Histoplasmosis affecting oral mucosa in an immunocompetent patient: A rarity in non-disseminated disease

Nocardia brasiliensis is the most common cause of cutaneous nocardiosis. Nocardia pseudobrasiliensis is an emerging species responsible for invasive and disseminated disease in immunocompromised patients. We describe a case of a 67-year-old immunocompetent patient without significant past medical history diagnosed with primary cutaneous nocardiosis with N pseudobrasiliensis as the causative organism. In our opinion, we report the first case of primary cutaneous nocardiosis in an immunocompetent patient with N pseudobrasiliensis being the causative agent.

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Adrenal histoplasmosis : a rare cause of bilateral adrenomegaly

Journal of Society of Surgeons of Nepal ◽

10.3126/jssn.v17i1.15181 ◽

2016 ◽

Vol 17 (1) ◽

pp. 42-43

Author(s):

PP Subedi ◽

S Chapagain ◽

DK Thakur ◽

S Poudyal ◽

BR Luitel ◽

...

Keyword(s):

Opportunistic Infection ◽

Histoplasma Capsulatum ◽

Immunocompetent Patient ◽

Dimorphic Fungus ◽

Disseminated Disease

Histoplasmosis is an opportunistic infection caused by a dimorphic fungus Histoplasma capsulatum. Histoplasmosis causing bilateral adrenal involvement is rare and usually occurs only in immunocompromised individuals with disseminated disease. Here we report a case of bilateral adrenal histoplasmosis with disseminated disease in an immunocompetent patient.

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Disseminated Cryptococcosis in an Immunocompetent Patient: A Case Report

Case Reports in Pathology ◽

10.1155/2012/652351 ◽

2012 ◽

Vol 2012 ◽

pp. 1-3 ◽

Cited By ~ 5

Author(s):

S. Suchitha ◽

C. S. Sheeladevi ◽

R. Sunila ◽

G. V. Manjunath

Keyword(s):

Needle Aspiration ◽

Immunocompetent Patient ◽

Aspiration Cytology ◽

Fine Needle ◽

Cryptococcal Infection ◽

Immunodeficiency Virus ◽

The World ◽

Cerebral Involvement ◽

Needle Aspiration Cytology ◽

Disseminated Disease

Cryptococcus neoformansis ubiquitous encapsulated yeast found throughout the world. It predominantly causes significant infections in immunocompromised individuals, of which 80–90% occur in people with human immunodeficiency virus (HIV) infection. Disseminated cryptococcal infection is uncommon and almost always occurs in HIV-infected patients. Disseminated disease, especially noncutaneous cryptococcal abscess in immunocompetent hosts, is exceedingly rare. We report a case of disseminated cryptococcosis with soft tissue, pulmonary, and cerebral involvement in an otherwise healthy immunocompetent patient initially diagnosed by fine needle aspiration cytology (FNAC).

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Trichosporon japonicum Fungemia and Ventricular Assist Device Infection in an Immunocompetent Patient

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz343 ◽

2019 ◽

Vol 6 (9) ◽

Cited By ~ 1

Author(s):

Felix Bongomin ◽

Akaninyene Otu ◽

Giorgio Calisti ◽

Malcolm D Richardson ◽

James Barnard ◽

...

Keyword(s):

Ventricular Assist Device ◽

Immunocompetent Patient ◽

Immunocompromised Patients ◽

Assist Device ◽

Ventricular Assist ◽

Biventricular Assist Device ◽

Device Infection ◽

Life Threatening ◽

Trichosporon Species ◽

Disseminated Disease

Abstract Trichosporon species are emerging opportunistic yeasts that cause life-threatening disseminated disease in severely immunocompromised patients. Trichosporon japonicum is a very rare cause of invasive trichosporonosis. We describe a case of Trichosporon japonicum fungemia in an immunocompetent patient with a transcutaneous biventricular assist device.

