scholarly journals Protective Effect of 17β Estradiol against Kidney Injury in a Mouse Model of Unilateral Renal Ischemia

2021 ◽  
Vol 7 (1) ◽  
pp. 1-10
Author(s):  
Carolyn M Ecelbarger ◽  
Keyword(s):  
Mouse Model ◽  
Protective Effect ◽  
Kidney Injury ◽  
Mechanisms Of Action ◽  
Renal Ischemia ◽  
Irreversible Damage ◽  
Ovarian Steroids ◽  
Young Females ◽  
Protective Actions ◽  
17Β Estradiol

Renal ischemia can lead to irreversible damage to the kidney including atrophy and fibrosis. Young females generally experience attenuated pathology due to the protective actions of ovarian steroids, in particular 17β-Estradiol (E2); however, the mechanisms of action remain murky.

scholarly journals The prominent impairment of liver/intestinal cytochrome P450 and intestinal drug transporters in sepsis-induced acute kidney injury over acute and chronic renal ischemia, a mouse model comparison

Renal Failure ◽  
2019 ◽  
Vol 41 (1) ◽  
pp. 314-325 ◽  
Author(s):  
Warumphon Sukkummee ◽  
Patcharin Jittisak ◽  
Piyanuch Wonganan ◽  
Supeecha Wittayalertpanya ◽  
Pajaree Chariyavilaskul ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cytochrome P450 ◽  
Mouse Model ◽  
Model Comparison ◽  
Drug Transporters ◽  
Kidney Injury ◽  
Renal Ischemia

scholarly journals Concordant Changes of Plasma and Kidney MicroRNA in the Early Stages of Acute Kidney Injury: Time Course in a Mouse Model of Bilateral Renal Ischemia-Reperfusion

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e93297 ◽  
Author(s):  
Melissa A. Bellinger ◽  
James S. Bean ◽  
Melissa A. Rader ◽  
Kathleen M. Heinz-Taheny ◽  
Jairo S. Nunes ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Mouse Model ◽  
Time Course ◽  
Ischemia Reperfusion ◽  
Kidney Injury ◽  
Renal Ischemia ◽  
Early Stages

scholarly journals Effect of Quercetin in the 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-Induced Mouse Model of Parkinson's Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Chuanfeng Lv ◽  
Tie Hong ◽  
Zhen Yang ◽  
Yu Zhang ◽  
Lu Wang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Superoxide Dismutase ◽  
Body Weight ◽  
Glutathione Peroxidase ◽  
Mouse Model ◽  
Protective Effect ◽  
Mechanisms Of Action ◽  
Quercetin Treatment

In this paper, the protective effect of the bioflavonoid quercetin on behaviors, antioxidases, and neurotransmitters in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-(MPTP-) induced Parkinson's disease (PD) was investigated. Quercetin treatment (50 mg/kg, 100 mg/kg and 200 mg/kg body weight) was orally administered for 14 consecutive days. The results show that quercetin treatment markedly improves the motor balance and coordination of MPTP-treated mice. Significant increases were observed in the activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), and Na+, K+-ATPase, AchE, the content of dopamine (DA) in the quercetin plus MPTP groups compared to those in the MPTP group. Significant reduction the 4-hydroxy-2-nonenal (4-HNE) immunoreactivity in striatum of brains was observed in the quercetin plus MPTP groups in comparison to the MPTP group. Taken together, we propose that quercetin has shown antiparkinsonian properties in our studies. More work is needed to explore detailed mechanisms of action.

The protective effect of ticagrelor on renal function in a mouse model of sepsis-induced acute kidney injury

Platelets ◽  
2018 ◽  
Vol 30 (2) ◽  
pp. 199-205 ◽  
Author(s):  
Xiuhua Li ◽  
Yusheng Li ◽  
Kan Shen ◽  
Hongqiang Li ◽  
Jianwen Bai
Keyword(s):  
Acute Kidney Injury ◽  
Renal Function ◽  
Mouse Model ◽  
Protective Effect ◽  
Kidney Injury

Protective effect of 17β-estradiol on ischemic acute kidney injury through the renal sympathetic nervous system

2012 ◽  
Vol 683 (1-3) ◽  
pp. 270-275 ◽  
Author(s):  
Ryosuke Tanaka ◽  
Hidenobu Tsutsui ◽  
Shuhei Kobuchi ◽  
Takahiro Sugiura ◽  
Masayo Yamagata ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Protective Effect ◽  
Kidney Injury ◽  
17Β Estradiol ◽  
Ischemic Acute Kidney Injury ◽  
Sympathetic Nervous ◽  
Renal Sympathetic

