scholarly journals Myroides Odoratum Osteomyelitis In A Diabetic Patient: Case Report And Review On A Rare Pathogen

2020 ◽  
Vol 7 (3) ◽  
pp. 1-4
Author(s):  
William Z Webster ◽  
Keyword(s):  
Drug Resistance ◽  
Blood Stream Infection ◽  
Blood Stream ◽  
Multi Drug Resistance ◽  
Resistance Pattern ◽  
Rare Presentation ◽  
Beta Lactamases ◽  
Drug Resistance Pattern ◽  
Patient Reported ◽  
Immunocompromised Hosts

Given the multi-drug resistance pattern and general unfamiliarity of the gram-negative bacillus known as Myroides species, this report focuses on a rare presentation with emphasis on drug resistance and pathogenesis. With only 48 reported cases of Myroides infection as of 2017, this case presents the first known report of osteomyelitis from Myroides species. The most common reported infections include urinary tract infection, cellulitis, and blood stream infection, all occurring in immunocompromised hosts except for one case of cellulitis following a pig bite in a pediatric patient. Reported cases are to be discussed with respect to incidence, presentation, and proposed mechanisms of resistance such as chromosome-encoded metallo-beta-lactamases, with similarities and differences highlighted between prior reports and this case of osteomyelitis.

scholarly journals Multi-drug Resistance Pattern of Staphylococcus aureus from Paediatric Ward, General Hospital, Ikot-Ekpaw, Mkpat Enin LGA, Akwa-Ibom State, Nigeria

2019 ◽  
pp. 1-6
Author(s):  
I. A. Ibanga ◽  
O. D. Akan ◽  
F. Z. Uyanga ◽  
E. C. Mantu ◽  
M. Asuquo
Keyword(s):  
Staphylococcus Aureus ◽  
Drug Resistance ◽  
General Hospital ◽  
Skin Wound ◽  
Multi Drug Resistance ◽  
Resistance Pattern ◽  
Antibiotics Resistance ◽  
Paediatric Ward ◽  
Mannitol Salt Agar ◽  
Drug Resistance Pattern

Aim: This study evaluated the Multi-drug resistance (MDR) pattern of Staphylococcus aureus from a paediatric ward and was conducted using standard clinical microbiological procedures. Location and Duration of Study: The study was carried out on infant samples collected from the Paediatric ward, General Hospital, Ikot-Ekpaw,  Mkpat Enin LGA, Akwa-Ibom State, Nigeria, over three (3) months period. Design of Study: Hundred swab-samples were inoculated on Mannitol salt agar. Positive growths were further biochemically confirmed for Staphylococcus aureus. Confirmed isolates were then used for MDR evaluation. Results and Interpretation: Of the 100 samples from skin, wound, ear, throat and nose swabs, 28 isolates were confirmed as S. aureus and were subjected to a range of selected commercially available antibiotics like: Amoxicillin, ampiclox, chloramphenicol, ciprofloxacin, erythromycin, gentamicin, levofloxacin, norfloxacin, rifampicin and streptomycin, to evaluate their susceptibilities. The wound swabs gave the highest isolate percentage yield (32%) followed by skin swabs (29%). Susceptibility results showed that amoxicillin and ampiclox were more resisted by the isolates, while ciprofloxacin, levofloxacin and norfloxacin were more effective against the isolates. The Multiple antibiotics resistance (MAR) indices showed that 85.7% of the isolates had confirmed multi-drug resistance status, with 60.7% of the isolates showing resistance to between four or more of the tested antimicrobials. MAR indices revealed that 96.4% of the isolates had 0.3, indicating that the resistance resulted from isolates that adapted to the tested drugs due to some form of abuse. Restricted use of these drugs would help curtail the high resistance currently observed amongst microorganisms.

scholarly journals Anti-tuberculosis Drug Resistance Pattern among Different Category of Tuberculosis Patients

1970 ◽  
Vol 10 (2) ◽  
pp. 45-47 ◽  
Author(s):  
Mostafizur Rahman ◽  
SM Mostafa Kamal ◽  
Fazle Rabbi Mohammed ◽  
Md Billal Alam ◽  
HAM Nazmul Ahasan
Keyword(s):  
Drug Resistance ◽  
Susceptibility Testing ◽  
Absolute Number ◽  
Drug Susceptibility ◽  
Drug Susceptibility Testing ◽  
Therapeutic Interventions ◽  
Multi Drug Resistance ◽  
Resistance Pattern ◽  
Drug Resistance Pattern ◽  
Mdr Tb

