scholarly journals Clinical and Epidemiologic Characteristics of Castration Resistant Prostate Cancer Patients in Sulaimaniyah, Iraqi Kurdistan

2020 ◽  
Vol 11 (3) ◽  
pp. 3675-3683
Author(s):  
Khalid Anwar Hama Ghareeb ◽  
Zahira Metwally Gad ◽  
NohaAwad ◽  
Mohammed Ibrahim Mohialdeen Gubari ◽  
Jwan Jalal Rasheed shwana ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Castration Resistant Prostate Cancer ◽  
Chi Square ◽  
Face To Face ◽  
Development Of Resistance ◽  
Castration Resistant ◽  
Iraqi Kurdistan ◽  
Chi Square Test ◽  
Epidemiologic Characteristics

Prostate cancer is prevalent among men aged over 65 and has been reported as the fourth most common cause of mortality of males all over the world. In addition to age, family history, and race, there are some lifestyle features such as diet, obesity, alcohol, and smoking are believed to play a role in its development. The present study was carried out in order to examine the clinical and epidemiologic characteristics of castration-resistant prostate cancer patients identify predictive factors for development of resistance to hormonal therapy. The present retrospective cohort study was carried out on 150 patients who were diagnosed with prostate cancer at Hiwa Cancer hospital in Sulaimania, Iraqi Kurdistan over the period of 2009-2014. Required data were collected using face-to-face or phone interviews using a questionnaire and the patients’ hospital records. The collected data were analyzed using descriptive statistics, one-sample Kolmogorov-Smirnov test, independent samples t-test, Mann Whitney test, and Pearson’s Chi-square test through SPSS 20.0.

scholarly journals Utility of prophylactic antibiotics for preventing febrile neutropenia during cabazitaxel therapy for castration-resistant prostate cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Keitaro Watanabe ◽  
Takeo Kosaka ◽  
Hiroshi Hongo ◽  
Mototsugu Oya
Keyword(s):  
Prostate Cancer ◽  
Febrile Neutropenia ◽  
Prophylactic Antibiotics ◽  
University Hospital ◽  
Negative Group ◽  
Castration Resistant Prostate Cancer ◽  
Chi Square ◽  
Positive Group ◽  
Castration Resistant ◽  
Chi Square Test

AbstractThe aim was to investigate the efficacy of prophylactic antibiotics for the prevention of febrile neutropenia (FN) during cabazitaxel therapy for castration-resistant prostate cancer (CRPC) with G-CSF. We retrospectively studied 443 cycles of cabazitaxel therapy given to 56 patients with CRPC at Keio University Hospital between May 2012 and August 2018. Statistical analysis was conducted to determine whether the combination of prophylactic G-CSF and antibiotics was more effective in preventing FN, compared with prophylactic G-CSF alone. Prophylactic PEG-G-CSF or G-CSF was administered in all 443 cycles. Only fluoroquinolones were used as prophylactic antibiotics and were administered in 328 cycles (74.0%). FN occurred in 5 cycles (1.1%). Prophylactic antibiotics were administered in 327 cycles (74.6%) in the FN-negative group and in only 1 cycle (20.0%) in the FN-positive group. Chi-square test indicated the incidence of FN was significantly lower in the group that received prophylactic antibiotics compared with the group that did not receive prophylactic antibiotics (P = 0.017). Compared with prophylactic G-CSF alone, prophylactic G-CSF and antibiotics significantly suppressed the occurrence of FN.

scholarly journals Novel, non-invasive markers for detecting therapy induced neuroendocrine differentiation in castration-resistant prostate cancer patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Divya Bhagirath ◽  
Michael Liston ◽  
Theresa Akoto ◽  
Byron Lui ◽  
Barbara A. Bensing ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Neuroendocrine Differentiation ◽  
Extracellular Vesicle ◽  
Machine Learning Algorithms ◽  
Castration Resistant Prostate Cancer ◽  
Cellular Models ◽  
Non Invasive ◽  
Castration Resistant ◽  
Neuroendocrine Prostate Cancer

AbstractNeuroendocrine prostate cancer (NEPC), a highly aggressive variant of castration-resistant prostate cancer (CRPC), often emerges upon treatment with androgen pathway inhibitors, via neuroendocrine differentiation. Currently, NEPC diagnosis is challenging as available markers are not sufficiently specific. Our objective was to identify novel, extracellular vesicles (EV)-based biomarkers for diagnosing NEPC. Towards this, we performed small RNA next generation sequencing in serum EVs isolated from a cohort of CRPC patients with adenocarcinoma characteristics (CRPC-Adeno) vs CRPC-NE and identified significant dysregulation of 182 known and 4 novel miRNAs. We employed machine learning algorithms to develop an ‘EV-miRNA classifier’ that could robustly stratify ‘CRPC-NE’ from ‘CRPC-Adeno’. Examination of protein repertoire of exosomes from NEPC cellular models by mass spectrometry identified thrombospondin 1 (TSP1) as a specific biomarker. In view of our results, we propose that a miRNA panel and TSP1 can be used as novel, non-invasive tools to identify NEPC and guide treatment decisions. In conclusion, our study identifies for the first time, novel non-invasive exosomal/extracellular vesicle based biomarkers for detecting neuroendocrine differentiation in advanced castration resistant prostate cancer patients with important translational implications in clinical management of these patients that is currently extremely challenging.

Prognostic parameters for response to enzalutamide after docetaxel and abiraterone treatment in metastatic castration-resistant prostate cancer patients; a possible time relation

The Prostate ◽  
2015 ◽  
Vol 76 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Sushil K. Badrising ◽  
Vincent van der Noort ◽  
Alfons J.M. van den Eertwegh ◽  
Paul Hamberg ◽  
Inge M. van Oort ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Prognostic Parameters ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant ◽  
Time Relation
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