scholarly journals Gambaran Kadar Trombosit, Besar Limpa dan Kadar Albumin Serum pada Pasien Sirosis Hati dengan Varises Esofagus

2016 ◽  
Vol 5 (3) ◽  
Author(s):  
Vella Paraditha ◽  
Saptino Miro ◽  
Eti Yerizel
Keyword(s):  
Liver Cirrhosis ◽  
Platelet Count ◽  
Esophageal Varices ◽  
Albumin Level ◽  
Spleen Size ◽  
Medical Record Data ◽  
Cirrhosis Patient ◽  
Liver Cirrhosis Patient ◽  
Physical Laboratory ◽  
Record Data

Gambaran Kadar Trombosit, Besar Limpa dan Kadar AlbuminSerum pada Pasien Sirosis Hati dengan Varises EsofagusVella Paraditha1, Saptino Miro2, Eti Yerizel3AbstrakVarises esofagus merupakan komplikasi sirosis hati yang didiagnosis dengan endoskopi. Pada keadaantertentu, pemeriksaan endoskopi tidak dapat dilaksanakan, sehingga diperlukan cara lain sebagai alternatif untukmenilai varises esofagus. Tujuan penelitian ini adalah mengetahui gambaran kadar trombosit, besar limpa dan kadaralbumin serum pasien sirosis hati pada berbagai derajat varises esofagus. Penelitian ini berupa deskriptif retrospektifdengan instrumen data rekam medik pasien sirosis hati dengan varises esofagus yang telah menjalani pemeriksaanfisik, laboratorium dan endoskopi di RSUP dr. M. Djamil Padang dari Januari 2010 sampai Juli 2012. Sampel yangdidapatkan berjumlah 33 pasien. Sebagian besar pasien mengalami trombositopenia. Penurunan kadar trombosit tidakberhubungan dengan peningkatan derajat varises esofagus. Besar limpa pada sebagian besar pasien dengan varisesesofagus derajat 1, 2, maupun 3 adalah ≤ S1. Seluruh pasien mengalami hipoalbuminemia. Penurunan kadar albuminserum tidak berhubungan dengan peningkatan derajat varises esofagus. Penelitian ini menunjukkan bahwa penurunankadar trombosit dan kadar albumin serum tidak berhubungan dengan peningkatan derajat varises esofagus. Tidakterdapat perbedaan besar limpa yang signifikan antara pasien dengan varises esofagus derajat 1, 2, maupun 3.Direkomendasikan agar menggunakan jumlah sampel yang lebih banyak pada penelitian selanjutnya dan data yangdigunakan sebaiknya diperoleh dari pemeriksa yang sama.Kata kunci: kadar trombosit, besar limpa, kadar albumin, derajat varises esofagusAbstractEsophageal varices is a complication in liver cirrhosis which can be diagnosed by endoscopy. However, oncertain conditions, endoscopy examination can not be performed. Another method is needed as an alternative toassess the esophageal varices. The objective of this study was to recognize platelet count, spleen size and serumalbumin level of liver cirrhosis patient in each esophageal varices degree. This is a retrospective descriptive study. Theinstruments used in this study are the medical record data of liver cirrhosis patients that have esophageal varices, whohave undergone physical, laboratory and endoscopy examinations in dr. M. Djamil Hospital Padang on January 2010-July 2012. Thirty-three patients were eligible for this study. The most of patients had thrombocytopenia. The decreasein platelet count was not related to the increase in esophageal varices degree. Spleen size in most of patients with first,second, and third degree esophageal varices was ≤ S1. All of patients had hypoalbuminemia. The decrease in albuminlevel was not related to the increase in esophageal varices degree. This study showed that the decrease in plateletcount and albumin level were not related to the increase in esophageal varices degree. There was no significantdifference in spleen size between patients with first, second, or third degree esophageal varices.Keywords: platelet count, spleen size, albumin level, esophageal varices degree

scholarly journals Significance of Non-Invasive Markers as Predictor of Esophageal Varices in Liver Cirrhosis

2017 ◽  
Vol 56 (208) ◽  
pp. 412-6 ◽  
Author(s):  
Dipendra Khadka ◽  
Sushil Prajapati ◽  
Sudhamshu KC ◽  
Jeetendra Kaji Shrestha ◽  
Niyanta Karki ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Platelet Count ◽  
Esophageal Varices ◽  
Complete Blood Count ◽  
Clinical Expertise ◽  
Spleen Size ◽  
Cross Sectional ◽  
Cutoff Value ◽  
Non Invasive ◽  
Pugh Class

