The pharmacotherapy of acute viral hepatitis b: a clinical pharmacist's view

2020 ◽  
Vol 26 (4) ◽  
pp. 29-38
Author(s):  
O.Yu. Horodnycha ◽  
◽  
T.B. Ryvak ◽  
Keyword(s):  
Hepatitis B ◽  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Pharmaceutical Care ◽  
Acute Viral Hepatitis ◽  
Case Reports ◽  
Drug Related Problems ◽  
Rational Pharmacotherapy ◽  
Acute Hepatitis B ◽  
Viral Hepatitis B

Aim. To conduct the analysis and estimation of acute viral hepatitis B pharmacotherapy through identification of drug-related problems; to form a list of recommendations with elements of pharmaceutical care concerning some aspects of acute viral hepatitis B pharmacotherapy. Materials and Methods. The objects of research: 27 medical records of patients with acute viral hepatitis B who were hospitalized to one of Lviv City Hospitals in the first quarter of 2016; medical and technological documents on acute viral hepatitis B management; results of clinical research and clinical case reports; The Pharmaceutical Care Network Europe classification (version 5.01) for drug-related problems. Methods: systemic approach, clinical-pharmaceutical, clinical-pharmacological, statistical, and analytical. Results and Discussion. All patients with acute hepatitis B received only pathogenetic and/or symptomatic pharmacotherapy which corresponds to modern scientific approaches of rational pharmacotherapy of acute hepatitis B. The total number of identified drug-related problems was 192 (a mean of 7,1±1,4 drug-related problems per patient), out of them: 30,1% - potential drug-drug interactions; 27,5% - insufficient dosage of drugs; 14,6% - co-administration of medications with the same active ingredients (duplicate prescriptions); 11,5% - excessive duration of pharmacotherapy; 6,3% - incorrect drugs; 4,7% - incorrect route of drug administration; 1,6% - contraindicated use of drugs; 1,6% - excessive dosage of drugs; 1,6% - technical drug-related problems; and 0,5% - insufficient duration of pharmacotherapy. Conclusions. According to the results of this study, the list of clinical pharmacist's recommendations (messages of pharmaceutical care) have been formed which can be used for improving the quality and safety of pharmacotherapy. Key words: clinical pharmacist, acute viral hepatitis B, drug-related problems, rational pharmacotherapy

Epidemiological situation of hepatitis B in the Samara region

2020 ◽  
pp. 9-16
Author(s):  
O. Churbakova ◽  
V. Akimkin ◽  
D. Pechkurov
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Chronic Hepatitis B ◽  
Causative Agent ◽  
Child Population ◽  
Acute Hepatitis B ◽  
Viral Hepatitis B ◽  
Epidemiological Situation

The article presents an analysis of the primary incidence of hepatitis B in the Samara region from 1997 to 2018. It was noted that during the 1997–2000 period there was an increase in the carrying levels of viral hepatitis B agent, the incidence of acute hepatitis B, first detected by chronic hepatitis B. Since 2000–2001, there has been a dynamic decrease in the incidence of hepatitis B. It should be noted that from the 2006 (beginning of immunoprophylaxis) to 2018. in the Samara region more intensive decrease in indicators of incidence of hepatitis B was noted. Rates of decrease in incidence of an acute hepatitis In from 2006 to 2018 in the Samara region from 7,10 ⁄ 0000 to 0,70 ⁄ 0000v 10,1 times were observed (p < 0.01). Decrease in incidence of chronic hepatitis B was noted from 2006 to 2018 by 1.4 times (p < 0.01) from 14,50 ⁄ 0000 to 10,30 ⁄ 0000. Decrease in indicators of carriage of the causative agent of viral hepatitis B from 2006 to 2018 happened more in high gear, in comparison with indicators of incidence of chronic hepatitis B to 55,60 ⁄ 0000 to 6,60 ⁄ 0000 by 8.4 times (p < 0.01). From 2008 to 2018, the vaccination coverage against hepatitis B of the child population was 99.3–99.5 %, which led to a significant decrease in the incidence of hepatitis B in the Samara region. From 2011 to 2018, no cases of acute hepatitis B of the child population of the Samara region were registered. In the last three years, no cases of chronic hepatitis B of the child population have been recorded in the Samara region.

scholarly journals Prevention of hepatitis B in Italy: lessons from surveillance of type-specific acute viral hepatitis

