Metabolic Syndrome and Ethnic Groups Second edition

Author(s):  
Mohammadhosain Afrand ◽  
Mohammad Afkhami-Ardekani ◽  
Ahmad Shojaoddiny-Ardekani ◽  
Azita Ariaeinejad

Metabolic syndrome is defined as the co-occurrence of metabolic risk factors for both type 2 diabetes and cardiovascular disease (i.e. abdominal obesity, hyperglycemia, dyslipidemia, and hypertension). Indeed, metabolic syndrome is an important risk factor for subsequent development of type 2 diabetes and/or CVD. Thus, the key clinical implication of a diagnosis of metabolic syndrome is the identification of a patient who needs aggressive lifestyle modification focused on weight reduction and increased physical activity. Multiple different phenotypes and ethnic-specific values for waist circumference are included within metabolic syndrome, with indications for differing treatment strategies. This book covers several aspects of metabolic syndrome, including its definition, diagnostic criteria, preventive measures, and treatment, as well as the possible association between ethnicity and the occurrence of metabolic syndrome.

Background. Nowadays the importance of lifestyles in the prevention of type 2 diabetes and the metabolic syndrome has been largely accertained. Objective. The purpose of our work is to implement programs that promote a nutritional culture in adolescents and young adults of the La Sabana University. Methods. The methodology entailed, after the corresponding informed consent, taking measures of the triceps and supraescapular skinfolds, waist circumference, body mass index (BMI), lean mass, and fat mass. Fasting blood samples were also taken to quantify cholesterol, triglycerides, high density lipoprotein (HDL) and low density lipoprotein (LDL). Results. The results obtained show that of the 165 students, 10.3% were underweight, 13.93% were overweight and 0.6% were obese. With regards to gender, 4.8% of the men and 9% of the women were overweight, 3% of the men and 7.2% of the women were underweight, and 0.6% of the women were obese. The blood chemistry showed that 30% had hypercholesterolemia, 18% hypertriglyceridemia, 17% reported low HDL levels and 67% reported high LDL levels. Of all the cases studied, 40% are at risk of a metabolic syndrome. 60% claimed not to practice any physical activity - especially women who reported 44.70%. Conclusions. These findings have allowed us at the institution to implement a culture of healthy habits. The have also allowed us to identify students with risk factors for type 2 diabetes and metabolic syndrome. This is why the cardiometabolic monitoring and control based on healthy eating and physical activity are important.


Diabetologia ◽  
2013 ◽  
Vol 57 (1) ◽  
pp. 73-82 ◽  
Author(s):  
Andrew J. M. Cooper ◽  
Soren Brage ◽  
Ulf Ekelund ◽  
Nicholas J. Wareham ◽  
Simon J. Griffin ◽  
...  

2021 ◽  
Vol 20 (Supplement_1) ◽  
Author(s):  
A Harris ◽  
D Keegan ◽  
S Seery ◽  
D Dunne ◽  
Z Mc Crudden ◽  
...  

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Health Service Executive Health and Wellbeing, Saolta University Healthcare Group OnBehalf Croí the West of Ireland Cardiac Foundation, Galway, Ireland and the National Institute for Prevention and Cardiovascular Health Introduction People living with obesity are at an increased risk of cardiovascular disease (CVD). While development of obesity is multifactorial, lifestyle modification is fundamental to obesity treatment and risk factor reduction. We sought to measure the effects of a structured lifestyle modification programme on the physical and mental health of people living with obesity. Purpose This study investigated the impact of a 10-week, community based, lifestyle modification programme on CVD risk factors in people living with obesity (BMI ≥35kg/m2 with a co-morbidity or BMI ≥40kg/m2) who were referred from a specialist bariatric service. Methods Delivered by an interdisciplinary team (Nurse, Dietitian & Physiotherapist) the programme included weekly group-based exercise sessions and health promotion workshops. A wide range of topics were addressed in workshops, including nutrition, food labels, emotional eating, physical activity, sedentary behaviour, stress management and CVD risk factor reduction. Outcomes were measured at initial and end of programme assessments. Results 1122 people participated in the intervention between 2013 and 2019 with 78% (n = 877) completing the programme. At initial assessment 26.7% of participants had a diagnosis of type 2 diabetes; 37.3% were at high or very high risk of CVD; 44.7% were hypertensive and 31.4% had a history of depression. Mean BMI was 47.0kg/m2 with 56.4% of participants having a BMI >45kg/m2. The intervention had significant positive impacts on key outcomes such as psychosocial health, lipid profiles, blood pressure, adiposity and cardiovascular fitness. One of the most significant outcomes observed was the improvement in psycho-social health. Scores of anxiety and depression, assessed using the HADS, decreased by 1.5 and 2.2 points respectively (p <0.001). Mean EQ-VAS score increased by 11 points (p <0.001). There were significant changes in total cholesterol levels with a mean reduction in total cholesterol from 4.69mmol/l to 4.54mmol/l (p <0.001) and LDL cholesterol from 2.79mmol/l to 2.64mmol/l (p <0.001). There were also significant improvements in blood pressure with mean systolic blood pressure reducing by 15.7mmHg (p <0.001) and diastolic blood pressure reducing by 1.4mmHg (p <0.001). For people with type 2 diabetes, there was an increase in those achieving the recommended HbA1c target (<53mmol/l) from 47.6% to 57.4% (p <0.001). Mean reduction in bodyweight was 2.0kg (p <0.001), with 27.2% achieving a weight loss of >3% of initial bodyweight. The percentage of participants achieving the recommended physical activity guidelines increased by 31% (p <0.001). Conclusions A lifestyle modification programme delivered by an interdisciplinary team, aimed at individuals living with obesity, is not only acceptable to participants but also significantly reduces CVD risk factors. These findings should influence the design of future programmes and healthcare policies in Ireland and abroad.


