Database Development and Topology Optimization for 3D Printed Microstructures

2021 ◽  
Author(s):  
Kiara L. McMillan ◽  
Pinar Acar
2019 ◽  
Vol 34 ◽  
pp. 683-694 ◽  
Author(s):  
Jiayi Wang ◽  
Santosh Reddy Sama ◽  
Paul C. Lynch ◽  
Guha Manogharan

Micromachines ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 579
Author(s):  
Yukihito Moritoki ◽  
Taichi Furukawa ◽  
Jinyi Sun ◽  
Minoru Yokoyama ◽  
Tomoyuki Shimono ◽  
...  

The development of handling technology for microscopic biological samples such as cells and spheroids has been required for the advancement of regenerative medicine and tissue engineering. In this study, we developed micro-tweezers with a compliant mechanism to manipulate organoids. The proposed method combines high-resolution microstereolithography that uses a blue laser and topology optimization for shape optimization of micro-tweezers. An actuation system was constructed using a linear motor stage with a force control system to operate the micro-tweezers. The deformation of the topology-optimized micro-tweezers was examined analytically and experimentally. The results verified that the displacement of the tweezer tip was proportional to the applied load; furthermore, the displacement was sufficient to grasp biological samples with an approximate diameter of several hundred micrometers. We experimentally demonstrated the manipulation of an organoid with a diameter of approximately 360 µm using the proposed micro-tweezers. Thus, combining microstereolithography and topology optimization to fabricate micro-tweezers can be potentially used in modifying tools capable of handling various biological samples.


2019 ◽  
Vol 61 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Ali Rıza Yıldız ◽  
Ulaş Aytaç Kılıçarpa ◽  
Emre Demirci ◽  
Mesut Doğan

2018 ◽  
Vol 56 (9) ◽  
pp. 801-808
Author(s):  
K. Wada ◽  
H. Sakurai ◽  
K. Takimoto ◽  
S. Yamamoto

2021 ◽  
Vol 11 (8) ◽  
pp. 3538
Author(s):  
Mauricio Arredondo-Soto ◽  
Enrique Cuan-Urquizo ◽  
Alfonso Gómez-Espinosa

Cellular Materials and Topology Optimization use a structured distribution of material to achieve specific mechanical properties. The controlled distribution of material often leads to several advantages including the customization of the resulting mechanical properties; this can be achieved following these two approaches. In this work, a review of these two as approaches used with compliance purposes applied at flexure level is presented. The related literature is assessed with the aim of clarifying how they can be used in tailoring stiffness of flexure elements. Basic concepts needed to understand the fundamental process of each approach are presented. Further, tailoring stiffness is described as an evolutionary process used in compliance applications. Additionally, works that used these approaches to tailor stiffness of flexure elements are described and categorized. Finally, concluding remarks and recommendations to further extend the study of these two approaches in tailoring the stiffness of flexure elements are discussed.


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