scholarly journals Interleukin-6 gene polymorphism (-174 G/C) association with seropositive Toxoplasma gondii infection patients in Al-Diwaniyah hospital

2019 ◽  
Vol 10 (3) ◽  
pp. 1948-1952
Author(s):  
Fatima Ibrahim Mohammad ◽  
Mustafa Ali Abdul Ameer
Keyword(s):  
Toxoplasma Gondii ◽  
Gene Polymorphism ◽  
Pregnant Women ◽  
Interleukin 6 ◽  
Control Group ◽  
Women Patients ◽  
Healthy Control ◽  
Toxoplasma Gondii Infection

The present study aims to detection Interleukin-6 gene polymorphism (-174 G/C) from seropositive Toxoplasma gondii pregnant women patients and healthy control from individuals reviewers to AL-Diwaniyah hospital. 80 samples were collected for the period from October 2018- April 2019, including two groups of 30 samples healthy control and 50 samples from pregnant women infected with Toxoplasma gondii. The results of the present study indicated the presence of IL-6 (-174 G/C) polymorphism in pregnant women infected with Toxoplasma gondii and healthy control. Where was observed that CG genotype more frequent in patients indicating the association of this genotype with the disease compared to the control group where CG genotype appears less. Also, the results of the current study indicate the appearance of allele C more frequently in pregnant women patients compared to healthy control. We can conclude from the present study there association of appearance allele C with Toxoplasma gondii infection.

scholarly journals Cytokines Level (Il8 and Il17) in Pregnant Women with Toxoplasmosis in Khartoum State

2019 ◽  
Vol 1 (1) ◽  
pp. 8-12
Author(s):  
Wahaj M. M ◽  
Satti, A. B ◽  
Abdalla H.S ◽  
Ahmed S. Kabbashi
Keyword(s):  
Toxoplasma Gondii ◽  
Serum Level ◽  
Pregnant Women ◽  
Venous Blood ◽  
Control Group ◽  
Cross Sectional ◽  
Study Population ◽  
Patient’S Information ◽  
The Mean ◽  
Toxoplasma Gondii Infection

Toxoplasmosis is one of the most important zoonotic diseases worldwide caused by Toxoplasma gondii that leads to abortion or hydrocephalus during pregnancy. It’s a comparative cross-sectional one designed to assess immunoglobulins and cytokines in pregnant women. A total of 300 venous blood samples were collected from each pregnant woman and centrifuged to obtain serum. Patient’s information was recorded in a questionnaire previously designed for the purpose of analysis. In addition, 40 uninfected women were enrolled in the study as control group to assess the level of IL8 and IL17 cytokines. The overall seropositive rate of Toxoplasma gondii infection was 22.6%. Within the positive cases of study population, only 16 and 13 showed positive results of IL8, IL17 respectively. The results showed highly significant increase in the mean serum level of IL8 (210.25pg/ml) and IL17 (203.15 pg/ml) when compared to the control group who showed 68.9 pg/ml and 54.8 pg/ml respectively. The serum level of proinflammatory cytokines investigated in this study seems to be increased in patients with serological evidence of Toxoplasma gondii infection. Our study concludes that IL-17 and IL-8 involved in the induction of inflammation and toxoplasmosis disease.

scholarly journals Spiramycin Treatment of Toxoplasma gondii Infection in Pregnant Women Impairs the Production and the Avidity Maturation of T. gondii-Specific Immunoglobulin G Antibodies

2009 ◽  
Vol 16 (10) ◽  
pp. 1517-1520 ◽  
Author(s):  
V. Meroni ◽  
F. Genco ◽  
C. Tinelli ◽  
P. Lanzarini ◽  
L. Bollani ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Pregnant Women ◽  
Immunoglobulin G ◽  
Adult Patients ◽  
Control Group ◽  
Igg Antibody ◽  
Specific Immunoglobulin ◽  
Specific Igg ◽  
Toxoplasma Gondii Infection ◽  
Avidity Maturation

ABSTRACT The aim of the study was to evaluate the influence of treatment with spiramycin on the increase of immunoglobulin G (IgG) titers and IgG avidity indexes (AI) in pregnant women with seroconversion from the beginning of therapy until delivery and after delivery. This group was compared with adult patients with recently acquired untreated toxoplasmosis. One hundred four samples from 32 pregnant women with seroconversion for toxoplasmosis and/or very low IgG AI were followed from the beginning of therapy with spiramycin until delivery. Twenty-nine women were further followed some months after delivery and interruption of therapy. Thirty-eight samples from 16 untreated, nonpregnant patients were evaluated as the control group. The Toxoplasma gondii-specific IgG antibody and the T. gondii-specific IgG AI were significantly delayed in pregnant women receiving therapy compared to nonpregnant, untreated controls, and the findings were consistent with the results of assays from two different manufacturers. The T. gondii-specific IgG AI increased in pregnant women after they gave birth. Avidity maturation is delayed during pregnancy and treatment, and low-avidity antibodies in pregnant women within 3 to 4 months cannot be taken as a sign of infection.

scholarly journals Seroprevalence and risk factors of Toxoplasma gondii infection in pregnant women from Bobo Dioulasso, Burkina Faso

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Sanata Bamba ◽  
Mamoudou Cissé ◽  
Ibrahim Sangaré ◽  
Adama Zida ◽  
Souleymane Ouattara ◽  
...  
Keyword(s):  
Risk Factors ◽  
Toxoplasma Gondii ◽  
Burkina Faso ◽  
Pregnant Women ◽  
Bobo Dioulasso ◽  
Toxoplasma Gondii Infection

The Effect of lnterleukin-6 Gene Polymorphism on Pediatric Pneumonia

2020 ◽  
Author(s):  
Guode SU ◽  
Lili DING ◽  
Zhenkun ZHANG
Keyword(s):  
Gene Polymorphism ◽  
Allele Frequency ◽  
Interleukin 6 ◽  
Control Group ◽  
Healthy Children ◽  
Observation Group ◽  
Gene Fragment ◽  
Time Period ◽  
Pediatric Pneumonia

Background: To investigate the effect of interleukin-6 (IL-6) gene polymorphism on pediatric pneumonia. Methods: Overall, 438 patients with pediatric pneumonia (Observation group) treated in Xuzhou Children Hospital, Cinna from July 2013 to July 2018 were randomly enrolled. Meanwhile, 423 healthy children (Control group) in the same time period were randomly selected. PCR was applied to amplify the IL-6-572 gene fragment. The IL-6-572 polymorphism was detected, and the impacts of gene polymorphism difference on pediatric pneumonia were observed. pneumonia were observed. Results: There were differences in the IL-6 genotypes between the two groups (P<0.05). Among the CG+GG genotypes in Observation group, G allele frequency was higher than that in control group (P<0.05). The risk of pediatric pneumonia for GC genotype was 2.13 times as high as that for CC genotype, and the risk of pediatric pneumonia for GG genotype was 5.56 times as high as that for CC genotype. Conclusion: IL-6 gene polymorphism might be related to the pediatric pneumonia and the population with G allele at this locus may be more prone to pediatric pneumonia.

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