scholarly journals Localized scleroderma: assessment of the therapeutic response to phototherapy

2012 ◽  
Vol 87 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Roberta Buense ◽  
Ida Alzira Gomes Duarte ◽  
Marcio Bouer
Keyword(s):  
Therapeutic Response ◽  
Skin Lesions ◽  
Therapeutic Modality ◽  
Localized Scleroderma ◽  
Treatment Comparison ◽  
Dermal Thickness ◽  
Evolutive Stage ◽  
Skin Ultrasound ◽  
Development Literature ◽  
Chronic Autoimmune Disease

BACKGROUND: Scleroderma is a chronic autoimmune disease characterized by progressive connective tissue sclerosis and microcirculatory changes. Localized scleroderma is considered a limited disease. However, in some cases atrophic and deforming lesions may be observed that hinder the normal development. Literature reports indicate phototherapy as a therapeutic modality with favorable response in cutaneous forms of scleroderma. OBJECTIVES: This study had the purpose of assessing the phototherapy treatment for localized scleroderma. METHODS: Patients with localized scleroderma were selected for phototherapy treatment. They were classified according to the type of localized scleroderma and evolutive stage of the lesions. Clinical examination and skin ultrasound were used to demonstrate the results thus obtained. RESULTS: Some clinical improvement was observed after an average of 10 phototherapeutic sessions. All skin lesions were softer at clinical palpation with scores reduction upon pre and post treatment comparison. The ultrasound showed that most of the assessed lesions presented a decrease in dermal thickness, and only five maintained their previous measure. Treatment response was similar regardless of the type of phototherapeutic treatment employed. CONCLUSIONS: The proposed treatment was effective for all lesions, regardless of the phototherapeutic modality employed. The improvement was observed in all treated skin lesions and confirmed by clinical evaluation and skin ultrasound.

scholarly journals Impressic Acid Ameliorates Atopic Dermatitis-Like Skin Lesions by Inhibiting ERK1/2-Mediated Phosphorylation of NF-κB and STAT1

2021 ◽  
Vol 22 (5) ◽  
pp. 2334
Author(s):  
Jae Ho Choi ◽  
Gi Ho Lee ◽  
Sun Woo Jin ◽  
Ji Yeon Kim ◽  
Yong Pil Hwang ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Lesions ◽  
Histopathological Analysis ◽  
Mrna Levels ◽  
Chemokine Production ◽  
Dermal Thickness ◽  
Skin Symptoms ◽  
Tnf Α ◽  
Ifn Γ ◽  
In Cells

Impressic acid (IPA), a lupane-type triterpenoid from Acanthopanax koreanum, has many pharmacological activities, including the attenuation of vascular endothelium dysfunction, cartilage destruction, and inflammatory diseases, but its influence on atopic dermatitis (AD)-like skin lesions is unknown. Therefore, we investigated the suppressive effect of IPA on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin symptoms in mice and the underlying mechanisms in cells. IPA attenuated the DNCB-induced increase in the serum concentrations of IgE and thymic stromal lymphopoietin (TSLP), and in the mRNA levels of thymus and activation regulated chemokine(TARC), macrophage derived chemokine (MDC), interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-13 (IL-13), tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) in mice. Histopathological analysis showed that IPA reduced the epidermal/dermal thickness and inflammatory and mast cell infiltration of ear tissue. In addition, IPA attenuated the phosphorylation of NF-κB and IκBα, and the degradation of IκBα in ear lesions. Furthermore, IPA treatment suppressed TNF-α/IFN-γ-induced TARC expression by inhibiting the NF-κB activation in cells. Phosphorylation of extracellular signalregulated protein kinase (ERK1/2) and the signal transducer and activator of transcription 1 (STAT1), the upstream signaling proteins, was reduced by IPA treatment in HaCaT cells. In conclusion, IPA ameliorated AD-like skin symptoms by regulating cytokine and chemokine production and so has therapeutic potential for AD-like skin lesions.

scholarly journals Gender, clinical and topographic features of the localized scleroderma lesions in anogenital area

2020 ◽  
Vol 23 (3) ◽  
pp. 165-173
Author(s):  
Elena S. Snarskaya ◽  
Yulia A. Semenchak
Keyword(s):  
Clinical Symptoms ◽  
Skin Lesions ◽  
Localized Scleroderma ◽  
Steady Increase ◽  
Family Doctors ◽  
Topographic Features ◽  
Anogenital Area ◽  
Clinical Variants ◽  
Limited Scleroderma ◽  
And Gender

