scholarly journals Comparative evaluation of chitosan-based multifunctional wound dressings: a multistage randomised controlled experimental trial

2021 ◽  
Vol 28 (3) ◽  
pp. 78-96
Author(s):  
D. I. Ushmarov ◽  
S. E. Gumenyuk ◽  
A. S. Gumenyuk ◽  
T. V. Gayvoronskaya ◽  
S. Ya. Karablina ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Wound Dressing ◽  
Soft Tissues ◽  
Comprehensive Evaluation ◽  
Statistical Significance ◽  
Wound Dressings ◽  
Male Rats ◽  
Traumatic Injuries ◽  
Good Laboratory ◽  
Randomised Controlled

Background. Wounds of various aetiology are among the most frequent traumatic injuries. A prospective route to improve treatment of this nosology is the development of novel or advancement of the already on-stage dressing materials.Objectives. A comparative experimental assay of novel chitosan-based wound dressings in the healing of soft tissue wounds of different genesis using ultrasound to control biodegradation of the developed dosage form.Methods. Soft tissue wounds were modelled in experimental animals, conventional and lineage male rats, 275 (± 25) g body weight, and male rabbits, 2,900 (± 150) g weight, using a proprietary methodology (Patent on invention RU No. 2703709 dated 23 August, 2018).Two wound dressing samples selected as most promising and applicable in large-volume soft tissue aseptic wounds were tested in the final step of experiment. Ultrasound imaging of the model wound area during the sample material biodegradation was used to control the wound process in more detail. At all steps of experiment, animal models were handled in compliance with GOST 33044-2014 “Principles of Good Laboratory Practice”.Histomorphological assays were carried out with common protocols. Variation statistics was used for the data analysis, including the mean (M) and standard mean error (± m) estimation. The level of statistical significance was p < 0.05.Results. The animal assays and comprehensive evaluation of the obtained data revealed a high healing efficacy of chitosan-based wound coatings. The analyses of wound dressing samples have confirmed their predesigned properties: scaffold stability, capillarity, biodegradability and matrix capacities for the carried drug delivery.Additionally, ultrasound was proved effective to estimate dynamics of the coated wound healing and biopolymer biodegradation processes.Conclusion. The developed chitosan-based wound dressings exhibited efficacy in an experimental model of the soft tissues wound process.The use of ultrasound to study dynamics of the wound process and coating biodegradation provided an adequate congruence between the imaging and tissue histomorphology data, as well as the structure and properties of coating material.

scholarly journals Retained Metallic Foreign Body in Cheek: A Diagnostic and Surgical Challenge

2013 ◽  
Vol 4 (2) ◽  
pp. 107-109
Author(s):  
Varsha Sunil Manekar ◽  
Ankush Chavan
Keyword(s):  
Foreign Body ◽  
Soft Tissue ◽  
Unusual Case ◽  
Foreign Bodies ◽  
Soft Tissues ◽  
Metallic Foreign Body ◽  
Industrial Accidents ◽  
Traumatic Injuries ◽  
Orofacial Region ◽  
Head Neck

ABSTRACT Foreign body lodged in the soft tissue is fairly common in the vehicular or industrial accidents. Traumatic injuries in orofacial region often drive foreign bodies in the soft tissues. The immediate closure of the soft tissue wounds become the emergency treatment for the control of bleeding. The foreign body may sometimes remain unnoticed. The purpose of reporting this unusual case of metallic foreign object in the cheek is to highlight the difficulties in detection of foreign bodies and discuss its clinical management. We also discuss the usefulness of various imaging modalities for assessment of its nature, location, size, shape and relation to vital structures. How to cite this article Manekar VS, Chavan A. Retained Metallic Foreign Body in Cheek: A Diagnostic and Surgical Challenge. Int J Head Neck Surg 2013;4(2):107-109.

Comparison of sterile polyacrylate wound dressing with activated carbon cloth and a standard non-adhesive hydrocellular foam dressing with silver: a randomised controlled trial protocol

2019 ◽  
Vol 28 (11) ◽  
pp. 722-728
Author(s):  
Sebastian Probst ◽  
Camille Saini ◽  
Monika Buehrer Skinner
Keyword(s):  
Wound Healing ◽  
Activated Carbon ◽  
Randomised Controlled Trial ◽  
Wound Dressing ◽  
Wound Care ◽  
Controlled Trial ◽  
Wound Dressings ◽  
Carbon Cloth ◽  
Activated Carbon Cloth ◽  
Randomised Controlled

