scholarly journals Plants as Sources of Anti-Inflammatory Agents

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3726 ◽  
Author(s):  
Clara dos Reis Nunes ◽  
Mariana Barreto Arantes ◽  
Silvia Menezes de Faria Pereira ◽  
Larissa Leandro da Cruz ◽  
Michel de Souza Passos ◽  
...  
Keyword(s):  
New Drugs ◽  
Naturally Occurring ◽  
Current Article ◽  
Inflammatory Drugs ◽  
The Subject ◽  
Anti Inflammatory ◽  
Transnational Industries ◽  
Plant Sources ◽  
Minimize Tissue Damage ◽  
Inflammatory Action

Plants represent the main source of molecules for the development of new drugs, which intensifies the interest of transnational industries in searching for substances obtained from plant sources, especially since the vast majority of species have not yet been studied chemically or biologically, particularly concerning anti-inflammatory action. Anti-inflammatory drugs can interfere in the pathophysiological process of inflammation, to minimize tissue damage and provide greater comfort to the patient. Therefore, it is important to note that due to the existence of a large number of species available for research, the successful development of new naturally occurring anti-inflammatory drugs depends mainly on a multidisciplinary effort to find new molecules. Although many review articles have been published in this regard, the majority presented the subject from a limited regional perspective. Thus, the current article presents highlights from the published literature on plants as sources of anti-inflammatory agents.

scholarly journals EVALUATION OF BIOACTIVE CONSTITUENTS AND IN-VIVO ANTI-INFLAMATORY ACTIVITY OF HYDROALCOHOLIC LEAVES EXTRACT OF GREWIA HIRSUTA

2021 ◽  
Vol 10 (2) ◽  
pp. 09-14
Author(s):  
Mr. Mahendra Jaiswal ◽  
Dr. C.K. Tyagi ◽  
Dr. Prabhakar Budholiya
Keyword(s):  
New Drugs ◽  
Phytochemical Analysis ◽  
Bioactive Constituents ◽  
Current Article ◽  
Inflammatory Drugs ◽  
Phytochemical Profile ◽  
Anti Inflammatory ◽  
Transnational Industries ◽  
Inflammatory Action

Plants represent the main source of molecules for the development of new drugs, which intensifies the interest of transnational industries in searching for substances obtained from plant sources, especially since the vast majority of species have not yet been studied chemically or biologically, particularly concerning anti-inflammatory action. Anti-inflammatory drugs can interfere in the pathophysiological process of inflammation, to minimize tissue damage and provide greater comfort to the patient. Therefore, it is important to note that due to the existence of a large number of species available for research, the successful development of new naturally occurring anti-inflammatory drugs depends mainly on a multidisciplinary effort to find new molecules. Although many review articles have been published in this regard, the majority presented the subject from a limited regional perspective. Thus, the current article presents highlights from the published literature on plants as sources of anti-inflammatory agents. A search for effective medication with lesser or no side effects is the need of the hour. Hence the current study is focused at evaluating the anti-inflamatory  potential of Grewia hirsuta. The leaves of G. hirsuta were subjected to solvent extraction with ethanol. The best screened extract was further evaluated for it phytochemical profile by qualitative and quantitative phytochemical analysis. The results of the study suggest that Grewia hirsuta possesses significant anti-inflamatory potential. With further mechanistic studies it can be proved as a better source of natural anti-inflamatory agents.  

scholarly journals Peripheral Tramadol in Dentistry: A New Use for an Old Drug

2016 ◽  
Vol 18 (2) ◽  
pp. 10
Author(s):  
Daniel Chavarría DDS, MSc, PhD ◽  
Amaury Pozos DDS, MSc, PhD
Keyword(s):  
Adverse Effects ◽  
Opioid Receptors ◽  
Analgesic Effect ◽  
Health Sciences ◽  
Analgesic Drug ◽  
Orofacial Region ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
New Perspective ◽  
Inflammatory Action

