scholarly journals In Vitro and In Vivo Evaluation of Antibiotic Combinations against Multidrug Resistant Proteus Mirabilis Isolated from Admitted Patients of Dhaka Medical College Hospital, Dhaka

2021 ◽  
Vol 05 (03) ◽  
Author(s):  
Rizwana Zaman ◽  
S.M. Shamsuzzaman
Keyword(s):  
Proteus Mirabilis ◽  
Multidrug Resistant ◽  
Medical College Hospital ◽  
In Vivo Evaluation ◽  
College Hospital ◽  
Medical College

scholarly journals In vitro fertilization (IVF) centre at Dhaka Medical College Hospital - A New hope for Infertile couple!

2021 ◽  
Vol 28 (2) ◽  
pp. 129-130
Author(s):  
Nilufar Sultana
Keyword(s):  
In Vitro Fertilization ◽  
Medical College Hospital ◽  
Infertile Couple ◽  
College Hospital ◽  
Vitro Fertilization ◽  
Medical College

Abstract not available J Dhaka Medical College, Vol. 28, No.2, October, 2019, Page 129-130

scholarly journals Characterization of extended spectrum β-Lactamase producing bactieria isolated from urinary tract infections

2019 ◽  
Vol 45 (1) ◽  
pp. 23-33
Author(s):  
Munawar Sultana ◽  
Anowar Khasru Parvez ◽  
Khandokar Fahmida Sultana ◽  
Sanjoy Kumer Mukharje ◽  
M Anwar Hossain
Keyword(s):  
Urinary Tract ◽  
Multidrug Resistant ◽  
Medical College Hospital ◽  
Urine Samples ◽  
Rrna Gene ◽  
College Hospital ◽  
Unique Challenge ◽  
Medical College ◽  
Extended Spectrum ◽  
Tract Infections

Background: A unique challenge for clinical microbiologists, clinicians, infection control professionals is to deal with extended-spectrum β-lactamase (ESBL) producing pathogens. The study was aims to isolate ESBL producing bacteria from urine samples of Urinary Tract Infection (UTI)-patients and to analyses their phenotypic and genotypic characteristics. Methods: A total of 90 urine samples from UTI patients were collected from Enam Medical College Hospital and Gonoshastha Medical College Hospital, Savar, Dhaka, Bangladesh; between May-2012 to August-2012. A total 75gram negative isolates were retrieved and screened for ESBL production by the Double Disk Diffusion Synergy Test (DDST). Isolates with ESBL phenotype were further characterised by antibiotic susceptibility testing, PCR and sequencing of β-lactamase genes. Results: Cultural and biochemical assay combined with 16S rRNA gene based phylogenetic identification confirmed that Escherichia spp. were predominant pathogens associate with UTI (41%), and the rest were distributed within the genus Enterobacter spp. 26%, Klebsiella spp. 21% , and Pseudomonas spp.10%. Total 31 isolates were phenotypically confirmed as ESBLs through DDST. The multidrug resistant (MDR) and ESBL producing bacteria showed high resistance to cefotaxime (96%), cefixime (90%) and imipenem (32%). PCR reaction was carried out targeting the genes blaTEM, blaCTX. Dominant ESBL class was CTX-M (65%) followed by TEM (52%). All ESBL isolates except 7 possesses multiple plasmids indicating possibility of both chromosomal and plasmid inheritance of ESBLs. Conclusions: This study shows a high prevalence of ESBL producing MDR in UTI patients among these two hospitals of Bangladesh indicating the necessity of alternative therapeutic intervention. Bangladesh Med Res Counc Bull 2019; 45: 23-33

scholarly journals In Vitro and In Vivo Evaluation of the Antifungal Activity of APX001A/APX001 against Candida auris

2018 ◽  
Vol 62 (3) ◽  
pp. e02319-17 ◽  
Author(s):  
Christopher L. Hager ◽  
Emily L. Larkin ◽  
Lisa Long ◽  
Fatima Zohra Abidi ◽  
Karen J. Shaw ◽  
...  
Keyword(s):  
Geographical Area ◽  
Multidrug Resistant ◽  
High Morbidity ◽  
Candida Auris ◽  
In Vivo Evaluation ◽  
Content Type ◽  
Log Reduction ◽  
Invasive Infections

ABSTRACT Candida auris is an emerging multidrug-resistant yeast that has been responsible for invasive infections associated with high morbidity and mortality. C. auris strains often demonstrate high fluconazole and amphotericin B MIC values, and some strains are resistant to all three major antifungal classes. We evaluated the susceptibility of 16 C. auris clinical strains, isolated from a wide geographical area, to 10 antifungal agents, including APX001A, a novel agent that inhibits the fungal protein Gwt1 (glycosylphosphatidylinositol-anchored wall transfer protein 1). APX001A demonstrated significantly lower MIC50 and MIC90 values (0.004 and 0.031 μg/ml, respectively) than all other agents tested. The efficacy of the prodrug APX001 was evaluated in an immunocompromised murine model of disseminated C. auris infection. Significant efficacy (80 to 100% survival) was observed in all three APX001 treatment groups versus 50% survival for the anidulafungin treatment group. In addition, APX001 showed a significant log reduction in CFU counts in kidney, lung, and brain tissue (1.03 to 1.83) versus the vehicle control. Anidulafungin also showed a significant log reduction in CFU in the kidneys and lungs (1.5 and 1.62, respectively) but did not impact brain CFU. These data support further clinical evaluation of this new antifungal agent.