Objective: Hard-to-heal wounds such as leg (LU) or diabetic foot ulcers (DFU) are slow healing, have a high recurrence rate and are associated with infection, smell and exudate. Current therapeutic approaches are multifaceted and focus on improving wound healing and preventing recurrences. Advanced wound dressings, especially super absorbent dressings are an important aspect of wound care, as hard-to-heal wounds tend to produce excessive amounts of exudate, which may contribute to maceration and excoriation, thus delaying wound healing. Additionally, excessive wound exudate is associated with malodour. Therefore, an important aspect of care is the management of exudate and odour. The use of effective advanced wound dressings is a promising strategy to achieve adequate absorption of wound exudate and malodour promoting wound healing. The aim of the current study is to determine whether there is a difference in wound size reduction between wounds dressed with either a sterile polyacrylate wound dressing with activated carbon cloth or a hydrocellular foam dressing with silver. Method: A randomised controlled trial with 248 participants in one wound care outpatient clinic is proposed. Randomisation will be concealed. The outcome assessor will be blinded to the group allocation of participants. Conclusion: This research project compares two wound dressings in an everyday care setting. Since the cost of hard-to-heal wounds to individuals, the economy and society is high, an evaluation of which wound dressing leads to a faster reduction of wound size and subsequent wound healing is an important issue/question for the individuals affected, their families, society and the health-care system.

scholarly journals SIMULATION OF WOUND PROCESS IN EXPERIMENTAL SURGERY

2019 ◽  
Vol 26 (2) ◽  
pp. 18-25
Author(s):  
Sergey E. Gumenyuk ◽  
Tatiana V. Gaivoronskaya ◽  
Alexander S. Gumenyuk ◽  
Denis I. Ushmarov ◽  
Diana R. Isyanova
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Animal Experiments ◽  
Porous Polymer ◽  
Cumulative Distribution ◽  
Male Rats ◽  
Layer By Layer ◽  
Morphological Studies ◽  
Polymer Implant ◽  
Study Results

Aim. To study morphological changes in aseptic and purulent soft-tissue wounds using the developed models in animal experiments.Materials and methods. The study was conducted on 70 white non-linear laboratory male rats aged 5 months and weighing 300–350 g. All the investigations were performed in accordance with ethical norms and documents regulating animal experiments. An experimental wound was simulated with the introduction of an implant into soft tissues using a layer-by-layer incision to the required depth. A sterile hydrophilic polymer implant was used for simulating an aseptic wound. A purulent wound was simulated using a porous polymer implant initially saturated with a suspension of a bacterial pathogen at a concentration of 10 5–10 12 microbial cells per 1 ml of suspension. The wounds were sutured layer by layer to form corresponding models. The implants was removed surgically on the 7th day. Statistical analysis of the study results was carried out by Windows 10 operating system using STATISTICA 6.1 (StatSoft Inc., USA) and Excel (Microsoft Offi ce 2010). The hypothesis of normal cumulative distribution in the samples was verifi ed via the Shapiro — Wilk and Kolmogorov — Smirnov tests. The signifi cance level threshold was set to p<0.05. Differences between quantitative parameters with a normal distribution were evaluated using the Student’s t-test, whereas independent samples were assessed via the non-parametric Mann — Whitney test. In all cases, differences were considered statistically signifi cant at p<0.05. The signifi cance level of the relationship between the two qualitative variables was verifi ed using the Pearson’s chi squared test (χ2 ). The study was approved at a meeting of the Independent Ethics Committee of the Kuban State Medical University (Minutes No. 63 of 21 May 2018).Results. The analysis of the obtained results has allowed optimal models for the formation of aseptic and purulent soft-tissue wounds in animal experiments to be selected.Conclusion. The proposed method of modeling aseptic and purulent wounds in animal experiments can be used in clinical and morphological studies of the wound process, as well as in assessing the effectiveness of various wound treatment methods. 

The Early Distribution of 239Pu, 241Am and 233U in the Soft Tissues and Skeleton of Old Rats. A Comparative Study

1983 ◽  
Vol 2 (1) ◽  
pp. 91-100 ◽  
Author(s):  
W. Sontag
Keyword(s):  
Soft Tissue ◽  
Comparative Study ◽  
Soft Tissues ◽  
Male Rats ◽  
Sprague Dawley ◽  
Old Rats ◽  
Radionuclide Activity

1 Female and male rats of the Sprague-Dawley strain, aged about 13 months, were injected intravenously with monomeric 239Pu-(0.83 μCi/kg), 241Am-(1.48 μCi/kg) or 233U-citrate (1.53 μCi/kg) and sacrificed 7 days and 28 days after injection. 2 The wet weights and the radionuclide contents of the organs and the different bones were measured. Whereas in the soft tissue organs the radionuclide activity differs between female and male rats and between 7 days and 28 days, in the bones the relative radionuclide contents show no differences except in the femora of the 239Pu and 233U animals which are significantly different at 7 days and 28 days.

scholarly journals Oral disorders in Chilean rodeo horses submitted for dental evaluation between 2010 and 2013

