Wpływ żywienia na występowanie nowotworów

2019 ◽  
Vol 22 (4) ◽  
Author(s):  
Paulina Zegartowska
Keyword(s):  
Blood Glucose ◽  
High Body Mass Index ◽  
Glycaemic Index ◽  
World Health ◽  
Postprandial Blood Glucose ◽  
High Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Risk Of Cancer ◽  
Diet And Lifestyle

Many studies conducted in recent years have shown that the incidence of cancer is still on the rise. According to the World Health Orgnization (WHO), most of these cases are a consequence of poor diet and lifestyle. Excess dietary carbohydrates, low-glycaemic index carbohydrates in particular, and low intake of fibre promote carcinogenesis. Many studies led to a conclusion that high body mass index (BMI) and waist to hip ratio (WHR) contribute to the risk of cancer. High blood glucose levels are one of the main factors predisposing to cancer. High postprandial blood glucose, which is most commonly observed in patients with type 2 diabetes, is also one of the factors that disturb metabolic transformations, which may promote carcinogenesis. It is worth following the principles of rational nutrition as part of cancer prevention. Manufacturers meet consumers' demands by developing improved food products, such as jams made from vegetables, which are higher in fibre and lower in sugar compared to fruit jams.

scholarly journals SYSTEMATIC REVIEW ON MEDICAMENTS USED IN MANAGEMENT OF DIABETES MELLITUS

2020 ◽  
pp. 21-29
Author(s):  
ANUPAM JAMWAL
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Low Income ◽  
Developed Countries ◽  
World Health ◽  
Low Income Countries ◽  
Limb Amputation ◽  
High Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels

Diabetes has a global prevalence in developed countries and rapidly flexing its roots in middle-and low-income countries. According to the World Health Organization, it is a major cause of kidney collapse, heart problems, and lower limb amputation. Diabetes mellitus is a metabolic disorder showing an uncontrolled increase in blood glucose levels. To date, no permanent cure has been developed for the complete restoration of impaired glucose haemostasis. With the use of therapeutic agents and nontherapeutic agents, glucose levels can be kept in control for a very long time. The foremost goal of all current ongoing treatments is to control high blood glucose levels, reduction in elevated lipid levels, and delay in the progression of diabetes-related complications. Various therapeutics agents are developed in recent decades, which shown very promising results in the management of diabetes mellitus. These agents prescribed after reviewing the clinical symptoms and situation of an individual patient. This review compiles noteworthy information related to clinically approved medicaments for diabetes mellitus. Review emphasis on categorization, mechanism of action, noted adverse effects along with the physiological responses of used medicines to treat diabetes mellitus.

scholarly journals KADAR GLUKOSA DARAH SEWAKTU PADA PASIEN DIABETES MELITUS TIPE 2 DI PUSKESMAS BAHU KOTA MANADO

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Suci M. J. Amir ◽  
Herlina Wungouw ◽  
Damajanty Pangemanan
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Community Health Center ◽  
World Health Organisation ◽  
World Health ◽  
High Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels

Abstract: World Health Organisation (WHO) predicts that the number of people with diabetes in Indonesia will increase from 8.4 million in 2000 to 21.3 million in 2030. Riskesdas in 2013 showed that North Sulawesi was one of the provinces with the highest prevalence of diabetes in Indonesia. Therefore, it is necessary to check blood glucose levels regularly for screening and diagnosis of diabetes mellitus. This study aimed to determine blood glucose levels in patients with type 2 diabetes mellitus (T2DM) in Community Health Center Bahu Manado. This study was a descriptive cross sectional study design. Respondents were 22 T2DM patients that had signed the informed consent. The results showed that of the 22 respondents, 11 (50%) had high blood glucose level with an average of 267.8 mg/dL, 4 (18.2%) had moderate high blood glucose level with an average of 153.2 mg/dL, and 7 (31.8%) had normal blood glucose level with an average of 123 mg/dL. Conclusion: Most of T2DM patients in Community Health Center Bahu Manado showed high blood glucose levels with poor blood glucose control.Keywords: type 2 diabetes, blood glucose levelAbstrak: World Health Organisation (WHO) memprediksi kenaikan jumlah penyandang diabetes melitus tipe 2 (DMT2) di Indonesia dari 8,4 juta pada tahun 2000 menjadi 21,3 juta pada tahun 2030. Laporan Riskesdas tahun 2013 menunjukkan bahwa Sulawesi Utara merupakan salah satu provinsi dengan angka prevalensi DMT2 yang tertinggi di Indonesia. Oleh karena itu diperlukan pemeriksaan kadar glukosa darah secara berkala untuk skrining dan diagnosis DMT2, salah satunya pemeriksaan glukosa darah sewaktu. Penelitian ini bertujuan untuk mengetahui kadar glukosa darah sewaktu pada pasien DMT2 di Puskesmas Bahu Kota Manado. Penelitian ini bersifat deskriptif dengan rancangan potong lintang. Didapatkan 22 pasien DMT2 yang bersedia menjadi responden serta menandatangani informed consent. Hasil penelitian menunjukkan bahwa dari 22 responden, 11 (50%) memiliki rerata kadar glukosa darah yang buruk yaitu 267,8 mg/dL, 4 (18,2%) memiliki kadar glukosa darah yang sedang dengan rerata 153,2 mg/dL, dan 7 (31,8%) memiliki kadar glukosa darah yang baik dengan rerata 123 mg/dL. Simpulan: Pasien DMT2 di Puskesmas Bahu Kota Manado menunjukkan sebagian besar memiliki rerata kadar glukosa darah sewaktu yang tinggi dengan kendali glukosa darah yang buruk.Kata kunci: DMT2, glukosa darah sewaktu