Tramadol is a well known central acting analgesic drug, used in a wide variety of treatments within health sciences; including dentistry. Due to its lack of anti-inflammatory action and some adverse effects related mainly to opioid receptors agonism, it is not use as a routine alternative; keeping mainly for patients allergic to non-steroideal anti-inflammatory drugs or as an adjuvant to manage severe odontogenic pain.  Since new available evidence supports the possible analgesic effect of this drug when is applied locally in different sites, recent reports have been done to explore the same effect in the orofacial region, especially to improve the local management of odontogenic pain. This new perspective article summarize some of the current efforts develop to explore the peripheral Tramadol in dentistry; “a new use for an old drug”. 

scholarly journals An Ethanolic Extract of Boehmeria caudata Aerial Parts Displays Anti-inflammatory and Anti-tumor Activities

2020 ◽  
Vol 7 (01) ◽  
pp. e17-e25 ◽  
Author(s):  
Paula Pereira de Paiva ◽  
Fabiana Regina Nonato ◽  
Ana Lúcia Tasca Gois Ruiz ◽  
Ilza Maria de Oliveira Sousa ◽  
Rafael Rosolen Teixeira Zafred ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Ethanolic Extract ◽  
Experimental Models ◽  
New Drugs ◽  
Antiproliferative Effects ◽  
Aerial Parts ◽  
Anti Inflammatory ◽  
Inflammatory Action ◽  
Effective Source

AbstractThe tumor microenvironment presents several therapeutic targets, with inflammation being one of them. In search of new drugs, plants have shown to be an effective source of potent anti-inflammatory and anticancer agents. This study aimed to evaluate the antitumoral and inflammatory activities of Boehmeria caudata aerial parts extract. Bioguided in vitro antiproliferative screening showed that phenanthroquinolizidine obtained from the aerial B. caudata ethanolic extract had a straight relationship with activity. Moreover, the orally administered ethanolic extract reduced Ehrlich solid tumor growth and displayed an anti-inflammatory effect in both evaluated experimental models (carrageenan-induced paw edema and croton oil-induced ear edema). These results suggest that the antitumor activity of the ethanolic extract could be explained by antiproliferative effects associated with anti-inflammatory action.

scholarly journals A Review of Markers in Ayurveda for Anti-Inflammatory Drugs

2021 ◽  
Vol 12 (2) ◽  
pp. 1602-1610
Author(s):  
Vineetha R ◽  
Vijey Aanandhi M ◽  
Shanmugasundaram P ◽  
Binoy Varghese Cherian E
Keyword(s):  
Analytical Techniques ◽  
Ayurvedic Medicine ◽  
Special Importance ◽  
Hyphenated Techniques ◽  
Ich Guidelines ◽  
Validation Parameters ◽  
Analytical Development ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Action

From the ancient days itself the ayurvedic medicine has special importance. This ayurvedic system of medicine originated in India. In India nearly 70% of people use ayurvedic system of medicine along the western system of medicine. The Ayurveda mainly come under three classes are vata, pitta and the kapha. Chemically identified constituents of an herbal medicine that are of concern for quality control purposes are known as markers. Some of the markers are widely used for anti-inflammatory agents are Boswellia, sunthi, gokshuru, guduchi, guggulu  this marker possess anti-inflammatory action that reduces pain, swelling of joints, Arthritis, joint complaints, Muscular injuries etc. The chromatographical / spectroscopical analytical development can be done for markers. The analytical development possess the way to the analytical information about the markers. The technique such as HPLC, HPTLC, LC-MS, UPLC-PDA are properly validated by ICH guidelines using validation parameters such as accuracy, recovery, precision, LOD, LOQ, Robustness etc. For many markers there is lack of development of Hyphenated techniques. By increasing the analytical techniques, research is prone to be more effective and successful to promote quality, safety and efficacy.

scholarly journals Pharmacological activity and mechanism of action of plants with anti-inflammatory properties found in brazilian flora