2016 ◽  
Vol 4 (3) ◽  
Author(s):  
Sebastian Guerra ◽  
Mario Pineda ◽  
Luis De Negri ◽  
Aiko Adell ◽  
Felipe Correa ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Confidence Intervals ◽  
Tissue Damage ◽  
Soft Tissues ◽  
Statistical Significance ◽  
Age Groups ◽  
Type I ◽  
Premolar Extraction ◽  
Dental Diseases ◽  
Oral Examinations

Dental disorders are common in horses. The objetive of the study was determined the frequency of dental problems in Chilean Rodeo Horses and described the most common dental treatments used in Chile. Oral examinations were performed on 456 Chilean rodeo horses and the disorders were observed as follows: Oral soft tissues, 259 horses (56%) presented lacerations and/or ulcers. Regarding the first premolar, it was present in 32% of the horses, all maxillary positioned. In canines, 245 (54%) were present and overlong tooth. Disorders found in incisors show supererupted (Tooth overlong) in 147 (32%); ventral curvature in 116 (25%), nevertheless 102 (22%) horses showed no abnormalities. About the diseases found in cheek teeth (premolars and molars), the more prevalent ones was enamel points in 426 (93%), rostral or caudal hooks in 354 (78%), and ramps in 231 (51%). Confidence intervals between all dental diseases found in the study showed no statistical significance when was analyzed for age or gender. When age groups were made, statistical significance appear X² Pearson (p=0,01), were mostly malocclusion type I was the more common in young, mature and geriatric horses. Other disorders such as problems at the time of eruption, development and periodontal disease are statiscally similar X² (p=0,07). About the treatments it is important to mention that in 453 (99%) horses received odontoplasty and 147 (32%) first premolar extraction. This study shows that Chilean rodeo horses have dental disorders similar to other horse breeds, except by small increase in soft tissue damage and incisors problems.

Internal Derangements of the Elbow

2019 ◽  
pp. 192-209
Author(s):  
Kathryn J. Stevens
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Imaging Modality ◽  
Joint Effusion ◽  
Stress Injury ◽  
Elbow Pain ◽  
Traumatic Injuries ◽  
Recreational Athletes ◽  
Tissue Contrast ◽  
Osteochondral Injury

Chapter 105 covers elbow pain, which is a common presenting complaint, particularly in professional or recreational athletes, and can result in significant morbidity. Although radiographs, US, and CT may have a role to play in the investigation of elbow pain, MRI with its high spatial resolution, excellent soft tissue contrast, and multiplanar imaging capabilities, has emerged as the imaging modality of choice for diagnosis of soft tissue pathology and osteochondral injury around the elbow. MRI is invaluable in the evaluation of acute traumatic injuries of bone and soft tissues structures, particularly if a joint effusion is detected radiographically. Articular cartilage is well seen on MRI, particularly in the presence of a joint effusion. MRI is also beneficial in the evaluation of chronic elbow pain and overuse injuries and can diagnose osseous stress injury, osteochondral pathology, ligamentous instability, nerve pathology, and denervation changes of muscle.

Orbital Dysmorphology in Unilateral Coronal Synostosis

1996 ◽  
Vol 33 (3) ◽  
pp. 190-197 ◽  
Author(s):  
Lun-Jou Lo ◽  
Jeffrey L. Marsh ◽  
Alex A. Kane ◽  
Michael W. Vannier
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Statistical Significance ◽  
Three Dimensional ◽  
Contralateral Side ◽  
Orbital Surgery ◽  
Orbital Cavity ◽  
Coronal Synostosis ◽  
The Difference ◽  
Tissue Contents

Unilateral coronal synostosis (UCS) produces overt craniofacial dysmorphology. UCS surgery in infancy aims to release the osseous restriction and normalize the fronto-orbital deformity. The quantitative effect of this surgery on the orbit and its contents is unknown. This study was conducted to quantify the preoperative orbital dysmorphology and its surgical outcome in patients with unilateral coronal synostosis. Twenty-eight UCS patients had preoperative three-dimensional computerized tomographic (CT) scans (at mean age 4.0 months), cranio-orbital reconstructive surgery (at 4.7 months), and postoperative scans (at 18.1 months). The CT data were analyzed using a computer workstation and AnalyzeTM biomedical imaging software. Four measurements were performed on both ipsilateral (same side as synostosis) and contralateral (opposite to synostosis) orbits of each scan: orbital index (OI, 100 × height/width of orbit), orbital cavity volume (OV), ocular globe volume (GV), and ventral globe index (VGI, 100 × globe volume ventral to the anterior surface of orbital cavity/GV). The data were analyzed for statistical significance using Student's t test. Preoperatively, the OI was significantly greater on the ipsilateral than on the contralateral side (113.7 vs. 87.3). There was a significant improvement on both sides of the orbit postoperatively, with ipsilateral 99.1 and contralateral 92.1. However, the difference between both sides remained significant. The OV was smaller in the ipsilateral orbits both pre- and postoperatively, with ipse/contralateral ratios of 95.8 and 95.2, respectively. Importantly, the GV was consistently smaller in the ipsilateral orbits preoperatively, with an ipse/contralateral ratio of 93.3. The ratio increased to 97.1 postoperatively, a statistically significant change. In the ipsilateral orbits, the preoperative VGI was significantly greater. The VGI improved postoperatively. These data indicate that UCS affects the development of the osseous orbit as well as its soft-tissue contents. After cranio-orbital surgery, there is diminution of asymmetry of both the bony orbit and its soft-tissue contents. Partial normalization of orbital dysmorphology occurred during the first postoperative year. UCS surgery in infancy does not prevent growth of orbital hard or soft tissues, and it seems to permit normalization of previously impaired growth.

