scholarly journals A Review of Markers in Ayurveda for Anti-Inflammatory Drugs

2021 ◽  
Vol 12 (2) ◽  
pp. 1602-1610
Author(s):  
Vineetha R ◽  
Vijey Aanandhi M ◽  
Shanmugasundaram P ◽  
Binoy Varghese Cherian E
Keyword(s):  
Analytical Techniques ◽  
Ayurvedic Medicine ◽  
Special Importance ◽  
Hyphenated Techniques ◽  
Ich Guidelines ◽  
Validation Parameters ◽  
Analytical Development ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Action

From the ancient days itself the ayurvedic medicine has special importance. This ayurvedic system of medicine originated in India. In India nearly 70% of people use ayurvedic system of medicine along the western system of medicine. The Ayurveda mainly come under three classes are vata, pitta and the kapha. Chemically identified constituents of an herbal medicine that are of concern for quality control purposes are known as markers. Some of the markers are widely used for anti-inflammatory agents are Boswellia, sunthi, gokshuru, guduchi, guggulu  this marker possess anti-inflammatory action that reduces pain, swelling of joints, Arthritis, joint complaints, Muscular injuries etc. The chromatographical / spectroscopical analytical development can be done for markers. The analytical development possess the way to the analytical information about the markers. The technique such as HPLC, HPTLC, LC-MS, UPLC-PDA are properly validated by ICH guidelines using validation parameters such as accuracy, recovery, precision, LOD, LOQ, Robustness etc. For many markers there is lack of development of Hyphenated techniques. By increasing the analytical techniques, research is prone to be more effective and successful to promote quality, safety and efficacy.

scholarly journals Peripheral Tramadol in Dentistry: A New Use for an Old Drug

2016 ◽  
Vol 18 (2) ◽  
pp. 10
Author(s):  
Daniel Chavarría DDS, MSc, PhD ◽  
Amaury Pozos DDS, MSc, PhD
Keyword(s):  
Adverse Effects ◽  
Opioid Receptors ◽  
Analgesic Effect ◽  
Health Sciences ◽  
Analgesic Drug ◽  
Orofacial Region ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
New Perspective ◽  
Inflammatory Action

Tramadol is a well known central acting analgesic drug, used in a wide variety of treatments within health sciences; including dentistry. Due to its lack of anti-inflammatory action and some adverse effects related mainly to opioid receptors agonism, it is not use as a routine alternative; keeping mainly for patients allergic to non-steroideal anti-inflammatory drugs or as an adjuvant to manage severe odontogenic pain.  Since new available evidence supports the possible analgesic effect of this drug when is applied locally in different sites, recent reports have been done to explore the same effect in the orofacial region, especially to improve the local management of odontogenic pain. This new perspective article summarize some of the current efforts develop to explore the peripheral Tramadol in dentistry; “a new use for an old drug”. 

scholarly journals Peripheral Tramadol in Dentistry: A New Use for an Old Drug

2016 ◽  
Vol 18 (2) ◽  
pp. 10
Author(s):  
Daniel Chavarría DDS, MSc, PhD ◽  
Amaury Pozos DDS, MSc, PhD
Keyword(s):  
Adverse Effects ◽  
Opioid Receptors ◽  
Analgesic Effect ◽  
Health Sciences ◽  
Analgesic Drug ◽  
Orofacial Region ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
New Perspective ◽  
Inflammatory Action

Tramadol is a well known central acting analgesic drug, used in a wide variety of treatments within health sciences; including dentistry. Due to its lack of anti-inflammatory action and some adverse effects related mainly to opioid receptors agonism, it is not use as a routine alternative; keeping mainly for patients allergic to non-steroideal anti-inflammatory drugs or as an adjuvant to manage severe odontogenic pain.  Since new available evidence supports the possible analgesic effect of this drug when is applied locally in different sites, recent reports have been done to explore the same effect in the orofacial region, especially to improve the local management of odontogenic pain. This new perspective article summarize some of the current efforts develop to explore the peripheral Tramadol in dentistry; “a new use for an old drug”. 

scholarly journals Evaluation oEvaluation of anti-inflammatory action of Laurus nobilis-an in vitro studyf anti-inflammatory action of Laurus nobilis-an in vitro study