2021 ◽  
Vol 13 (1) ◽  
pp. e5663
Author(s):  
Kessya Lanny Sousa Dantas ◽  
Kassyo Lenno Sousa Dantas ◽  
Eduardo Soares Dos Santos ◽  
Júlio Evangelista De Lucena ◽  
Milena Sousa Freitas ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Therapeutic Potential ◽  
New Drugs ◽  
Mentha Piperita ◽  
The Social ◽  
Brazilian Flora ◽  
Anti Inflammatory ◽  
New Treatments ◽  
Inflammatory Action

Objective: To describe the importance of medicinal plants in the social and pharmacological context, demonstrating the anti-inflammatory therapeutic potential and the mechanism of action of drugs present in the chemical composition of four plants present in the Brazilian flora. Methods: A bibliographic survey on the topic was carried out, using the descriptors: Activity, Anti-inflammatory, Plants, Flora, Brazilian. In Scielo, Google Scholar and PUBMED databases. For the inclusion of works, the following criteria were used: Articles from research relevant to the topic (regardless of date) and relevant publications from the year 2007. Results: The inflammatory process is a target for the treatment of various diseases and development new treatments are needed. We discuss here the anti-inflammatory potential and the mechanism of action of the following plants: Uncaria tomentosa, Schinus terebinthifolius Raddi and Mentha piperita demonstrated through in vitro studies and murine models of diseases. The species showed anti-inflammatory action by reducing the production of inflammatory mediators and inhibiting the activity of important pro-inflammatory enzymes, such as phospholipase A2 and cycloxygenase. Final considerations: The four plant species covered in this article had significant anti-inflammatory effects, therefore, they can be suggested as a source of potential new drugs.

Naproxen (naprosyn) and ketoprofen (orudis)

1974 ◽  
Vol 12 (7) ◽  
pp. 25-27
Keyword(s):  
Prostaglandin Synthesis ◽  
New Drugs ◽  
Inflammatory Activity ◽  
Inhibit Prostaglandin Synthesis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Low Incidence ◽  
Gastric Irritation

Naproxen (Naprosyn - Syntex) and ketoprofen (Orudis - M & B) are new drugs for treating various forms of arthropathy. For both drugs the manufacturers claim good anti-inflammatory activity with a low incidence of unwanted effects, particularly gastric irritation, in comparison with other non-steroidal anti-inflammatory drugs. If these claims can be substantiated these preparations would be valuable. Like aspirin and other non-steroidal anti-inflammatory drugs they both inhibit prostaglandin synthesis. Both are chemically related to other such drugs, for example ibuprofen (Brufen - Boots).

scholarly journals Peripheral Tramadol in Dentistry: A New Use for an Old Drug

2016 ◽  
Vol 18 (2) ◽  
pp. 10
Author(s):  
Daniel Chavarría DDS, MSc, PhD ◽  
Amaury Pozos DDS, MSc, PhD
Keyword(s):  
Adverse Effects ◽  
Opioid Receptors ◽  
Analgesic Effect ◽  
Health Sciences ◽  
Analgesic Drug ◽  
Orofacial Region ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
New Perspective ◽  
Inflammatory Action

Tramadol is a well known central acting analgesic drug, used in a wide variety of treatments within health sciences; including dentistry. Due to its lack of anti-inflammatory action and some adverse effects related mainly to opioid receptors agonism, it is not use as a routine alternative; keeping mainly for patients allergic to non-steroideal anti-inflammatory drugs or as an adjuvant to manage severe odontogenic pain.  Since new available evidence supports the possible analgesic effect of this drug when is applied locally in different sites, recent reports have been done to explore the same effect in the orofacial region, especially to improve the local management of odontogenic pain. This new perspective article summarize some of the current efforts develop to explore the peripheral Tramadol in dentistry; “a new use for an old drug”. 

scholarly journals Evaluation oEvaluation of anti-inflammatory action of Laurus nobilis-an in vitro studyf anti-inflammatory action of Laurus nobilis-an in vitro study

