Endometrial adenocarcinoma: an accurate diagnosis is possible on routine liquid based cervical cytology

2018 ◽  
Author(s):  
Andreas Luebke ◽  
Andrea Hinsch
Keyword(s):  
Endometrial Adenocarcinoma ◽  
Accurate Diagnosis ◽  
Cervical Cytology

scholarly journals Correlation of colposcopy with biopsy in cases of abnormal cervical cytology

2019 ◽  
Vol 14 (1) ◽  
pp. 36-39
Author(s):  
Kirtipal Subedi
Keyword(s):  
Predictive Value ◽  
Prospective Observational Study ◽  
Accurate Diagnosis ◽  
Cervical Cytology ◽  
Histopathological Diagnosis ◽  
Cervical Biopsy ◽  
Abnormal Cervical Cytology ◽  
Disease Threshold ◽  
Sensitivity Specificity

Aims: This study aims to find out the role of colposcopy and its correlation with cervical biopsy in detection of pre malignant cervical lesion. Methodology: This is hospital based prospective observational study on 60 cases with abnormal cervical cytology reports conducted in the Department of Obstetrics and Gynecology, PMWH, Thapathali, Kathmandu. Colposcopy guided biopsies were done and findings noted. Results: Among 60 cases enrolled in the study the most common cervical cytology finding was ASCUS, LSIL, HSIL and ASC-H present in 46.6%, 31.6%, 15% and 6.6% respectively.  The colposcopy finding among these cases was normal, CIN1, CIN 2 and CIN 3 in 45%, 23.3%, 16.7% and 9% respectively. Among these cases the most common biopsy finding was normal, CIN 1, CIN 2, CIN 3 and squamous cell carcinoma in 55%, 18.3%, 8.3%, 15% and 3.3% respectively. The sensitivity, specificity, positive predictive value and negative predictive value of colposcopy with CIN 1 as disease threshold was calculated to be 80.6%, 93.1%, 81.8% and 92.6% respectively. While evaluating the validity of colposcopy with histopathology, colposcopy seems to make an accurate diagnosis in 75% of cases, overestimating in 15% and underestimating in 8% of cases. Conclusions: There is a good correlation of colposcopy with histopathological diagnosis of cervical cancer. Keywords: colposcopy, cytology, diagnosis, premalignant  

scholarly journals Detecting uterine glandular lesions: Role of cervical cytology

CytoJournal ◽  
2016 ◽  
Vol 13 ◽  
pp. 3 ◽  
Author(s):  
Baneet Bansal ◽  
Parikshaa Gupta ◽  
Nalini Gupta ◽  
Arvind Rajwanshi ◽  
Vanita Suri
Keyword(s):  
Diagnostic Accuracy ◽  
Sensitivity And Specificity ◽  
Endometrial Adenocarcinoma ◽  
Cervical Cytology ◽  
Glandular Cell ◽  
Pap Smears ◽  
Diagnostic Utility ◽  
Endocervical Adenocarcinoma ◽  
Liquid Based Cytology

Background: The sensitivity of cervical cytology for detection of glandular lesions is reported to be low. We conducted this study to assess the diagnostic accuracy of cervical Papanicolaou (Pap) smears for uterine glandular lesions and to compare the diagnostic utility of conventional and liquid-based cytology (LBC) smears for glandular lesions. Materials and Methods: Archived histopathology records of all cases reported as endocervical and endometrial adenocarcinoma in the study period were identified and the available corresponding Pap smears (in preceding 1 year) were retrieved. In addition, the Pap smears reported as glandular cell abnormalities (GCA) during the same study period were retrieved. The overall prevalence of GCA, sensitivity, and specificity of Pap smears for the detection of GCA was calculated. The diagnostic accuracy of conventional and LBC smears for the diagnosis of GCA was also compared. Results: The prevalence of GCA in our study was 0.32%. The overall specificity of Pap smears for the diagnosis of GCA was 60.8%, this was not significantly different between conventional and LBC smears (P = 0.4). The overall sensitivity of Pap smears for the detection of GCA was 41.8%; LBC smears had significantly better sensitivity as compared to conventional smears for the detection of endometrial as compared to endocervical adenocarcinoma (P < 0.05). Conclusions: The prevalence of GCA in Pap smears is low. The specificity of Pap smears, for diagnosis of GCA, was found to be moderate. However, the overall sensitivity of Pap smears for the detection of GCA was low, though better for LBC as compared to conventional smears.

