scholarly journals Cytotoxic activities of zinc oxide nanoparticles on non-invasive human breast and prostate cancer cell lines

2021 ◽  
Vol 12 (1) ◽  
pp. 749-756
Author(s):  
Fakhria A Al-joufi ◽  
Jawaher AlEnzi ◽  
Madawy Alhazmi ◽  
Hassan A Elgebaly
Keyword(s):  
Zinc Oxide ◽  
Cancer Cells ◽  
Sol Gel ◽  
Research Work ◽  
Cytotoxic Activities ◽  
Dependent Manner ◽  
Anticancer Activities ◽  
Zno Nps ◽  
Gel Method ◽  
Sol Gel Method

ZnO-NPs have displayed anticancer activity against a broad range of tumor cells. The present research work was planned to formulate highly pure and well-characterized ZnO-NPs, in addition, to investigate their cytotoxicity against two types of cancer cells. The cancer cells that had been investigated in the present study were breast (MCF7) and prostate (PC3) cancer cells. The aqueous sol-gel method is a powerful and cost-effective technique for the synthesis of high pure ZnO-NPs. While the anticancer activities of ZnO-NPs on both MCF7 and PC3 were determined by MTT assay. Characterizations of ZnO-NPs were fundamentally evaluated by their morphological and structural properties, in addition to their particle size distribution with the aid of SEM and EDX, respectively. ZnO NPs were successfully prepared using sol-gel method in a range of nano-scale. Scanning electron microscopy (SEM) has shown flower-like nanoparticles of zinc oxide, their nano-size has ranged from 4.497 nm. to 143.7 nm. Results of EDX characterization has exhibited a good purity of ZnO-NPs (zinc content of 50% and Oxygen content of 50 %). There was size-dependent effectiveness of ZnO-NPs as an anticancer agent on both MCF7 and PC3. In addition, there were positive correlation between anticancer activities and low toxicity with the size of ZnO-NPs. At 12.2 μg/ml, ZnO-NPs has exhibited around 51% reduction in the viability of cancerous cells. In conclusion, the results of this study have shown that there was an effective and notable dose-dependent manner in the treatment of MCF7 and PC3 with ZnO-NPs, in the cell line approaches. 

scholarly journals Optical Properties of Sn Doped ZnO Thin Film Prepared Using Sol-Gel Method for Optical Limiting Application

2021 ◽  
Vol 24 (3) ◽  
pp. 38-42
Author(s):  
Marwa Mudfer Alqaisi ◽  
◽  
Alla J. Ghazai ◽  
Keyword(s):  
Thin Films ◽  
Zinc Oxide ◽  
Optical Properties ◽  
Sol Gel ◽  
Visible Region ◽  
Optical Limiting ◽  
Pure Zinc ◽  
Gel Method ◽  
Sol Gel Method ◽  
Doped Zno

In this work, pure Zinc oxide and tin doped Zinc oxide thin films nanoparticles with various volume concentrations of 2, 4, 6, and 8V/V% were prepared by using the sol-gel method. The optical properties were investigated by using UV-Visible spectroscope, and the value exhibits the direct allowed transition. The average of transmittance was around ~(17-23) %in visible region. The optical energy band gap was calculated with wavelength (300-900) nm for pure ZnO and Sn doped ZnO thin films which decreases with increasing concentration from 3.4 eV to 3.1 eV respectively and red shift. The real dielectric(εr) and the imaginary dielectric εiare the same behavior of the refractive index(n) the extinction coefficient (k) respectively. The optical limiting properties were studied by using an SDL laser with a wavelength of 235 nm. ZnO and doping thin films an found efficient as optic limiting and depend on the concentration of the all samples.

scholarly journals Growth and Characterization of Indium-Doped Zinc Oxide Thin Films Prepared by Sol-Gel Method

2012 ◽  
Vol 121 (1) ◽  
pp. 217-220 ◽  
Author(s):  
M.S. Kim ◽  
K.G. Yim ◽  
S. Kim ◽  
G. Nam ◽  
D.Y. Lee ◽  
...  
Keyword(s):  
Thin Films ◽  
Zinc Oxide ◽  
Sol Gel ◽  
Oxide Thin Films ◽  
Gel Method ◽  
Sol Gel Method

Structural and Physical Characterisation of Zinc Oxide Thin Films Prepared from Zinc Acetate via the Sol-gel Method

2007 ◽  
Vol 1035 ◽  
Author(s):  
Shane O'Brien ◽  
Lee H.K. Koh ◽  
Mehmet Copuroglu ◽  
Gabriel M. Crean
Keyword(s):  
Zinc Oxide ◽  
Film Thickness ◽  
Zinc Acetate ◽  
Annealing Temperature ◽  
Sol Gel ◽  
Major Influence ◽  
Acetate Concentration ◽  
Gel Method ◽  
Sol Gel Method ◽  
Zinc Oxide Films

AbstractThe influence of zinc acetate concentration in the range 0.3 – 1.3M and annealing temperature in the range 450 – 550°C on the microstructure of zinc oxide films prepared by the sol-gel method was investigated. Zinc acetate concentration of the sol-gel deposited was found to be the major influence on the microstructure and in particular c-axis or (002) preferred orientation of the resulting film, due to its impact on film thickness, for a single sol-gel deposition employing fixed deposition conditions. Preferentially (002) orientated films were obtained from 0.3M zinc acetate sol-gels. However, an increase in zinc acetate concentration resulted in an increase in film thickness and a loss of preferentially (002) orientation. It was found that thick preferentially (002) oriented films could be produced by using multiple depositions of a 0.7M zinc acetate sol-gel using higher drying temperatures.

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