scholarly journals MONOHYDRIC PHENOL IMPACT ON THE STATE OF CEREBRAL BLOOD FLOW, VEGETATIVE NERVOUS SYSTEM AND COGNITIVE FUNCTIONS OF CHILDREN

Author(s):  
Alfiia Aminova
2019 ◽  
Vol 62 (5) ◽  
pp. 249-253
Author(s):  
N. I. Novichkova ◽  
D. Yu. Kallistov ◽  
Anna V. Sukhova ◽  
E. A. Romanova ◽  
A. I. Romanov

The higher prevalence and variety of clinical manifestation of disorders of falling asleep and sleep maintenance (insomnia) in persons of able-bodied age condition necessity of development of personified prevention programs subject to main pathophysiologic mechanisms conditioning risks of development of sleep disorders and related to them somatic diseases. Purpose of study. To analyze functional state of brain and cerebral blood flow in brain workers with higher level of professional stress and sleep disorders and to determine risk factors of development of established disorders for scientific substantiation of preventive activities. Material and methods. The examination was applied to two groups of brain workers with higher level of work intensity (class 3.3) and professional stress. The main group included 77 individuals stated availability of insomnia (index of insomnia severity 20.4±3.1 points). The control group included 88 individuals without significant sleep disorders. The clinical instrumental examination was implemented including questionnaire survey, night polysome graphic analysis, electroencephalography (EEG) and rheography analysis. Results. The high level of professional stress in workers with sleep disorders was statistically related to decreasing of efficiency of total time of sleep, decreasing of slow-wave sleep шт its structure, increased sleep fragmentation due to increasing of reactions of EEG-activation (r=0.35). The study of cerebral blood flow established that in 50% of individuals with sleep disorders and 32% of individuals without sleep disorders the instability of vascular tone was registered. According data of prospective observation, the signs of sleep disorders continued in 92% of patients with non-specific alterations of EEG with predominance of low-amplitude high-frequency activity and in 65% of patients with absence of similar alterations. The detected alterations can be considered as markers of condition of increased reactivity of central and vegetative nervous system being predisposing factor of changing from acute or transitory insomnia to chronic form.


1988 ◽  
Vol 255 (3) ◽  
pp. H563-H568
Author(s):  
C. D. Kurth ◽  
L. C. Wagerle ◽  
M. Delivoria-Papadopoulos

We examined cerebral blood flow (CBF) regulation by the sympathetic nerves in 12 newborn lambs (3–11 days old) during seizures, a potent reflex stimulator of the sympathetic nervous system. CBF was measured with microspheres, and seizures were induced with bicuculline. In six of these lambs, one hemibrain was denervated (D) chronically by interrupting the ipsilateral cervical sympathetic trunk; the other hemibrain remained innervated (I). Before and after 10, 35, and 70 min of seizures, cerebral gray matter blood flow (mean +/- SE ml.min-1.100 g-1) was, respectively, 12 +/- 3 (9%), 71 +/- 12 (21%), 120 +/- 15 (38%), and 54 +/- 5 (14%) greater (P less than 0.05) in the D than in the I hemibrain. In the cerebral white matter, hippocampus, caudate, and thalamus blood flows to the D and I hemibrains were similar before seizures but during seizures they were 10–39% greater (P less than 0.05) in the D than in the I hemibrain. Midbrain, brainstem, and cerebellum D and I blood flows were always similar. In the other six lambs, acute denervation during seizures increased ipsilateral cerebral gray and hippocampus blood flow by 10–31%, but unilateral electrical stimulation decreased ipsilateral cerebral gray, cerebral white, hippocampus, thalamus, and caudate blood flow by 17–27%. The data demonstrate that, during seizures, sympathetic nerve activity modifies regional CBF and the effect is sustained, suggesting a role for the sympathetic nervous system in newborn CBF regulation.


