Safety of SGLT2-I During the Month of Ramadan in Patients with T2DM in Pakistani population -An observational study.

Background: Lumbosacral joint carries whole body weight and transmits it to tibia. As the 5th Lumbar Vertebra transits into first Sacral Vertebra, fifth Lumbar Vertebra may be fused on one or both sides to the first Sacral Vertebra, Condition known as ‘Sacralisation’. Aim: To find the frequency of sacralisation of 5th Lumbar Vertebra in South Punjab Pakistani Population. Methods: It was a descriptive observational study conducted in Anatomy Department Quaid-e-Azam Medical College, Bahawalpur. This was descriptive observational study conducted on cadaveric sacra collected in last 7 years. 86 dry Human adult sacra of known sex were observed and results were noted for Sacralisation of Lumbar Vertebra. Results: Out of 86 cadaveric Sacra, Sacralisation was found in 12(14%). Out of these 12, 8 Sacra showed complete Sacralisation while 4 Sacra showed incomplete Sacralisation. Conclusion: Sacralisation of 5th Lumbar Vertebra is common (14%) in cadaveric sacra of South Punjab, Pakistani Population. Key words: Lumbar Vertebra, Sacralisation, Cadaveric, L5 (5th lumbar vertebrae), S1 (1st Sacral Vertebrae).

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Clinical outcomes of Sodium-glucose cotransporter-2 inhibitors in patients with Type 2 Diabetes Mellitus: An observational study from Pakistan

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.37.5.3901 ◽

2021 ◽

Vol 37 (5) ◽

Author(s):

Bhagwan Das ◽

Aisha Sheikh ◽

Bilal Ahmed ◽

Najmul Islam

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Glycemic Control ◽

Observational Study ◽

Serum Creatinine ◽

Pakistani Population ◽

Sodium Glucose Cotransporter

Objective: To determine the efficacy and safety of Sodium-glucose cotransporter-2 inhibitors (SGLT2i) use in the Pakistani population. Methods: Retrospective review of initial 100 patients who were prescribed with any agent of the SGLT2i group from July 1, 2018 to January 2019 at Aga Khan University Hospital, Karachi. SGLT2i was offered to patients of above 18 years of age with inadequate glycemic control on existing antidiabetic agents. Changes in HbA1c, the Body Mass Index (BMI), serum creatinine, any decrease in the requirement of insulin and sulphonylurea dose along with any side effects reported by the patients on follow-up visits. Results: Most study participants were females (56%) with the mean age of 52±10 years. Substantial changes were observed in the HbA1c (7.5±1.1%, 7.9±1.2% from 8.7±1.5%, p < 0.01), BMI (31.4±5.8, 31.8±5.8 from 32.4±5.9kg/m2, p < 0.01) and in creatinine (0.71±0.1, 0.75±0.1 from 0.79±0.1 mg/dl, p < 0.01) at three and six months of follow up visits. The reduction in insulin and sulphonylurea doses was also significant. Adverse drug events that led to drug discontinuation in 14 individuals were, Urinary tract infection (UTI) (seven patients), Genital infection (three patients), nausea +UTI, abdominal pain +UTI, mild Diabetic Ketoacidosis, and polyuria (one patient each). None reported Fournier’s gangrene, limb amputation, or fracture. Conclusion: SGLT2i significantly improved glycemic control, BMI, and serum creatinine in the Pakistani population with a very low number of observed adverse events. doi: https://doi.org/10.12669/pjms.37.5.3901 How to cite this:Das B, Sheikh A, Ahmed B, Islam N. Clinical outcomes of Sodium-glucose cotransporter-2 inhibitors in patients with Type 2 Diabetes Mellitus: An observational study from Pakistan. Pak J Med Sci. 2021;37(5):---------. doi: https://doi.org/10.12669/pjms.37.5.3901 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Therapeutic interventions of remdesivir in diabetic and non‐diabetic COVID‐19 patients: A prospective observational study conducted on Pakistani population

Journal of Medical Virology ◽

10.1002/jmv.27256 ◽

2021 ◽

Author(s):

Qiadat Hasnain Qureshi ◽

Taimoor Ashraf ◽

Kanwal Rehman ◽

Muhammad Kaleem Khosa ◽

Muhammad Sajid Hamid Akash

Keyword(s):

Observational Study ◽

Prospective Observational Study ◽

Therapeutic Interventions ◽

Pakistani Population

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Abstract #842: Novel Action of Saroglitazar in Patients with Diabetic Dyslipidemia – An Observational Study.

Endocrine Practice ◽

10.1016/s1530-891x(20)45176-6 ◽

2016 ◽

Vol 22 ◽

pp. 183-184

Author(s):

Hemant Thacker ◽

Rupal Shrimanker ◽

Rahul Tulle

Keyword(s):

Observational Study ◽

Diabetic Dyslipidemia

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47 Long-term outcome of patients treated with cardiac resynchronization. Results of a multicenter European observational study

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(05)80013-x ◽

2005 ◽

Vol 4 (1) ◽

pp. 6-6

Keyword(s):

Observational Study ◽

Cardiac Resynchronization ◽

Term Outcome ◽

Long Term Outcome

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First clinical experience with the Multi-LOC multiple stent delivery system for focal stenting in long femoro-popliteal lesions

VASA ◽

10.1024/0301-1526/a000658 ◽

2017 ◽

Vol 46 (6) ◽

pp. 452-461 ◽

Cited By ~ 4

Author(s):

Klaus Amendt ◽

Ulrich Beschorner ◽

Matthias Waliszewski ◽

Martin Sigl ◽

Ralf Langhoff ◽

...

Keyword(s):

Observational Study ◽

Clinical Experience ◽

Delivery System ◽

Target Lesion ◽

Lesion Length ◽

Elastic Recoil ◽

Delivery Device ◽

Clinical Assessments ◽

Balloon Catheters ◽

Considerable Length

Abstract. Background: The purpose of this observational study is to report the six-month clinical outcomes with a new multiple stent delivery system in patients with femoro-popliteal lesions. Patients and methods: The LOCOMOTIVE study is an observational multicentre study with a primary endpoint target lesion revascularization (TLR) rate at six months. Femoro-popliteal lesions were prepared with uncoated and/or paclitaxel-coated peripheral balloon catheters. When flow limiting dissections, elastic recoil or recoil due to calcification required stenting, up to six short stents per delivery device, each 13 mm in length, were implanted. Sonographic follow-ups and clinical assessments were scheduled at six months. Results: For this first analysis, a total of 75 patients 72.9 ± 9.2 years of age were enrolled. The majority of the 176 individually treated lesions were in the superficial femoral artery (76.2 %, 134/176) whereas the rate of TASC C/D amounted to 51.1 % (90/176). The total lesion length was 14.5 ± 9.0 cm with reference vessel diameters of 5.6 ± 0.7 mm. Overall 47 ± 18 % of lesion lengths could be saved from stenting. At six months, the patency was 90.7 % (68/75) and all-cause TLR rates were 5.3 % (4/75) in the overall cohort. Conclusions: The first clinical experience at six months suggests that the MSDS strategy was safe and effective to treat femoro-popliteal lesions of considerable length (14.5 ± 9.0 cm). Almost half of the lesion length could be saved from stenting while patency was high and TLR rates were acceptably low.

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