A Prelude to Biogermylene Chemistry
Keyword(s):
<p><b>Abstract:</b> The biological applications of germylenes remain an unconceivable domain owing to their unstable nature. We report the isolation of air, water, and culture-medium stable germylene DPMGeOH (<b>3</b>) and its potential biological application (DPM = dipyrromethene ligand). Compound <b>3 </b>exhibits antiproliferative effects comparable to that of cisplatin in human cancer cells. The cytotoxicity of compound <b>3 </b>on normal epithelial cells is minimal and is similar to that of the currently used anti-cancer drugs. These findings provide a framework for a plethora of biological studies using germylenes and have important implications for low-valent main group chemistry.</p>
2012 ◽
Vol 2012
◽
pp. 1-11
◽
Keyword(s):
Keyword(s):
2007 ◽
Vol 97
(5)
◽
pp. 628-636
◽
2016 ◽
Vol 26
(9)
◽
pp. 2164-2169
◽
2008 ◽
Vol 18
(14)
◽
pp. 4044-4046
◽
Keyword(s):
2016 ◽
Vol 253
◽
pp. 112-124
◽
2021 ◽
Keyword(s):
Keyword(s):