Introduction: Upper gastro-intestinal endoscopy remains the gold standard for screening for esophageal varices but it has its own limitations. It is an invasive, expensive and uncomfortable procedure and needs clinical expertise. Accordingly, this study was conducted to establish the role of non-invasive markers for prediction of esophageal varices in liver cirrhosis. Methods: A hospital based descriptive cross-sectional study was carried out in Liver unit of National Academy of Medical Sciences, Bir Hospital, from October 2016 to September 2017. Complete blood count, liver function test, liver ultrasound and upper gastro-intestinal endoscopy were done for all patients to detect esophageal varices and to correlate with different non-invasive markers. Results: Total 191 patients of liver cirrhosis were studied after exclusion. Platelet count of 92082.00±43435.83/mm3 and spleen size of 144.21±10.71 mm was found to be good predictors of presence of EV (P≤0.001). Significant association between Child-Turcotte-Pugh class and presence of varices was observed (P≤0.001). AST/ALT ratio with cutoff value of 1.415 showed sensitivity of 82.4% and specificity of 36.4%. APRI at a cutoff value of 1.3 showed a sensitivity of 83.2% and specificity of 50%. Conclusions: Platelet count, spleen size and Child-Turcotte-Pugh class are good predictors of presence of esophageal varices in patients with liver cirrhosis. AST/ALT ratio and APRI score are not good substitutes for upper gastro-intestinal endoscopy.   Keywords:  esophageal varices; liver cirrhosis; non-invasive markers; portal hypertension; upper gastro-intestinal.

scholarly journals Long-Term Outcome of Cardiac Surgery in 1,040 Liver Cirrhosis Patient　― Nationwide Population-Based Cohort Study ―

2017 ◽  
Vol 81 (4) ◽  
pp. 476-484 ◽  
Author(s):  
An-Hsun Chou ◽  
Tien-Hsing Chen ◽  
Chun-Yu Chen ◽  
Shao-Wei Chen ◽  
Chao-Wei Lee ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Liver Cirrhosis ◽  
Cohort Study ◽  
Population Based ◽  
Cirrhosis Patient ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Liver Cirrhosis Patient

scholarly journals Splenomegaly and thrombocytopenia in patients with liver cirrhosis

2010 ◽  
Vol 67 (2) ◽  
pp. 166-169 ◽  
Author(s):  
Jelena Djordjevic ◽  
Petar Svorcan ◽  
Dusica Vrinic ◽  
Branka Dapcevic
Keyword(s):  
Risk Factors ◽  
Liver Cirrhosis ◽  
Platelet Count ◽  
Portal Hypertension ◽  
Hepatic Dysfunction ◽  
Spleen Size ◽  
Hepatitis Viruses ◽  
Decompensated Liver Cirrhosis ◽  
Splenic Sequestration ◽  
Frequent Finding

Backgroud/Aim. Splenomegaly is a frequent finding in patients with liver cirrhosis and portal hypertension and may cause hypersplenism. The occurrence of thrombocytopenia in those patients can be considered as an event with multiple etiologies. Two mechanisms may act alone or synergistically with splenic sequestration. One is central which involves either myelosuppression because of hepatitis viruses or the toxic effects of alcohol abuse on the bone marrow. The second one involves the presence of antibodies against platelets. It also depends upon the stage and etiology of liver disease. The aim of the study was to investigate a correlation between the platelet count and spleen size and the risk factors for thrombocytopenia in patients with liver cirrhosis. Methods. We studied 40 patients with decompensated liver cirrhosis who were hospitalized in the Department of Gastroenterohepatology. The liver function was graded according to Child Pugh score. Spleen size was defined ultrasonografically on the basis of craniocaudal length. Suspicion of portal hypertension was present when longitudinal spleen length was more than 11 cm. Thrombocytopenia was determined by platelet count under 150 000/mL. Results. We did not find any significant correlation between hepatic dysfunction and spleen size (p = 0.9), and between hepatic dysfunction and thrombocytopenia (p = 0.17). Our study did not find any significant correlation between spleen size and peripheral platelet count (p = 0.5), but we found a significant correlation between thrombocytopenia and etiology of cirrhosis - decreased platelet count was more common among patients with cirrhosis of alcoholic etiology than in other etiologies of cirrhosis (p = 0.001). Conclusion. According to our study, liver cirrhosis, portal hypertension and thrombocytopenia could be present even in the absence of enlarged spleen suggesting the involvement of other mechanisms of decreasing platelet account.

scholarly journals Establishment of integration free iPSC clones, NCCSi011-A and NCCSi011-B from a liver cirrhosis patient of Indian origin with hepatic encephalopathy

