scholarly journals Thermosensitive Fluorescent Liposomes

2021 ◽  
Author(s):  
Jin Heng Lim ◽  
Ken Chi Lik Lee
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Squaraine Dyes ◽  
Squaraine Dye

Liposomes are versatile nanomaterials used in a variety of applications such as drug delivery and bioimaging. In this study, three asymmetrical squaraine dyes were synthesized and embedded in liposomes in the efforts to find a suitable dye that can be used for bioimaging procedures involving liposomes. The optical properties of the synthesized dyes as well as their liposomes were studied and compared to the previously synthesized asymmetrical squaraine dye SQR22 and its liposome form. <br>

scholarly journals Thermosensitive Fluorescent Liposomes

2021 ◽  
Author(s):  
Jin Heng Lim ◽  
Ken Chi Lik Lee
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Squaraine Dyes ◽  
Squaraine Dye

Liposomes are versatile nanomaterials used in a variety of applications such as drug delivery and bioimaging. In this study, three asymmetrical squaraine dyes were synthesized and embedded in liposomes in the efforts to find a suitable dye that can be used for bioimaging procedures involving liposomes. The optical properties of the synthesized dyes as well as their liposomes were studied and compared to the previously synthesized asymmetrical squaraine dye SQR22 and its liposome form. <br>

scholarly journals Nature of intermolecular interaction in squaraine dimers

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Anna Kaczmarek-Kędziera ◽  
Piotr S. Żuchowski ◽  
Dariusz Kędziera
Keyword(s):  
Optical Properties ◽  
Perturbation Theory ◽  
Quantum Chemistry ◽  
Harmonic Generation ◽  
Second Harmonic ◽  
Detailed Knowledge ◽  
New Materials ◽  
Squaraine Dyes ◽  
Squaraine Dye ◽  
Infra Red

AbstractSquaraine dyes are known for their particular optical properties. They exhibit intense photochemically stable fluorescence in usually (near) infra red region that can be quenched by intermolecular interactions. Moreover, even the centrosymmetric dyes feature non-zero second harmonic generation upon aggregation. Therefore, the detailed knowledge of the squaraine dye interaction nature both in homogenic aggregates and with other species present in the environment can be of importance for the design of new materials of desired properties. In the present study, interaction in squaraine dimers is investigated with quantum chemistry tools. Four structures: two stacked and two hydrogen-bonded are analyzed in terms of supermolecular approach and symmetry-adapted perturbation theory. MP2C/aug-cc-pVTZ supermolecular calculations confirm the particular stability of the stacked dimers and the favoured dispersion attraction for the long-displaced system.

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

scholarly journals Preparation and application of various nanoparticles in biology and medicine

2013 ◽  
Vol 3 (1) ◽  
pp. 2 ◽  
Author(s):  
Vardan Gasparyan
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Optical Properties ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Gold And Silver Nanoparticles ◽  
Mri Contrast ◽  
Cellular Processes ◽  
Magnetic Resonance Imaging Mri

The present paper considers prospects for application of various nanoparticles in biology and medicine. Here are presented data on preparation of gold and silver nanoparticles, and effects of shape of these nanoparticles on their optical properties. Application of these nanoparticles in diagnostics, for drug delivery and therapy, and preparation of magnetic nanoparticles from iron and cobalt salts are also discussed. Application of these nanoparticles as magnetic resonance imaging (MRI) contrast agents and as vehicles for drug delivery, and preparation of quantum dots and their application as prospective nanoparticles for multiplex analysis and for visualization of cellular processes will be tackled. Finally, prospects for new types of nanocomposites (metallic nano-shells) will be not overlooked.

scholarly journals Coated silver nanoparticles: synthesis, cytotoxicity, and optical properties

RSC Advances ◽  
2019 ◽  
Vol 9 (35) ◽  
pp. 20118-20136 ◽  
Author(s):  
Heba Mohamed Fahmy ◽  
Ayaat Mahmoud Mosleh ◽  
Aya Abd Elghany ◽  
Engy Shams-Eldin ◽  
Esraa Samy Abu Serea ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Optical Properties ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nanoparticles Synthesis

Coated silver nanoparticles (AgNPs) have recently become a topic of interest due to the fact that they have several applications such as in electronic, antimicrobial, industrial, optical, and medical fields as biosensors and drug delivery systems.

Effect of Substituents on Optical Properties and Charge-Carrier Polarity of Squaraine Dyes

2014 ◽  
Vol 118 (4) ◽  
pp. 1793-1799 ◽  
Author(s):  
Andrea M. Della Pelle ◽  
Paul J. Homnick ◽  
Youngju Bae ◽  
Paul M. Lahti ◽  
S. Thayumanavan
Keyword(s):  
Optical Properties ◽  
Charge Carrier ◽  
Effect Of Substituents ◽  
Squaraine Dyes

Squaraine dyes for organic photovoltaic cells

2015 ◽  
Vol 3 (28) ◽  
pp. 14517-14534 ◽  
Author(s):  
Guo Chen ◽  
Hisahiro Sasabe ◽  
Tsukasa Igarashi ◽  
Ziruo Hong ◽  
Junji Kido
Keyword(s):  
Photovoltaic Cells ◽  
Organic Photovoltaic ◽  
Organic Photovoltaic Cells ◽  
Squaraine Dyes ◽  
Recent Advances ◽  
Squaraine Dye

In this review, we present the recent advances in squaraine dye materials and their applications to organic photovoltaic cells.

The History of Azulenyl Squaraines

2017 ◽  
Vol 70 (8) ◽  
pp. 857 ◽  
Author(s):  
Daniel E. Lynch ◽  
Darren G. Hamilton
Keyword(s):  
Absorption Maximum ◽  
Scientific Literature ◽  
Organic Dyes ◽  
Research Activity ◽  
Squaraine Dyes ◽  
Maximum Value ◽  
Squaraine Dye ◽  
Patent Literature ◽  
History Of

The synthesis of the first azulenyl squaraine dye was reported in 1966 and the paucity of activity in the scientific literature since that time has given the false impression that they have remained relatively unexplored as organic dyes. In contrast, a wealth of research activity on azulenyl squaraines has been recorded in the patent literature and it is the purpose of this review to bring these reports to the attention of scientists that have an interest in the chemistry and applications of squaraine dyes. This review shows that it is possible to prepare, via targeted substitution of the azulene ring, a dye with an absorption maximum value ranging from 650 to 840 nm.

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

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