overlying brown–black rupioid crusts. Then he was confirmed human immunodeficiency virus infection. Malignant syphilis was diagnosed by positive markers and biopsy pathology. After application of benzathine penicillin for 3 weeks, the symptoms improved and rapid plasma regain (RPR) decreased from 1:64 to 1:4 in 8 months. But the patient appeared with rashes that was accurately the same with rashes before 13 months later，and RPR rose to 1:128, that was likely to be re-infection after frequent sexual activity. And he responded well to doxycycline treatment. Conclusion: Malignant syphilis is a rare form of secondary syphilis, but tends to occur in acquired immune deficiency syndrome patients because of poor immunity. Although the clinical manifestations of malignant syphilis are severe, the response to the therapy of penicillin and doxycycline are excellent, even with repeated infection.

A 42-year-old man with nodular skin lesions

2021 ◽  
Vol 6 (2) ◽  
pp. 168-172
Author(s):  
Majid Darraj ◽  
Andrew Walkty ◽  
John Toole ◽  
Thomas Marrie ◽  
Leah Huzel ◽  
...  
Keyword(s):  
Skin Lesions ◽  
Punch Biopsy ◽  
Secondary Syphilis ◽  
Penicillin G ◽  
Silver Stain ◽  
Current Increase ◽  
Cutaneous Eruption ◽  
Benzathine Penicillin G ◽  
Timely Fashion ◽  
Dermatologic Manifestations

Nodular skin lesions are infrequently reported among patients with syphilis. We describe a 42-year-old man with secondary syphilis who presented with a nodular cutaneous eruption involving his neck, upper chest, back, arms, and legs. Because there was uncertainty regarding the diagnosis at presentation, the patient underwent a punch biopsy of one of the lesions. Spirochetes were not seen with a Steiner silver stain, but they were visualized on subsequent immunohistochemical staining. The diagnosis was confirmed with serology, and the patient responded well to treatment with benzathine penicillin G. Given the current increase in syphilis cases across North America, it is critical that clinicians become familiar with some of the less common dermatologic manifestations of this infection so that the diagnosis is entertained and appropriate serologic testing is ordered in a timely fashion.

scholarly journals Extra ocular sebaceous adenocarcinoma in HIV-positive patient - case report

2013 ◽  
Vol 88 (6 suppl 1) ◽  
pp. 19-22 ◽  
Author(s):  
Carla Kellen da Silva Menezes ◽  
Nathália Matos Gomes ◽  
Alex Panizza Jalkh ◽  
Emily dos Santos Franco ◽  
Thalita Gomes Martins
Keyword(s):  
Immune Deficiency ◽  
Immune Deficiency Syndrome ◽  
Acquired Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Hiv Positive ◽  
Patient Case ◽  
Adnexal Tumor ◽  
The Face ◽  
Adnexal Tumors ◽  
Acquired Immune Deficiency

Sebaceous adenocarcinoma is a rare adnexal tumor that can affect the skin and is divided into ocular, a more common form and extra ocular, of a rarer occurrence. We report the case of a patient diagnosed with Acquired Immune Deficiency Syndrome (AIDS) who developed an extra ocular, bulky and fast-growing sebaceous adenocarcinoma on the face. The literature has suggested that transplanted patients and HIV-positive patients have an excess risk for developing adnexal tumors, including sebaceous adenocarcinoma.

scholarly journals Sexual abuse leading to secondary syphilis in an intellectually disabled person: a case report

2021 ◽  
Vol 7 (6) ◽  
pp. 872
Author(s):  
Rajesh Munusamy ◽  
Nithin Nagaraja
Keyword(s):  
Sexual Abuse ◽  
Venereal Disease ◽  
Treponema Pallidum ◽  
Secondary Syphilis ◽  
Penicillin G ◽  
Intellectually Disabled ◽  
Transmitted Infection ◽  
Sexual Transmitted Infection ◽  
Benzathine Penicillin G

<p class="abstract">Syphilis is a sexual transmitted infection (STI) caused by a spirochete, <em>Treponema pallidum</em>. Condylomata lata is a characteristic lesion seen in secondary syphilis. Here we reported a case of 24 year old unmarried male with intellectual disability who presented with condyloma lata over the scrotum, prepuce and perianal region and with moth eaten alopecia over scalp since 1 month. Here the patients mother revealed he had promiscuous relationship with multiple friends, which is a sexual abuse since the patient is intellectually disabled. Clinically diagnosed as secondary syphilis. Venereal disease research laboratory (VDRL) test titre was reactive at 1:32 and <em>Treponema pallidum </em>hemagglutination test (TPHA) was positive. Biopsy was also done, which confirmed diagnosis. Single dose of injection benzathine penicillin G, 2.4 million units was administered intramuscularly. Patient did not develop a Jarisch-herxheimer reaction. On follow up his lesions healed and VDRL titres also came down and non-reactive at 3 months. Here in this case sexual abuse lead to secondary syphilis since patient was intellectually disabled so he couldn’t address his complaints clearly. Hence counselling was done to the patient and family members by dermatologist and psychiatrist.</p><p class="abstract"> </p>

scholarly journals Diffuse Hair Loss in Secondary Syphilis in HIV Positive Man: Case Report