Background: Currently, there is an increase in the number of skin lesions of anogenital localization, which is a silent epidemic, both due to the steady increase in the incidence of this pathology, and the interdisciplinary aspect of this problem. Materials and methods: In the article, the authors first analyzed and presented the data of clinical and morphological analysis of 104 patients with various clinical variants of limited scleroderma, on the basis of which the main phenotypic and gender-specific clinical and topographical features of anogenital zone lesions in this group of patients are presented. Results: Scleroatrophic lichen is one of the clinical variants of limited scleroderma, which is characterized by damage to the mucous membranes of the external genitals in both women and men. Lesions of such localization are late and often mistakenly diagnosed by specialists of related disciplines (obstetricians, gynecologists, urologists, family doctors, allergists, cosmetologists), which leads to high risks of developing genitourenal syndrome. Conclusions: The development of scleroatrophic lesions in the anogenital zone is accompanied by pronounced clinical symptoms, including: itching, pain of varying intensity, dysuria, dyspareunia and significant sexual dysfunction.

scholarly journals Chamaejasmine Isolated from Wikstroemia dolichantha Diels Suppresses 2,4-Dinitrofluoro-benzene-Induced Atopic Dermatitis in SKH-1 Hairless Mice

Biomolecules ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 697 ◽  
Author(s):  
Tae-Young Kim ◽  
No-June Park ◽  
Jonghwan Jegal ◽  
Sangho Choi ◽  
Sang Woo Lee ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Clinical Symptoms ◽  
Skin Barrier ◽  
Topical Administration ◽  
Skin Lesions ◽  
Specific Ige ◽  
Transepidermal Water Loss ◽  
Skin Barrier Function ◽  
Enzyme Linked Immunosorbent Assay ◽  
Dermal Thickness

Plants of the genus Wikstroemia have long been used as traditional medicines to treat diseases like pneumonia, rheumatism, and bronchitis. This study was designed to determine the effect of chamaejasmine, a biflavonoid present in W. dolichantha, on atopic dermatitis (AD)-like skin lesions in a 2,4-dinitrochlorobenzene (DNCB)-induced murine model of AD. Initially, we examined the anti-allergic activities of ten flavonoids from W. dolichantha by measuring β-hexosaminidase release from RBL-2H3 cells. Subsequently, an SKH-1 hairless mouse model of AD was developed based on the topical application of DNCB. Chamaejasmine (0.5%) or pimecrolimus (1%, positive control) were applied to dorsal skins of DNCB-sensitized AD mice for two weeks. Serum IL-4 and IgE levels were determined using enzyme-linked immunosorbent assay kits and transepidermal water loss (TEWL) and skin hydration were measured using a Tewameter TM210 and a SKIN-O-MAT, respectively. Of the ten flavonoids isolated from W. dolichantha, chamaejasmine most potently inhibited DNP-specific IgE-induced degranulation in RBL-2H3 cells. Topical administration of chamaejasmine attenuated the clinical symptoms of DNCB-induced dermatitis (i.e., itching, dryness, erythema, and edema). Histological analyses demonstrated that dermal thickness and mast cell infiltration in dermis were significantly reduced by chamaejasmine. In addition, 0.5% chamaejasmine inhibited DNCB-induced increases in total IL-4 and IgE levels in serum, improved skin barrier function, and increased epidermis moisture. Our findings suggest chamaejasmine might be an effective therapeutic agent for the treatment of atopic diseases.

Disseminated Scleroderma of a Japanese Patient Successfully Treated with Bath PUVA Photochemotherapy

2001 ◽  
Vol 5 (2) ◽  
pp. 135-139 ◽  
Author(s):  
Yoshinori Aragane ◽  
Akira Kawada ◽  
Akira Maeda ◽  
Rieko Isogai ◽  
Noritaka Isogai ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Clinical Improvement ◽  
Skin Disorder ◽  
Japanese Patient ◽  
Japanese Woman ◽  
Therapeutic Modality ◽  
Localized Scleroderma ◽  
Puva Therapy ◽  
Old Japanese

Background: Localized scleroderma is known to be resistant to therapies. Recently, it has been reported that bath PUVA photochemotherapy is effective for treating this dermatosis. Objectives: Although according in earlier reports mainly white populations have been treated successfully with bath PUVA therapy, there is little knowledge of whether it is effective in treating colored populations. We treated a 64-year-old Japanese woman suffering from disseminated scleroderma with bath PUVA photochemotherapy to see its effects. Conclusion: Although rather high cumulative UVA doses were required for this patient compared with those needed in earlier reports, no adverse effects were observed. The lesions were markedly improved, suggesting that this therapeutic modality is well-tolerated and useful for colored patients such as the Japanese. Furthermore, it turns out that the thermographical assessment is useful to estimate clinical improvement of this sclerosing skin disorder.

