scholarly journals Simultaneous Occurrence of Ocular, Disseminated Mucocutaneous, and Multivisceral Involvement of Leishmaniasis

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Cyriac Abby Philips ◽  
Chetan Ramesh Kalal ◽  
K. N. Chandan Kumar ◽  
Chhagan Bihari ◽  
Shiv Kumar Sarin
Keyword(s):  
Bone Marrow ◽  
Visceral Leishmaniasis ◽  
New World ◽  
Case Reports ◽  
Bone Marrow Involvement ◽  
Immunocompetent Patient ◽  
Simultaneous Occurrence ◽  
Ocular Involvement ◽  
Disseminated Disease ◽  
Visceral Disease

Leishmaniasis is a tropical infection caused by the protozoan, belonging to the group ofLeishmaniawhich causes Old World and New World disease. These are typically divided into cutaneous, mucocutaneous, visceral, viscerotropic, and disseminated disease. Cutaneous leishmaniasis in the presence of visceral disease is a rarity. Isolated case reports have documented this occurrence, in the immunocompromised setting, and few otherwise. The concurrent presence of visceral leishmaniasis (bone marrow involvement) with solitary cutaneous and ocular disease and also solitary cutaneous and visceral disease (bone marrow involvement) has been reported before. Here, we present an immunocompetent patient who was diagnosed to have visceral leishmaniasis (liver and bone marrow involvement) along with simultaneous disseminated mucocutaneous and ocular involvement, a combination that has never been reported before.

scholarly journals Bone marrow involvement as a rare manifestation of relapsed choroidal melanoma

2020 ◽  
Vol 8 (8) ◽  
pp. 3110
Author(s):  
Nusrat Bashir ◽  
Farzana Manzoor ◽  
Bilal Musharaf ◽  
Ruby Reshi
Keyword(s):  
Bone Marrow ◽  
Case Reports ◽  
Bone Marrow Involvement ◽  
Choroidal Melanoma ◽  
Bone Marrow Aspiration ◽  
Bone Marrow Metastasis ◽  
Common Site ◽  
Immune Histochemistry ◽  
Rare Manifestation ◽  
Disseminated Disease

Choroidal Melanoma is the most common primary intra-ocular malignancy. Incidence of primary choroidal melanoma is about 6 cases per 1 million population. It disseminates hematogenously. The most common site of metastasis is liver. Metastatic melanoma involving the bone marrow is rare, occurring in 5% of patients with disseminated disease. However, Choroid melanoma with bone marrow involvement is very rare. Only a few case reports are published in literature.  Authors present a case of bone marrow metastasis from choroid melanoma in 55 years old female who has been treated for primary choroidal melanoma by enucleation of left eye three years back. In the evaluation of symptomatic anemia, features suggestive of bone marrow infiltration by choroidal melanoma were observed on bone marrow aspiration and biopsy. The diagnosis was confirmed by positivity of immune-histochemistry markers HMB-45 and Melana.

scholarly journals Postmortem Findings in Italian Patients With COVID-19: A Descriptive Full Autopsy Study of Cases With and Without Comorbidities

2020 ◽  
Vol 222 (11) ◽  
pp. 1807-1815 ◽  
Author(s):  
Laura Falasca ◽  
Roberta Nardacci ◽  
Daniele Colombo ◽  
Eleonora Lalle ◽  
Antonino Di Caro ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Case Reports ◽  
Bone Marrow Involvement ◽  
Whole Body ◽  
Pathological Features ◽  
Autopsy Study ◽  
Multisystem Disease ◽  
Transmission Electron ◽  
Significant Pathology ◽  
Postmortem Studies

Abstract Background Descriptions of the pathological features of coronavirus disease-2019 (COVID-19) caused by the novel zoonotic pathogen severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emanate from tissue biopsies, case reports, and small postmortem studies restricted to the lung and specific organs. Whole-body autopsy studies of COVID-19 patients have been sparse. Methods To further define the pathology caused by SARS-CoV-2 across all body organs, we performed autopsies on 22 patients with COVID-19 (18 with comorbidities and 4 without comorbidities) who died at the National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS Hospital, Rome, Italy. Tissues from the lung, heart, liver, kidney, spleen, and bone marrow (but not the brain) were examined. Only lung tissues were subject to transmission electron microscopy. Results COVID-19 caused multisystem pathology. Pulmonary and cardiovascular involvement were dominant pathological features. Extrapulmonary manifestations included hepatic, kidney, splenic, and bone marrow involvement, and microvascular injury and thrombosis were also detected. These findings were similar in patients with or without preexisting medical comorbidities. Conclusions SARS-CoV-2 infection causes multisystem disease and significant pathology in most organs in patients with and without comorbidities.