2019 ◽  
Vol 10 (2) ◽  
pp. 1209-1213 ◽  
Author(s):  
Maajida Aafreen M ◽  
Geetha RV ◽  
Lakshmi Thangavelu
Keyword(s):  
Protein Denaturation ◽  
In Vitro Study ◽  
Flowering Plant ◽  
Laurus Nobilis ◽  
Inflammatory Drugs ◽  
Medicinal Properties ◽  
Anti Inflammatory ◽  
Inflammatory Action ◽  
Denaturation Of Proteins

Bay leaf is also called as Laurus nobilis an aromatic evergreen tree or large shrub with green, glabrous leaves, in the flowering plant family Lauraceae. It is native to the Mediterranean region and is used as a bay leaf for seasoning in cooking. Its common names include bay laurel, sweet bay, bay (esp. United Kingdom) true laurel, Grecian laurel, laurel tree or simply laurel. Bay leaf refers to the aromatic leaves of several plants which are used in cooking for their distinctive flavour and fragrance. It has many medicinal properties which can also be used to treat cancer as well as gastric problems. Bay leaf is also commonly used to treat muscles and joint pain. Aqueous extracts of bay laurel can also be used as astringents and even as a reasonable salve for open wounds. The anti-inflammatory activity of bay leaf was determined but its ability to inhibit protein denaturation where denaturation of proteins is a well-documented cause of inflammation. The anti-inflammatory effect of the herb was comparable to reference analgesics and non-steroid anti-inflammatory drugs. The present study makes the herb worthy of further investigation.

scholarly journals Analge­tic and Anti-Inflammatory Therapy in Early Postoperative Period in Patients with Injuries and Diseases of Loco-Motor System

2005 ◽  
Vol 12 (1) ◽  
pp. 46
Author(s):  
L. L Silin ◽  
A. V Garkavi ◽  
A. E Pikhlak ◽  
S. M Mezhidov
Keyword(s):  
Drug Therapy ◽  
Motor System ◽  
Pain Syndrome ◽  
Early Postoperative Period ◽  
Control Group ◽  
Complex Treatment ◽  
Local Inflammatory Reaction ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Action

A protocol for gradual use of nonsteroid anti-inflammatory drugs with mainly analgetic action (Ketorol) and mainly anti-inflammatory action (Nise) are suggested for complex treatment after operations on loco-motor system. It is shown that the protocol (applied in 38 patients) allows to cup off both pain syndrome and local inflammatory reaction in the operation zone more effective as compared with the routine drug therapy (40 patients — control group).

scholarly journals Uso de medicamentos fitoterápicos como opção anti-inflamátoria na odontologia

2020 ◽  
Vol 11 (2) ◽  
pp. 167
Author(s):  
Vivian Lopes Moreira ◽  
Andréa Padre Peixoto ◽  
Antônio Marcio Teixeira Marchionni
Keyword(s):  
Cost Reduction ◽  
Observational Studies ◽  
Therapeutic Option ◽  
Herbal Medicines ◽  
Unified Health System ◽  
Primary Health ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
The Cost ◽  
Inflammatory Action

The term phytotherapy comes from the Latin, "phyton" which means plant, and "therapy" related to treatment, whose first handwritten account in 1500 BC entitled "Papers of Ebers". Phytotherapy is the science that uses plants for the treatment of various human diseases. In Brazil, studies show an interest of the Unified Health System (SUS) regarding herbal medicines between the 70s and 80s, mainly in primary health care due to the cost reduction, however few observational studies are found in the literature regarding their use in the system. The present study is a literature review in order to report the main herbal medicines with anti-inflammatory action, as a therapeutic option for patients who cannot or do not wish to use non-steroidal anti-inflammatory drugs (NSAIDs). For its construction, a search was performed for articles in the PubMed, Scielo and BVSalud databases, with a timeline established from 2009 to 2020. It was concluded that herbal medicines can be used as a safe therapeutic alternative in replacement of NSAIDs, as it offers a similar mechanism of action and reduced or even zero side effects. Thus, it can become a reality in dental practice by Dental Surgeons.

scholarly journals Chemomicrobiomic analysis of glucosamine sulfate, prebiotics and non-steroidal anti-inflammatory drugs

2020 ◽  
Vol 13 (3) ◽  
pp. 270-282
Author(s):  
O. A. Gromova ◽  
I. Yu. Torshin ◽  
A. V. Naumov ◽  
V. A. Maksimov
Keyword(s):  
Pathogenic Bacteria ◽  
Human Microbiome ◽  
Area Under The Curve ◽  
Inhibitory Effect ◽  
Glucosamine Sulfate ◽  
Pharmaceutical Drugs ◽  
Representative Sampling ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Action