2020 ◽  
Vol 48 ◽  
pp. 101992
Author(s):  
Arun Vaidyanath ◽  
Mohsina Khan ◽  
Bhumika Vaishnav ◽  
Arjun Lal Kakrani ◽  
Swapnil Patil ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatic Encephalopathy ◽  
Cirrhosis Patient ◽  
Liver Cirrhosis Patient ◽  
Indian Origin

scholarly journals Platelet Count/Spleen Diameter Ratio as a Predictor of Esophageal Varices in Patients with Liver Cirrhosis

2017 ◽  
Vol 15 (2) ◽  
pp. 37-40
Author(s):  
Dipendra Khadka ◽  
Sudhamshu KC ◽  
Sandip Khadka ◽  
Kiran Regmi ◽  
Pooja KC
Keyword(s):  
Liver Cirrhosis ◽  
Platelet Count ◽  
Esophageal Varices ◽  
Complete Blood Count ◽  
Liver Function Tests ◽  
Cross Sectional Study ◽  
Diameter Ratio ◽  
Cross Sectional ◽  
Predictive Values ◽  
Non Invasive

Introduction: Upper gastro-intestinal endoscopy still remains the gold standard for screening of patients suspected to have esophageal varices but not without limitations. So, this study was conducted to access the diagnostic validity and correlation between non-invasive parameters like platelet count, spleen diameter and their ratio with esophageal varices (EV) in patients with liver cirrhosis. Methods: A hospital based descriptive cross-sectional study was carried out in Liver unit of National Academy of Medical Sciences, Bir Hospital, from October 2016 to September 2017. Complete blood count, liver function tests, liver ultrasound and UGI endoscopy were done for all patients included in the study to detect esophageal varices and the platelet count/spleen diameter (PC/SD) ratio was calculated and analyzed to determine whether it can predict the presence of esophageal varices or not. Results: Total patients of liver cirrhosis studied after exclusion were 191 EV was present in 125 patients (65.4%). The platelet count/spleen diameter ratio using a cutoff value of ≤ 909 to detect EV independent of the grade had 93% sensitivity and 100% specificity and positive and negative predictive values of 100% and 91% respectively. Conclusions: PC/SD ratio now can be used as a predictor of presence of esophageal varices in liver cirrhosis.

scholarly journals Platelet Count/Splenic Diameter Ratio to Predict Oesophageal Varices in Portal Hypertension

2019 ◽  
Vol 2 (2) ◽  
pp. 192-196
Author(s):  
Buddhi Sagar Lamichhane ◽  
Manoj Koirala ◽  
Bishwo Raj Baral
Keyword(s):  
Liver Cirrhosis ◽  
Platelet Count ◽  
Portal Hypertension ◽  
Esophageal Varices ◽  
Rural Areas ◽  
Predictive Value ◽  
Tertiary Hospital ◽  
Diameter Ratio ◽  
Oesophageal Varices ◽  
Cirrhosis Of Liver

Background: One of the major causes of morbidity and mortality in Nepal is portal hypertension due to liver cirrhosis. In rural areas where a lot of cases of cirrhosis of liver are prevalent and endoscopic expertise and facilities are not available, predicting the presence of esophageal varices through non-invasive means may reduce a large number of unnecessary endoscopies. This study is to identify the relationship of platelet count /splenic bipolar diameter ratio with the presence of esophageal varices in portal hypertension. Materials and methods: Eighty patients were included in this study between Jestha 2072 to Baisakh 2073 with the diagnosis of portal hypertension admitted in Bir hospital, Kathmandu which is a tertiary hospital of government of Nepal, which were mostly due to liver cirrhosis. The patients fulfilling the inclusion criteria underwent lab investigations, ultra sonogram and UGI endoscopy. The data were assessed for descriptive studies and means were compared using t-test. The cut off value of platelet count to spleen diameter ratio of 1150 was used to predict the presence or absence of oesophageal varices. Statistical analysis was done using SPSS 20 software Results: Platelet count to splenic diameter ratio with a cut off value of 1150 has sensitivity of 89.7%, specificity of 83.3%, positive predictive value of 96.8% and negative predictive value of 58.8% (p= 0.002, CI=95%) with 89.5 % accuracy. Conclusion: Platelet count to splenic bipolar diameter ratio can be a good predictor of presence of esophageal varices in patients with portal hypertension in the resource poor settings.

scholarly journals A Case of Pasteurella multocida Subsp. multocida Septicemia due to Cat Bites in Liver Cirrhosis Patient

1995 ◽  
Vol 69 (11) ◽  
pp. 1302-1306 ◽  
Author(s):  
Takeshi SHIMIZU ◽  
Kiyoshi HASEGAWA ◽  
Youko MITSUHASHI ◽  
Shinji KOJIMA ◽  
Kayo ISHIKAWA ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Pasteurella Multocida ◽  
Cirrhosis Patient ◽  
Liver Cirrhosis Patient
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