What factors affect the effectiveness of long - term analgesic therapy for osteoarthritis? Data analysis of the multi - center 3-month PARACELSUS study

There are factors that can affect the effectiveness of treatment of osteoarthritis (OA). Aim to identify factors affecting the effectiveness of long - term analgesic therapy in OA. Materials and methods. The study included 6448 patients (70.9% female and 29.1% male), middle age 57.8±10.2 years, with severe pain [≥40 mm on the visual analog scale]. All patients received the preparation of avocado - soybean unsaponifiables (ASU) 300 mg/day. For pain relief at the beginning and during the study, the drug Ketoprofen lysine salt (KLS) 320 mg/day was used. The efficiency criterion was pain reduction ≥50% and satisfaction with treatment ≥4 on a 5-point scale. The influence of a number of factors on the result of treatment was evaluated. Results. For 3 months of treatment, the pain decreased from 63.7±12.0 to 14.2±11.7 mm VAS. The result was evaluated as "good" or "excellent" 81.7% of patients. Adverse reactions were rare. In total, a good response to therapy was noted in 87.4% of patients. Gender, body mass index ≥30 kg/m2, type 2 diabetes mellitus, poor effect of non - steroidal anti - inflammatory drugs (NSAIDs) and Symptomatic Slow-Acting Drugs in Osteoarthritis (SYSADOA) in history did not affect the result. The effect was lower in persons >65 years [odds ratio (OR) 0.418; 95% confidence interval (CI) 0.342-0.509, p2 by Kellgren-Lawrence (OR 0.556; 95% CI 0.298-0.738, p

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Personalization of the use of non-steroidal anti-inflammatory drugs for musculoskeletal diseases. Resolution on the results of the Meeting of Experts of December 13, 2017

Medical Council ◽

10.21518/2079-701x-2018-18-76-84 ◽

2018 ◽

pp. 76-84 ◽

Cited By ~ 1

Author(s):

A. E. Karateev ◽

A. M. Lila ◽

I. S. Dydykina ◽

P. R. Kamchatnov ◽

S. O. Mazurenko ◽

...

Keyword(s):

Musculoskeletal Diseases ◽

Modern Medicine ◽

Individual Characteristics ◽

Analgesic Therapy ◽

Acute Pain Therapy ◽

Inflammatory Drugs ◽

The Individual ◽

Key Aspects

The personalization of therapy is one of the innovative approaches gaining an increasingly strong foothold in modern medicine, implying an individual approach to each patient, taking into account the individual characteristics of the patient and the specific clinical case. This same standpoint of personified therapy should be used to plan rational analgesic therapy, the most important component of managing patients with the most common and socially significant diseases, with conditions that have a significant impact on the patient’s quality of life and worsen the course of concomitant diseases. The Meeting of Experts of different specialties such as rheumatologists, neurologists, cardiologists and clinical pharmacologists considered the key aspects of the prescription of NSAIDs, the most widely used class of painkillers, including those used for the relief of musculoskeletal pain. It was noted that when choosing NSAIDs, the practitioner should take into account the diagnosis, the planned duration of analgesic therapy, the intensity of pain, medical history data, the presence of comorbid diseases and risk factors for drug complications. There are different types of NSAIDs, some of which are most useful for urgent acute pain therapy (eg, ketoprofen), while others are most suitable for long-term pain management in chronic diseases (eg, etoricoxib). In any case, the practitioner should take into account the priority of patient safety and pay the utmost attention to the prevention of NSAIDassociated complications, and also keep in mind the duration of the specific drug administration permitted by the patient information leaflet. It was also noted that the launch of a new generic etoricoxib (Kostarox®) expands the possibilities of analgesic therapy for the Russian practitioners.

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Anti-Inflammatory Functional Foods

Complementary and Alternative Medicine ◽

10.4018/978-1-5225-7039-4.ch009 ◽

2019 ◽

pp. 205-235

Author(s):

Charu Gupta ◽

Consuelo Pacheco ◽

Dhan Prakash

Keyword(s):

Fruits And Vegetables ◽

Epigallocatechin Gallate ◽

Protective Mechanisms ◽

Over Expression ◽

Severe Haemorrhage ◽

Anti Oxidant ◽

Inflammatory Drugs ◽

Anti Inflammatory

Chronic inflammation is caused by an over-expression or lack of control of the normal protective mechanisms and has been linked to heart disease, osteoporosis, cognitive decline and Alzheimer's, type-2 diabetes and arthritis. Current medications include treatment with steroids that reduce inflammation or swelling. Long-term use of non-steroidal anti-inflammatory drugs can cause several side effects and in extreme cases can cause severe haemorrhage and renal effects. There are other various anti-inflammatory nutrients which reduce the level of these biomarkers. The polyphenols show significant anti-inflammatory, anti-oxidant and anti-DNA damaging effects. Anti-inflammatory foods such as whole grains, fruits and vegetables, which provide valuable antioxidant polyphenols, resveratrol, lycopene, phytosterols, curcuminoids, quercetin, epigallocatechin gallate, phenolic acids, alleviates inflammation, as well as strengthening the immune system. The present chapter would thus focus on the phytochemicals of nutraceutical importance for combating inflammation naturally.

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