A Systematic Review and Meta-analysis of the Mortality Rate of Electroconvulsive Therapy (ECT)

2017 ◽  
Author(s):  
Soren Dinesen Ostergaard
Keyword(s):  
Systematic Review ◽  
Mortality Rate ◽  
Electroconvulsive Therapy ◽  
Meta Analysis

762. The Mortality Rate of Electroconvulsive Therapy: Results from a Systematic Review and Meta-Analysis

2017 ◽  
Vol 81 (10) ◽  
pp. S309-S310
Author(s):  
Nina Torring ◽  
Sohag N Sanghani ◽  
Georgios Petrides ◽  
Charles H Kellner ◽  
Soren Dinesen Ostergaard
Keyword(s):  
Systematic Review ◽  
Mortality Rate ◽  
Electroconvulsive Therapy ◽  
Meta Analysis

A systematic review and meta-analysis of the mortality rate of electroconvulsive therapy (ECT)

2017 ◽  
Vol 41 (S1) ◽  
pp. S375-S375
Author(s):  
N. Torring ◽  
S.N. Sanghani ◽  
G. Petrides ◽  
C.H. Kellner ◽  
S.D. Ostergaard
Keyword(s):  
Systematic Review ◽  
Mortality Rate ◽  
Electroconvulsive Therapy ◽  
Meta Analysis ◽  
Risk Of Death ◽  
Full Picture ◽  
Competing Interest ◽  
Meta Analyses ◽  
Specific Number ◽  
Related Mortality

IntroductionElectroconvulsive therapy (ECT) is an efficacious treatment for many mental disorders, but is underutilized because of fears of adverse effects, including the risk of death.Objectives and aimsTo provide a full picture of the magnitude of ECT-related mortality worldwide.MethodsWe performed a systematic review and meta-analysis (PubMed and Embase) in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. Only publications reporting on a specific number of ECT treatments as well as specific number of ECT-related deaths were included in our analysis. The ECT-related mortality rate was calculated by dividing the total number of ECT-related deaths by the total number of ECT treatments. The 95% confidence interval (95% CI) of this estimate was calculated using Bernoullis principle of distribution.ResultsFourteen studies with data from 32 countries reporting on a total of 757,662 ECT treatments met the predefined inclusion criteria. Fifteen cases of ECT-related death were reported – yielding an ECT-related mortality rate of 2.0 per 100,000 treatments (95% CI: 1.0–3.0). In the eight studies published after 2001 (covering 406,229 treatments), no ECT-related deaths were reported.ConclusionsThe ECT-related mortality rate was estimated at 2 per 100,000 treatments. For comparison, a recent meta-analysis on the mortality of general anaesthesia in relation to surgical procedures reported a mortality rate of 3.4 per 100,000. Thus, our systematic review and meta-analysis documents that death caused by ECT is extremely rare. This information can be used to reassure patients in need of ECT.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Repetitive transcranial magnetic stimulation treatment for peripartum depression: systematic review & meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hyune June Lee ◽  
Sung Min Kim ◽  
Ji Yean Kwon
Keyword(s):  
Systematic Review ◽  
Transcranial Magnetic Stimulation ◽  
Side Effects ◽  
Electroconvulsive Therapy ◽  
Effect Size ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Peripartum Depression

Abstract Background Peripartum depression is a common disorder with very high potential hazards for both the patients and their babies. The typical treatment options include antidepressants and electroconvulsive therapy. However, these treatments do not ensure the safety of the fetus. Recently, repetitive transcranial magnetic stimulation has emerged as a promising treatment for neuropathies as well as depression. Nevertheless, many studies excluded pregnant women. This systematic review was conducted to confirm whether repetitive transcranial magnetic stimulation was a suitable treatment option for peripartum depression. Methods We performed a systematic review that followed the PRISMA guidelines. We searched for studies in the MEDLINE, PsycINFO, EMBASE, and Cochrane library databases published until the end of September 2020. Eleven studies were selected for the systematic review, and five studies were selected for quantitative synthesis. Data analysis was conducted using Comprehensive Meta-Analysis 3 software. The effect size was analyzed using the standardized mean difference, and the 95% confidence interval (CI) was determined by the generic inverse variance estimation method. Results The therapeutic effect size of repetitive transcranial magnetic stimulation for peripartum depression was 1.394 (95% CI: 0.944–1.843), and the sensitivity analysis effect size was 1.074 (95% CI: 0.689–1.459), indicating a significant effect. The side effect size of repetitive transcranial magnetic stimulation for peripartum depression was 0.346 (95% CI: 0.214–0.506), a meaningful result. There were no severe side effects to the mothers or fetuses. Conclusions From various perspectives, repetitive transcranial magnetic stimulation can be considered an alternative treatment to treat peripartum depression to avoid exposure of fetuses to drugs and the severe side effects of electroconvulsive therapy. Further research is required to increase confidence in the results.

Intracranial Hypertension After Spontaneous Intracerebral Hemorrhage: A Systematic Review and Meta-analysis of Prevalence and Mortality Rate

2018 ◽  
Vol 31 (1) ◽  
pp. 176-187 ◽  
Author(s):  
Daniel Agustín Godoy ◽  
Rafael A. Núñez-Patiño ◽  
Andres Zorrilla-Vaca ◽  
Wendy C. Ziai ◽  
J. Claude Hemphill
Keyword(s):  
Systematic Review ◽  
Mortality Rate ◽  
Intracerebral Hemorrhage ◽  
Intracranial Hypertension ◽  
Meta Analysis ◽  
Spontaneous Intracerebral Hemorrhage

scholarly journals Effect of electroconvulsive therapy on hippocampal and amygdala volumes: systematic review and meta-analysis

2018 ◽  
Vol 212 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Akihiro Takamiya ◽  
Jun Ku Chung ◽  
Kuo-ching Liang ◽  
Ariel Graff-Guerrero ◽  
Masaru Mimura ◽  
...  
Keyword(s):  
Systematic Review ◽  
Electroconvulsive Therapy ◽  
Animal Studies ◽  
Brain Volume ◽  
Meta Analysis ◽  
Brain Structures ◽  
Volume Increase ◽  
Left Hippocampus ◽  
Before And After ◽  
Underlying Mechanisms

BackgroundElectroconvulsive therapy (ECT) is one of the most effective treatments for depression, although the underlying mechanisms remain unclear. Animal studies have shown that electroconvulsive shock induced neuroplastic changes in the hippocampus.AimsTo summarise volumetric magnetic resonance imaging studies investigating the effects of ECT on limbic brain structures.MethodA systematic review and meta-analysis was conducted to assess volumetric changes of each side of the hippocampus and amygdala before and after ECT. Standardised mean difference (SMD) was calculated.ResultsA total of 8 studies (n = 193) were selected for our analyses. Both right and left hippocampal and amygdala volumes increased after ECT. Meta-regression analyses revealed that age, percentage of those responding and percentage of those in remission were negatively associated with volume increases in the left hippocampus.ConclusionsECT increased brain volume in the limbic structures. The clinical relevance of volume increase needs further investigation.Declaration of interestNone.

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