scholarly journals Dietary Fiber's Effect on High Sensitivity C-reactive Protein Serum in Sedentary Workers

2021 ◽  
Vol 5 (1) ◽  
pp. 40
Author(s):  
Livia Kurniati Saputra ◽  
Dian Novita Chandra ◽  
Ninik Mudjihartini
Keyword(s):  
Body Weight ◽  
High Sensitivity ◽  
The Body ◽  
Low Grade ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Dietary Fiber Intake ◽  
Anti Inflammatory ◽  
Low Grade Inflammation ◽  
Inflammatory Effect

Low grade inflammation has been recognized of being involved in the pathogenesis of chronic disease pandemic. Individual lifestyle plays a major role in the development of low grade inflammation. Sedentary workers are at risk of low grade inflammation due to the nature of their work. Dietary habit also contributes to inflammatory status in the body. Dietary fiber intake indirectly affects the immune system. It has been hypothesized that fiber has anti-inflammatory effects, both body weight-related and body weight-unrelated This review will focus more on body weight-unrelated anti-inflammatory effect of fiber, especially through fiber’s fermentation metabolites, the short chain fatty acid (SCFA). Its anti-inflammatory effect can be seen by monitoring a biomarker of inflammation in the body, the high sensitivity C-reactive protein (hsCRP). This review’s objective is to cover the mechanisms and role of dietary fiber intake on serum hsCRP level as a marker of low grade inflammation on sedentary workers. 

Analysis of variability of high sensitivity C‐reactive protein in lowland ecuador reveals no evidence of chronic low‐grade inflammation

2012 ◽  
Vol 24 (5) ◽  
pp. 675-681 ◽  
Author(s):  
Thomas W. Mcdade ◽  
Paula S. Tallman ◽  
Felicia C. Madimenos ◽  
Melissa A. Liebert ◽  
Tara J. Cepon ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Low Grade ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Low Grade Inflammation

scholarly journals C-Reactive Protein Levels Among U.S. Adults Exposed to Parental Incarceration

2014 ◽  
Vol 17 (5) ◽  
pp. 574-584 ◽  
Author(s):  
Samantha J. Boch ◽  
Jodi L. Ford
Keyword(s):  
Multinomial Logistic Regression ◽  
Childhood Adversity ◽  
High Sensitivity ◽  
Parental Incarceration ◽  
Low Grade ◽  
Adult Health ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Low Grade Inflammation

Previous studies have linked childhood adversity to low-grade inflammation via C-reactive protein (CRP) levels. This study analyzed the association between low-grade inflammation and prior biological parental incarceration. Data from the National Longitudinal Study of Adolescent to Adult Health (1994–2008) were analyzed using multinomial logistic regression models. Measures included high-sensitivity (hs)-CRP (<3 mg/L = reference, 3–10 mg/L = low-grade inflammation, and >10 mg/L = acute inflammation), parent incarceration occurring in the child’s lifetime, and frequency and timing of incarceration with respect to child’s age (0–18 years or >18 years vs. never) of incarceration. Analyses were stratified by child’s gender. Final sample sizes were n = 5,396 males and n = 6,447 females for maternal incarceration and n = 4,956 males and n = 5,860 females for paternal incarceration. In models with and without potential mediators, females whose fathers were ever incarcerated were more likely to have hs-CRP levels of 3–10 mg/L than females whose fathers were never incarcerated (adjusted odds ratio [AOR]: 1.44, 95% confidence interval [CI]: [1.09, 1.91]). Additionally, daughter’s age (<18 years; AOR: 1.48, 95% CI: [1.11, 1.97]) and frequency of father’s incarceration were significant (AOR: 1.24, 95% CI: [1.04, 1.49]). No mediating effects were observed. Males whose fathers were incarcerated when they were ≥18 years were less likely to have hs-CRP levels of 3–10 mg/L than those whose father was never incarcerated; the association was nonsignificant in the mediated model. Further investigation is needed on the physiological effects of exposure to parental incarceration and interventions to support children.

scholarly journals Effect of Moderate-Intensity Exercise on Plasma C-Reactive Protein and Aortic Endothelial Function in Type 2 Diabetic Mice

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Nada Sallam ◽  
Majid Khazaei ◽  
Ismail Laher
Keyword(s):  
Body Weight ◽  
Endothelial Function ◽  
Moderate Intensity ◽  
Low Grade ◽  
C Reactive Protein ◽  
Moderate Intensity Exercise ◽  
Necrosis Factor Alpha ◽  
Reactive Protein ◽  
Low Grade Inflammation ◽  
Aortic Endothelial

