Low-Field Magnetic Stimulation (LFMS) decreases cuprizone-induced cognitive impairment and brain pathology in mice

The purpose of the investigation was to study the nootropic effects of rhythmic transcranial magnetic stimulation (rTMS) using low-intensity magnetic field with the induction rate of 45 mT, base frequency of 50 Hz, modulation frequency of 10 Hz in combination with standard medical and psychological therapy in the rehabilitation of patients with post-stroke cognitive impairment (PSCI). Materials and methods. The rehabilitation outcomes in 98 patients with PSCI syndrome were studied. The patients were subdivided into 2 groups: 53 patients of the control group were treated with the standard nootropic medications and neuropsychological procedures; 45 patients of the main group were additionally treated with rTMS by the low-intensive running pulsed magnetic field of 10 Hz modulation frequency. The dynamics of the score increase according to Rivermid, Karnovsky, Roshina, MMSE, mRS, HDRS, SF-36 scales were analyzed. Conclusion. Application of rTMS with low-intensive running pulsed magnetic field of 10 Hz modulation frequency in combination with a standard program of cognitive rehabilitation contributes to a significant improvement in the recovery of mental calculation function in ischemic stroke patients, as well as normalization in mood swings in the patients who had suffered a hemorrhagic stroke and post-stroke depression. This variant of rTMS can be safely used in patients with PSCI syndrome in the early recovery period, 3 weeks after the onset of stroke.

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Transcranial magnetic stimulation (TMS)/repetitive TMS in mild cognitive impairment and Alzheimer's disease

Acta Neurologica Scandinavica ◽

10.1111/ane.12223 ◽

2014 ◽

Vol 129 (6) ◽

pp. 351-366 ◽

Cited By ~ 47

Author(s):

R. Nardone ◽

F. Tezzon ◽

Y. Höller ◽

S. Golaszewski ◽

E. Trinka ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Transcranial Magnetic Stimulation ◽

Magnetic Stimulation ◽

Repetitive Tms

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Theta Burst Magnetic Stimulation Improves Parkinson’s-Related Cognitive Impairment: A Randomised Controlled Study

Neurorehabilitation and Neural Repair ◽

10.1177/15459683211041311 ◽

2021 ◽

Vol 35 (11) ◽

pp. 986-995

Author(s):

Weijia He ◽

Jia-Chi Wang ◽

Po-Yi Tsai

Keyword(s):

Cognitive Impairment ◽

Magnetic Stimulation ◽

Single Photon ◽

Repetitive Transcranial Magnetic Stimulation ◽

Photon Emission ◽

Controlled Study ◽

Emission Computed Tomography ◽

Randomised Controlled ◽

Theta Burst

Background. Evidence remains mixed as to the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in treating mild cognitive impairment (MCI) in patients with Parkinson’s disease (PD). Objective. In this study, we examined the short- and long-term effects of patterned rTMS. Methods. We randomly assigned 35 patients with PD with MCI to two groups. One group received intermittent theta burst stimulation (iTBS; n = 20), and the other received its sham counterpart (n = 15). The stimulations were applied over the left dorsolateral prefrontal cortex for 10 consecutive weekdays. Measurements based on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Montreal Cognitive Assessment (MoCA) were conducted at three time points: at baseline, immediately after the last intervention and at 3-month follow-up. Each patient received a 99mTc-TRODAT-1 single-photon emission computed tomography (SPECT) brain scan at baseline. Results. The iTBS group exhibited significantly greater improvement than the sham group did in total RBANS and MoCA scores ( p < .001 for both) immediately after intervention and at the 3-month follow-up. Radiotracer uptake in the bilateral basal ganglion in baseline SPECT was positively correlated with response to iTBS conditioning with respect to improvements in MoCA scores ( p = .021). Conclusion. This randomised controlled trial provides evidence that a consecutive iTBS protocol can achieve a persistent and wide-ranging therapeutic effect in patients with PD with MCI.

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Neurostimulation therapies

Oxford Textbook of Old Age Psychiatry ◽

10.1093/med/9780198807292.003.0014 ◽

2020 ◽

pp. 217-232

Author(s):

Daniel W. O’Connor ◽

Christos Plakiotis ◽

Peter Farnbach

Keyword(s):

Cognitive Impairment ◽

Deep Brain Stimulation ◽

Transcranial Magnetic Stimulation ◽

Side Effects ◽

Magnetic Stimulation ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Treatment Of Depression ◽

Electrical Impulses ◽

The Brain

Electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS) all entail the delivery of electrical impulses to the brain with the aim of relieving mental disorders. ECT is an effective treatment of depression, mania and catatonia and, to a lesser extent, of schizophrenia. Its side effects, principally cognitive impairment, are mitigated through the use of individually tailored, unilateral delivery. TMS is more convenient but of lesser effectiveness. DBS, while reversible and thus safer than lesional surgery, is a major undertaking that is reserved at present for profoundly disabling depression, obsessive-compulsive disorder (OCD), and Tourette’s syndrome.

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