2012 ◽  
Vol 29 (4) ◽  
pp. 193-197 ◽  
Author(s):  
Milan Bjekić
Keyword(s):  
Hair Loss ◽  
Scalp Hair ◽  
Secondary Syphilis ◽  
Penicillin G ◽  
Hiv Positive ◽  
Oral Lesions ◽  
Benzathine Penicillin ◽  
Serological Tests ◽  
Benzathine Penicillin G ◽  
Macular Rash

SUMMARY Hair loss is not a common feature of secondary syphilis. There are two types of syphilitic alopecia: “symptomatic” type where hair loss is associated with other symptoms of secondary syphilis, and “essential” alopecia that is either patchy (“moth-eaten” type), diffuse pattern with a generalized thinning of the scalp hair, or a combination of both without any other mucocutaneous signs of syphilis. This article presents a case of syphilitic alopecia in a 30-year-old homosexual man. The patient had diffuse non-scarring alopecia of his scalp and loss of eyelashes and eyebrows. A macular rash with palmar-plantar involvement and oral lesions coexisted with the hair loss. Serological tests for syphilis were positive. The patient was treated with a single dose of benzathine penicillin G, 2.4 million units intramuscularly. Within three months there was dramatic hair regrowth, and all syphilitic lesions resolved. Patient was councelled and tested on HIV. The HIV seropositivity was confirmed by Western blot analysis. Syphilitic alopecia should not be overlooked in patients with non-scarring hair loss. Serologic testing for syphilis is recommended in patients with unexplained rapid hair loss. However, all patients presenting with syphilis should be offered HIV testing.

scholarly journals PROFIL DERMATITIS SEBOROIK DI POLIKLINIK KULIT DAN KELAMIN RSUP PROF. DR. R. D. KANDOU MANADO PERIODE JANUARI-DESEMBER 2012

e-CliniC ◽  
2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Ranita O. Terroe ◽  
Marlyn G. Kapantow ◽  
Renate T. Kandou
Keyword(s):  
Skin Disease ◽  
Antifungal Agent ◽  
Seborrheic Dermatitis ◽  
Descriptive Study ◽  
Skin Lesions ◽  
Age Group ◽  
Sebaceous Glands ◽  
The Face ◽  
Combined Medication

Abstract: Seborrheic dermatitis (SD) is a chronic, recurrent skin disease in areas which are abundant in sebaceous glands, with a prevalence of 3-5% worldwide. Though its pathogenesis is still unknown, SD is related to sebum overproduction and the fungus Malassezia. SD can be suffered by all kinds of ages, most commonly found in men. The skin lesions found are erythematous, yellowish, oily squamas with uncircumscribed border. Pitiriasis sika, also known as dandruff, is a mild type of SD often suffered by people.This research is a retrospective descriptive study based on the number of cases, gender, age, location of lesion, and type of medication. Results shown that out of 134 seborrheic dermatitis cases (3,3%), this disease is often suffered by the age group 45-65 years old (55,2%) and male (67,2%), with most lesions located on the face (53,7%) and with combined medication of corticosteroid + antifungal agent (62,7%).Keywords: seborrheic dermatitisAbstrak: Dermatitis seboroik (DS) adalah penyakit kulit kronis berulang pada area yang memiliki banyak kelenjar sebasea, dengan prevalensi 3-5% di dunia. Patogenesis DS belum diketahui, namun DS memiliki hubungan terhadap produksi sebum yang berlebih dan adanya jamur Malassezia.DS dapat diderita oleh semua golongan umur, biasanya lebih sering diderita laki-laki.Kelainan kulit DS berwujud ritema dan skuama berminyak dan agak kekuningan dengan batas kurang tegas.Pitiriasis sika, atau ketombe, adalah jenis ringan DS yang paling sering diderita.Penelitian ini merupakan penelitian deskriptif retrospektif berdasarkan jumlah kasus, jenis kelamin, umur, lokasi lesi, dan jenis pengobatan.Hasil penelitian ini menunjukkan bahwa dari 134 kasus dermatitis seboroik (3,3%), penyakit ini sering terjadi pada kelompok umur 45-65 tahun (55,2%), jenis kelamin laki-laki (67,2%), lokasi lesi wajah (53,7%), dan pengobatan kombinasi topikal antara kortikosteroid + antijamur (62,7%).Kata kunci: dermatitis seboroik