The aim of this study was to evaluate the effects of moderate-intensity exercise on plasma levels of C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) as markers of low-grade inflammation and endothelial function in diabetic (db/db) mice. Control and db/db mice were divided into sedentary and exercised groups. Aortic endothelial function was evaluated after two- and six-week exercises using a wire myograph. Plasma CRP levels were measured at baseline, and after two and six weeks of exercise. Baseline plasma CRP levels were significantly higher in db/db mice compared to control (P<.05). After two weeks of exercise, aortic endothelial function was significantly improved without affecting body weight or plasma CRP levels. Six weeks of exercise not only improved endothelial function, but also significantly reduced body weight and plasma CRP levels in db/db mice. Thus short-term exercise has beneficial effect on endothelial function without reducing low-grade inflammation while more prolonged exercise periods are required to reduce inflammatory markers.

scholarly journals A Prophetic Medicine: Potential Therapeutic Effect of Nigella sativa for Osteoarthritis

2020 ◽  
Vol 1 (2) ◽  
pp. 68-73
Author(s):  
Aufar Zimamuz Zaman Al Hajiri ◽  
Diaz Syafrie Abdillah ◽  
Mohammad Qoimam Bilqisthi Zulfikar
Keyword(s):  
Therapeutic Agent ◽  
Nigella Sativa ◽  
Complementary Therapy ◽  
The Body ◽  
C Reactive Protein ◽  
Toxicological Effects ◽  
Reactive Protein ◽  
Herbal Plants ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Osteoarthritis (OA) is the most common type of arthritis (inflammation of the joints). OA can affect all cartilage throughout the body, including the spine, but mainly attacks the legs from the pelvis, especially the knee to the ankle which affects about 10% of men and 18% of women over 60 years old. Pharmacotherapy, surgery, and complementary therapy are the currently managements of OA. Nigella sativa (NS) is one of the herbal plants which is part of the prophet's medicines in the Islamic world which still used. Thymoquinone (TQ) is one of NS compound, has an anti-inflammatory effect by inhibit the formation of eicosanoids in leukocytes and lipid peroxidation, or inhibit the expression of PF NF-κB subunits and p50 subunits with TNF-a promoters, and reduce levels of C-reactive protein (CRP). TQ also has a chondroprotective effects mechanism by decreases prostaglandin E2 (PGE) mediated by IL-1β and inhibits MMP synthesis in chondrocytes. Through its anti-inflammatory and chondroprotective effect, NS is a potential therapeutic agent which beneficial use for OA management without toxicological effects when given.

scholarly journals Oxidative Stress Is Increased in Combined Oral Contraceptives Users and Is Positively Associated with High-Sensitivity C-Reactive Protein

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1070
Author(s):  
Sabina Cauci ◽  
Serena Xodo ◽  
Cinzia Buligan ◽  
Chiara Colaninno ◽  
Mattia Barbina ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Sensitivity ◽  
Low Grade ◽  
Strong Positive Correlation ◽  
Obese Women ◽  
C Reactive Protein ◽  
Oxidative Stress Biomarkers ◽  
Free Oxygen Radical ◽  
Reactive Protein ◽  
Healthy Women

Information concerning the mechanisms underlying oxidative stress and low-grade inflammation in young healthy women predisposing eventually to future diseases is scarce. We investigated the relationship of oxidative stress and high-sensitivity C-reactive protein (hsCRP) in fertile-age women by oral combined contraceptive (OC) use. Caucasian Italian healthy non-obese women (n = 290; 100 OC-users; 190 non-OC-users; mean age 23.2 ± 4.7 years) were analyzed. Blood hydroperoxides, as oxidative stress biomarkers, were assessed by Free Oxygen Radical Test (FORT). Serum hsCRP was determined by an ultra-sensitive method (hsCRP). Markedly elevated oxidative stress (≥400 FORT Units) was found in 77.0% of OC-users and 1.6% of non-OC-users, odds ratio (OR) = 209, 95% CI = 60.9–715.4, p < 0.001. Elevated hsCRP levels ≥ 2.0 mg/L, considered risky for cardiovascular diseases (CVDs), were found in 41.0% of OC-users and 9.5% of non-OC-users, OR = 6.6, 95%CI 3.5–12.4, p < 0.001. Hydroperoxides were strongly positively correlated to hsCRP in all women (rs = 0.622, p < 0.001), in OC-users (rs = 0.442, p < 0.001), and in non-OC-users (rs = 0.426, p < 0.001). Women with hydroperoxides ≥ 400 FORT Units were eight times as likely to have hsCRP ≥ 2 mg/L. In non-OC-users only, hydroperoxides values were positively correlated with weight and body mass index, but negatively correlated with red meat, fish and chocolate consumption. Our research is the first finding a strong positive correlation of serum hydroperoxides with hsCRP, a marker of low-grade chronic inflammation, in young healthy women. Further research is needed to elucidate the potential role of these two biomarkers in OC-use associated side-effects, like thromboembolism and other CVDs.

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