Cervical Cytology and Immunohistochemical Features in Endometrial Adenocarcinoma Simulating Microglandular Hyperplasia

2000 ◽  
Vol 44 (4) ◽  
pp. 661-666 ◽  
Author(s):  
Vinod B. Shidham ◽  
Anne M. Dayer ◽  
Zainab Basir ◽  
Andre Kajdacsy-Balla
Keyword(s):  
Endometrial Adenocarcinoma ◽  
Cervical Cytology

Endometrial adenocarcinoma mimicking cervical glandular neoplasia in liquid-based cervical cytology samples

Cytopathology ◽  
2012 ◽  
Vol 24 (2) ◽  
pp. 138-140
Author(s):  
S. A. Thiryayi ◽  
N. Narine ◽  
D. N. Rana
Keyword(s):  
Endometrial Adenocarcinoma ◽  
Cervical Cytology

Immunocytochemical localization of β1-4 galactosyltransferase in endometrial carcinoma cells

1990 ◽  
Vol 48 (3) ◽  
pp. 944-945
Author(s):  
Ichiro Yamamoto ◽  
Toshiaki Tachibana ◽  
Hiroko Maruyama ◽  
Noriyuki Komatsu ◽  
Hiroyuki Kuramoto ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Cell Lines ◽  
Endometrial Adenocarcinoma ◽  
Protein A ◽  
Rabbit Antiserum ◽  
Carcinoma Cells ◽  
Affinity Column ◽  
Antibody Technique ◽  
Galactosyl Transferase ◽  
C Terminus

We have paid attention to the alteration of glycosyltransferase in carcinoma cells, because it might be related to the malignancy of the cells. In this connection, localization of β1-4 galactosyl transferase (β1-4 Gal T) in human endometrial carcinoma cells was examined immunocytochemically using two kinds of cell lines, each of which showed different degree of differentiation.An antibody was purified from the rabbit antiserum against the synthetic peptide, IFNRLVFRGMSC (W89) of human β1-4 Gal T coupled with KLH (keyhole limpet hemocyanine) by protein A column and peptide-affinity column chromatography. The anti-W89 serum reacts to the C-terminus of human β 1-4 Gal T and to both membrane-bound and soluble forms of the enzyme. Cell line of well differentiated endometrial adenocarcinoma (I) and that of poorly differentiated endometrial adenocarcinoma (50B) were cultivated respectively in MEM medium containing 15% FCS and 2 mM glutamine for 4 d at 37°C under 5% CO2. The cells were fixed in a mixture of 4% paraformaldehyde and 0.1% glutaraldehyde in 0.1 M Soerensen’s phosphate buffer (pH 7.4) at 4°C for 30 min, washed with PBS, then freezed and thawed. The indirect method of the peroxidase- labeled antibody technique was used for immunocytochemistry of both LM and TEM on the cell lines. The cells were dehydrated in ethanol and embedded in TAAB 812. Ultrathin sections were observed under a TEM, JEM-100S.

Coding for Evaluation and Treatment

2008 ◽  
Vol 18 (1) ◽  
pp. 9-20 ◽  
Author(s):  
Mark Kander ◽  
Steve White
Keyword(s):  
Medical Record ◽  
Treatment Session ◽  
Accurate Diagnosis ◽  
Third Party ◽  
Speech Language Pathologists ◽  
Adequate Information ◽  
Diagnosis Codes ◽  
Coding Rules ◽  
Procedure Codes ◽  
The Web

Abstract This article explains the development and use of ICD-9-CM diagnosis codes, CPT procedure codes, and HCPCS supply/device codes. Examples of appropriate coding combinations, and Coding rules adopted by most third party payers are given. Additionally, references for complete code lists on the Web and a list of voice-related CPT code edits are included. The reader is given adequate information to report an evaluation or treatment session with accurate diagnosis, procedure, and supply/device codes. Speech-language pathologists can accurately code services when given adequate resources and rules and are encouraged to insert relevant codes in the medical record rather than depend on billing personnel to accurately provide this information. Consultation is available from the Division 3 Reimbursement Committee members and from [email protected] .

Abstract #1126: Clinical Validity of Rosettagx Reveal for the Accurate Diagnosis of Preoperative Medullary Thyroid Carcinoma Utilizing FNA Smears

2017 ◽  
Vol 23 ◽  
pp. 303
Author(s):  
Michal Kushnir ◽  
Nicole Massoll ◽  
Brianna Sewell ◽  
Alexis Smith ◽  
Lisa Goodman ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Accurate Diagnosis ◽  
Clinical Validity ◽  
Medullary Thyroid
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