Localized scleroderma manifesting with skin lesions associated with mechanical stress

2019 ◽  
Vol 29 (4) ◽  
pp. 439-440
Author(s):  
Satoshi Toyama ◽  
Shinichi Sato ◽  
Yoshihide Asano
Keyword(s):  
Mechanical Stress ◽  
Skin Lesions ◽  
Localized Scleroderma

scholarly journals New Features for Measuring Disease Activity in Pediatric Localized Scleroderma

2018 ◽  
Vol 45 (12) ◽  
pp. 1680-1688 ◽  
Author(s):  
Suzanne C. Li ◽  
Xiaohu Li ◽  
Elena Pope ◽  
Katie Stewart ◽  
Gloria C. Higgins ◽  
...  
Keyword(s):  
Disease Activity ◽  
Age Of Onset ◽  
Skin Lesions ◽  
Inactive Disease ◽  
Localized Scleroderma ◽  
Relative Importance ◽  
Skin Texture ◽  
Disease Patterns ◽  
Disease Extension ◽  
Multicenter Prospective Study

Objective.To identify clinical features that define disease activity in pediatric localized scleroderma (LS), and determine their specificity and importance.Methods.We conducted a multicenter prospective study of patients with active and inactive LS skin lesions. A standardized evaluation of a single designated study lesion per subject was performed at 3 visits. We evaluated the pattern and correlation between assessed features and physician’s global assessments of activity (PGA-A).Results.Ninety of 103 subjects had evaluable data; 66 had active and 24 inactive disease. Subjects had similar age of onset, sex, and disease patterns. Linear scleroderma was the most common subtype. Features specific for active disease included erythema, violaceous color, tactile warmth, abnormal skin texture, and disease extension. Scores for these variables changed over time and correlated with PGA-A of the lesion. Active and inactive lesions could not be distinguished by the presence or level of skin thickening, either of lesion edge or center. However, in active lesions, skin thickening scores did correlate with PGA–A scores. Regression analysis identified the combination of erythema, disease extension, violaceous color, skin thickening, and abnormal texture as predictive of PGA-A at study entry. Damage features were common irrespective of activity status.Conclusion.We identified variables strongly associated with disease activity, expanding upon those used in current measures, and determined their relative importance in physician activity scoring. Skin thickening was found to lack specificity for disease activity. These results will help guide development of a sensitive, responsive activity tool to improve care of patients with LS.

Clinical Manifestations of Scleroderma

1995 ◽  
Vol 16 (2) ◽  
pp. 49-49
Author(s):  
Patricia L. Haber
Keyword(s):  
Systemic Sclerosis ◽  
Connective Tissue ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Localized Scleroderma ◽  
Unknown Etiology ◽  
Collagen Deposition ◽  
Muscle Fibrosis ◽  
Favorable Prognosis ◽  
Organ Systems

Scleroderma is a connective tissue disease of unknown etiology. Its most characteristic feature is thickening of the skin due to increased collagen deposition. However, the disease may involve multiple other organ systems. Two broad categories of scleroderma have been defined: localized and systemic. Although all forms of scleroderma are rare, localized scleroderma occurs more frequently than systemic sclerosis and has a more favorable prognosis. Several types of localized scleroderma exist. Morphea is characterized by the presence of one or more patches of hard, ivory-colored skin lesions. They begin with erythema and progress to nonpitting edema before becoming sclerotic. The margins of active lesions often have a violaceous hue. Underlying muscle fibrosis and atrophy may occur.

Avaliação do Efeito da Microcorrente na Reparação de Feridas Cutâneas em Ratos

UNICIÊNCIAS ◽  
2018 ◽  
Vol 22 (2) ◽  
pp. 62
Author(s):  
Belle Virginia Da Silva Coimbra Rodrigues ◽  
Suellen Borges de Souza ◽  
Thayanne Caroline Pereira Munhoz ◽  
Gracieli Nonato Bressanin ◽  
Alessandra Aparecida Cunha Lopes ◽  
...  
Keyword(s):  
Tissue Repair ◽  
Specific Treatment ◽  
Low Frequency ◽  
Repair Process ◽  
Skin Lesions ◽  
Treated Group ◽  
Therapeutic Modality ◽  
Cervical Region ◽  
Control Group ◽  
And Control