High Blood Glucose Levels Affect Auditory Brainstem Responses after Acoustic Overexposure in Rats

2021 ◽  
pp. 1-8
Author(s):  
Jae-Hun Lee ◽  
Sang Hee Ji ◽  
Jae Yun Jung ◽  
Min Young Lee ◽  
Chi-Kyou Lee
Keyword(s):  
Blood Glucose ◽  
Hearing Threshold ◽  
Auditory Brainstem ◽  
Diabetic Rats ◽  
Control Groups ◽  
High Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Hearing Function ◽  
Brainstem Response

Introduction: Diabetes mellitus (DM) is a systemic disease characterized by hyperglycemia and several pathological changes. DM-related hearing dysfunctions are associated with histological changes. Here, we explore hearing function and synaptic changes in the inner hair cells (IHCs) of rats with streptozotocin (STZ)-induced diabetes. Methods: STZ was injected to trigger diabetes. Rats with DM were exposed to narrow-band noise (105 dB SPL) for 2 h, and hearing function was analyzed 1, 3, 7, and 14 days later. Both the hearing threshold and the peak 1 amplitude of the tone auditory brainstem response were assessed. After the last functional test, animals were sacrificed for histological evaluation. Results: We found no changes in the baseline hearing threshold; however, the peak 1 amplitude at the low frequency (4 kHz) was significantly higher in both DM groups than in the control groups. The hearing threshold had not fully recovered at 14 days after diabetic rats were exposed to noise. The peak 1 amplitude at the higher frequencies (16 and 32 kHz) was significantly larger in both DM groups than in the control groups. The histological analysis revealed that the long-term DM group had significantly more synapses in the 16 kHz region than the other groups. Conclusions: We found that high blood glucose levels increased peak 1 amplitudes without changing the hearing threshold. Diabetic rats were less resilient in threshold changes and were less vulnerable to peak 1 amplitude and synaptic damage than control animals.

scholarly journals Evaluation of the impact of orally administered carbohydrates on postprandial blood glucose levels in different pre-clinical models

2016 ◽  
Vol 52 (4) ◽  
pp. 761-769 ◽  
Author(s):  
Any de Castro Ruiz Marques ◽  
Fabiana Percinoto Monteiro Schiavon ◽  
Patricia Batista Travassos ◽  
Vanessa Fontana Eik ◽  
Guilherme Godoy ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Postprandial Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Clinical Models ◽  
The Impact

Influence of glucose levels on clinical outcome after mechanical thrombectomy for large-vessel occlusion: a systematic review and meta-analysis

2021 ◽  
pp. neurintsurg-2021-017771
Author(s):  
Carlos Perez-Vega ◽  
Ricardo A Domingo ◽  
Shashwat Tripathi ◽  
Andres Ramos-Fresnedo ◽  
Samir Kashyap ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Clinical Outcome ◽  
Mechanical Thrombectomy ◽  
Meta Analysis ◽  
Large Vessel Occlusion ◽  
Vessel Occlusion ◽  
High Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Increased Risk

