Probiotics in obstetric practice: efficacy and safety

The intestinal microbiota modulates immune programming and can prevent the realization of an allergic phenotype. For the formation of a normal microbiocenosis of the intestine, skin and oral cavity, a sufficient quantitative and qualitative bacterial colonization of the newborn is necessary during the transition from a sterile intrauterine environment to microbial colonization, resulting in the appearance of more than 1014 microorganisms. Low levels of bifidobacteria and early colonization of potentially pathogenic bacteria are associated with the development of severe allergic reactions. Prescribing probiotics containing Lactobacillus rhamnosus GG (LGG) at a concentration of 1081010 CFU from 36 weeks of gestation and during the first 34 months of lactation is associated with a 21% reduction in the risk of allergic reactions in the child.

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Lactobacillus rhamnosus GG and Biochemical Agents Enrich the Shelf Life of Fresh-Cut Bell Pepper (Capsicum annuum L. var. grossum (L.) Sendt)

Foods ◽

10.3390/foods9091252 ◽

2020 ◽

Vol 9 (9) ◽

pp. 1252

Author(s):

Kandasamy Saravanakumar ◽

Anbazhagan Sathiyaseelan ◽

Arokia Vijaya Anand Mariadoss ◽

Ramachandran Chelliah ◽

Xiaowen Hu ◽

...

Keyword(s):

Bacterial Colonization ◽

Antioxidant Properties ◽

Lactobacillus Rhamnosus ◽

Probiotic Strain ◽

Bell Pepper ◽

Microbial Colonization ◽

Lactobacillus Rhamnosus Gg ◽

Combined Application ◽

Fresh Cut

This work analyzed the individual and combined effects of biochemical additives and probiotic strain Lactobacillus rhamnosus GG on red and yellow fresh-cut bell pepper (R- and Y-FCBP, respectively) stored at two different temperatures (4 °C and 15 °C) for 15 days. The results revealed that the combined application of biochemical additives and L. rhamnosus GG inhibited the colonization of total bacterial counts (25.10%), total Salmonella counts (38.32%), total Listeria counts (23.75%), and total fungal counts (61.90%) in FCBP. Total bacterial colonization was found to be higher in R-FCBP (1188.09 ± 9.25 CFU g−1) than Y-FCBP (863.96 ± 7.21 CFU g−1). The storage at 4 °C was prevented 35.38% of microbial colonization in FCBP. Importantly, the L. rhamnosus GG count remained for up to 12 days. Moreover, the combined inoculation of the biochemical additives and L. rhamnosus GG treatments (T3) maintained the quality of R- and Y-FCBP for up to 12 days at 4 °C without any loss of antioxidant properties. This work reports the successful utilization of L. rhamnosus GG as a preservative agent for maintaining the quality of FCBP by preventing microbial colonization.

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The world of synbiotics: a review of literature and clinical evidence in diarrhoea from the lens of a paediatrician

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20185219 ◽

2018 ◽

Vol 6 (1) ◽

pp. 233

Author(s):

Pramod Jog

Keyword(s):

Clinical Evidence ◽

Lactobacillus Rhamnosus ◽

Acute Diarrhoea ◽

Efficacy And Safety ◽

Review Of Literature ◽

Rota Virus ◽

Lactobacillus Rhamnosus Gg ◽

Virus Origin ◽

The World ◽

Better Than

The use of synbiotics in the management of acute diarrhoea in children is becoming a common practice in India. However, since this is an upcoming modality of treatment, it is essential to review the scientific rationale and evidence on clinical efficacy and safety in the context of paediatric diarrhoea. In addition, most synbiotics contain a combination of multiple probiotics along with a prebiotic. Thus arises, a parallel need to understand whether a combination of probiotics performs better than single probiotics, hence justifying the rationale for such combinations. A review of available evidence suggests that synbiotics are indeed safe and superior in efficacy to single probiotics (like Bacillus clausii, Lactobacillus rhamnosus GG etc) and that there is a good body of evidence to support the efficacy and tolerability of synbiotics in the management of paediatric acute gastroenteritis. There is also evidence to suggest that combination probiotics have superior benefits compared to single probiotics, thus justifying their use as part of synbiotics. The overall benefits of synbiotics reported in various clinical trials on paediatric diarrhoea include, a rapid normalization of the gastrointestinal flora, a reduction in the duration of diarrhoea, quicker improvement in stool consistency, lesser administration of additional medications like antibiotics, antiemetics and antipyretics, higher physician reported treatment satisfaction scores and enhanced overall efficacy against gastrointestinal pathogens, including diarrhoea of rota virus origin. Hence, synbiotics put up a strong case to look beyond probiotics and single probiotic formulations in paediatric diarrhoea.

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