A Prelude to Biogermylene Chemistry

2020 ◽  
Author(s):  
Pritam Mahawar, ◽  
Mishi Kaushal Wasson ◽  
Mahendra Kumar Sharma ◽  
Chandan Kumar Jha ◽  
Goutam Mukherjee ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Culture Medium ◽  
Human Cancer ◽  
Biological Applications ◽  
Biological Application ◽  
Antiproliferative Effects ◽  
Human Cancer Cells ◽  
Main Group Chemistry ◽  
Biological Studies ◽  
Anti Cancer

<p><b>Abstract:</b> The biological applications of germylenes remain an unconceivable domain owing to their unstable nature. We report the isolation of air, water, and culture-medium stable germylene DPMGeOH (<b>3</b>) and its potential biological application (DPM = dipyrromethene ligand). Compound <b>3 </b>exhibits antiproliferative effects comparable to that of cisplatin in human cancer cells. The cytotoxicity of compound <b>3 </b>on normal epithelial cells is minimal and is similar to that of the currently used anti-cancer drugs. These findings provide a framework for a plethora of biological studies using germylenes and have important implications for low-valent main group chemistry.</p>

A Prelude to Biogermylene Chemistry

2020 ◽  
Author(s):  
Pritam Mahawar, ◽  
Mishi Kaushal Wasson ◽  
Mahendra Kumar Sharma ◽  
Chandan Kumar Jha ◽  
Goutam Mukherjee ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Culture Medium ◽  
Human Cancer ◽  
Biological Applications ◽  
Biological Application ◽  
Antiproliferative Effects ◽  
Human Cancer Cells ◽  
Main Group Chemistry ◽  
Biological Studies ◽  
Anti Cancer

<p><b>Abstract:</b> The biological applications of germylenes remain an unconceivable domain owing to their unstable nature. We report the isolation of air, water, and culture-medium stable germylene DPMGeOH (<b>3</b>) and its potential biological application (DPM = dipyrromethene ligand). Compound <b>3 </b>exhibits antiproliferative effects comparable to that of cisplatin in human cancer cells. The cytotoxicity of compound <b>3 </b>on normal epithelial cells is minimal and is similar to that of the currently used anti-cancer drugs. These findings provide a framework for a plethora of biological studies using germylenes and have important implications for low-valent main group chemistry.</p>

scholarly journals Momordica charantiaExtract Induces Apoptosis in Human Cancer Cells through Caspase- and Mitochondria-Dependent Pathways

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Chia-Jung Li ◽  
Shih-Fang Tsang ◽  
Chun-Hao Tsai ◽  
Hsin-Yi Tsai ◽  
Jong-Ho Chyuan ◽  
...  
Keyword(s):  
Cell Death ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Dna Fragmentation ◽  
Human Cancer ◽  
Momordica Charantia ◽  
Carcinoma Cells ◽  
Human Cancer Cells ◽  
Adenocarcinoma Cells ◽  
Anti Cancer

Plants are an invaluable source of potential new anti-cancer drugs.Momordica charantiais one of these plants with both edible and medical value and reported to exhibit anticancer activity. To explore the potential effectiveness ofMomordica charantia, methanol extract ofMomordica charantia(MCME) was used to evaluate the cytotoxic activity on four human cancer cell lines, Hone-1 nasopharyngeal carcinoma cells, AGS gastric adenocarcinoma cells, HCT-116 colorectal carcinoma cells, and CL1-0 lung adenocarcinoma cells, in this study. MCME showed cytotoxic activity towards all cancer cells tested, with the approximate IC50ranging from 0.25 to 0.35 mg/mL at 24 h. MCME induced cell death was found to be time-dependent in these cells. Apoptosis was demonstrated by DAPI staining and DNA fragmentation analysis using agarose gel electrophoresis. MCME activated caspase-3 and enhanced the cleavage of downstream DFF45 and PARP, subsequently leading to DNA fragmentation and nuclear condensation. The apoptogenic protein, Bax, was increased, whereas Bcl-2 was decreased after treating for 24 h in all cancer cells, indicating the involvement of mitochondrial pathway in MCME-induced cell death. These findings indicate that MCME has cytotoxic effects on human cancer cells and exhibits promising anti-cancer activity by triggering apoptosis through the regulation of caspases and mitochondria.