2020 ◽  
Vol 129 (2) ◽  
pp. 283-296
Author(s):  
Lauren K. Park ◽  
Elizabeth J. Parks ◽  
Ryan J. Pettit-Mee ◽  
Makenzie L. Woodford ◽  
Thaysa Ghiarone ◽  
...  

This report provides evidence that in sedentary subjects with type 2 diabetes diminished insulin-stimulated increases in leg vascular conductance and ensuing blunted capillary perfusion in skeletal muscle are not restorable by increased walking alone. More innovative physical activity interventions that ultimately result in a robust mitigation of metabolic risk factors may be vital for reestablishing skeletal muscle microvascular insulin sensitivity in type 2 diabetes.


2021 ◽  
Author(s):  
Xiu Li Guo ◽  
Mei Tu ◽  
Yang Chen ◽  
Wei Wang

Abstract Objective Increasing evidences suggested that perirenal fat thickness (PrFT) was associated with metabolic risk factors, this study aimed to assess the association between PrFT with components of metabolic syndrome (MetS) and explore the value of PrFT in predicting MetS among Newly-Diagnosed type 2 diabetes(T2DM). Method A total of 445 patients with Newly-Diagnosed T2DM from southern China were enrolled into this study. Demographic and anthropometric information were collected. PrFT was evaluated by CT scanning on Revolution VCT 64. Binomial logistic regression analysis and receiver operating characteristics (ROC) curves were conducted to assess the value and optimal cutoff of PrFT for predicting MetS divided by sex. Results The prevalence of MetS was 58.2% in Newly-Diagnosed T2DM.Correlation analysis showed that PrFT was significantly correlated with metabolic risk factors (BMI, WC, TG, HDL-c, SBP, DBP, UA and HOMA-IR). PrFT was also shown to be independently associated with MetS after adjustment for other confounders, the ORs(95%CI) were 1.33(1.01~1.74) in men and 1.53(1.08~2.17) in women(P<0.05). ROC curves showed a good predictive value of PrFT for MetS, the the areas under the curve of ROC values of PrFT predicting MetS were 0.895(95% CI 0.852~0.939) in men and 0.910(95% CI 0.876~0.953) in women(P<0.001). The optimal cut-off values of PrFT were 14.6 mm (sensitivity: 83.8%, specificity: 89.6%) for men and 13.1 mm (sensitivity: 87.6%, specificity: 91.1%) for women. Conclusions PrFT was significantly independent with MetS and showed a powerful predictive value for MetS, which suggested PrFT could be a potential indicator to help clinicians to screen high-risk groups in Newly-Diagnosed T2DM. Clinical Trial Registration: This study was registered in Clinical Trials. Gov (ChiCTR2100052032).


2007 ◽  
Vol 32 (1) ◽  
pp. 76-88 ◽  
Author(s):  
Timo A. Lakka ◽  
David E. Laaksonen

Randomised controlled trials have shown that exercise training has a mild or moderate favourable effect on many metabolic and cardiovascular risk factors that constitute or are related to the metabolic syndrome (MetS). Epidemiological studies suggest that regular physical activity prevents type 2 diabetes, cardiovascular disease, and premature mortality in large part through these risk factors. Although randomized controlled trials with the prevention or treatment of the MetS as the main outcome have not been published, several large randomized controlled trials provide strong evidence that favourable lifestyle changes, including regular physical activity, are effective in the prevention of type 2 diabetes in individuals who are overweight and have impaired glucose tolerance. Compliance with the current recommendations to increase the total volume of moderate-intensity physical activity and to maintain good cardiorespiratory and muscular fitness appears to markedly decrease the likelihood of developing the MetS, especially in high-risk groups. Walking is the most common form of physical activity— it improves health in many ways and is generally safe. Therefore, brisk walking for at least 30 min daily can be recommended as the principal form of physical activity at the population level. If there are no contraindications, more vigorous physical exercise or resistance training should also be considered to obtain additional health benefits. Unstructured and low-intensity physical activity may also decrease the likelihood of developing the MetS, especially when substituted for sedentary behaviours such as watching television. The measurement of maximal oxygen consumption may provide an efficient means to target even individuals with relatively few metabolic risk factors who may benefit from more intensive intervention.


2019 ◽  
Vol 87 (March) ◽  
pp. 851-851
Author(s):  
YASMIN M. ABD EL-MONIM, M.Sc. NESREEN G. EL-NAHAS, Ph.D. ◽  
SALLY A. HAKEM, M.D.

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