1990 ◽  
Vol 104 (1) ◽  
pp. 135-141 ◽  
Author(s):  
A. Mele ◽  
M. A. Stazi ◽  
O. N. Gill ◽  
P. Pasquini ◽  
Keyword(s):  
Risk Factors ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Acute Viral Hepatitis ◽  
Control Programme ◽  
Italian Population ◽  
Relative Contribution ◽  
Hbsag Carriers ◽  
Acute Hepatitis B

SUMMARYThe relative contribution of various risk factors to the incidence of acute hepatitis B in Italy was estimated using a special surveillance system (SEIEVA) for type-specific acute viral hepatitis. At present 146 health departments (USLs) which contain 21% of the Italian population participate in SEIEVA out of the total of 650. Data on 2460 hepatitis B cases and 708 hepatitis A cases were compared.Hospitalization, surgical intervention, dental therapy, other percutaneous exposures, barber shop shaving, i.v. drug abuse and household contact with HBsAg carriers were associated with acute hepatitis B and a large number of cases were attributable to these risk factors.Because the control programme based on vaccination will not be effective in the short term at reducing hepatitis B incidence, other additional interventions are recommended.

scholarly journals Acute viral hepatitis prevalence in the last five years at „Sf. Cuv. Parascheva“ Infectious Diseases Clinical Hospital, Galati

2015 ◽  
Vol 18 (2-3) ◽  
pp. 99-102
Author(s):  
Miruna Drăgănescu ◽  
◽  
Alina Iancu ◽  
◽  
◽  
...  
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Infectious Diseases ◽  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Acute Viral Hepatitis ◽  
Acute Hepatitis C ◽  
Clinical Hospital ◽  
Acute Hepatitis B ◽  
National Trends

Introduction. Acute viral hepatitis is a major pathology under national and international surveillance due to both lethal or chronic evolution. Objectives. To evaluate the prevalence of acute viral hepatitis in the last five years in Galati. Methods. Retrospective study based on patients dossiers addmited for acute viral hepatitis between 01.01.2010-31.12.2014 in Infectious Diseases Clinical Hospital from Galati. Results. The decreasing prevalence of acute hepatitis of 1.7 times was based on reduction of acute hepatitis B cases; the year 2013 has shown an epidemic increase of acute hepatitis A cases, similar to the national data. Acute hepatitis C had the same prevalence over the years. For 1/3 of cases no A, B, C etiology was found. Correlation (p < 0.0001) between etiology and patients age was found. Acute hepatitis B has shown the most severe cases due to jaundice and citolysis intensity. No differences between gender was found but the illness was more frequent in urban area. Conclusions. Our study has shown the decreasing hepatitis B prevalence while hepatitis C had the similar prevalence, as the national trends.

scholarly journals Epidemiological features of acute and chronic hepatitis B in the Kyrgyz Republic over the 20-year period (1997-2017)

2018 ◽  
Vol 99 (6) ◽  
pp. 986-993 ◽  
Author(s):  
S T Tobokalova ◽  
D S Bekenova ◽  
G M Zairova ◽  
Z Sh Nurmatov ◽  
Zh N Nazarbaeva ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Chronic Hepatitis B ◽  
Kyrgyz Republic ◽  
Epidemiological Features ◽  
Acute Hepatitis B ◽  
Viral Hepatitis B ◽  
Acute And Chronic Hepatitis

Aim. To determine epidemiological features of acute and chronic viral hepatitis B in the Kyrgyz Republic over the period 1997-2017. Меthоds. Analysis was performed on data bases of the National accounting forms on treated cases of acute and chronic hepatitis B cumulated by the Medical Information Centre of the Ministry of Health of Kyrgyz Republic for the period of 1997 to 2017 as well as 384 medical records of patients with chronic hepatitis B treated in the Hepatologic Centre “Tsadmir”. Results. In the Kyrgyz Republic among all acute cases of acute viral hepatitides, hepatitis A comprises 60.5 %, hepatitis B - 16.9 %, the ratio of unverified non-A non-C viral hepatitis - 15.2%. With the introduction of HBV vaccination of children (2000) and improvement of infectious control in healthcare settings, a decline of acute HBV incidence is observed - from 26.7 0/0000 to 5.3 0/0000 due to the decrease of acute hepatitis B among children and adolescents to isolated cases, adults from risk groups. The highest incidence of acute hepatitis B is recorded in Osh and Bishkek, in Jalal-Abad and Chuy Regions. This can be explained by that in the southern and northern capitals of the Kyrgyz Republic and in the near lying areas with high population density, access to laboratory and instrumental methods of diagnosis of viral hepatitides is better, along with the higher awareness of its inhabitants regarding the prevention compared to other regions. At the same time an increase of chronic hepatitis B incidence is observed. Predominant modes of transmission are medical-parenteral exposure and household contact (60.9 %), with frequent formation of family clusters (23.8 %). Imperfections were found in the early detection, reporting and accounting of cases of chronic viral hepatitides as well as in examination of hepatitis B virus carriers. Conclusion. The performed analysis of the incidence and prevalence of acute and chronic hepatitis B in the Kyrgyz Republic allowed assessing the dynamics of the epidemiologic situation in the country regarding this disease, revealed shortcomings in the detection and examination of viral hepatitis B carriers, contributed to development of a new guide for epidemiological surveillance of viral hepatitides.