scholarly journals Peripheral blood and bone marrow involvement by visceral leishmaniasis

Blood ◽  
2017 ◽  
Vol 130 (5) ◽  
pp. 692-692 ◽  
Author(s):  
Parker W. Clement ◽  
K. David Li
Keyword(s):  
Bone Marrow ◽  
Visceral Leishmaniasis ◽  
Peripheral Blood ◽  
Bone Marrow Involvement

Unusual primary presentations of mantle cell lymphoma in the urinary tract and testes.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e18503-e18503
Author(s):  
Deniz Peker ◽  
Timothy Edward Kubal ◽  
Eduardo M. Sotomayor ◽  
Lubomir Sokol ◽  
Jennifer L. Cultrera ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Urinary Tract ◽  
Complete Remission ◽  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
Bone Marrow Involvement ◽  
Genitourinary Tract ◽  
Cancer Center ◽  
Mantle Cell ◽  
Disseminated Disease

e18503 Background: The initial clinical presentation of Mantle Cell Lymphoma is protean, ranging from single sites of indolent disease followed for years without therapy to aggressive disseminated disease that requires treatment within weeks of diagnosis. While many cases of Mantle Cell Lymphoma present with disseminated disease, other patients may present with symptoms related to a primary extranodal site of disease. The majority of these primary extranodal cases are diagnosed in the gastrointestinal tract, other cases have been noted in the skin, conjunctiva, testes and male genitourinary tract. Methods: Database review of 204 patients diagnosed with Mantle Cell Lymphoma at Moffitt Cancer Center between May 1992 and December 2010. Results: Three cases of Mantle Cell Lymphoma presented with symptoms related to primary extranodal sites in the urinary tract and male genital organs. Two cases of testicular involvement presented with gradual enlargement of the testes. In patient 1, the orchiectomy specimen harbored both seminoma and mantle cell lymphoma. Low level bone marrow involvement by mantle cell lymphoma was present and in the presence of indolent features he was treated for his primary seminoma and followed expectantly for mantle cell lymphoma. In patient 2, orchiectomy revealed a pleomorphic variant of mantle cell lymphoma with no other sites of disease on staging workup. He was treated with 6 cycles of R-CHOP and prophylactic IT methotrexate with a complete remission. A third patient presented with obstructive urinary symptoms and was found to have mantle cell lymphoma of the prostate. Additional staging revealed diffuse lymphadenopathy, colon and bone marrow involvement. A complete remission was obtained with 6 cycles of R-CHOP. None of these three patients was found to have evidence of CNS involvement at diagnosis or in followup with only the second patient receiving intrathecal prophylaxis. Conclusions: Mantle Cell Lymphoma may present with unusual extranodal involvement at diagnosis including sites and symptoms related to the genitourinary tract and testes. Diagnostic lumbar puncture and intrathecal prophylaxis should be considered in these patients.

scholarly journals Bone marrow granulomatosis: two case reports

2019 ◽  
Vol 13 (3) ◽  
pp. 181-184
Author(s):  
Giacomo Andreani ◽  
Alessandro Morotti ◽  
Matteo Dragani ◽  
Francesca Caciolli ◽  
Bruna Crea ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Case Reports ◽  
Bone Marrow Involvement ◽  
Common Finding ◽  
Diagnostic Challenge ◽  
Muscle Invasive Bladder Cancer ◽  
Causative Factors ◽  
Wide Range ◽  
Mycobacterium Avium Intracellulare ◽  
Muscle Invasive

Bone marrow granulomatosis is not a common finding and remains a diagnostic challenge. Here below we report two bizarre but not so rare cases of bone marrow granulomatosis: bone marrow involvement by Mycobacterium avium-intracellulare and reaction to intravesical administration of Bacillus Calmette-Guérin for non-muscle-invasive bladder cancer; two distinct culprits suggesting the wide range of possible causative factors of this histopathological pattern. In the discussion we provide a brief overview of causes and suggestions for a diagnostic approach.

scholarly journals Extensive vascular thrombosis in immunocompetent patients with acute cytomegalovirus infection: a case report of a peculiar phenomenon