A bioeletricidade tem se tornado cada vez mais reconhecida no mundo científico devido a sua importante contribuição na cicatrização de feridas. Dentro desta modalidade terapêutica está inserida a terapia com microcorrente, que por ter baixa frequência e pequena intensidade é capaz de promover o restabelecimento do potencial elétrico das células. Por se tratar de uma corrente de elevado potencial, durante o processo de reparação tecidual, esta pode atuar tanto na fase inflamatória quanto na proliferativa. Dessa maneira, este estudo teve por objetivo principal avaliar a resposta cicatricial quanto ao efeito da microcorrente em lesões cutâneas em ratos. Para tanto, foram utilizados 28 ratos Wistar, divididos em dois grupos: grupo tratado (GT) e grupo controle (GC). Os animais de ambos os grupos foram submetidos a procedimento cirúrgico de lesão cutânea região cervical dorsal, seguido de tratamento com microcorrente durante 21 dias no GT, e sem tratamento específico no GC. Também foi realizada a avaliação termográfica a cada três dias de todos os animais. Após este período, foi feita eutanásia com posterior coleta de pele na região da lesão para avaliação histopatológica. Os resultados obtidos mostraram, a partir dos parâmetros analisados, a presença de um recurso capaz de incrementar a formação de novos vasos, embora não apresentasse efeito significativo em relação à proliferação de fibroblastos. Diante disso, sugere-se que a utilização da microcorrente possa ter favorecido a neovascularização nos tecidos dos animais analisados. Palavras-chave: Rato. Microcorrente. Angiogênese. Reparo tecidual. AbstractBioelectricity has become increasingly recognized in the scientific world because of its important contribution to wound healing. Within this therapeutic modality the therapy with microcurrent is inserted, which because of low frequency and small intensity is able to promote the reestablishment of the cells electric potential. Because it is a  high potential v during the tissue repair process, it can act both in the inflammatory and proliferative phases. Thus, this study had as main objective to evaluate the healing response regarding the microcurrent effect  on rats’ skin lesions. For this, 28 Wistar rats were divided into two groups: treated group (GT) and control group (CG). The animals of both groups underwent a surgical procedure of skin lesion in the dorsal cervical region, followed by treatment with microcurrent for 21 days in the GT, and without specific treatment in the CG. A thermographic evaluation was also performed every three days of all the animals. After this period, euthanasia was performed with subsequent skin collection in the lesion region for histopathological evaluation. The obtained results showed, from the analyzed parameters, the presence of a resource able to increase the  new vessels formation, although it did not present significant effect in relation to the  fibroblasts proliferation. Therefore, it is suggested that the use of microcurrent may have favored neovascularization in the tissues of the animals analyzed.Keywords: Mouse. Microcurrent. Angiogenesis. Tissue repair. 

Pros, cons and future prospects of ALA-photodiagnosis, phototherapy and pharmacology in cancer therapy – A mini review

2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Zvi Malik
Keyword(s):  
Cancer Therapy ◽  
Aminolevulinic Acid ◽  
Skin Lesions ◽  
Therapeutic Modality ◽  
Medical Community ◽  
Multi Drug Resistance ◽  
Practice Research ◽  
Future Research ◽  
Simple Method ◽  
Predictive Values

Abstract5-Aminolevulinic acid (ALA)-induced photodynamic therapy (ALA-PDT) has achieved remarkable research accomplishments over the past 30 years, yet its application in medical oncology still awaits clear recognition as a valid alternative therapeutic modality. It is well documented that topical ALA-PDT enables the treatment of multiple skin lesions simultaneously, and provides excellent cosmetic results with no acquired multi-drug resistance (MDR). Furthermore, upon disease recurrence the treatment can be repeated resulting in the same therapeutic efficacy. Additionally, in oncological surgery, ALA fluorescence-guided resection is a practical and simple method for visualizing intra-operative brain and urological tumors with millimeter accuracy. The urgent challenge is to direct future research of ALA-phototherapy and fluorescence diagnosis to the maturation of their medical status in oncology. Therefore, the future objectives are to amplify critical evidence-based results of ALA-PDT safety and efficacy and to validate its unique advantages over other technologies. Strong statistical PDT documentation and the positive predictive values of protoporphyrin IX (PpIX)-guided surgery will persuade the medical community to implement ALA-based therapeutics into standard clinical and surgical oncology practice. Research must address the phenomenon that no MDR develops as a consequence of PDT, since MDR is the major stumbling block in oncological therapeutics. A feasible goal should be to improve ALA administration protocols based on recent knowledge that preactivation of the enzyme porphobilinogen deaminase enhances PpIX accumulation in cancer cells and photodestruction. Moreover the recent introduction of multifunctional ALA prodrugs that maximize photosensitizer biosynthesis, targeting multiple sub-cellular targets, may increase PDT anti-cancer efficacy in additional disease settings. In conclusion, well-documented clinical results, new ALA delivery protocols, and novel multifunctional ALA prodrugs may advance ALA-PDT to becoming a front-line cancer therapy.

Sign in / Sign up

Export Citation Format

Share Document