Skin microbiomein adult atopic dermatitis

2018 ◽  
pp. 209-214
Author(s):  
О.В. Кандалова ◽  
И.В. Елистратова ◽  
О.Б. Иванченко ◽  
А.В. Гречко ◽  
С.Г. Морозов
Keyword(s):  
Atopic Dermatitis ◽  
Environmental Factors ◽  
Bacterial Infection ◽  
Adaptive Immunity ◽  
Bacterial Contamination ◽  
Proteolytic Enzymes ◽  
Regulatory Proteins ◽  
Skin Microbiome ◽  
Innate And Adaptive Immunity

Данный миниобзор посвящен изучению роли микробиома кожи и, в частности, роли стафилококков в обострении атопического дерматита у взрослых людей. Были проанализированы предпосылки бактериальной контаминации кожи и роль факторов внешней среды. Представлены данные по влиянию S. aureaus на разные звенья природного и адаптивного иммунитета за счет синтеза специфических регуляторных белков, протеолитических ферментов и гидролаз. Обозначены некоторые направления борьбы с бактериальной инфекцией для предупреждения обострения атопического дерматита у взрослых. In this mini review we have analyzed the role of skin microbiome in the atopic dermatitis relapse in adults, in particular, a role of S. aureaus in this process. The background for the skin bacterial contamination under the influence of environmental factors has been analyzed. We reviewed some S. aureaus effects on the components of innate and adaptive immunity due to the secretion of specific regulatory proteins, a number of proteolytic enzymes, and some hydrolases. There were indicated some ways to eliminate the bacterial infection to prevent the atopic dermatitis relapse in adults

scholarly journals The Skin and Gut Microbiome and Its Role in Common Dermatologic Conditions

2019 ◽  
Vol 7 (11) ◽  
pp. 550 ◽  
Author(s):  
Samantha R. Ellis ◽  
Mimi Nguyen ◽  
Alexandra R. Vaughn ◽  
Manisha Notay ◽  
Waqas A. Burney ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Environmental Factors ◽  
Gut Microbiome ◽  
The Body ◽  
Skin Microbiome ◽  
Disease States ◽  
Normal Microflora ◽  
The Impact ◽  
The Relationship

Microorganisms inhabit various areas of the body, including the gut and skin, and are important in maintaining homeostasis. Changes to the normal microflora due to genetic or environmental factors can contribute to the development of various disease states. In this review, we will discuss the relationship between the gut and skin microbiome and various dermatological diseases including acne, psoriasis, rosacea, and atopic dermatitis. In addition, we will discuss the impact of treatment on the microbiome and the role of probiotics.

scholarly journals The Implications of Pruritogens in the Pathogenesis of Atopic Dermatitis

2021 ◽  
Vol 22 (13) ◽  
pp. 7227
Author(s):  
Lai-San Wong ◽  
Yu-Ta Yen ◽  
Chih-Hung Lee
Keyword(s):  
Atopic Dermatitis ◽  
Environmental Factors ◽  
Immune Responses ◽  
Immune Cells ◽  
Inflammatory Disease ◽  
Targeted Therapies ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Inflammatory Molecules

Atopic dermatitis (AD) is a prototypic inflammatory disease that presents with intense itching. The pathophysiology of AD is multifactorial, involving environmental factors, genetic susceptibility, skin barrier function, and immune responses. A recent understanding of pruritus transmission provides more information about the role of pruritogens in the pathogenesis of AD. There is evidence that pruritogens are not only responsible for eliciting pruritus, but also interact with immune cells and act as inflammatory mediators, which exacerbate the severity of AD. In this review, we discuss the interaction between pruritogens and inflammatory molecules and summarize the targeted therapies for AD.