scholarly journals Acute viral hepatitis B complicated by acute pancreatitis.

2017 ◽  
Vol 16 (3) ◽  
pp. 455-457
Author(s):  
Mohammad Mushtaque Ahmad ◽  
Praveen Kumar Malik ◽  
Abhinav Jain ◽  
Shridhar Dwivedi
Keyword(s):  
Acute Pancreatitis ◽  
Hepatitis B ◽  
Liver Failure ◽  
Viral Hepatitis ◽  
Acute Viral Hepatitis ◽  
Medical Science ◽  
Radiological Features ◽  
Severe Pancreatitis ◽  
Acute Hepatitis B ◽  
Viral Hepatitis B

Majority of acute viral hepatitis cases resolve spontaneously in due course of time. Few cases that develop acute liver failure are prone to develop various complications, including acute pancreatitis. However, development of acute pancreatitis in patients with uncomplicated acute viral hepatitis is very rare and extremely rare in case of Acute Hepatitis B. In this case, a young boy with acute non-fulminant hepatitis B developed acute moderately severe pancreatitis, diagnosed by clinical, enzymatic and radiological features. He was managed conservatively and improved. Acute pancreatitis must be considered in patients with acute viral hepatitis who develop abdominal pain.Bangladesh Journal of Medical Science Vol.16(3) 2017 p.455-457

scholarly journals Clinical and biochemical manifestation of acute viral hepatitis B in Republic of Moldova

2014 ◽  
Vol 14 (S7) ◽  
Author(s):  
Lilia Cojuhari ◽  
Victor Pântea ◽  
Gheorghe Plăcintă ◽  
Valentin Cebotarescu ◽  
Olga Chirita ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
Acute Viral Hepatitis ◽  
Republic Of Moldova ◽  
Viral Hepatitis B

scholarly journals An Investigation into the High Prevalence of Hepatitis B in a Rural Area of Kerala State, India: Hypothesis on Chrysops sp. (Diptera: Tabanidae) Transmission

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Mariamma Kuriakose ◽  
Abraham M. Ittyachen
Keyword(s):  
Hepatitis B ◽  
Acute Viral Hepatitis ◽  
Field Studies ◽  
Southern India ◽  
Mechanical Transmission ◽  
Number Of Patients ◽  
High Prevalence ◽  
Acute Hepatitis B ◽  
Viral Hepatitis B ◽  
Kerala State

Objective. Since 2005 there have been several reports of hepatitis B outbreak in the state of Kerala in southern India. Objective of this study was to analyze such outbreaks and to explore hypothesis pertaining the transmission mode. Methods. Retrospective observational study involving cases of acute hepatitis B acquired between 1 January 2015 and 31 December 2015 and their family members residing in Mazhuvanoor village in Ernakulam district of Kerala State in southern India. Results. 59 houses were included in the survey. The number of patients diagnosed to have acute viral hepatitis B was 59. Majority (66.10%) were over 50 years old. There were no cases below the age of 15 years. All 59 patients claimed to have been bitten frequently by a fly which was identified as “deer fly” belonging to the genus Chrysops. Conclusion. Given the current understanding of mechanical transmission of pathogens in both humans and animals by insects belonging to the Tabanidae family which also includes Chrysops, it is plausible that the same mechanism may hold true for hepatitis B also. However this needs to be proven in further studies both at the laboratory level and at field studies.

Sign in / Sign up

Export Citation Format

Share Document