Introduction. The pharmaceutical drugs used in the treatment of osteoarthritis (OA) differ not only in the mechanisms of anti-inflammatory action but also in the effects on the human microbiome.Purpose. Evaluation of the influence of some drugs used in the therapy of OA on the human microbiome by the method of chemoinformation analysis.Materials and methods. Сomparative chemomicrobiome analysis of glucosamine sulfate (GS), diclofenac, acetylsalicylic acid (ASA), and three prebiotics (lactose, lactulose, fructose) as molecules of comparison. For each substance, estimates of the area under the curve (AUC) were obtained for a representative sampling of human microbiota (38 commensal bacteria). The minimum inhibitory concentrations (MIC) were established for more than 120 pathogenic bacteria.Results. On average, according to a representative sampling of microbiota, the profile of the action of GS on the microbiome was almost identical to the profile of the action of lactose (AUC=0.23±0.18). The most effective growth of the microbiome was provided by fructose and lactulose (AUC=0.58±0.21). The effects of diclofenac and ASA on the commensals of microbiome were comparable to the effects of GS (AUC=0.27±0.22). However, the analysis of the obtained MIC values for pathogenic bacteria showed that diclofenac supported the growth of the pathogenic flora (MIC=35±1.4 μg/ml) to a greater extent than GS (MIC=16±1.5 μg/ml) and ASA (MIC=23±2.2 μg/ml).Conclusion. The effects of GS on the microbiome are comparable to the effects of the prebiotic lactose whereas the inhibitory effect of GS and ASA on pathogenic bacteria is more pronounced than that of diclofenac. The inhibition of pathogenic bacteria by the GS helps to reduce inflammation.

scholarly journals EVALUATION OF BIOACTIVE CONSTITUENTS AND IN-VIVO ANTI-INFLAMATORY ACTIVITY OF HYDROALCOHOLIC LEAVES EXTRACT OF GREWIA HIRSUTA

2021 ◽  
Vol 10 (2) ◽  
pp. 09-14
Author(s):  
Mr. Mahendra Jaiswal ◽  
Dr. C.K. Tyagi ◽  
Dr. Prabhakar Budholiya
Keyword(s):  
New Drugs ◽  
Phytochemical Analysis ◽  
Bioactive Constituents ◽  
Current Article ◽  
Inflammatory Drugs ◽  
Phytochemical Profile ◽  
Anti Inflammatory ◽  
Transnational Industries ◽  
Inflammatory Action

Plants represent the main source of molecules for the development of new drugs, which intensifies the interest of transnational industries in searching for substances obtained from plant sources, especially since the vast majority of species have not yet been studied chemically or biologically, particularly concerning anti-inflammatory action. Anti-inflammatory drugs can interfere in the pathophysiological process of inflammation, to minimize tissue damage and provide greater comfort to the patient. Therefore, it is important to note that due to the existence of a large number of species available for research, the successful development of new naturally occurring anti-inflammatory drugs depends mainly on a multidisciplinary effort to find new molecules. Although many review articles have been published in this regard, the majority presented the subject from a limited regional perspective. Thus, the current article presents highlights from the published literature on plants as sources of anti-inflammatory agents. A search for effective medication with lesser or no side effects is the need of the hour. Hence the current study is focused at evaluating the anti-inflamatory  potential of Grewia hirsuta. The leaves of G. hirsuta were subjected to solvent extraction with ethanol. The best screened extract was further evaluated for it phytochemical profile by qualitative and quantitative phytochemical analysis. The results of the study suggest that Grewia hirsuta possesses significant anti-inflamatory potential. With further mechanistic studies it can be proved as a better source of natural anti-inflamatory agents.  

scholarly journals Plants as Sources of Anti-Inflammatory Agents

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3726 ◽  
Author(s):  
Clara dos Reis Nunes ◽  
Mariana Barreto Arantes ◽  
Silvia Menezes de Faria Pereira ◽  
Larissa Leandro da Cruz ◽  
Michel de Souza Passos ◽  
...  
Keyword(s):  
New Drugs ◽  
Naturally Occurring ◽  
Current Article ◽  
Inflammatory Drugs ◽  
The Subject ◽  
Anti Inflammatory ◽  
Transnational Industries ◽  
Plant Sources ◽  
Minimize Tissue Damage ◽  
Inflammatory Action

Plants represent the main source of molecules for the development of new drugs, which intensifies the interest of transnational industries in searching for substances obtained from plant sources, especially since the vast majority of species have not yet been studied chemically or biologically, particularly concerning anti-inflammatory action. Anti-inflammatory drugs can interfere in the pathophysiological process of inflammation, to minimize tissue damage and provide greater comfort to the patient. Therefore, it is important to note that due to the existence of a large number of species available for research, the successful development of new naturally occurring anti-inflammatory drugs depends mainly on a multidisciplinary effort to find new molecules. Although many review articles have been published in this regard, the majority presented the subject from a limited regional perspective. Thus, the current article presents highlights from the published literature on plants as sources of anti-inflammatory agents.