ROLE OF INNATE AND ADAPTIVE IMMUNITY ON ATHEROSCLEROSIS IN SUBJECTS WITH FAMILIAL HYPERCHOLESTEROLEMIA

2019 ◽  
Vol 73 (9) ◽  
pp. 1867
Author(s):  
Maria Cristina Izar ◽  
Waleria Fonzar ◽  
Francisco Fonseca ◽  
Henrique Fonseca ◽  
Tuany P. Silva ◽  
...  
Keyword(s):  
Familial Hypercholesterolemia ◽  
Adaptive Immunity ◽  
Innate And Adaptive Immunity

scholarly journals Sexual dimorphism in immune function: The role of sex steroid hormones

2018 ◽  
Vol 51 ◽  
pp. 02007
Author(s):  
Anna Mihailova ◽  
Indrikis Krams
Keyword(s):  
Immune System ◽  
Sexual Dimorphism ◽  
Infectious Diseases ◽  
Immune Function ◽  
Steroid Hormones ◽  
Adaptive Immunity ◽  
Gonadal Hormones ◽  
Sex Steroid ◽  
Innate And Adaptive Immunity

There is evidence of the relation of sex steroid hormones and sexual dimorphism in immune system response to infectious diseases. The aim of this review was to identify the role of sex hormones in immune function and sexual dimorphism of immune reactions. Gonadal hormones together with the immune system play an important role in process of immune responses to the disease [1]. Estrogens, progesterone and testosterone have different impacts on immune cells and different gonadal hormones are of high importance for responses of innate and adaptive immunity [1, 2]. Estrogens mainly enhance immune function while testosterone has a suppressive role. Higher progesterone during pregnancy leads to autoimmune disease remission and an elevated susceptibility toward certain infectious diseases [2, 3, 4]. The intensity and prevalence of viral infections are typically higher in males, whereas disease outcome could be worse for females [5]. Sexual dimorphism of immune function is based on different concentrations of sex hormones in males and females and on a specific mediating role of these hormones in immune function and response along with differences in innate and adaptive immunity.

scholarly journals The role of the skin microbiome in atopic dermatitis

2019 ◽  
Vol 122 (3) ◽  
pp. 263-269 ◽  
Author(s):  
Teruaki Nakatsuji ◽  
Richard L. Gallo
Keyword(s):  
Atopic Dermatitis ◽  
Skin Microbiome

scholarly journals Exploring the Role of Staphylococcus Aureus Toxins in Atopic Dermatitis

Toxins ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 321 ◽  
Author(s):  
Fabio Seiti Yamada Yoshikawa ◽  
Josenilson Feitosa de Lima ◽  
Maria Notomi Sato ◽  
Yasmin Álefe Leuzzi Ramos ◽  
Valeria Aoki ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Complex Disease ◽  
Skin Barrier ◽  
Inflammatory Skin Disease ◽  
Innate And Adaptive Immunity ◽  
Concise Review ◽  
Intense Pruritus ◽  
Immunological Factors

Atopic dermatitis (AD) is a chronic and inflammatory skin disease with intense pruritus and xerosis. AD pathogenesis is multifactorial, involving genetic, environmental, and immunological factors, including the participation of Staphylococcus aureus. This bacterium colonizes up to 30–100% of AD skin and its virulence factors are responsible for its pathogenicity and antimicrobial survival. This is a concise review of S. aureus superantigen-activated signaling pathways, highlighting their involvement in AD pathogenesis, with an emphasis on skin barrier disruption, innate and adaptive immunity dysfunction, and microbiome alterations. A better understanding of the combined mechanisms of AD pathogenesis may enhance the development of future targeted therapies for this complex disease.

scholarly journals Role of IL-5 in Innate and Adaptive Immunity to LarvalStrongyloides stercoralisin Mice

2000 ◽  
Vol 165 (8) ◽  
pp. 4544-4551 ◽  
Author(s):  
De’Broski R. Herbert ◽  
James J. Lee ◽  
Nancy A. Lee ◽  
Thomas J. Nolan ◽  
Gerhard A. Schad ◽  
...  
Keyword(s):  
Adaptive Immunity ◽  
Innate And Adaptive Immunity

scholarly journals The Role of Innate and Adaptive Immunity in Parkinson's Disease

2013 ◽  
Vol 3 (4) ◽  
pp. 493-514 ◽  
Author(s):  
George T. Kannarkat ◽  
Jeremy M. Boss ◽  
Malú G. Tansey
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Adaptive Immunity ◽  
Innate And Adaptive Immunity
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