scholarly journals Analysis of Factors Associated with Temporal Hollowing after Pterional Craniotomy

2020 ◽  
Vol 53 (01) ◽  
pp. 071-082
Author(s):  
Thanakorn Thiensri ◽  
Akaluk limpoka ◽  
Chairat Burusapat
Keyword(s):  
Soft Tissue ◽  
Predictive Factors ◽  
Operative Time ◽  
Soft Tissues ◽  
Statistical Significance ◽  
Preoperative Imaging ◽  
Temporalis Muscle ◽  
Temporal Area ◽  
Pterional Craniotomy ◽  
Soft Tissue Volume

Abstract Background Temporal hollowing is a common complication after pterional craniotomy. Etiologies of hollowing are still in debate and inconclusive. The objective of this study is to determine the etiology and predictive factors of temporal hollowing after pterional craniotomy. Methods A retrospective study of patients who underwent pterional craniotomy was conducted. Inclusion criteria included older than 18 years, having undergone unilateral pterional craniotomy, and with no craniofacial anomaly or temporal defect. Volumes of bone, temporalis muscle, and extratemporalis layer were calculated. Results A total of 51 patients were included. Bone volumes of surgical and nonsurgical sites were 219.12 + 23.02 cm3, and 228.39 + 22.76 cm3, respectively (p = 0.04). Difference of bony volume was 9.10 cm3 (3.99%). Volumes of temporalis muscle in surgical and nonsurgical sites were 12.86 + 3.95 cm3, and 18.10 + 6.08 cm3, respectively (p < 0.005). Difference of muscle volume was 5.08 cm3 (28.32%). Volume of extratemporalis soft tissue in surgical and nonsurgical sites were 11.99 + 5.70 cm3, and 17.31 + 7.76 cm3, respectively (p < 0.005). Difference of soft tissue volume was 5.56 cm3 (31.68%). No statistical significance of the difference of bony, muscle, and soft tissue volumes were found between causes of disease, operative time, and postoperative radiation. Conclusions Hollowing after pterional craniotomy is an unavoidable result. Bone, temporalis muscle, and soft tissues are combined etiologies. No predictive factors including age, sex, causes, operative time, radiation, and surgical technique are demonstrated. Volume of temporal area reduction was 19.74 cm3. Immediate reconstruction is recommended and volume of reconstruction is calculated from preoperative imaging.

Imaging Features of Primary Tumors of the Hand

2020 ◽  
Vol 16 ◽  
Author(s):  
Filippo Boriani ◽  
Edoardo Raposio ◽  
Costantino Errani
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Epithelioid Sarcoma ◽  
Case Series ◽  
Malignant Neoplasm ◽  
Benign Tumors ◽  
Imaging Features ◽  
Primary Tumors ◽  
Therapeutic Decisions ◽  
Tumors Of The Hand

: Musculoskeletal tumors of the hand are a rare entity and are divided into skeletal and soft tissue tumors. Either category comprises benign and malignant or even intermediate tumors. Basic radiology allows an optimal resolution of bone and related soft tissue areas, ultrasound and more sophisticated radiologic tools such as scintigraphy, CT and MRI allow a more accurate evaluation of tumor extent. Enchondroma is the most common benign tumor affecting bone, whereas chondrosarcoma is the most commonly represented malignant neoplasm localized to hand bones. In the soft tissues ganglions are the most common benign tumors and epithelioid sarcoma is the most frequently represented malignant tumor targeting hand soft tissues. The knowledge regarding diagnostic and therapeutic management of these tumors is often deriving from small case series, retrospective studies or even case reports. Evidences from prospective studies or controlled trials are limited and for this lack of clear and supported evidences data from the medical literature on the topic are controversial, in terms of demographics, clinical presentation, diagnosis prognosis and therapy.The correct recognition of the specific subtype and extension of the tumor through first line and second line radiology is essential for the surgeon, in order to effectively direct the therapeutic decisions.

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