Neonatology ◽  
1990 ◽  
Vol 58 (4) ◽  
pp. 192-199 ◽  
Author(s):  
Pierre Monin ◽  
François Feillet ◽  
Jean-Michel Hascoet ◽  
Paul Vert

1939 ◽  
Vol 85 (358) ◽  
pp. 902-902
Author(s):  
E. Arnold Carmichael

Outline of physiology of sympathetic nervous system and its effect on the cerebral blood-vessels. Other factors controlling cerebral blood-vessels, such as local intra-arterial pressure and gas tension. The action of adrenalin-like and cholin-like substances on the cerebral blood-vessels. Alteration in cerebral blood flow during a convulsion, and the accompanying changes in cerebro-spinal fluid pressure. Evidence for systemic sympathetic disturbance during a convulsion. Discussion of “vaso-vagal” attacks and “diencephalitic” epilepsy.


Neurosurgery ◽  
1987 ◽  
Vol 21 (6) ◽  
pp. 843-848 ◽  
Author(s):  
Phillip D. Hylton ◽  
Howard O. Reichman ◽  
Roberta Palutsis

Abstract The early transient postirradiation effects in the central nervous system are well known; however, no specific means of objective follow-up have been devised. The xenon (133Xe) inhalation technique for measurement of regional cerebral blood flow (rCBF) is easily reproducible. Serial rCBF measurements corresponding to the clinical presentation and course of the early postirradiation syndrome have not been previously reported. It is our belief that the global decline in rCBF identified in these patients represents a generalized metabolic derangement induced by whole brain irradiation rather than primary vascular changes. A distinction between tumor recurrence and the early transient postirradiation effects can be made utilizing this technique. It also provides a reproducible monitor of the clinical and metabolic impact of radiotherapy for brain tumors. A series of seven such patients is presented with appropriate case histories and graphic representations of the serial rCBF measurements.


Stroke ◽  
1994 ◽  
Vol 25 (2) ◽  
pp. 309-317 ◽  
Author(s):  
S Mori ◽  
S Sadoshima ◽  
S Ibayashi ◽  
K Lino ◽  
M Fujishima

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Leonie Steiner ◽  
Andrea Federspiel ◽  
Jasmine Jaros ◽  
Nedelina Slavova ◽  
Roland Wiest ◽  
...  

AbstractAdaptive recovery of cerebral perfusion after pediatric arterial ischemic stroke (AIS) is sought to be crucial for sustainable rehabilitation of cognitive functions. We therefore examined cerebral blood flow (CBF) in the chronic stage after stroke and its association with cognitive outcome in patients after pediatric AIS. This cross-sectional study investigated CBF and cognitive functions in 14 patients (age 13.5 ± 4.4 years) after pediatric AIS in the middle cerebral artery (time since AIS was at least 2 years prior to assessment) when compared with 36 healthy controls (aged 13.8 ± 4.3 years). Cognitive functions were assessed with neuropsychological tests, CBF was measured with arterial spin labeled imaging in the anterior, middle, and posterior cerebral artery (ACA, MCA, PCA). Patients had significantly lower IQ scores and poorer cognitive functions compared to healthy controls (p < 0.026) but mean performance was within the normal range in all cognitive domains. Arterial spin labeled imaging revealed significantly lower CBF in the ipsilesional MCA and PCA in patients compared to healthy controls. Further, we found significantly higher interhemispheric perfusion imbalance in the MCA in patients compared to controls. Higher interhemispheric perfusion imbalance in the MCA was significantly associated with lower working memory performance. Our findings revealed that even years after a pediatric stroke in the MCA, reduced ipsilesional cerebral blood flow occurs in the MCA and PCA and that interhemispheric imbalance is associated with cognitive performance. Thus, our data suggest that cerebral hypoperfusion might underlie some of the variability observed in long-term outcome after pediatric stroke.


2000 ◽  
Vol XXXII (3-4) ◽  
pp. 28-31
Author(s):  
S. P. Yakupova ◽  
M. F. Ismagilov ◽  
J. G. Salikhov

There are presented the results of combined examination of the state of vegetative nervous system in 94 patients with rheumatoid arthritis. By studying the variablity of cardiac rhythm in the sphere of vegetative regulation in patients dominance of sympathic tonicity mainly with asympathicotonic reactivity and deficient vegetative support of activity is determined. In majority of patients (90,4%) symptom complexes of vegetative dysfunction are found. Inclusion of dimephosphonum in combined therapy of rheumatoid arthritis led to normalization of indices of vegetative regulation and to significant diminishing of clinical manifestations of vegetative dysfunction.


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