Background: Anti-Tuberculosis (TB) drug resistance is emerging as a new global health problem. No national data on drug resistance is available in Bangladesh. The absolute number of multidrug resistant TB (MDR-TB) is expected to be high considering high TB burden. This study was aimed to determine the resistance pattern of mycobacterium tuberculosis (MTB) isolates among different category of patient. Method: A total 1123 randomly selected patients having clinical and or radiological features of tuberculosis attending out patients department of NIDCH were enrolled in this study during January to December, 2008. Sputum were collected and processed for culture by digestion, decontamination and concentration following modified Petroff's method and were inoculated on to two slopes of Lowenstein- Jensen (L-J) media for six weeks. The identity of the isolates was made by growth rate, colony morphology, P-nitrobenzoic acid (PNB) susceptibility, catalase and nitrate reduction tests. Ultimately drug susceptibility testing (DST) were performed. Result: Drug susceptibility testing for Isoniazid (INH), Rifampicin (RIF), Ethambutol (EMB) and Streptomycin (SM) was done among 363 cases. Resistance rates for INH, RIF, EMB and SM were 76.03%, 71.63%, 27.55% and 55.65% respectively. According to DST report, total 221 cases were detected as multi drug resistant TB (MDR-TB). Among them, 87% cases were MDR-TB in category II (CAT - II) failure and 13% were MDR-TB in category I (CAT - I) failure and it was 0% in new cases. Conclusion: Pattern of anti TB drug resistance was identified in this study. More surveillance and immediate therapeutic interventions should be performed in order to combat the threat of MDR-TB to the general population. Keywords: Tuberculosis, Multi drug resistance, Drug susceptibility testing.   doi: 10.3329/jom.v10i2.2812 J MEDICINE 2009; 10 : 45-47

scholarly journals Bacterial profile and multi-drug resistance pattern of bacterial isolates among septicemia suspected cases: a meta-analysis report in Ethiopia

2021 ◽  
Vol 45 (3) ◽  
pp. 167-178
Author(s):  
Mengistu Abayneh ◽  
Shewangizaw HaileMariam ◽  
Molla Asnake
Keyword(s):  
Drug Resistance ◽  
Blood Culture ◽  
Meta Analysis ◽  
Multi Drug Resistance ◽  
Resistance Pattern ◽  
Bacterial Isolates ◽  
Gram Positive ◽  
Gram Negative ◽  
Drug Resistance Pattern ◽  
Culture Positive

Abstract Background Bloodstream infections (BSIs) are one of the most common infections seen in all age groups and in all locations. The current knowledge on the patterns of bacterial profile, and its antibiotic resistance are essential to design and implement appropriate interventions. This study was conducted to assess the prevalence and multi-drug resistance pattern of bacterial isolates among septicemia and/or bacteremia suspected cases in Ethiopia. Methods Searching was conducted in databases of PubMed, Research Gate, Scopus and Google Scholar. In addition, manual searching is also conducted in bibliographies of included studies and in other meta-analysis studies. Required data were extracted from articles published up to 2020 on the bacterial profile of septicemia in Ethiopia, and analyzed using comprehensive meta-analysis version 3.3.0 software. Results A total of 5,823 septicemia suspected cases were extracted from 18 included studies and the overall blood culture positive rate of 31.9% (95% CI: 0.261–0.382). Of these, the overall Gram positive and Gram negative isolates was 57.8% (95% CI: 0.534–0.584) and 42.2% (95% CI: 0.416–0.466), respectively. Among Gram positives, predominantly reported isolates was Staphylococcus  aureus (47.9%: 480 of 1,003), followed by Coagulase-Negative Staphylococcus (42.7%: 428 of 1,003), whereas among Gram negatives, the most frequently reported isolates was Klebsiella species (29.8%: 218 of 731), followed by Escherichia  coli (23.1%: 169 of 731). Significant levels of resistance was reported against ampicillin, amoxicillin, ceftriaxone, co-trimoxazole and tetracycline with a pooled resistance range of 40.6–55.3% in Gram positive and 52.8–85.7% in Gram negative isolates. The pooled estimates of multi-drugs resistance (MDR) was (66.8%) among Gram positives and (80.5%) among Gram negatives, with the overall MDR rate of (74.2%). Conclusions The reported blood culture positive rates among septicemia cases were relatively high. Second, the level of drug and multi-drug resistant isolates against commonly prescribed antibiotics was significant. However, the scarcity of data on culture confirmed septicemia cases as well as patterns of antimicrobial resistance may overshadow the problem.

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