scholarly journals Study on the interaction of some (E)-2-benzylidenebenzosuberone derivatives with serum albumin by UV-Vis method, inhibitory effect on topoisomerase

2020 ◽  
Vol 2 (1) ◽  
pp. 118-125
Author(s):  
Zsuzsanna Rozmer ◽  
◽  
Pál Perjési ◽  
Keyword(s):  
Serum Albumin ◽  
Inhibitory Effect

Lag phase alteration in the modified bovine serum albumin under the inducing and inhibitory effect of vitamin C

2018 ◽  
Vol 15 (6) ◽  
pp. 1337-1346
Author(s):  
E. Vahdat-Ahar ◽  
A. A. Moosavi-Movahedi ◽  
F. Taghavi ◽  
M. Habibi-Rezaei ◽  
N. Sheibani
Keyword(s):  
Bovine Serum Albumin ◽  
Vitamin C ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Inhibitory Effect ◽  
Lag Phase

scholarly journals THE BINDING OF FATTY ACIDS BY SERUM ALBUMIN, A PROTECTIVE GROWTH FACTOR IN BACTERIOLOGICAL MEDIA

1947 ◽  
Vol 86 (3) ◽  
pp. 215-228 ◽  
Author(s):  
Bernard D. Davis ◽  
René J. Dubos
Keyword(s):  
Oleic Acid ◽  
Fatty Acid ◽  
Growth Factor ◽  
Serum Albumin ◽  
Binding Capacity ◽  
Tween 80 ◽  
Inhibitory Effect ◽  
Liquid Media ◽  
Sorbitan Monooleate ◽  
The Media

Serum albumin is a protective bacterial growth factor; by binding traces of fatty acid in the media it permits initiation of growth by the smallest possible inocula of tubercle bacilli. Each molecule of albumin binds 3 to 6 molecules of oleic acid (1 to 2 per cent of the weight of the albumin) tightly enough to prevent bacteriostasis, and 9 molecules of oleic acid in equilibrium with a saturated neutral solution. The property requires undenatured albumin. Crystalline ß-lactoglobulin has a smaller capacity, and a number of other proteins no perceptible capacity to bind oleic acid. The inhibitory effect of the commercial product Tween 80 (polyoxyethylene sorbitan monooleate) on the growth of small inocula of tubercle bacilli in liquid media is caused by its content of unesterified oleic acid (0.6 per cent by weight). Purified Tween 80, freed of this contaminating fatty acid, not only permits growth of small inocula, but protects against small amounts of added oleic acid. The implications of the binding capacity of albumin for its possible physiological significance in the animal body (transport; protection against cytotoxins), and for the structure of the protein, are briefly discussed.

Inhibitory effect of human serum albumin on Cu-induced Aβ40 aggregation and toxicity

2015 ◽  
Vol 767 ◽  
pp. 160-164 ◽  
Author(s):  
Naihao Lu ◽  
Qin Yang ◽  
Jiayu Li ◽  
Rong Tian ◽  
Yi-Yuan Peng
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Inhibitory Effect

Effects of Cereal Prolamin Peptides on Differentiated CaCo-2 Cells

1996 ◽  
Vol 24 (4) ◽  
pp. 547-552
Author(s):  
Claudio Giovannini ◽  
Roberto Luchetti ◽  
Elena Mancini ◽  
Massimo de Vincenzi
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Cell Viability ◽  
Mtt Assay ◽  
Bovine Serum ◽  
Cytotoxic Effect ◽  
Cell Damage ◽  
Inhibitory Effect ◽  
Culture Cell ◽  
Glycoprotein Synthesis

The effects of peptic-tiyptic (PT) digests of prolamins derived from several cereals on differentiated CaCo-2 cells were studied on the nineteenth day of culture. Cell viability was determined by using the MTT assay and the colony-forming ability method. The metabolic consequences of peptide exposure were evaluated by measuring RNA, protein and glycoprotein synthesis. While PT digests from bovine serum albumin and durum wheat did not exert any effects, those derived from bread wheat, barley, rye and oats caused a dramatic inhibitory effect on metabolic synthesis and, when measured by using the colony-forming technique, a decrease in cell viability. The MTT assay did not indicate any changes in cell viability. These observations support the hypothesis that, although prolamin-derived peptides from these cereals do not exert an immediate cytotoxic effect, they are responsible for cell damage by impairment of metabolic processes.

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