DETERMINATION OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS ADULTERATED IN HERBAL MEDICINES BY LC-MS/MS

2018 ◽  
Vol 8 (3) ◽  
pp. 70-76
Author(s):  
Minh Dao Thi Cam ◽  
Chau Thai Khoa Bao ◽  
Dung Tran Huu ◽  
Ha Pham Thi Thanh ◽  
Anh Nguyen Thi Kieu
Keyword(s):  
Herbal Medicines ◽  
Correlation Coefficients ◽  
Herbal Medicinal Products ◽  
Ich Guidelines ◽  
Traditional Remedy ◽  
Key Words Paracetamol ◽  
Positive Mode ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Background: Nonsteroidal anti-inflammatory drugs commonly adulterated in herbal medicines, especially in products used in the treatment and supportive treatment of osteoarthritis, have caused a lot of toxicities, catastrophes for the sick. Objectives: Determination paracetamol, piroxicam, indomethacin and ketoprofen adultered in herbal medicines by LC-MS/MS; applied methods in real herbal preparations. Materials and methods: Blank matrix is based on a traditional remedy (Vietnam Pharmacopeia IV). The analytical method is developed and validated in accordance with AOAC and ICH guidelines. Results: The simple and rapid extraction method gives high extraction efficiency (over 85%). LC-MS condition using Electrospray Ionization technique with positive mode separated 4 substances clearly with good peak shapes and relatively short retention time, a low detection limit (0.076-0.5ng/ml), correlation coefficients r> 0.995; Repeatability meets AOAC requirements. Conclusions: Developed a method for the simultaneous analysis of paracetamol, piroxicam, indomethacin, and ketoprofen that can be mixed illegally in herbal medicines. Detected 3 positive samples with paracetamol, indomethacin in herbal medicinal products on the market. Key words: Paracetamol, piroxicam, indomethacin, ketoprofen, herbal medicines, LC-MS/MS

scholarly journals Efficacy of an Analgesic and Anti-inflammatory Ayurvedic Medicine to Control Postoperative Pain

2015 ◽  
Vol 6 (3) ◽  
pp. 164-168 ◽  
Author(s):  
Mukul Padhye ◽  
Suraj Pawar ◽  
Geetanjali Mandlik ◽  
Swapana Nayan ◽  
Maina Gite ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Healing Process ◽  
Study Drug ◽  
Ayurvedic Medicine ◽  
High Dose ◽  
Oral Surgical Procedures ◽  
Adequate Pain Relief ◽  
Stomach Acid ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

ABSTRACT Years ago, narcotics have been used as strong analgesics in relieving severe acute or chronic pain. However high dose of narcotics leads to many side-effects like respiratory depression, apnea, nausea, vomiting, physical and mental dependence, etc. Thus, narcotics along with other medicines known as nonsteroidal anti-inflammatory drugs (NSAIDs) are being increasingly used. The biggest risk with NSAIDs is severe and sometimes fatal gastrointestinal bleeding, increase in stomach acid, reduce the stomach's normal protective mucus layer, cause damage to the kidneys in people over 60; those with high blood pressure, heart disease, or pre-existing kidney disease. Ayurvedic medicines strengthen and enhance the body's own healing process. As all the ingredients are herbal, there is no fear of any adverse effects and hence effective results can be seen in relieving pain. The aim of our study is to evaluate the effectiveness of the study drug in providing efficient and adequate pain relief after minor oral surgical procedures. How to cite this article Mandlik G, Nayan S, Gite M, Padhye M, Pawar S, Vinit P, Aishwarya N, Shruti K. Efficacy of an Analgesic and Anti-inflammatory Ayurvedic Medicine to Control Postoperative Pain. World J Dent 2015;6(3):164-168.

Sign in / Sign up

Export Citation Format

Share Document