scholarly journals Antiproliferative effects of sapacitabine (CYC682), a novel 2′-deoxycytidine-derivative, in human cancer cells

2007 ◽  
Vol 97 (5) ◽  
pp. 628-636 ◽  
Author(s):  
M Serova ◽  
C M Galmarini ◽  
A Ghoul ◽  
K Benhadji ◽  
S R Green ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Antiproliferative Effects ◽  
Human Cancer Cells

scholarly journals Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells

2016 ◽  
Vol 26 (9) ◽  
pp. 2164-2169 ◽  
Author(s):  
Nikhil R. Madadi ◽  
Amit Ketkar ◽  
Narsimha R. Penthala ◽  
April C.L. Bostian ◽  
Robert L. Eoff ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Anti Cancer

Synthesis of phosphatidylated-monoterpene alcohols catalyzed by phospholipase D and their antiproliferative effects on human cancer cells

2008 ◽  
Vol 18 (14) ◽  
pp. 4044-4046 ◽  
Author(s):  
Yukihiro Yamamoto ◽  
Masashi Hosokawa ◽  
Hideyuki Kurihara ◽  
Takashi Maoka ◽  
Kazuo Miyashita
Keyword(s):  
Cancer Cells ◽  
Phospholipase D ◽  
Human Cancer ◽  
Antiproliferative Effects ◽  
Human Cancer Cells

An appraisal of cinnamyl sulfonamide hydroxamate derivatives (HDAC inhibitors) for anti-cancer, anti-angiogenic and anti-metastatic activities in human cancer cells

2016 ◽  
Vol 253 ◽  
pp. 112-124 ◽  
Author(s):  
Neetinkumar D. Reddy ◽  
M.H. Shoja ◽  
Subhankar Biswas ◽  
Pawan G. Nayak ◽  
Nitesh Kumar ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Hdac Inhibitors ◽  
Human Cancer Cells ◽  
Anti Cancer

scholarly journals Synthetic sphingolipid analogs and anti-cancer drugs synergistically induced human colon and pancreatic cancer cell death through inhibiting ceramide metabolism

2021 ◽  
Author(s):  
Jing Song ◽  
Arie Dagan
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Human Cancer ◽  
Human Colon ◽  
Cancer Drugs ◽  
Human Cancer Cells ◽  
Low Concentrations ◽  
Anti Cancer ◽  
Sphingolipid Analogs

AbstractCeramide metabolism is a potential target for anti-cancer therapy. Studies show that chemotherapeutic agents can induce apoptosis and it is mediated by ceramide. Synthesized sphingolipid analogs can induce cell death in human lymphocytes and leukemia cells. By screening a group of synthetic sphingolipid analogs, we found that low concentrations of AD2750 and AD2646 induced cell death in human cancer cells by preventing ceramide from converting to sphingomyelin, individually or in combination with commercial cancer drugs. The combination of low concentrations of Taxol and AD2750 or AD2646 significantly increased cell death on human colon cancer cells (HT29). Co-administering low concentrations of Doxorubicin with AD2750 or AD2646 elevated cellular toxicity on human pancreatic cancer cells (CRL1687). This synergistic effect is related to the elevated cellular ceramide. Combining AD2750 or AD2646 with chemotherapy drugs can be used to manipulate ceramide and sphingomyelin metabolism, potentially to affect the growth of human cancer cells and increase the effectiveness of anti-cancer drugs on killing cancer cells.

Sign in / Sign up

Export Citation Format

Share Document