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PULMONARY ASPERGILLOSIS LEADING TO DISSEMINATED DISEASE IN AN IMMUNOCOMPETENT PATIENT

CHEST Journal ◽

10.1016/j.chest.2019.08.663 ◽

2019 ◽

Vol 156 (4) ◽

pp. A685

Author(s):

Lovin Pappy ◽

Sandy Lee ◽

Asha Shah ◽

Michael Bernstein

Keyword(s):

Immunocompetent Patient ◽

Pulmonary Aspergillosis ◽

Disseminated Disease

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Myelitis due to Coccidioidomycosis in an Immunocompetent Patient

Case Reports in Infectious Diseases ◽

10.1155/2018/2176269 ◽

2018 ◽

Vol 2018 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Tetyana Vaysman ◽

Sean Villaflores ◽

Carlyn Estrella ◽

Suman Radhakrishna ◽

Antonio Liu

Keyword(s):

Altered Mental Status ◽

Immunocompetent Patient ◽

Resonance Imaging ◽

Fatal Complication ◽

Significant Past Medical History ◽

Uncommon Presentation ◽

Magnetic Resonance Imaging Mri ◽

Mri Study ◽

Disseminated Disease ◽

The Brain

Myelitis of the spinal cord is an uncommon presentation of disseminated coccidioidomycosis. Most infected patients present subclinically, but patients, especially those who are immunocompromised, may progress to disseminated disease. We present a 50-year-old immunocompetent patient with no significant past medical history exhibiting symptoms of altered mental status, dizziness, headache, nausea, and quadriplegia. Upon investigation with lumbar puncture, cerebrospinal fluid (CSF) culture, and coccidioidal antibody studies, the patient was found to have acute coccidioidomycosis. Magnetic resonance imaging (MRI) of the brain demonstrated meningeal enhancements suggestive of meningitis, and further MRI study of the cervical spine revealed myelitis. Treatment with IV fluconazole for 2 weeks and IV voriconazole therapy over 3 weeks yielded limited improvement. The presentation of myelitis due to coccidioidomycosis infection is very rare and has infrequently reported in the literature. Awareness of this potentially fatal complication in immunocompetent patients can aid in faster recognition and treatment.

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Simultaneous Occurrence of Ocular, Disseminated Mucocutaneous, and Multivisceral Involvement of Leishmaniasis

Case Reports in Infectious Diseases ◽

10.1155/2014/837625 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4 ◽

Cited By ~ 3

Author(s):

Cyriac Abby Philips ◽

Chetan Ramesh Kalal ◽

K. N. Chandan Kumar ◽

Chhagan Bihari ◽

Shiv Kumar Sarin

Keyword(s):

Bone Marrow ◽

Visceral Leishmaniasis ◽

New World ◽

Case Reports ◽

Bone Marrow Involvement ◽

Immunocompetent Patient ◽

Simultaneous Occurrence ◽

Ocular Involvement ◽

Disseminated Disease ◽

Visceral Disease

Leishmaniasis is a tropical infection caused by the protozoan, belonging to the group ofLeishmaniawhich causes Old World and New World disease. These are typically divided into cutaneous, mucocutaneous, visceral, viscerotropic, and disseminated disease. Cutaneous leishmaniasis in the presence of visceral disease is a rarity. Isolated case reports have documented this occurrence, in the immunocompromised setting, and few otherwise. The concurrent presence of visceral leishmaniasis (bone marrow involvement) with solitary cutaneous and ocular disease and also solitary cutaneous and visceral disease (bone marrow involvement) has been reported before. Here, we present an immunocompetent patient who was diagnosed to have visceral leishmaniasis (liver and bone marrow involvement) along with simultaneous disseminated mucocutaneous and ocular involvement, a combination that has never been reported before.

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Induction and Differentiation of Dental Epithelium in Vivo and in Vitro

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100053425 ◽

1982 ◽

Vol 40 ◽

pp. 142-145

Author(s):

E. J. Kollar

Keyword(s):

Connective Tissue ◽

Oral Mucosa ◽

Basal Lamina ◽

Functional Derivatives ◽

Specific Source ◽

Dental Epithelium ◽

Connective Tissue Stroma

The differentiation and maintenance of many specialized epithelial structures are dependent on the underlying connective tissue stroma and on an intact basal lamina. These requirements are especially stringent in the development and maintenance of the skin and oral mucosa. The keratinization patterns of thin or thick cornified layers as well as the appearance of specialized functional derivatives such as hair and teeth can be correlated with the specific source of stroma which supports these differentiated expressions.

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