scholarly journals Gouty (urate) nephropathy

2021 ◽  
Vol 23 (1) ◽  
pp. 11-14
Author(s):  
Viktor V. Fomin ◽  
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Acid Metabolism ◽  
Kidney Damage ◽  
Urate Nephropathy ◽  
Clinical Variants

Clinical variants of kidney damage in gout including asymptomatic disorders of uric acid metabolism are discussed. The risk factor for hyperuricemia and associated kidney damage, clinical variants of gouty nephropathy and approaches to its treatment are presented. Keywords: gout, urate nephropathy, hyperuricemia, uric acid For citation: Fomin VV. Gouty (urate) nephropathy. Consilium Medicum. 2021; 23 (1): 11–14. DOI: 10.26442/20751753.2021.1.200709

Pitfalls in the Evaluation of Uric Acid as a Risk Factor for Vascular Disease~!2009-10-29~!2009-12-23~!2010-04-08~!

2010 ◽  
Vol 3 (2) ◽  
pp. 44-50 ◽  
Author(s):  
Konstantinos Tziomalos ◽  
Vasilios G. Athyros ◽  
Asterios Karagiannis ◽  
Dimitri P. Mikhailidis
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Vascular Disease

Thyroid hormones modulate uric acid metabolism in patients with recent onset subclinical hypothyroidism by improving insulin sensitivity

2019 ◽  
Vol 15 (1) ◽  
pp. 67-71 ◽  
Author(s):  
Giovambattista Desideri ◽  
Raffaella Bocale ◽  
Anna Maria D’Amore ◽  
Giulia Carnassale ◽  
Stefano Necozione ◽  
...  
Keyword(s):  
Uric Acid ◽  
Insulin Sensitivity ◽  
Thyroid Hormones ◽  
Subclinical Hypothyroidism ◽  
Acid Metabolism ◽  
Recent Onset

scholarly journals STUDIES IN URIC ACID METABOLISM

1923 ◽  
Vol 55 (3) ◽  
pp. 373-384
Author(s):  
Howard B. Lewis ◽  
Ralph C. Corley
Keyword(s):  
Uric Acid ◽  
Acid Metabolism

scholarly journals STUDIES IN ENDOGENOUS URIC ACID METABOLISM

1914 ◽  
Vol 19 (4) ◽  
pp. 473-485
Author(s):  
G.W. Raiziss ◽  
H. Dubin ◽  
A.I. Ringer
Keyword(s):  
Uric Acid ◽  
Acid Metabolism

Abstract 14920: Uric Acid is Neither the Risk Factor nor Prognostic Factor for 3-year Clinical Events in Vasospastic Angina Patients Regardless of Gender

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Sang-Ho Park ◽  
Seung Woon Rha ◽  
Ung Jun ◽  
Byoung Geol Choi ◽  
Se Yeon Choi ◽  
...  
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Coronary Artery ◽  
Prognostic Factor ◽  
Uric Acid Level ◽  
Acid Level ◽  
Female Gender ◽  
Male Gender ◽  
Vasospastic Angina ◽  
Clinical Events

Background: It has been reported that a major cause of vasospastic angina is endothelial dysfunction of the coronary artery. However, it is controversial whether the uric acid level is associated with vasospastic angina, and can be a prognostic factor for vasospastic angina. Methods: A total 3828 patients (pts) underwent coronary angiography with acetylcholine (Ach) provocation test from Mar 2004 to Sep 2012 were enrolled. The definition of positive coronary artery spasm (CAS) was defined as transient luminal narrowing more than 70%. The uric acid level was categorized into 4 quartile groups; less than 3.8, 3.9~4.7, 4.8~5.7, and more than 5.8 mg/dL. Major adverse cardiovascular events (MACEs) defined as the composite of recurrent chest pain, cardiac death, myocardial infarction, and cerebrovascular accident were valuated up to 3 years. Results: The follow-up rate was the 61.1% (2340/3828). There was no difference in uric acid level between negative and positive CAS groups in female gender but in male gender, uric acid level was higher in negative CAS group (Table 1). However, when adjusted by age, the difference was disappeared (OR, 0.965; 95% CI, 0.898-1.037; P-value, 0.335). The incidence of MACE was 11.1% in male gender and 8.6% in female gender. In male gender, the serum uric acid level between the groups with and without MACE was similar but in female gender, the uric acid level was higher in the group with MACE. However, when adjusted by age, uric acid was not associated with MACE (Table 2). Conclusions: In our study, uric acid was neither the risk factor nor prognostic factor for 3-year clinical events in CAS patients regardless of gender.

Abstract P146: Uric Acid is an Independent Risk Factor for Developing Hypertension From Prehypertension: A 5-year Japanese Cohort Study

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Masanari Kuwabara ◽  
Shigeko Hara ◽  
Koichiro Niwa ◽  
Minoru Ohno ◽  
Ichiro Hisatome
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Risk Factor ◽  
Cohort Study ◽  
Serum Uric Acid ◽  
Independent Risk Factor ◽  
Drinking Habits

Objectives: Prehypertension frequently progresses to hypertension and is associated with cardiovascular diseases, stroke, excess morbidity and mortality. However, the identical risk factors for developing hypertension from prehypertension are not clarified. This study is conducted to clarify the risks. Methods: We conducted a retrospective 5-year cohort study using the data from 3,584 prehypertensive Japanese adults (52.1±11.0 years, 2,081 men) in 2004 and reevaluated it 5 years later. We calculated the cumulative incidences of hypertension over 5 years, then, we detected the risk factors and calculated odds ratios (ORs) for developing hypertension by crude analysis and after adjustments for age, sex, body mass index, smoking and drinking habits, baseline systolic and diastolic blood pressure, pulse rate, diabetes mellitus, dyslipidemia, chronic kidney disease, and serum uric acid. We also evaluated whether serum uric acid (hyperuricemia) provided an independent risk for developing hypertension. Results: The cumulative incidence of hypertension from prehypertension over 5 years was 25.3%, but there were no significant differences between women and men (24.4% vs 26.0%, p=0.28). The cumulative incidence of hypertension in subjects with hyperuricemia (n=726) was significantly higher than those without hyperuricemia (n=2,858) (30.7% vs 24.0%, p<0.001). After multivariable adjustments, the risk factors for developing hypertension from prehypertension were age (OR per 1 year increased: 1.023; 95% CI, 1.015-1.032), women (OR versus men: 1.595; 95% CI, 1.269-2.005), higher body mass index (OR per 1 kg/m 2 increased: 1.051; 95% CI 1.021-1.081), higher baseline systolic blood pressure (OR per 1 mmHg increased: 1.072; 95% CI, 1.055-1.089) and diastolic blood pressure (OR per 1 mmHg increased: 1.085; 95% CI, 1.065-1.106), and higher serum uric acid (OR pre 1 mg/dL increased: 1.149; 95% CI, 1.066-1.238), but not smoking and drinking habits, diabetes mellitus, dyslipidemia, and chronic kidney diseases. Conclusions: Increased serum uric acid is an independent risk factor for developing hypertension from prehypertension. Intervention studies are needed to clarify whether the treatments for hyperuricemia in prehypertensive subjects are useful.

Sign in / Sign up

Export Citation Format

Share Document