Mechanical thrombectomy (MT) represents the mainstay of treatment for patients with acute ischemic stroke due to large-vessel occlusion (LVO). Intravenous thrombolysis has been associated with worse clinical outcome in patients presenting with high blood glucose levels at admission; to date the true effect of hyperglycemia in the setting of MT has not been fully elucidated. In this meta-analysis, we analyzed the influence of high blood glucose levels at admission on clinical outcome after MT. Ovid EMBASE, PubMed, Scopus, and Cochrane Library databases were searched from their dates of inception up to March 2021. An initial search identified 2118 articles representing 1235 unique studies. After applying selection criteria, three prospective and five retrospective studies were analyzed, yielding a pooled cohort of 5861 patients (2041 who presented with hyperglycemia, and 3820 who presented with normal blood glucose levels). Patients in the hyperglycemia group were less likely to have a modified Ranking Scale (mRS) score <3 (risk ratio (RR): 0.65; 95% CI 0.59 to 0.72; p<0.0001; I2=13%), and had an increased risk of symptomatic intracranial hemorrhage (sICH) (RR: 2.07; 95% CI 1.65 to 2.60; p<0.0001; I2=0%) and mortality (RR: 1.73; 95% CI 1.57 to 1.91; p<0.0001; I2=0%). Patients who present with hyperglycemia and undergo MT for treatment of LVO have an increased risk of unfavorable clinical outcome, sICH, and mortality. Glucose levels at admission appear to be a prognostic factor in this subset of patients. Further studies should focus on evaluating control of the glucose level at admission as a modifiable risk factor in patients undergoing MT for LVO.

Sitagliptin: A DPP-4 Inhibitor for the Treatment of Type 2 Diabetes Mellitus

2011 ◽  
Vol 3 ◽  
pp. CMT.S6227 ◽  
Author(s):  
Kathryn MS Johnson ◽  
Kathleen Schurr
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Diabetes Therapy ◽  
High Blood Glucose ◽  
Adverse Side Effects ◽  
Glucose Levels ◽  
Blood Glucose Levels

Type 2 diabetes mellitus (T2DM) has become an epidemic, with worldwide projections indicating that more than 336 million people will be afflicted with the disease by 2030. T2DM is characterized by inappropriately high blood glucose levels due to a deficiency in insulin secretion, action, or both. Despite the horrific complications that occur with chronic elevations of blood glucose levels, less than half of those with T2DM do not maintain proper glycemic control. Sitagliptin (Januvia, Merck and Co., Whitehouse Station, New Jersey) is a novel diabetes therapy approved for use in the U.S. and Europe. This small molecule inhibits the activity of DPP-4, a peptidase that degrades the glucoregulatory hormone GLP-1. Sitagliptin increases glucoregulation in individuals with T2DM both as a monotherapy and in combination with other antihyperglycemic drugs, with a low risk of adverse side effects.

scholarly journals Effects of Various Blending Ratios of Rice and Waxy Barley on Postprandial Blood Glucose Levels

2018 ◽  
Vol 71 (6) ◽  
pp. 283-288
Author(s):  
Seiichiro Aoe ◽  
Kozo Komae ◽  
Yutaka Inoue ◽  
Isamu Murata ◽  
Yuki Minegishi ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Postprandial Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels

scholarly journals High activity enables life on a high-sugar diet: blood glucose regulation in nectar-feeding bats

2011 ◽  
Vol 278 (1724) ◽  
pp. 3490-3496 ◽  
Author(s):  
Detlev H. Kelm ◽  
Ralph Simon ◽  
Doreen Kuhlow ◽  
Christian C. Voigt ◽  
Michael Ristow
Keyword(s):  
Blood Glucose ◽  
High Activity ◽  
Flight Time ◽  
Floral Nectar ◽  
High Blood Glucose ◽  
Natural Diet ◽  
Glucose Levels ◽  
Nectar Feeding ◽  
Blood Glucose Levels ◽  
Normal Feeding

High blood glucose levels caused by excessive sugar consumption are detrimental to mammalian health and life expectancy. Despite consuming vast quantities of sugar-rich floral nectar, nectar-feeding bats are long-lived, provoking the question of how they regulate blood glucose. We investigated blood glucose levels in nectar-feeding bats ( Glossophaga soricina ) in experiments in which we varied the amount of dietary sugar or flight time. Blood glucose levels increased with the quantity of glucose ingested and exceeded 25 mmol l −1 blood in resting bats, which is among the highest values ever recorded in mammals fed sugar quantities similar to their natural diet. During normal feeding, blood glucose values decreased with increasing flight time, but only fell to expected values when bats spent 75 per cent of their time airborne. Either nectar-feeding bats have evolved mechanisms to avoid negative health effects of hyperglycaemia, or high activity is key to balancing blood glucose levels during foraging. We suggest that the coevolutionary specialization of bats towards a nectar diet was supported by the high activity and elevated metabolic rates of these bats. High activity may have conferred benefits to the bats in terms of behavioural interactions and foraging success, and is simultaneously likely to have increased their efficiency as plant pollinators.

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