2020 ◽  
Vol 7 (11) ◽  
pp. 5070-5072
Author(s):  
Gida Ayada ◽  
Gal Sahaf Levin ◽  
Tamar Gottesman ◽  
Shaul Lev
Keyword(s):  
Case Reports ◽  
Immunocompetent Patient ◽  
Ocular Involvement ◽  
Cmv Infection ◽  
Case Presentation ◽  
Vascular Thrombosis ◽  
Therapeutic Anticoagulation ◽  
Rare Manifestation ◽  
Acute Cytomegalovirus ◽  
Immunocompetent Patients

Background: acute Cytomegalovirus (CMV) infection in the immunocompetent usually asymptomatic or may present as a mononucleosis syndrome, but sometimes it is present as colitis, meningitis, encephalitis, or as ocular involvement and others. Thrombosis is considered an extremely rare manifestation described only in a scarce number of case reports.   Case presentation: a 30-years-old immunocompetent patient present with extensive vascular thrombosis shortly after a diagnosis of CMV infectious mononucleosis was established. Other than morbid obesity, no other risk factors existed. Therapeutic anticoagulation was associated with clinical improvement.   Conclusion: CMV infection can be associated with acute venous thrombosis in immunocompetent patients. An active search for both underlying prothrombotic conditions and other organ involvement sounds reasonable and should be treated, if found, accordingly.

scholarly journals Could (Disseminated and Residual) Minimal Disease be a useful prognostic marker in non-Hodgkin paediatric Lymphomas?

2014 ◽  
Vol 8 (2) ◽  
pp. 37-44
Author(s):  
Lara Mussolin ◽  
Marta Pillon ◽  
Giuseppe Basso
Keyword(s):  
Bone Marrow ◽  
Hodgkin Lymphoma ◽  
Residual Disease ◽  
Bone Marrow Involvement ◽  
Tumour Cells ◽  
Non Hodgkin Lymphoma ◽  
Long Time ◽  
Risk Patients ◽  
Minimal Disseminated Disease ◽  
Disseminated Disease

Minimal Disseminated Disease (MDD) represents the small number of tumour cells in the patients' bone marrow at the time of diagnosis, whereas Minimal Residual Disease (MRD) represents the small number of tumour cells remaining in the bone marrow during treatment. Generally, MDD and MRD are measured by polymerase chain reaction, a highly sensitive technique. For a long time, bone marrow involvement has been considered an uncommon event in solid tumours. However, in recent years, several studies demonstrated that MDD and MRD could be powerful tools in paediatric non-Hodgkin lymphoma for stratifying patients in different prognostic groups. Risk stratification in future clinical trials on non-Hodgkin lymphoma based on these newly identified risk categories should be useful to improve therapies in order to increase survival for high-risk patients and decrease toxicity for low-risk patients.

scholarly journals Evaluation of qPCR on blood and skin microbiopsies, peripheral blood buffy coat smear, and urine antigen ELISA for diagnosis and test of cure for visceral leishmaniasis in HIV-coinfected patients in India: a prospective cohort study

BMJ Open ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. e042519
Author(s):  
Sophie I Owen ◽  
Sakib Burza ◽  
Shiril Kumar ◽  
Neena Verma ◽  
Raman Mahajan ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Visceral Leishmaniasis ◽  
Hiv Infection ◽  
Peripheral Blood ◽  
Medical Science ◽  
Bone Marrow Aspiration ◽  
Buffy Coat ◽  
Tropical Medicine ◽  
Urine Antigen ◽  
Antigen Elisa

IntroductionHIV coinfection presents a challenge for diagnosis of visceral leishmaniasis (VL). Invasive splenic or bone marrow aspiration with microscopic visualisation of Leishmania parasites remains the gold standard for diagnosis of VL in HIV-coinfected patients. Furthermore, a test of cure by splenic or bone marrow aspiration is required as patients with VL-HIV infection are at a high risk of treatment failure. However, there remain financial, implementation and safety costs to these invasive techniques which severely limit their use under field conditions.Methods and analysisWe aim to evaluate blood and skin qPCR, peripheral blood buffy coat smear microscopy and urine antigen ELISA as non-invasive or minimally invasive alternatives for diagnosis and post-treatment test of cure for VL in HIV-coinfected patients in India, using a sample of 91 patients with parasitologically confirmed symptomatic VL-HIV infection.Ethics and disseminationEthical approval for this study has been granted by The Liverpool School of Tropical Medicine, The Institute of Tropical Medicine in Antwerp, the University of Antwerp and the Rajendra Memorial Research Institute of Medical Science in Patna. Any future publications will be published in open access journals.Trial registration numberCTRI/2019/03/017908.

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