Zidovudine in synergistic combination with fosfomycin: an in vitro and in vivo evaluation against multidrug-resistant Enterobacterales

2021 ◽  
pp. 106362
Author(s):  
Roberta Maria Antonello ◽  
Stefano Di Bella ◽  
Jonathan Betts ◽  
Roberto La Ragione ◽  
Raffaela Bressan ◽  
...  
Keyword(s):  
Multidrug Resistant ◽  
In Vivo Evaluation ◽  
Synergistic Combination

scholarly journals Detection of resistance gene marker intl1 and antimicrobial resistance pattern of E. coli isolated from surgical site wound infection in Holy Family Red Crescent Medical College Hospital

2012 ◽  
Vol 4 (2) ◽  
pp. 19-23 ◽  
Author(s):  
Mohammad Murshed ◽  
Sabeena Shahnaz ◽  
Mohammad Abdul Malek
Keyword(s):  
Wound Infection ◽  
Resistance Gene ◽  
Multidrug Resistant ◽  
Medical College Hospital ◽  
Resistance Pattern ◽  
Gene Marker ◽  
College Hospital ◽  
Extended Spectrum Beta Lactamase ◽  
E Coli ◽  
Medical College

This study was carried out to determine the presence of resistance gene intl1 in E. coli isolated from surgical site wound infection in Holy Family Red Crescent Medical College Hospital. A total of 90 samples were collected from the different wound sites of patients admitted in surgical ward. The most predominant organism was E. coli 48(53.33%); followed by S. aureus 23(25.56%) and Pseudomonas 12(13.33%). Most of the isolated strains of E. coli were multidrug resistant. 46(96%) strains were shown resistant to ampicillin and most potent drug against E. coli was found to be imepenem. The extended spectrum Beta-lactamase (ESBL) producing E. coli were 21(43.75%).The resistance gene marker intl1 was detected in 32(67%) E. coli isolates.DOI: http://dx.doi.org/10.3329/bjmm.v4i2.10827 

In vitro and in vivo evaluation of the anti-inflammatory effects of Arzanol from Helichrysum italicum

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
J Bauer ◽  
F Dehm ◽  
A Koeberle ◽  
F Pollastro ◽  
G Appendino ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Anti Inflammatory

Chest Trauma Evaluation and Outcome of Management in a Tertiary Hospital - One Year Experience

2020 ◽  
Vol 22 (2) ◽  
pp. 110-117
Author(s):  
Md Mahmudul Islam ◽  
Khondkar AK Azad ◽  
Md Aminul Islam ◽  
Rivu Raj Chakraborty
Keyword(s):  
Road Traffic Accident ◽  
Traffic Accident ◽  
Chest Trauma ◽  
Road Traffic ◽  
Tube Thoracostomy ◽  
Rib Fracture ◽  
Medical College Hospital ◽  
College Hospital ◽  
Medical College ◽  
The Mean

Background: Chest trauma is responsible for 50% of deaths due to trauma. This kind of death usually occurs immediately after the trauma has occurred. Various therapeutic options have been reported for management of chest injuries like clinical observation, thoracocentesis, tube thoracostomy and open thoracotomy. Objective: To observe the pattern and outcome of management in chest trauma Methods: This is an observational study carried out in Casualty department of Chittagong Medical College Hospital (CMCH), Chittagong, between April 2015 to March 2016. Our study was included all patients, both sexes, following chest injury at Casualty units of Chittagong Medical College Hospital. All the data were recorded through the preformed data collection sheet and analyzed. Result: The mean age was found 37.7±18.1 years with range from 12 to 80 years. Male female ratio was 11.8:1. The mean time elapsed after trauma was found 6.1±3.1 hours with range from 1 to 72 hours. Almost one third (35.7%) patients was affecting road traffic accident followed by 42(27.3%) assault, 35(22.7%) stab injury, 15(9.7%) fall and 7(4.5%) gun shot . More than three fourth (80.5%) patients were managed by tube thoracostomy followed by 28(18.2%) observation and 2(1.3%) ventilatory support. No thoracotomy was done in emergency department. 42(27.2%) patients was found open pneumothorax followed by 41(26.6%) rib fracture, 31(20.1%) haemopneumothorax, 14(9%) simple pneumothorax, 12(7.8%) haemothorax, 6(3.9%) chest wall injury, 5(3.2%) tension pneumothorax, and 3(1.9%) flail chest. About the side of tube 60(39.0%) patients were given tube on left side followed by 57(37.0%) patients on right side, 9(5.8%) patients on both (left & right) side and 28(18.2%) patients needed no tube. Regarding the complications, 13(30%) patients had persistent haemothorax followed by 12(29%)tubes were placed outside triangle of safety, 6(13.9%) tubes were kinked, 6(13.9%) patients developed port side infection, 2(4.5%)tube was placed too shallow, 2(4.5%) patients developed empyema thoracis and 2(4.5%) patients developed bronchopleural fistula. The mean ICT removal information was found 8.8±3.6 days with range from 4 to 18 days. Reinsertion of ICT was done in 6(4.7%) patients. More than two third (68.2%) patients were recovered well, 43(27.9%) patients developed complication and 6(3.9%)patients died. More than two third (66.9%) patients had length of hospital stay 11-20 days. Conclusion: Most of the patients were in 3rd decade and male predominant. Road traffic accident and tube thoracostomy were more common. Open pneumothorax, rib fracture and haemopneumothorax were commonest injuries. Nearly one third of the patients had developed complications. Re-insertion of ICT needed almost five percent and death almost four percent. Journal of Surgical Sciences (2018) Vol. 22 (2) : 110-117

Histopathological study of prostatic lesions in a medical college hospital

2020 ◽  
Vol 3 (3) ◽  
pp. 234-237
Author(s):  
Dr. Avinash Priyadarshi ◽  
Dr. Debi Prosad Dasgupta ◽  
Dr. Ajay Kumar
Keyword(s):  
Medical College Hospital ◽  
Histopathological Study ◽  
College Hospital ◽  
Medical College
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