2019 ◽  
Vol 10 (2) ◽  
pp. 1209-1213 ◽  
Author(s):  
Maajida Aafreen M ◽  
Geetha RV ◽  
Lakshmi Thangavelu
Keyword(s):  
Protein Denaturation ◽  
In Vitro Study ◽  
Flowering Plant ◽  
Laurus Nobilis ◽  
Inflammatory Drugs ◽  
Medicinal Properties ◽  
Anti Inflammatory ◽  
Inflammatory Action ◽  
Denaturation Of Proteins

Bay leaf is also called as Laurus nobilis an aromatic evergreen tree or large shrub with green, glabrous leaves, in the flowering plant family Lauraceae. It is native to the Mediterranean region and is used as a bay leaf for seasoning in cooking. Its common names include bay laurel, sweet bay, bay (esp. United Kingdom) true laurel, Grecian laurel, laurel tree or simply laurel. Bay leaf refers to the aromatic leaves of several plants which are used in cooking for their distinctive flavour and fragrance. It has many medicinal properties which can also be used to treat cancer as well as gastric problems. Bay leaf is also commonly used to treat muscles and joint pain. Aqueous extracts of bay laurel can also be used as astringents and even as a reasonable salve for open wounds. The anti-inflammatory activity of bay leaf was determined but its ability to inhibit protein denaturation where denaturation of proteins is a well-documented cause of inflammation. The anti-inflammatory effect of the herb was comparable to reference analgesics and non-steroid anti-inflammatory drugs. The present study makes the herb worthy of further investigation.

scholarly journals Analge­tic and Anti-Inflammatory Therapy in Early Postoperative Period in Patients with Injuries and Diseases of Loco-Motor System

2005 ◽  
Vol 12 (1) ◽  
pp. 46
Author(s):  
L. L Silin ◽  
A. V Garkavi ◽  
A. E Pikhlak ◽  
S. M Mezhidov
Keyword(s):  
Drug Therapy ◽  
Motor System ◽  
Pain Syndrome ◽  
Early Postoperative Period ◽  
Control Group ◽  
Complex Treatment ◽  
Local Inflammatory Reaction ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Action

A protocol for gradual use of nonsteroid anti-inflammatory drugs with mainly analgetic action (Ketorol) and mainly anti-inflammatory action (Nise) are suggested for complex treatment after operations on loco-motor system. It is shown that the protocol (applied in 38 patients) allows to cup off both pain syndrome and local inflammatory reaction in the operation zone more effective as compared with the routine drug therapy (40 patients — control group).

scholarly journals Uso de medicamentos fitoterápicos como opção anti-inflamátoria na odontologia

2020 ◽  
Vol 11 (2) ◽  
pp. 167
Author(s):  
Vivian Lopes Moreira ◽  
Andréa Padre Peixoto ◽  
Antônio Marcio Teixeira Marchionni
Keyword(s):  
Cost Reduction ◽  
Observational Studies ◽  
Therapeutic Option ◽  
Herbal Medicines ◽  
Unified Health System ◽  
Primary Health ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
The Cost ◽  
Inflammatory Action

The term phytotherapy comes from the Latin, "phyton" which means plant, and "therapy" related to treatment, whose first handwritten account in 1500 BC entitled "Papers of Ebers". Phytotherapy is the science that uses plants for the treatment of various human diseases. In Brazil, studies show an interest of the Unified Health System (SUS) regarding herbal medicines between the 70s and 80s, mainly in primary health care due to the cost reduction, however few observational studies are found in the literature regarding their use in the system. The present study is a literature review in order to report the main herbal medicines with anti-inflammatory action, as a therapeutic option for patients who cannot or do not wish to use non-steroidal anti-inflammatory drugs (NSAIDs). For its construction, a search was performed for articles in the PubMed, Scielo and BVSalud databases, with a timeline established from 2009 to 2020. It was concluded that herbal medicines can be used as a safe therapeutic alternative in replacement of NSAIDs, as it offers a similar mechanism of action and reduced or even zero side effects. Thus, it can become a reality in dental practice by Dental Surgeons.

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