Cutaneous Cryptococcosis Mimicking Basal Cell Carcinoma in a Patient with AIDS

1998 ◽  
Vol 3 (1) ◽  
pp. 43-45 ◽  
Author(s):  
Rosemarie Ingleton ◽  
Evelyn Koestenblatt ◽  
Philip Don ◽  
Howard Levy ◽  
Wojciech Szaniawski ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Systemic Disease ◽  
Immune Deficiency Syndrome ◽  
Skin Lesions ◽  
Deficiency Syndrome ◽  
Cutaneous Manifestations ◽  
Systemic Involvement ◽  
Cutaneous Cryptococcosis

Background: Cryptococcosis is an opportunistic infection caused by the encapsulated yeast Cryptococcus neoformans. This ubiquitous organism has emerged as a frequent finding in immunosuppressed patients, especially those with underlying malignancies, organ transplants, and the acquired immune deficiency syndrome (AIDS). Cutaneous manifestations of cryptococcosis occur in 10 to 15% of patients having systemic involvement. These skin lesions may simulate a variety of different disease entities. Methods: A case of crytococcosis mimicking a basal cell carcinoma is the subject of a case report presentation. Results: A case of cutaneous cryptococcosis mimicking basal cell carcinoma occurred in a patient with AIDS, who did not appear to have dissemination, but was treated aggressively to stem possible occult systemic disease. Conclusion: Cutaneous crytococcosis may mimic other dermatologic disorders.

scholarly journals Pulmonary Kaposi Sarcoma: An Uncommon Cause of Respiratory Failure in the Era of Highly Active Antiretroviral Therapy—Case Report and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Stanley M. Nwabudike ◽  
Stefan Hemmings ◽  
Yonette Paul ◽  
Yordanis Habtegebriel ◽  
Octavius Polk ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Immune Deficiency Syndrome ◽  
Skin Lesions ◽  
Deficiency Syndrome ◽  
Cutaneous Lesions ◽  
Highly Active

Kaposi Sarcoma (KS) is the most common malignancy associated with Acquired Immune Deficiency Syndrome (AIDS) and is caused by Human Herpesvirus 8 (HHV 8) or Kaposi Sarcoma Herpesvirus (KSHV). In about 90% of cases Kaposi Sarcoma is associated with cutaneous lesions; however visceral disease can occur in the absence of cutaneous involvement. In the era of Highly Active Antiretroviral Therapy (HAART), the incidence of KS has declined. Clinical features of pulmonary KS might be difficult to distinguish from pneumonia in the immunocompromised patients and could lead to diagnostic challenges. First-line treatment of KS is with HAART and the incidence has declined with its use. Systemic chemotherapy may play a role depending on the extent of the disease. We report the case of a young man who presented with pulmonary symptoms and was later found to have pulmonary KS. Interestingly this diagnosis was made in the absence of the classic skin lesions. His disease was complicated by progressive respiratory failure and he eventually died.

Relapse of Secondary Syphilis After Benzathine Penicillin G

2004 ◽  
Vol 31 (3) ◽  
pp. 196-199 ◽  
Author(s):  
Michael Myint ◽  
Houman Bashiri ◽  
Robert D. Harrington ◽  
Christina M. Marra
Keyword(s):  
Secondary Syphilis ◽  
Penicillin G ◽  
Benzathine Penicillin ◽  
Benzathine Penicillin G

scholarly journals Lues Maligna as an Initial Presentation of Underlying HIV Infection in a Homosexual Man

2017 ◽  
Vol 9 (4) ◽  
pp. 159-162 ◽  
Author(s):  
Milan Bjekić
Keyword(s):  
Risk Factors ◽  
Hiv Infection ◽  
Western Blot ◽  
Clinical Characteristics ◽  
Skin Lesions ◽  
Secondary Syphilis ◽  
Initial Presentation ◽  
Serological Tests ◽  
The Face ◽  
Living With Hiv

Abstract Lues maligna is a rare ulcerative form of secondary syphilis. This clinical entity is predominantly found in patients living with HIV or AIDS. We report a case of a 32-year-old homosexual man with diffuse non-pruritic, papular skin lesions, ulcerated nodules and plaques disseminated on the face, trunk and extremities. The rash was followed by fever, malaise and joint pains. Serological tests for syphilis were positive. The patient was treated with intramuscular penicillin and the lesions resolved completely. Lues maligna was an initial presentation of underlying HIV infection. The HIV seropositivity was confirmed by Western blot analysis. Due to the increased number of syphilis cases and frequent HIV co-infection in Serbia, dermatologists must be able to recognize this condition based on clinical characteristics and risk factors and to diagnose and treat it promptly.

Sign in / Sign up

Export Citation Format

Share Document