Protective effect of sesamin in lipopolysaccharide-induced mouse model of acute kidney injury via attenuation of oxidative stress, inflammation, and apoptosis

2018 ◽  
Vol 40 (5) ◽  
pp. 423-429 ◽  
Author(s):  
Ali-Mohammad Rousta ◽  
Seyed-Mohamad-Sadegh Mirahmadi ◽  
Alireza Shahmohammadi ◽  
Davood Nourabadi ◽  
Mohammad-Reza Khajevand-Khazaei ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Kidney Injury ◽  
Mouse Model ◽  
Protective Effect ◽  
Kidney Injury

scholarly journals The protective effect of γ-aminobutyric acid on kidney injury induced by renal ischemia-reperfusion in ovariectomized estradiol-treated rats

2016 ◽  
Vol 7 (1) ◽  
pp. 6 ◽  
Author(s):  
Mehdi Nematbakhsh ◽  
Nahid Talebi ◽  
Ramesh Monajemi ◽  
Safoora Mazaheri ◽  
Ardeshir Talebi ◽  
...  
Keyword(s):  
Protective Effect ◽  
Ischemia Reperfusion ◽  
Kidney Injury ◽  
Renal Ischemia ◽  
Aminobutyric Acid

scholarly journals Mouse model of ischemic acute kidney injury: technical notes and tricks

2012 ◽  
Vol 303 (11) ◽  
pp. F1487-F1494 ◽  
Author(s):  
Qingqing Wei ◽  
Zheng Dong
Keyword(s):  
Acute Kidney Injury ◽  
Mouse Model ◽  
Drug Testing ◽  
Ischemia Reperfusion ◽  
Small Animal ◽  
Kidney Injury ◽  
Experimental Models ◽  
Renal Ischemia

Renal ischemia-reperfusion leads to acute kidney injury (AKI), a major kidney disease associated with an increasing prevalence and high mortality rates. A variety of experimental models, both in vitro and in vivo, have been used to study the pathogenic mechanisms of ischemic AKI and to test renoprotective strategies. Among them, the mouse model of renal clamping is popular, mainly due to the availability of transgenic models and the relatively small animal size for drug testing. However, the mouse model is generally less stable, resulting in notable variations in results. Here, we describe a detailed protocol of the mouse model of bilateral renal ischemia-reperfusion. We share the lessons and experiences gained from our laboratory in the past decade. We further discuss the technical issues that account for the variability of this model and offer relevant solutions, which may help other investigators to establish a well-controlled, reliable animal model of ischemic AKI.

scholarly journals A mouse model of renal ischemia-reperfusion injury solely induced by cold ischemia

2019 ◽  
Vol 317 (3) ◽  
pp. F616-F622 ◽  
Author(s):  
Jin Wei ◽  
Yingliang Wang ◽  
Jie Zhang ◽  
Lei Wang ◽  
Liying Fu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Mouse Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Kidney Injury ◽  
Renal Ischemia ◽  
Cold Ischemia ◽  
Preservation Solution ◽  
Renal Ischemia Reperfusion Injury

Transplanted kidneys usually experience several episodes of ischemia, including cold ischemia during allograft storage in preservation solution. However, previous studies focusing on cold renal ischemia were only carried out in vitro or ex vivo. In the present study, we developed and characterized an in vivo mouse model of renal ischemia-reperfusion injury (IRI) induced exclusively by cold ischemia. C57BL/6 mice underwent right kidney nephrectomy, and the left kidney was kept cool with circulating cold saline in a kidney cup, while body temperature was maintained at 37°C. We clamped the renal pedicle and flushed out the blood inside the kidney with cold saline via an opening on the renal vein. The severity of renal IRI was examined with different ischemic durations. We found that the mice with <2 h of cold ischemia exhibited no significant changes in renal function or histopathology; animals with 3 or 4 h of cold ischemia developed into mild to moderate acute kidney injury with characteristic features, including the elevation in plasma creatinine concentration and reduction in glomerular filtration rate and tubular necrosis, followed by a subsequent recovery. However, mice with 5 h of cold ischemia died in a few days with severe acute kidney injury. In summary, we generated a mouse model of renal IRI induced exclusively by cold ischemia, which mimics graft cold storage in preservation solution, and renal function can be evaluated in vivo.

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